EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

butyl salicylate
salicylic acid, butyl ester

Sponsors

Name:butyl 2-hydroxybenzoate
CAS Number: 2052-14-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:218-142-9
FDA UNII:QPR9LM8VZO
Nikkaji Web:J36.458D
Beilstein Number:2208904
MDL:MFCD00020038
CoE Number:614
XlogP3:4.60 (est)
Molecular Weight:194.23018000
Formula:C11 H14 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:901 butyl salicylate
FLAVIS Number:09.763 (Old)
DG SANTE Food Flavourings:09.763 butyl salicylate
FEMA Number:3650 butyl salicylate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: BUTYL SALICYLATE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.07000 to 1.08000 @ 25.00 °C.
Pounds per Gallon - (est).: 8.903 to 8.987
Refractive Index:1.50800 to 1.52000 @ 20.00 °C.
Melting Point: -5.90 °C. @ 760.00 mm Hg
Boiling Point: 271.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.004000 mm/Hg @ 25.00 °C. (est)
Flash Point:> 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 4.630
Soluble in:
 alcohol
 water, 19.8 mg/L @ 25 °C (exp)
Insoluble in:
 water
Stability:
 non-discoloring in most media
Similar Items:note
allyl salicylate
amyl salicylate
isoamyl salicylate
benzyl salicylate
bornyl salicylate
isobutyl salicylate
cinnamyl salicylate
ortho-cresyl salicylate
para-cresyl salicylate
cyclohexyl salicylate
decyl salicylate
2-ethyl hexyl salicylate
ethyl salicylate
heptyl salicylate
(E)-2-hexen-1-yl salicylate
(Z)-3-hexen-1-yl salicylate
hexyl salicylate
menthyl salicylate
homomenthyl salicylate
2-methyl butyl salicylate
methyl salicylate
octyl salicylate
phenethyl salicylate
3-phenyl propyl salicylate
phenyl salicylate
prenyl salicylate
propyl salicylate
isopropyl salicylate
 
Organoleptic Properties:
Odor Type: floral
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less
clover floral orchid herbal
Odor Description:at 10.00 % in dipropylene glycol. harsh clover ethyl benzoate
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
Axsyn
For experimental / research use only.
Benzoic acid,2-hydroxy-, butyl ester
BOC Sciences
For experimental / research use only.
Butyl Salicylate
Inoue Perfumery
BUTYL SALICYLATE
Penta International
n-BUTYL SALICYLATE, Kosher
PerfumersWorld
Butyl Salicylate
Odor: sweet aromatic medicinal slightly-fruity-wintergreen
Synerzine
n-Butyl Salicylate
TCI AMERICA
For experimental / research use only.
Butyl Salicylate >99.0%(GC)
 
Safety Information:
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1836 mg/kg
(Levenstein, 1975m)

oral-rat LD50 1700 mg/kg
Food and Cosmetics Toxicology. Vol. 16, Pg. 663, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
limits in the finished product for - "leave on the skin contact":
  0.2000 % Recommendation.
Recommendation for butyl salicylate usage levels up to:
  0.1000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.0007 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 12
 average usual ppmaverage maximum ppm
baked goods: -1.00000
beverages(nonalcoholic): -1.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -0.07000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: --
gelatins / puddings: -1.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: -1.50000
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23
View page or View pdf

Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):2052-14-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16330
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
butyl 2-hydroxybenzoate
Chemidplus:0002052144
RTECS:VO2000000 for cas# 2052-14-4
 
