EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

perillyl acetate
p-mentha-1,8-dien-7-yl acetate

Supplier Sponsors

Name:(4-prop-1-en-2-yl-1-cyclohexenyl)methyl acetate
CAS Number: 15111-96-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:239-162-4
FDA UNII:7P95D01XYJ
Nikkaji Web:J241.400G
CoE Number:10742
XlogP3-AA:2.70 (est)
Molecular Weight:178.27466000
Formula:C12 H18 O
NMR Predictor:Predict (works with chrome or firefox)
EFSA/JECFA Comments:
Stereoisomeric composition to be specified
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:975 p-mentha-1,8-dien-7-yl acetate
FLAVIS Number:09.278 (Old)
DG SANTE Food Flavourings:09.278 p-mentha-1,8-dien-7-yl acetate
FEMA Number:3561 p-mentha-1,8-dien-7-yl acetate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):15111-96-3 ; PERILLYL ACETATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:yellow to orange yellow clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.97200 to 0.98000 @ 25.00 °C.
Pounds per Gallon - (est).: 8.088 to 8.155
Refractive Index:1.47600 to 1.48700 @ 20.00 °C.
Optical Rotation:-71.00 to -79.00
Boiling Point: 218.00 to 223.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.014000 mmHg @ 25.00 °C. (est)
Flash Point: 200.00 °F. TCC ( 93.33 °C. )
logP (o/w): 3.610 (est)
Soluble in:
 alcohol
 water, very slightly
 water, 8.704 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: fruity
Odor Strength:medium
fruity woody raspberry berry
Odor Description:at 100.00 %. fruity woody raspberry
Flavor Type: berry
violet raspberry berry
Taste Description: ionone raspberry
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
DIHYDRO CUMINYL ACETATE 90.0%(GC)
Citrus and Allied Essences
Perilla Acetate
Odor: rich spicy herbaceous note.
Market Report
De Monchy Aromatics
dihydro cuminyl acetate
Nippon Terpene Chemicals
l-Perillyl acetate 90% up
Penta International
PERILLA ACETATE, Kosher
Reincke & Fichtner
p-Mentha-1,8-dien-7-yl acetate
Synerzine
Perillyl Acetate
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for perillyl acetate usage levels up to:
  2.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.35 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.07 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1300 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 11
 average usual ppmaverage maximum ppm
baked goods: -16.00000
beverages(nonalcoholic): -2.00000
beverages(alcoholic): -4.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -8.00000
fruit ices: --
gelatins / puddings: -4.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -3.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -16.00000
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 5.0000010.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 5.0000010.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 5.0000010.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000016.00000
Bakery wares (07.0): 7.2000016.00000
Meat and meat products, including poultry and game (08.0): 1.000003.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): --
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.500002.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 0.500002.00000
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 2.0000010.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 208 Revision 1 (FGE.208Rev1): Consideration of genotoxicity data on representatives for 10 alicyclic aldehydes with the a,▀-unsaturation in ring / side-chain and precursors from chemical subgroup 2.2 of
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 208 Revision 2 (FGE.208Rev2): Consideration of genotoxicity data on alicyclic aldehydes with a,▀-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 73, Revision 4 (FGE.73Rev4): consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting) structurally related to primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters evaluated by EFSA in FGE.12Rev5
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with a,▀-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):15111-96-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :61780
National Institute of Allergy and Infectious Diseases:Data
(4-prop-1-en-2-yl-1-cyclohexenyl)methyl acetate
Chemidplus:0015111963
 
