EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

homomenthyl salicylate
benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester

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CAS Number: 118-56-9Picture of molecule3D/inchi
Other(deleted CASRN):194304-23-9
ECHA EINECS - REACH Pre-Reg:204-260-8
Nikkaji Web:J5.301E
Beilstein Number:2731604
XlogP3-AA:5.00 (est)
Molecular Weight:262.34894000
Formula:C16 H22 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and stabilizers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:colorless to pale yellow clear viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.04800 to 1.05200 @ 25.00 °C.
Pounds per Gallon - (est).: 8.720 to 8.754
Refractive Index:1.51600 to 1.51900 @ 20.00 °C.
Boiling Point: 161.00 to 164.00 °C. @ 4.00 mm Hg
Vapor Pressure:0.000041 mmHg @ 25.00 °C. (est)
Flash Point: 308.00 °F. TCC ( 153.33 °C. )
logP (o/w): 5.947 (est)
Soluble in:
 fatty acid esters
 mineral oil
 vegetable oil
 water, 0.4195 mg/L @ 25 °C (est)
Insoluble in:
Similar Items:note
allyl salicylate
amyl salicylate
isoamyl salicylate
benzyl salicylate
bornyl salicylate
butyl salicylate
isobutyl salicylate
cinnamyl salicylate
ortho-cresyl salicylate
para-cresyl salicylate
cyclohexyl salicylate
decyl salicylate
2-ethyl hexyl salicylate
ethyl salicylate
heptyl salicylate
(Z)-3-hexen-1-yl salicylate
hexyl salicylate
menthyl salicylate
2-methyl butyl salicylate
methyl salicylate
octyl salicylate
phenethyl salicylate
3-phenyl propyl salicylate
phenyl salicylate
prenyl salicylate
propyl salicylate
isopropyl salicylate
Organoleptic Properties:
Odor Strength:low
Odor Description:at 100.00 %. mild menthol
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
uv absorbers
uv filters
BOC Sciences
For experimental / research use only.
Homosalate 98%
Odor: characteristic
Use: Homosalate could be commonly useful in sorts of cosmetics acting as a chemical UV filter. Homosalate could be commonly useful in sorts of cosmetics acting as a chemical UV filter.
Galaxy Surfactants
GalSORB Homosalate
Jiangyin Healthway
3,3,5-Trimethylcyclohexyl 2-hydroxybenzoate (Homosalate)
New functional food ingredients
Penta International
For experimental / research use only.
pharmaceutical secondary standard; traceable to USP
Neo Heliopan® HMS
Life Essentials - UV Protection
Odor: characteristic
Use: Neo Heliopan® HMS is an effective oil-soluble UVB absorber with a UV absorbance (E 1%/1cm) of min. 170 at 305nm for various applications.
For experimental / research use only.
3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture) >98.0%(GC)
Vigon International
Neo Heliopan HMS (Homosalate)
Odor: Mild menthol
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 36500 mg/kg

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
antioxidants and stabilizers
Recommendation for homomenthyl salicylate usage levels up to:
 not for fragrance use.
Recommendation for homomenthyl salicylate flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):118-56-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8362
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate
EPA/NOAA CAMEO:hazardous materials
 (3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:118-56-9
Pubchem (cid):8362
Pubchem (sid):134973878
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):D04450
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2918.23.5000
Potential Blenders and core components note
None Found
Potential Uses:
 skin conditioning
 u.v. absorbers
 u.v. filters
Occurrence (nature, food, other):note
 not found in nature
 benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester
 component of coppertone
 filtrosol A
2-hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester
homomenthyl salicylate USP
 neo heliopan HMS (Symrise)
 salicylic acid 3,3,5-trimethylcyclohexyl ester
 salicylic acid, 3,3,5-trimethylcyclohexyl ester
 salicylic acid, m-homomenthyl ester
3,3,5-trimethylcyclohexyl 2-hydroxybenzoate
3,3,5-trimethylcyclohexyl salicylate
(3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate


