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T-cadinol
(1S,4S,4aR,8aR)-4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol

Supplier Sponsors

Name:	(1S,4S,4aR,8aR)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
CAS Number:	5937-11-1	3D/inchi
FDA UNII:	Search
Nikkaji Web:	J15.462H
XlogP3-AA:	3.30 (est)
Molecular Weight:	222.37142000
Formula:	C15 H26 O
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:flavor and fragrance agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Appearance:	white crystalline solid (est)
Assay:	97.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	139.00 to 140.00 °C. @ 760.00 mm Hg
Boiling Point:	302.00 to 304.00 °C. @ 760.00 mm Hg
Flash Point:	263.00 °F. TCC ( 128.33 °C. )
logP (o/w):	4.899 (est)
Soluble in:
	alcohol
	water, 9.13 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor Type: balsamic

Odor Strength:none

balsamic earthy

Odor Description:at 100.00 %. pure has no odor but mixtures have balsam earthy

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for T-cadinol usage levels up to:
	7.0000 % in the fragrance concentrate.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :160799

National Institute of Allergy and Infectious Diseases:Data

(1S,4S,4aR,8aR)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol

Chemidplus:0005937111

References:

	(1S,4S,4aR,8aR)-1,6-dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	160799
Pubchem (sid):	135116958
Pherobase:	View

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEMBL:	View
HMDB (The Human Metabolome Database):	HMDB36646
FooDB:	FDB015571
Typical G.C.
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