References:
 (4-prop-1-en-2-yl-1-cyclohexenyl)methyl acetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:15111-96-3
Pubchem (cid):61780
Pubchem (sid):135260279
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):HMDB37231
FooDB:FDB016238
Export Tariff Code:2915.39.9050
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
para-
menth-1-en-9-al
FL/FR
aldehydic
aldehydic
agrumen nitrile
FR
balsamic
iso
bornyl propionate
FL/FR
fir carboxylate
FR
juniper berry oil CO2 extract
FL/FR
scotch
pine wood/needles resinoid
FR
tolu balsam replacer
FR
berry
methyl beta-ionyl acetate
FR
raspberry ketone
FL/FR
raspberry ketone methyl ether
FL/FR
cheesy
2-
heptanone
FL/FR
earthy
3-
octen-2-one
FL/FR
orris specialty
FR
fatty
hexyl pivalate
FR
floral
anise indene
FR
benzaldehyde propylene glycol acetal
FL/FR
boronia absolute
FL/FR
boronia absolute replacer
FL/FR
boronia fragrance
FR
bursera graveolens wood oil
FL/FR
coriander seed oil
FL/FR
2,4-
dimethyl cyclohexyl methyl acetate
FR
ethyl ortho-anisate
FL/FR
hyacinth ether
FR
alpha-
ionone
FL/FR
ionone mixed isomers
FL/FR
beta-
ionyl acetate
FL/FR
linalyl propionate
FL/FR
N-
methyl ionone
FR
alpha-iso
methyl ionone (70% min.)
FL/FR
orris fragrance
FR
orris rhizome absolute (iris germanica)
FL/FR
orris rhizome absolute (iris pallida)
FL/FR
orris rhizome resinoid (iris pallida)
FL/FR
fruity
berry hexanoate
FR
brandy extract
FL/FR
buchu wood specialty
FL/FR
1-(3,3-
dimethyl bicyclo(2.2.1)hept-2-yl)-2-methyl cyclohex-3-ene carbaldehyde
FR
1,4-
dimethyl bicyclo(3.2.1)oct-3-yl acetate
FR
1,2-
dimethyl butyl 2-butenoate
FR
ethyl para-methyl-beta-phenyl glycidate
FR
trans-1-
ethyl-2-methyl propyl 2-butenoate
FL/FR
geranyl acetoacetate
FL/FR
green acetate
FR
heptyl isovalerate
FL/FR
methyl (Z)-5-octenoate
FL/FR
neryl isobutyrate
FL/FR
octyl propionate
FL/FR
2-
pentanone
FL/FR
pineapple hydroxyhexanoate
FL/FR
prune glycidate
FR
raspberry dicarboxylate
FR
green
sec-
butyl-3-methyl but-2-ene thioate
FL/FR
carrot leaf oil (daucus carota ssp.maximus)
FR
privet dioxane
FR
herbal
bornyl 2-methyl butyrate
FL/FR
bornyl butyrate
FL/FR
carvacryl methyl ether
FL/FR
coriander seed absolute
FL/FR
coriander seed concrete
FR
herbal acetal
FR
herbal specialty
FR
herbal undecanone
FR
1-para-
menthen-9-yl acetate
FL/FR
methyl cyclogeranate (Firmenich)
FR
T-
muurolol
FL/FR
3-
nonanol
FL/FR
curled
parsley seed oil
FL/FR
saffron indenone
FL/FR
safranal
FL/FR
thymyl methyl ether
FL/FR
tricyclodecenyl propionate
FR
spicy
iso
butyl (E,E)-2,4-decadienamide
FL/FR
carrot weed oil
FL/FR
carvacryl ethyl ether
FL/FR
cinnamaldehyde dimethyl acetal