References:
 butyl 2-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:2052-14-4
Pubchem (cid):16330
Pubchem (sid):135204813
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB40730
FooDB:FDB020539
Export Tariff Code:2918.23.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
aldehydic
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
amber
cistus ladaniferus resinoid
FR
animal
para-
cresyl caprylate
FL/FR
anisic
para-
anisaldehyde
FL/FR
balsamic
iso
amyl benzoate
FL/FR
iso
amyl cinnamate
FL/FR
amyl cinnamate
FL/FR
amyris wood oil
FL/FR
siam
benzoin resinoid
FL/FR
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
iso
butyl benzoate
FL/FR
clover nitrile
FR
fir balsam absolute
FR
3-
phenyl propyl alcohol
FL/FR
floral
amyl anthranilate
FL/FR
alpha-
amyl cinnamaldehyde
FL/FR
amyl salicylate
FL/FR
iso
amyl salicylate
FL/FR
iso
butyl salicylate
FL/FR
cestrum nocturnum flower absolute
FR
coriander seed oil
FL/FR
dihydrojasmone
FL/FR
2-
ethyl hexyl salicylate
FR
floral pyranol
FR
heliotropyl acetone
FL/FR
alpha-
hexyl cinnamaldehyde
FL/FR
nerolidol
FL/FR
ocean propanal
FL/FR
phenethyl alcohol
FL/FR
propyl salicylate
FR
rose butanoate
FL/FR
green
dodecanal dimethyl acetal
FL/FR
(Z)-3-
hexen-1-yl benzoate
FL/FR
phenyl acetaldehyde
FL/FR
herbal
carum carvi fruit oil
FL/FR
clary sage oil france
FL/FR
hexyl salicylate
FL/FR
lavender absolute bulgaria
FL/FR
2-
methyl butyl salicylate
FL/FR
melon
watermelon ketone
FR
mossy
veramoss (IFF)
FR
spicy
cassia bark oil china
FL/FR
clove bud oil
FL/FR
ethyl isoeugenol
FL/FR
iso
eugenyl acetate
FL/FR
floral spice fragrance
FR
methyl isoeugenol
FL/FR
tonka
coumarin
FR
tonka bean absolute
FR
woody
cedarwood oil virginia
FR
methyl cedryl ketone
FL/FR
patchouli ethanone
FR
patchouli oil
FL/FR
santall
FR
woody acetate
FR
For Flavor
No flavor group found for these
amyl anthranilate
FL/FR
2-
methyl butyl salicylate
FL/FR
animal
animal
para-
cresyl caprylate
FL/FR
aromatic
amyl salicylate
FL/FR
balsamic
amyl cinnamate
FL/FR
siam
benzoin resinoid
FL/FR
benzyl benzoate
FL/FR
benzyl salicylate
FL/FR
berry
heliotropyl acetone
FL/FR
burnt
ethyl 2-furoate
FL
cooling
iso
butyl salicylate
FL/FR
creamy
para-
anisaldehyde
FL/FR
fatty
(Z)-3-
hexen-1-yl benzoate
FL/FR
10-
undecenal (aldehyde C-11 undecylenic)
FL/FR
floral
iso
amyl cinnamate
FL/FR
dihydrojasmone
FL/FR
ocean propanal
FL/FR
phenethyl alcohol
FL/FR
fruity
iso
amyl benzoate
FL/FR
iso
butyl benzoate
FL/FR
rose butanoate
FL/FR
green
iso
amyl salicylate
FL/FR
dodecanal dimethyl acetal
FL/FR
nerolidol
FL/FR
herbal
carum carvi fruit oil
FL/FR
clary sage oil france
FL/FR
coriander seed oil
FL/FR
hexyl salicylate
FL/FR
lavender absolute bulgaria
FL/FR
honey
phenyl acetaldehyde
FL/FR
spicy
cassia bark oil china
FL/FR
clove bud oil
FL/FR
ethyl isoeugenol
FL/FR
iso
eugenyl acetate
FL/FR
methyl isoeugenol
FL/FR
3-
phenyl propyl alcohol
FL/FR
tropical
alpha-
amyl cinnamaldehyde
FL/FR
waxy
alpha-
hexyl cinnamaldehyde
FL/FR
woody
amyris wood oil
FL/FR
methyl cedryl ketone
FL/FR
patchouli oil
FL/FR
 
Potential Uses:
FRacacia
FRanise
FRbalsam
FRblackberry
FRcarnation
FRcherry
FRclary sage oil replacer
FRclover
FRcurrant
FRfern
FRleather
 modifier
FRmulberry
FRorchid
FRoriental
FRpeach
FRpoppy red poppy
FRraspberry
FRroot beer
FRstrawberry
FRtuberose
FL/FRvalerian
FRwallflower
FRwintergreen
 
Occurrence (nature, food, other):note
 grape red grape skin
Search PMC Picture
 papaya mountain papaya
Search Trop Picture
 
Synonyms:
 benzoic acid, hydroxy-, butyl ester
 butyl (2-hydroxyphenyl) formate
 butyl (2-hydroxyphenyl)formate
 butyl 2-hydroxybenzoate
 butyl 2-hydroxyphenyl formate
 butyl o-hydroxybenzoate
N-butyl o-hydroxybenzoate
N-butyl ortho-hydroxybenzoate
N-butyl salicylate
 butylsalicylate
2-hydroxybenzoic acid butyl ester
 nefolia
 salicylic acid butyl ester
 salicylic acid, butyl ester
 

Articles:

PubMed:Ultrasound-assisted third-liquid phase-transfer catalyzed esterification of sodium salicylate in a continuous two-phase-flow reactor.
PubMed:DFT and ab initio study of structure of dyes derived from 2-hydroxy and 2,4-dihydroxy benzoic acids.
PubMed:Differentiated in vivo skin penetration of salicylic compounds in hairless rats measured by cutaneous microdialysis.
PubMed:Development of an in vivo animal model for skin penetration in hairless rats assessed by mass balance.
PubMed:In vivo skin penetration of salicylic compounds in hairless rats.
PubMed:The effect of topically applied salicylic compounds on serotonin-induced scratching behaviour in hairless rats.
 
Notes:
Present in mountain papaya (Carica pubescens). Flavouring agent
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