For Odor

No odor group found for these

(E)-

sabinene hydrate
FL/FR

anisic

anisic

para-

anisyl phenyl acetate
FL/FR

balsamic

siam

benzoin absolute
FL/FR

siam

benzoin resinoid
FL/FR

1-

benzoyl acetone
FL/FR

laevo-

bornyl acetate
FL/FR

brachyleana hutchinsii wood oil
FR

conifer acetate
FR

fir needle oil canada
FL/FR

fir needle oil terpeneless canada
FL/FR

guaiyl butyrate
FR

hemlock western oil (tsuga heterophylla) canada
FR

juniper berry absolute
FL/FR

myrrh absolute
FL/FR

myrrh resinoid
FR

tolu balsam absolute
FL/FR

tolu balsam resinoid
FL/FR

floral

cananga oil
FL/FR

cananga oil china
FL/FR

rose absolute (rosa centifolia) morocco
FL/FR

green

galbanum absolute
FL/FR

galbanum oleoresin
FL/FR

galbanum resinoid
FL/FR

valerian rhizome oil CO2 extract china
FL/FR

herbal

canarium luzonicum gum
FL/FR

rosemary absolute
FL/FR

rosemary oil morocco
FL/FR

rosemary oil spain
FL/FR

valerian rhizome oil
FL/FR

valerian rhizome oil china
FL/FR

spicy

elettaria cardamomum seed oil
FL/FR

nutmeg absolute
FL/FR

terpenic

elemi resinoid
FL/FR

pine needle oil dwarf
FL/FR

woody

copaiba balsam
FL/FR

guaiacwood oil 20% in gurjun balsam oil
FR

alpha-

gurjun balsam oil
FR

alpha-

4-

hydroxybenzaldehyde
FL/FR

patchouli oil
FL/FR

sandalwood oil
FL/FR

sandalwood oil west australia (santalum spicatum)
FR

santalyl butyrate
FL/FR

vetiverol
FL/FR

For Flavor

No flavor group found for these

1-

benzoyl acetone
FL/FR

fir needle oil canada
FL/FR

alpha-

(E)-

sabinene hydrate
FL/FR

santalyl butyrate
FL/FR

anisic

anisic

para-

anisyl phenyl acetate
FL/FR

balsamic

siam

benzoin resinoid
FL/FR

laevo-

bornyl acetate
FL/FR

fir needle oil terpeneless canada
FL/FR

juniper berry absolute
FL/FR

myrrh absolute
FL/FR

tolu balsam absolute
FL/FR

tolu balsam resinoid
FL/FR

creamy

4-

hydroxybenzaldehyde
FL/FR

floral

cananga oil
FL/FR

cananga oil china
FL/FR

rose absolute (rosa centifolia) morocco
FL/FR

fruity

valerian rhizome oil
FL/FR

valerian rhizome oil china
FL/FR

valerian rhizome oil CO2 extract china
FL/FR

green

canarium luzonicum gum
FL/FR

elemi resinoid
FL/FR

galbanum absolute
FL/FR

galbanum oleoresin
FL/FR

galbanum resinoid
FL/FR

herbal

rosemary absolute
FL/FR

rosemary oil morocco
FL/FR

rosemary oil spain
FL/FR

pine

pine needle oil dwarf
FL/FR

spicy

siam

benzoin absolute
FL/FR

elettaria cardamomum seed oil
FL/FR

galangal root oleoresin
FL

nutmeg absolute
FL/FR

woody

copaiba balsam
FL/FR

patchouli oil
FL/FR

sandalwood oil
FL/FR

vetiverol
FL/FR

Potential Uses:

None Found

Occurrence (nature, food, other):note

	amyris wood oil @ <0.10% Data GC Search Trop Picture
	angelica root oil @ 0.04% Data GC Search Trop Picture
	basil oil CO2 sweet @ 5.79% Data GC Search Trop Picture
	basil oil sweet @ 18.14% Data GC Search Trop Picture
	basil oil var. glabratum turkey @ 3.06% Data GC Search Trop Picture
	basil plant Search Trop Picture
	basil shoot oil Search Trop Picture
	cajuput oil vietnam @ trace% Data GC Search Trop Picture
	cananga leaf oil @ 0.9% Data GC Search Trop Picture
	cascarilla bark oil @ 1.00% Data GC Search Trop Picture
	cassinia laevis flower oil australia @ 2.50% Data GC Search Trop Picture
	cassinia laevis leaf oil australia @ 0.10% Data GC Search Trop Picture
	cinnamon fruit oil india @ 2.7-3.4% Data GC Search Trop Picture
	curry fruit oil india @ 0.10% Data GC Search Trop Picture
	curry leaf oil india @ 0.10% Data GC Search Trop Picture
	cypress cone oil egypt @ 0.2% Data GC Search Trop Picture
	erigeron graveolens l. oil iran @ 5.20% Data GC Search Trop Picture
	eucalyptus globulus fruit oil @ 0.28% Data GC Search Trop Picture
	geranium oil rwanda @ 0.35% Data GC Search Trop Picture
	hinoki root oil @ 5.88% Data GC Search Trop Picture
	hinoki wood oil @ 10.61% Data GC Search Trop Picture
	hyssop leaf Search Trop Picture
	hyssop oil CO2 extract @ 0.4% Data GC Search Trop Picture
	hyssop shoot Search Trop Picture
	labdanum oil @ 0.81% Data GC Search Trop Picture
	laurel leaf oil turkey @ trace% Data GC Search Trop Picture
	lavandin oil abrialis @ 0.21% Data GC Search Trop Picture
	lavandin oil grosso @ 0.20% Data GC Search Trop Picture
	lavender oil france @ 0.99% Data GC Search Trop Picture
	lavender oil spike france @ 0.06% Data GC Search Trop Picture
	lavender oil spike spain @ 0.08% Data GC Search Trop Picture
	lemon balm shoot Search Trop Picture
	lemon verbena oil morocco @ 0.9% Data GC Search Trop Picture
	lemon verbena oil turkey @ 0.97% Data GC Search Trop Picture
	marjoram pot oil turkey @ 0.00-0.12% Data GC Search Trop Picture
	microstrobos niphophilus leaf oil australia @ 0.70% Data GC Search Trop Picture
	mikania cordata (burm. f.) b.l. robinson var. cordata leaf oil france @ 0.10% Data GC Search Trop Picture
	pepper tree berry oil @ 1.39% Data GC Search Trop Picture
	pepper tree leaf oil @ 4.70% Data GC Search Trop Picture
	peppermint oil CO2 extract @ 0.60% Data GC Search Trop Picture
	phoebe oil brazil @ 0.78% Data GC Search Trop Picture
	pimenta leaf oil @ 6.64% Data GC Search Trop Picture
	pine needle oil dwarf @ 2.17% Data GC Search Trop Picture
	pinus formosana hayata Search Trop Picture
	pinus pentaphylla Search Trop Picture
	polyalthia australis (benth.) jessup leaf oil australia @ 0.90% Data GC Search Trop Picture
	pteronia oil @ 0.40% Data GC Search Trop Picture
	rosemary oil france @ 0.00-0.12% Data GC Search Trop Picture
	rosemary oil morocco @ 0.00-0.11% Data GC Search Trop Picture
	salvia officinalis seed oil tunisia @ 0.15% Data GC Search Trop Picture
	salvia plebeia oil @ 10.21% Data GC Search Trop Picture
	salvia sclarea seed oil tunisia @ 0.52% Data GC Search Trop Picture
	satureja viminea l. oil costa rica @ trace% Data GC Search Trop Picture
	sideritis montana l. oil bulgaria @ 1.80% Data GC Search Trop Picture
	thyme oil wild or creeping canada @ 1.00% Data GC Search Trop Picture
	thyme oil wild or creeping france @ 3.40% Data GC Search Trop Picture
	thymus richardii pers. subsp. nitidus (guss.) jalas oil italy @ 4.00% Data GC Search Trop Picture
	torreya nucifera Search Trop Picture
	yarrow oil @ 0.40% Data GC Search Trop Picture
	yarrow oil greece @ 0.10% Data GC Search Trop Picture
	zanthoxylum bracchyacanthum l. leaf oil australia @ 0.30% Data GC Search Trop Picture

