cubeb oil
essential oil obtained from the unripe fermented ripe fruits of the tailed pepper, piper cubeba l., piperaceae
 
Notes:
Steam distilled from the unripe, dried, crushed fruit of Piper Cubeba cultivated in Sunda Islands and Ceylon. tsca definition 2008: extractives and their physically modified derivatives. piper cubeba, piperaceae.
  • Berjé
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    • Hermitage Oils
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      Cubeb Essential Oil
      Adam Michael has this to say “Indonesian cubeb, distilled from the unripe berries from the fruit tree. The smell is warming with similarities to black pepper and similar therapeutic uses as well. Diluted down heavily in carrier oil, cubeb can be considered useful for treating flatulence, aiding digestion and easing general muscle aches. The natural chemistry comprises mainly of alpha- & beta cubebene, cubebol, alpha-copaene, delta-cadinene, sabinene.”
       
       
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
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    • Lluch Essence S.L.
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      CUBEB OIL
       
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  • Ernesto Ventós
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    Flavor Demo Formulas
Name: piper cubeba fruit oil
CAS Number: 8007-87-2 
FDA UNII: HDE20IN4M5
CoE Number: 131
Also Contains: cinnamomum cassia leaf extract
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Perfumer and Flavorist: Search
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US Patents: Search
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PubMed: Search
NCBI: Search
FDA Mainterm: CUBEB, OIL (PIPER CUBEBA L. F.)
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.510 Natural flavoring substances and natural substances used in conjunction with flavors.
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Physical Properties:
Appearance: pale yellow to bluish green clear liquid (est)
Food Chemicals Codex Listed: No
Optical Rotation: -12.00 to -43.00
Acid Value: 2.00 max. KOH/g
Flash Point: 180.00 °F. TCC ( 82.22 °C. )
Soluble in:
 alcohol
 water, 4.581 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
Odor Type: spicy
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
 fresh  spicy  bois de rose  herbal  smoky  
Odor Description:
at 10.00 % in dipropylene glycol. 
fresh spicy bois de rose herbal smokey
Luebke, William tgsc, (1986)
 cubeb  
Taste Description:
cubeb
Substantivity: 268 Hour(s)
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
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Suppliers:
Berjé
Cubeb Oil
Specialties
Blue Pacific Flavors
Cubeb Oil
Bristol Botanicals
Cubebs essential oil Piper cubeba, Indonesia
Ernesto Ventós
CUBEB OIL 851 INDESSO
Odor: MINT- LIKE, SPICY
Hermitage Oils
Cubeb Essential Oil
Odor: characteristic
Use: Adam Michael has this to say “Indonesian cubeb, distilled from the unripe berries from the fruit tree. The smell is warming with similarities to black pepper and similar therapeutic uses as well. Diluted down heavily in carrier oil, cubeb can be considered useful for treating flatulence, aiding digestion and easing general muscle aches. The natural chemistry comprises mainly of alpha- & beta cubebene, cubebol, alpha-copaene, delta-cadinene, sabinene.”
The Vault
Jiangyin Healthway
Cubeb Oil
New functional food ingredients
Liberty Natural Products
CUBEB INDONESIA
Lluch Essence
CUBEB OIL
Moellhausen
CUBEB EO
Odor: citric, fresh, characteristic of orange peel
Flavor: terpenic, aromatic, spicy, pepper note
Noble Molecular Research
For experimental / research use only.
Cubeb Oil
Penta International
CUBEB OIL FCC, NATURAL, Kosher
Reincke & Fichtner
Cubeb Oil organic + NOP
Reincke & Fichtner
Cubeb Oil
Ultra International
Cubeb Oil
White Lotus Aromatics
Cubeb essential oil
Odor: fresh, warm spicy-peppery, camphoraceous bouquet with dry woody undertone
Use: In natural perfumes used in culinary bases, spice accords, incense bouquets, apothecary blends.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for cubeb oil usage levels up to:
  1.0000 % in the fragrance concentrate.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -4.60000
beverages(nonalcoholic): -2.40000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -33.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.25000
fruit ices: -0.25000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -1.80000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 25.0000030.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
EPI System: View
EPA Substance Registry Services (TSCA): 8007-87-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 piper cubeba fruit oil
Chemidplus: 0008007872
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References:
 piper cubeba fruit oil
Canada Domestic Sub. List: 8007-87-2
Pubchem (sid): 135274884
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Other Information:
FDA Everything Added to Food in the United States (EAFUS): View
Export Tariff Code: 3301.29.6000
 Typical G.C.
Wikipedia: View
FAO: BASIC PRINCIPLES OF STEAM DISTILLATION
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Potential Blenders and core components note
 