FL/FR
clove bud absolute
FL/FR
clove bud oil
FL/FR
clove bud oil replacer
FR
clove fragrance
FR
(-)-
cubenol
FL/FR
cuminyl alcohol
FL/FR
black
currant bud absolute
FL/FR
N,N-
diethyl octanamide
FR
green oxane
FR
origanum majorana oil
FL/FR
origanum majorana oil cuba
FL/FR
origanum majorana oil morocco
FL/FR
pepper tree berry oil CO2 extract
FL/FR
sulfurous
buchu mercaptan
FL/FR
waxy
orris rhizome oil CO2 extract
FL/FR
woody
dihydro-beta-ionone
FL/FR
melozol acetate
FR
patchouli absolute
FR
spicy pentanone
FL/FR
1-(5',5',6'-
trimethyl bicyclo(2.2.1)hept-2'-ylidene) propan-2-one
FR
For Flavor
No flavor group found for these
bornyl 2-methyl butyrate
FL/FR
bornyl butyrate
FL/FR
boronia absolute replacer
FL/FR
buchu wood specialty
FL/FR
bursera graveolens wood oil
FL/FR
iso
butyl (E,E)-2,4-decadienamide
FL/FR
sec-
butyl-3-methyl but-2-ene thioate
FL/FR
carvacryl ethyl ether
FL/FR
carvacryl methyl ether
FL/FR
2,4-
dimethyl anisole
FL
ethyl ortho-anisate
FL/FR
trans-1-
ethyl-2-methyl propyl 2-butenoate
FL/FR
heptyl isovalerate
FL/FR
ionone mixed isomers
FL/FR
para-
menth-1-en-9-al
FL/FR
T-
muurolol
FL/FR
3-
nonanol
FL/FR
hexyl 3-mercaptobutanoate
FL
balsamic
balsamic
iso
bornyl propionate
FL/FR
juniper berry oil CO2 extract
FL/FR
berry
raspberry ketone
FL/FR
raspberry ketone methyl ether
FL/FR
cheesy
2-
heptanone
FL/FR
creamy
3-
octen-2-one
FL/FR
dairy
methyl (Z)-5-octenoate
FL/FR
estery
octyl propionate
FL/FR
floral
alpha-
ionone
FL/FR
alpha-iso
methyl ionone (70% min.)
FL/FR
orris flavor
FL
orris rhizome resinoid (iris pallida)
FL/FR
fruity
benzaldehyde propylene glycol acetal
FL/FR
boronia absolute
FL/FR
brambleberry flavor
FL
brandy extract
FL/FR
1-para-
menthen-9-yl acetate
FL/FR
neryl isobutyrate
FL/FR
2-
pentanone
FL/FR
pineapple hydroxyhexanoate
FL/FR
spicy pentanone
FL/FR
green
carrot weed oil
FL/FR
herbal
coriander seed absolute
FL/FR
coriander seed oil
FL/FR
linalyl propionate
FL/FR
origanum majorana oil
FL/FR
curled
parsley seed oil
FL/FR
saffron indenone
FL/FR
musty
geranyl acetoacetate
FL/FR
thymyl methyl ether
FL/FR
spicy
cinnamaldehyde dimethyl acetal
FL/FR
clove bud absolute
FL/FR
clove bud oil
FL/FR
(-)-
cubenol
FL/FR
cuminyl alcohol
FL/FR
black
currant bud absolute
FL/FR
origanum majorana oil cuba
FL/FR
origanum majorana oil morocco
FL/FR
pepper tree berry oil CO2 extract
FL/FR
sulfurous
buchu mercaptan
FL/FR
sweet
orris rhizome absolute (iris germanica)
FL/FR
orris rhizome absolute (iris pallida)
FL/FR
woody
dihydro-beta-ionone
FL/FR
beta-
ionyl acetate
FL/FR
orris rhizome oil CO2 extract
FL/FR
safranal
FL/FR
 