Synonyms:

	amorphan-3-en-9beta-ol
(-)-	amorphan-3-en-9beta-ol
10bH-	cadin-4-en-10-ol
	cadin-4-en-10beta-ol
.tau.-	cadinol
10-epi	cadinol
10-epi-a-	cadinol
epi-alpha-	cadinol
	cedrelanol
(1S,4S,4aR,8aR)-1,6-	dimethyl-4-(propan-2-yl)-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
(1S,4S,4aR,8aR)-1,6-	dimethyl-4-propan-2-yl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-ol
sesqui	goyol
1-	naphthalenol, 1,2,3,4,4a,7,8,8a-octahydro-1,6-dimethyl-4-(1-methylethyl)-, (1S,4S,4aR,8aR)-
(1S-(1alpha,4alpha, 4aalpha,8abeta))- 1,2,3,4,4a,7,8,8a-	octahydro-1,6-dimethyl-4-(1-methyl ethyl)-1-naphthalenol
	pilgerol
(1S,4S,4aR,8aR)-4-iso	propyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-ol
	torreyol

Articles:

PubMed:Comparison of the volatile oil composition of three Atalantia species.

PubMed:Chemical composition, antibacterial and cytotoxic activities of the essential oil from the flowers of Tunisian Convolvulus althaeoides L.

PubMed:Essential oils of Chiliadenus lopadusanus (Asteraceae).

PubMed:Headspace solid-phase microextraction-gas chromatography-mass spectrometry characterization of propolis volatile compounds.

PubMed:[Sesquiterpenes from stem of Schisandra glaucescens].

PubMed:Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.

PubMed:Changes in volatile compound composition of Antrodia camphorata during solid state fermentation.

PubMed:Bioactive phytochemicals of leaf essential oils of Cinnamomum osmophloeum prevent lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced acute hepatitis in mice.