For Odor
No odor group found for these
 calamenene 
para-menth-1-en-9-alFL/FR
aldehydic
 agrumen nitrileFR
cheesy
2-heptanoneFL/FR
earthy
3-octen-2-oneFL/FR
 octyl phenyl acetateFL/FR
floral
 bois de rose oil brazilFL/FR
 coranol (Firmenich)FR
 coriander seed oilFL/FR
 dihydrojasmoneFL/FR
 dihydrolinaloolFL/FR
3,6-dimethyl-3-octanolFL/FR
 ethyl linaloolFR
 ethyl linalyl acetalFR
 ethyl linalyl acetateFR
 ethyl linalyl etherFL/FR
 ho leaf oilFR
 ho wood oilFR
 linaloolFL/FR
dextro-linaloolFL/FR
laevo-linaloolFL/FR
 linalool oxideFL/FR
 linalyl anthranilateFL/FR
 terpinyl isobutyrateFL/FR
 tetrahydrolinaloolFL/FR
 perillyl acetateFL/FR
green
sec-butyl-3-methyl but-2-ene thioateFL/FR
 carrot leaf oil (daucus carota ssp.maximus)FR
 privet dioxaneFR
herbal
 carvacryl methyl etherFL/FR
 coriander seed absoluteFL/FR
 dehydroxylinalool oxideFL/FR
 herbal acetalFR
1-para-menthen-9-yl acetateFL/FR
T-muurololFL/FR
3-nonanolFL/FR
3-octanon-1-olFL/FR
curled parsley seed oilFL/FR
 saffron indenoneFL/FR
 safranalFL/FR
 thymyl methyl etherFL/FR
minty
 betula lenta bark oil americaFL/FR
spicy
isobutyl (E,E)-2,4-decadienamideFL/FR
 carrot weed oilFL/FR
 carvacryl ethyl etherFL/FR
 cinnamaldehyde dimethyl acetalFL/FR
(-)-cubenolFL/FR
 cuminyl alcoholFL/FR
black currant bud absoluteFL/FR
 ginger oleoresin africaFL/FR
sweet marjoram oil (origanum majorana var. tenuifolium weston) cyprus 
 origanum majorana oilFL/FR
 origanum majorana oil cubaFL/FR
 origanum majorana oil moroccoFL/FR
woody
 patchouli absoluteFR
 
For Flavor
 
No flavor group found for these
isobutyl (E,E)-2,4-decadienamideFL/FR
sec-butyl-3-methyl but-2-ene thioateFL/FR
 calamenene 
 carvacryl ethyl etherFL/FR
 carvacryl methyl etherFL/FR
 dihydrolinaloolFL/FR
2,4-dimethyl anisoleFL
3,6-dimethyl-3-octanolFL/FR
 ethyl linalyl etherFL/FR
laevo-linaloolFL/FR
dextro-linaloolFL/FR
 linalyl anthranilateFL/FR
sweet marjoram oil (origanum majorana var. tenuifolium weston) cyprus 
para-menth-1-en-9-alFL/FR
T-muurololFL/FR
3-nonanolFL/FR
3-octanon-1-olFL/FR
 octyl phenyl acetateFL/FR
 saffron indenoneFL/FR
 terpinyl isobutyrateFL/FR
 hexyl 3-mercaptobutanoateFL
berry
 perillyl acetateFL/FR
cheesy
2-heptanoneFL/FR
citrus
 linaloolFL/FR
creamy
3-octen-2-oneFL/FR
floral
 bois de rose oil brazilFL/FR
 dihydrojasmoneFL/FR
 tetrahydrolinaloolFL/FR
fruity
1-para-menthen-9-yl acetateFL/FR
 carrot weed oilFL/FR
 linalool oxideFL/FR
herbal
 coriander seed absoluteFL/FR
 coriander seed oilFL/FR
 origanum majorana oilFL/FR
curled parsley seed oilFL/FR
minty
 betula lenta bark oil americaFL/FR
musty
 thymyl methyl etherFL/FR
spicy
 cinnamaldehyde dimethyl acetalFL/FR
(-)-cubenolFL/FR
 cuminyl alcoholFL/FR
black currant bud absoluteFL/FR
 ginger oleoresin africaFL/FR
 origanum majorana oil cubaFL/FR
 origanum majorana oil moroccoFL/FR
woody
 dehydroxylinalool oxideFL/FR
 safranalFL/FR
 
