EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isopropyl amine
isopropylamine

Sponsors

Name:propan-2-amine
CAS Number: 75-31-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-860-9
FDA UNII:P8W26T4MTD
Nikkaji Web:J1.451F
Beilstein Number:0605259
MDL:MFCD00008082
CoE Number:10480
XlogP3-AA:0.10 (est)
Molecular Weight:59.11173000
Formula:C3 H9 N
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:1581 isopropylamine
FLAVIS Number:11.018 (Old)
DG SANTE Food Flavourings:11.018 isopropylamine
FEMA Number:4238 isopropylamine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: ISOPROPYLAMINE
 
Physical Properties:
Appearance:colorless to yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.68700 to 0.69300 @ 25.00 °C.
Pounds per Gallon - (est).: 5.717 to 5.766
Refractive Index:1.36700 to 1.37300 @ 20.00 °C.
Melting Point:-101.00 to -99.00 °C. @ 760.00 mm Hg
Boiling Point: 32.00 to 34.00 °C. @ 760.00 mm Hg
Vapor Pressure:607.728027 mm/Hg @ 25.00 °C. (est)
Vapor Density:2.04 ( Air = 1 )
Flash Point: -26.00 °F. TCC ( -32.22 °C. )
logP (o/w): 0.260
Soluble in:
 alcohol
 water, 8.381e+005 mg/L @ 25 °C (est)
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: fishy
Odor Strength:high ,
recommend smelling in a 0.10 % solution or less
fishy ammoniacal
Odor Description:at 0.10 % in propylene glycol. fishy ammoniacal
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: buffering agents
 
Suppliers:
Eastman Chemical
Monoisopropylamine 70%
EMD Millipore
For experimental / research use only.
isoPropylamine
Penta International
ISOPROPYLAMINE NATURAL 5% IN ETHYL ALCOHOL, Kosher
Penta International
ISOPROPYLAMINE, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
isopropylamine
Sigma-Aldrich: Aldrich
For experimental / research use only.
Isopropylamine 99%
SysKem Chemie
monoisoPropylamine
Taminco (Eastman)
isoPropylamine
TCI AMERICA
For experimental / research use only.
isoPropylamine >99.0%(GC)(T)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 12 - Extremely flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 111 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: OTHER CHANGES
National Technical Information Service. Vol. OTS0542011

oral-guinea pig LD50 2700 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.

oral-mouse LD50 2200 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.

oral-rabbit LD50 3200 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(3), Pg. 79, 1980.

unreported-mammal (species unspecified) LD50 500 mg/kg
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

intraperitoneal-rat LDLo 50 mg/kg
Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968.

Dermal Toxicity:
skin-rabbit LD50 380 mg/kg
Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974

Inhalation Toxicity:
inhalation-rat LC50 4000 ppm/4H
Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974

inhalation-mammal (species unspecified) LC50 1800 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

inhalation-mouse LCLo 7000 ppm/40M
Shell Chemical Company. Unpublished Report. Vol. -, Pg. 7, 1961.

 
Safety in Use Information:
Category: flavoring agents
Recommendation for isopropyl amine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.02 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 340 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
 average usual ppmaverage maximum ppm
baked goods: 2.0000010.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: 0.200001.00000
cheese: 0.400002.00000
chewing gum: --
condiments / relishes: 0.100000.50000
confectionery froastings: 1.000005.00000
egg products: --
fats / oils: 0.100000.50000
fish products: 0.200001.00000
frozen dairy: 0.400002.00000
fruit ices: 0.400002.00000
gelatins / puddings: --
granulated sugar: --
gravies: 0.100000.50000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 0.200001.00000
milk products: 0.400002.00000
nut products: --
other grains: 0.200001.00000
poultry: 0.200001.00000
processed fruits: 0.400002.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 0.100000.50000
snack foods: 1.000005.00000
soft candy: --
soups: 0.100000.50000
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):75-31-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6363
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1221
WGK Germany:1
propan-2-amine
Chemidplus:0000075310
EPA/NOAA CAMEO:hazardous materials
RTECS:75-31-0
 
References:
 propan-2-amine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:75-31-0
Pubchem (cid):6363
Pubchem (sid):134970892
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
UM BBD:Search
KEGG (GenomeNet):C06748
HMDB (The Human Metabolome Database):Search
FooDB:FDB009650
Export Tariff Code:2921.19.6190
Haz-Map:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 buffering agents
FLcereal
FLcheese
FLdairy
FLfish
 fruit
FLmeat
 
Occurrence (nature, food, other):note
 corn seed
Search Trop Picture
 not found in nature
 soybean seed
Search Trop Picture
 
Synonyms:
1-amino-2-methylethane
2-amino-propaan
2-amino-propane
2-amino-propano
2-aminopropane
1-methyl ethyl amine
1-methylethyl amine
 propan-2-amine
2-propanamine
2-propane amine
 propane, 2-amino-
2-propaneamine
2-propyl amine
monoisopropyl amine
sec-propyl amine
2-propylamine
isopropylamine
sec-propylamine
isopropylamine natural 5% in ethyl alcohol
 
 
Notes:
None found
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