PubMed:Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats.
PubMed:Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity.
PubMed:Lichenic extracts and metabolites as UV filters.
PubMed:UV filters, ingredients with a recognized anti-inflammatory effect.
PubMed:Determination of ultraviolet filters in environmental water samples by temperature-controlled ionic liquid dispersive liquid-phase microextraction.
PubMed:Ionic liquid-based ultrasound-assisted dispersive liquid-liquid microextraction followed high-performance liquid chromatography for the determination of ultraviolet filters in environmental water samples.
PubMed:Simultaneous determination of ultraviolet filters in aqueous samples by plunger-in-needle solid-phase microextraction with graphene-based sol-gel coating as sorbent coupled with gas chromatography-mass spectrometry.
PubMed:Determination of ultraviolet filters in water samples by vortex-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry.
PubMed:An overview of UV-absorbing compounds (organic UV filters) in aquatic biota.
PubMed:Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV-filters.
PubMed:Development and application of a HPLC method for eight sunscreen agents in suncare products.
PubMed:Preparation, characterization and evaluation of sun protective and moisturizing effects of nanoliposomes containing safranal.
PubMed:Fast liquid chromatography-diode array detection assisted by chemometrics for quantification of seven ultraviolet filters in effluent wastewater.
PubMed:Occurrence and profiles of organic sun-blocking agents in surface waters and sediments in Japanese rivers and lakes.
PubMed:Simultaneous determination of some ultraviolet-absorbing chemicals in sunscreen cosmetics using a high-performance liquid chromatography method.
PubMed:On-line renewable solid-phase extraction hyphenated to liquid chromatography for the determination of UV filters using bead injection and multisyringe-lab-on-valve approach.
PubMed:Does saffron have antisolar and moisturizing effects?
PubMed:Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry.
PubMed:Non-porous membrane-assisted liquid-liquid extraction of UV filter compounds from water samples.
PubMed:Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry.
PubMed:Quercetin and rutin as potential sunscreen agents: determination of efficacy by an in vitro method.
PubMed:Dosage de l'octyl dimethyl PABA, de l'homosalate et de l'octyl salicylate dans les produits de protection solaire.
PubMed:3,3,5-Trimethylcyclohexanols and derived esters: green synthetic procedures, odour evaluation and in vitro skin cytotoxicity assays.
PubMed:Validation of a HPLC method for simultaneous determination of five sunscreens in lotion preparation.
PubMed:Photoprotective activity of propolis.
PubMed:Study of the efficacy of 18 sun filters authorized in European Union tested in vitro.
PubMed:Determination of UV filters and antimicrobial agents in environmental water samples.
PubMed:Design of a photostabilizer having built-in antioxidant functionality and its utility in obtaining broad-spectrum sunscreen formulations.
PubMed:Spectroscopic and photochemical properties of the lichen compound lobaric acid.
PubMed:Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks.
PubMed:Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays.
PubMed:Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography.
PubMed:Liquid chromatographic assay for common sunscreen agents: application to in vivo assessment of skin penetration and systemic absorption in human volunteers.
PubMed:Active ingredients in sunscreens act as topical penetration enhancers for the herbicide 2,4-dichlorophenoxyacetic acid.
PubMed:UV filters with antagonistic action at androgen receptors in the MDA-kb2 cell transcriptional-activation assay.
PubMed:Skin penetration and sun protection factor of five UV filters: effect of the vehicle.
PubMed:Comments on "In vitro and in vivo estrogenicity of UV screens".
PubMed:Determination of the UV filters worldwide authorised in sunscreens by high-performance liquid chromatography. Use of cyclodextrins as mobile phase modifier.
PubMed:Determination of UV-filters in sunscreens by HPLC.
PubMed:In vitro and in vivo estrogenicity of UV screens.
PubMed:A predictive mouse ear-swelling model for investigating topical photoallergy.
PubMed:Contact photoallergy testing of sunscreens in guinea pigs.
PubMed:Contact dermatitis to homomenthyl salicylate.
PubMed:Influence of sunscreening agents on color stability of tablets coated with certified dyes III: FD&C Yellow No. 6.
PubMed:Detection of pharmaceuticals and other personal care products in groundwater beneath and adjacent to onsite wastewater treatment systems in a coastal plain shallow aquifer.
cpd not photoallergenic.
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