Potential Uses:
FRherbal
FRoriental
FRspice
 
Occurrence (nature, food, other):note
 bergamot plant wild
Search Trop Picture
 lime oil expressed florida @ trace%
Data GC Search Trop Picture
 mandarin fruit
Search Trop Picture
 mikan peel oil @ 0.01%
Data GC Search Trop Picture
 sunflower flower
Search Trop Picture
 wormwood oil cuba @ 0.20%
Data GC Search Trop Picture
 
Synonyms:
 acetic acid perillyl ester
1-cyclohexene-1-methanol, 4-(1-methylethenyl)-, acetate
 dihydro cuminyl acetate
 dihydrocuminyl acetate
p-mentha-1,8-dien-7-ol, acetate
p-mentha-1,8-dien-7-yl acetate
para-mentha-1,8-dien-7-yl acetate
 menthadien-7-carbinyl acetate
1,8-p-menthadien-7-yl acetate
1,8-para-menthadien-7-yl acetate
4-methyl vinyl cyclohexene-1-methyl acetate
4-(1-methyl vinyl) cyclohex-1-ene-1-methyl acetate
4-(1-methylethenyl)-1-cyclohexene-1-methyl acetate
4-(1-methylvinyl)cyclohex-1-ene-1-methyl acetate
 perilla acetate
 perillyl acetate
(4-prop-1-en-2-yl-1-cyclohexenyl)methyl acetate
[4-(prop-1-en-2-yl)cyclohex-1-en-1-yl]methyl acetate
(4-isopropenyl-1-cyclohexen-1-yl)methyl acetate
4-isopropenyl-1-cyclohexene carbinol acetate
 

Articles:

PubMed:Coupling limonene formation and oxyfunctionalization by mixed-culture resting cell fermentation.
PubMed:Improved antioxidant activity in transgenic Perilla frutescens plants via overexpression of the ╬│-tocopherol methyltransferase (╬│-tmt) gene.
PubMed:Medicinal plants from the genus Acalypha (Euphorbiaceae)--a review of their ethnopharmacology and phytochemistry.
PubMed:A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1╬▓-treated hepatocytes.
PubMed:The oxygen-independent metabolism of cyclic monoterpenes in Castellaniella defragrans 65Phen.
PubMed:Anti-inflammatory and antipruritic effects of luteolin from Perilla (P. frutescens L.) leaves.
PubMed:Rosmarinic acid extract for antioxidant, antiallergic, and ╬▒-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves.
PubMed:Rapid identification of aldose reductase inhibitory compounds from Perilla frutescens.
PubMed:Structural characterization of phenolic antioxidants from purple perilla (Perilla frutescens var. acuta) leaves.
PubMed:Skin repair properties of d-Limonene and perillyl alcohol in murine models.
PubMed:Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo.
PubMed:A QuEChERS-based extraction method for the residual analysis of pyraclofos and tebufenpyrad in perilla leaves using gas chromatography: application to dissipation pattern.
PubMed:In vitro biological activities of the essential oil from the 'resurrection plant' Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar.
PubMed:Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.
PubMed:Optimization of antibacterial activity of Perilla frutescens var. acuta leaf against Staphylococcus aureus using evolutionary operation factorial design technique.
PubMed:Volatile oil profiles of the aerial parts of Jordanian garland, Chrysanthemum coronarium.
PubMed:Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis.
PubMed:Gateways to clinical trials.
PubMed:A fluorometric assay to determine antioxidant activity of both hydrophilic and lipophilic components in plant foods.
PubMed:[Determination of difenoconazole residue in foods by gas chromatography-negative chemical ionization mass spectrometry].
PubMed:Evaluation of characteristic aroma compounds of Citrus natsudaidai Hayata (Natsudaidai) cold-pressed peel oil.
PubMed:Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor.
PubMed:Volatile constituents of redblush grapefruit (Citrus paradisi) and pummelo (Citrus grandis) peel essential oils from Kenya.
PubMed:Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages.
PubMed:Gateways to clinical trials.
PubMed:Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism.
PubMed:Gateways to clinical trials.
PubMed:Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects.
PubMed:Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model.
PubMed:Gateways to clinical trials.
PubMed:Inhibitory effect of Perilla leaf extract and luteolin on mouse skin tumor promotion.
PubMed:Differences in the fragrances of pollen, leaves, and floral parts of garland (Chrysanthemum coronarium) and composition of the essential oils from flowerheads and leaves.
PubMed:Luteolin as an anti-inflammatory and anti-allergic constituent of Perilla frutescens.
PubMed:Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.
PubMed:Anti-inflammatory and anti-allergic actions by oral administration of a perilla leaf extract in mice.
PubMed:Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.
PubMed:Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells.
PubMed:Inhibition of tumor necrosis factor-alpha production by orally administering a perilla leaf extract.
PubMed:Analysis of perillic acid in plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
PubMed:Benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II from Acinetobacter calcoaceticus. Substrate specificities and inhibition studies.
 
Notes:
Flavouring ingredient
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