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Potential Uses:
 carnation dianthus oeilletFR
 pepper 
 pepper treeFL/FR
 spiceFR
 woodyFR
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Natural Occurrence in: note
 piper cubeba
GRIN Trop Picture
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Synonyms:
 cubeb EO
 cubeb oil
 cubeb oil FCC
 essential oil obtained from the unripe fermented ripe fruits of the tailed pepper, piper cubeba l., piperaceae
 piper cubeba fruit oil
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Articles:
PubMed: Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.
PubMed: Evaluation of lignan (-)-cubebin extracted from Piper cubeba on human colon adenocarcinoma cells (HT29).
PubMed: Cytotoxic activity of Piper cubeba extract in breast cancer cell lines.
PubMed: Evaluation of the effectiveness of Piper cubeba extract in the amelioration of CCl4-induced liver injuries and oxidative damage in the rodent model.
PubMed: Biological activities of Zingiber officinale (Zingiberaceae) and Piper cubeba (Piperaceae) essential oils against pulse beetle, Callosobruchus chinensis (Coleoptera: Bruchidae).
PubMed: In vitro antiparasitic activity and chemical composition of the essential oil obtained from the fruits of Piper cubeba.
PubMed: Variation in manuka oil lure efficacy for capturing Xyleborus glabratus (Coleoptera: Curculionidae: Scolytinae), and cubeb oil as an alternative attractant.
PubMed: A comparative study of the modulatory effects of (-)-cubebin on the mutagenicity/recombinogenicity induced by different chemical agents.
PubMed: The lignan (-)-cubebin inhibits vascular contraction and induces relaxation via nitric oxide activation in isolated rat aorta.
PubMed: Mutagenicity and antimutagenicity of (-)-hinokinin a trypanosomicidal compound measured by Salmonella microsome and comet assays.
PubMed: Nephroprotective effect of Kabab chini (Piper cubeba) in gentamycin-induced nephrotoxicity.
PubMed: Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants.
PubMed: Identification of ambiguous cubeb fruit by DART-MS-based fingerprinting combined with principal component analysis.
PubMed: Essential and toxic elements in three Pakistan's medicinal fruits (Punica granatum, Ziziphus jujuba and Piper cubeba) analysed by INAA.
PubMed: In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni.
PubMed: Radical scavenging ability of some compounds isolated from Piper cubeba towards free radicals.
PubMed: Was the famous astronomer Copernicus also a nephrologist.
PubMed: The effect of the dibenzylbutyrolactolic lignan (-)-cubebin on doxorubicin mutagenicity and recombinogenicity in wing somatic cells of Drosophila melanogaster.
PubMed: Effect of the dibenzylbutyrolactone lignan (-)-hinokinin on doxorubicin and methyl methanesulfonate clastogenicity in V79 Chinese hamster lung fibroblasts.
PubMed: Molluscicidal activity of Piper cubeba Linn., Piper longum Linn. and Tribulus terrestris Linn. and their combinations against snail Indoplanorbis exustus Desh.
PubMed: Piper cubeba demonstrates anti-estrogenic and anti-inflammatory properties.
PubMed: Piper cubeba targets multiple aspects of the androgen-signalling pathway. A potential phytotherapy against prostate cancer growth?
PubMed: Evaluation of piper cubeba extract, (-)-cubebin and its semi-synthetic derivatives against oral pathogens.
PubMed: (-)-Hinokinin causes antigenotoxicity but not genotoxicity in peripheral blood of Wistar rats.
PubMed: Effect of some medicinal plants on plasma antioxidant system and lipid levels in rats.
PubMed: Metabolite-cytochrome P450 complex formation by methylenedioxyphenyl lignans of Piper cubeba: mechanism-based inhibition.
PubMed: Potent CYP3A4 inhibitory constituents of Piper cubeba.
PubMed: Enzymatic and non-enzymatic antioxidants in selected Piper species.
PubMed: Investigations of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida.
PubMed: Inhibitory effects of sudanese medicinal plant extracts on hepatitis C virus (HCV) protease.
PubMed: [Constituents of Aristolochia triangularis].
PubMed: Comparison of vegetative anatomy of piperales. I. Juvenile xylem of twigs.
PubMed: The occurrence of mature fruits of Piper cubeba in recently imported cubeb.
PubMed: The problem of foreign botanicals.
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