PubMed:Phytochemical analysis and in vitro antimicrobial and free-radical-scavenging activities of the essential oils from Euryops arabicus and Laggera decurrens.

PubMed:A novel brominated cuparene-derived sesquiterpene ether from the red alga Laurencia sp.

PubMed:Essential oil composition and in vivo volatiles emission by different parts of Coleostephus myconis capitula.

PubMed:Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves.

PubMed:Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.).

PubMed:Chemical analysis and biological activity of the essential oils of two endemic Soqotri Commiphora species.

PubMed:Sesquiterpenoids from Teucrium ramosissimum.

PubMed:Essential oil variability in natural populations of Picea omorika, a rare European conifer.

PubMed:Antibacterial terpenes from the oleo-resin of Commiphora molmol (Engl.).

PubMed:Dendritic Cells Promoted by Ginseng Saponins Drive a Potent Th1 Polarization.

PubMed:Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs.

PubMed:Chemical composition and antimicrobial activity of the essential oil of Teucrium ramosissimum (Lamiaceae).

PubMed:Sesquiterpenes from the wood of Juniperus lucayana.

PubMed:Chemical composition and in vitro antifungal and antioxidant activity of the essential oil and methanolic extract of Teucrium sauvagei Le Houerou.

PubMed:Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana.

PubMed:T-cadinol and calamenene induce dendritic cells from human monocytes and drive Th1 polarization.

PubMed:Three abietane diterpenes and two diterpenes incorporated sesquiterpenes from the bark of Cryptomeria japonica.

PubMed:Larvicidal, antimycobacterial and antifungal compounds from the bark of the Peruvian plant Swartzia polyphylla DC.

PubMed:Analysis of the essential oil composition of eight Anthemis species from Greece.

PubMed:New constituents of Leontopodium alpinum and their in vitro leukotriene biosynthesis inhibitory activity.

PubMed:Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth.

PubMed:Antifouling substances against larvae of the barnacle Balanus amphitrite from the marine sponge, Acanthella cavernosa.

PubMed:A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi.

PubMed:GC-MS analysis of essential oil of Shorea robusta bast.

PubMed:Cadinane-type sesquiterpenes from the roots of Taiwania cryptomerioides Hayata.

PubMed:Influence of the parasite Viscum cruciatum Sieber on the chemical constituents of Crataegus monogyna Jacq.

PubMed:Two octanordammarane triterpenes from Commiphora kua.

PubMed:Five new cadinane-type sesquiterpenes from the heartwood of Chamaecyparis obtusa var. formosana.

PubMed:Antimite activity of essential oils and their constituents from Taiwania cryptomerioides.

PubMed:17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).

PubMed:Minor components with smooth muscle relaxing properties from scented myrrh (Commiphora guidotti).

PubMed:(+)-10 alpha-Hydroxy-4-muurolen-3-one, a new inhibitor of leukotriene biosynthesis from a Favolaschia species. Comparison with other sesquiterpenes.

PubMed:Calcium antagonistic properties of the sesquiterpene T-cadinol and related substances: structure-activity studies.

PubMed:Calcium channels at the adrenergic neuroeffector junction in the rabbit ear artery.

PubMed:Calcium antagonistic properties of the sesquiterpene T-cadinol: a comparison with nimodipine in the isolated rat aorta.

PubMed:T-cadinol: a pharmacologically active constituent of scented myrrh: introductory pharmacological characterization and high field 1H- and 13C-NMR data.

PubMed:Sterol conjugates of two phenotypically different calli of Beta vulgaris.

PubMed:The essential oil from Thymus praecox ssp. arcticus growing in Iceland.

PubMed:Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin.

PubMed:Sterol biosynthesis in the echinoderm Asterias rubens.

PubMed:The sterols of the echinoderm Asterias rubens.

Notes:

extract of scented myrrh. Constit. of Juniperus communis (juniper)

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