licorice oil
oils, licorice
tsca definition 2008: extractives and their physically modified derivatives. glycyrrhiza, leguminosae.
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CAS Number: 97676-23-8 
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Soluble in:
 water, 73.14 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor Type: licorice
Odor Strength: medium
Odor Description:
at 100.00 %. 
Taste Description:
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Cosmetic Information:
None found
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 97676-23-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0097676238
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Canada Domestic Sub. List: 97676-23-8
Pubchem (sid): 135272755
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Other Information:
Household Products: Search
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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secondary acid liquor
tertiary acid liquor
tertiary licorice extract
 oils, licorice
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PubMed: Lipidomics investigation of reversal effect of glycyrrhizin (GL) towards lithocholic acid (LCA)-induced alteration of phospholipid profiles.
PubMed: Cosmetic benefits of natural ingredients.
PubMed: Synergy of licorice extract and pea protein hydrolysate for oxidative stability of soybean oil-in-water emulsions.
PubMed: Short communication: an in vitro assessment of the antibacterial activity of plant-derived oils.
PubMed: Effects of oils and emulsifiers on the skin penetration of stearyl glycyrrhetinate in oil-in-water emulsions.
PubMed: Effect of licorice flavonoid oil on cholesterol metabolism in high fat diet rats.
PubMed: Phytoestrogens and the metabolic syndrome.
PubMed: Herbal products that may contribute to hypertension.
PubMed: Volatiles profiling in medicinal licorice roots using steam distillation and solid-phase microextraction (SPME) coupled to chemometrics.
PubMed: Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis.
PubMed: [The study of corrective role of plant--based drugs with antioxidant action in experimental intoxication with potassium dichromate].
PubMed: Formulation and evaluation of herbal anti-acne moisturizer.
PubMed: Preparing glabridin-in-water nanoemulsions by high pressure homogenization with response surface methodology.
PubMed: [Study on the effects of different compatibility of guizhi decoction on component of volatile oil from Cinnamomum cassia by GC-MS].
PubMed: Dietary supplements and hypertension: potential benefits and precautions.
PubMed: Hepatoprotective and antioxidant effects of licorice extract against CClâ‚„-induced oxidative damage in rats.
PubMed: Tooth brushing, oil pulling and tissue regeneration: A review of holistic approaches to oral health.
PubMed: Utility of nano-sized, water-in-oil emulsion as a sustained release formulation of glycyrrhizin.
PubMed: A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity.
PubMed: Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
PubMed: Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome.
PubMed: The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.
PubMed: Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex.
PubMed: Botanicals in dermatology: an evidence-based review.
PubMed: The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats.
PubMed: Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay.
PubMed: Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: A randomized, double-blind, placebo-controlled study.
PubMed: Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats.
PubMed: "Natural" ingredients in cosmetic dermatology.
PubMed: Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats.
PubMed: Genotoxicity studies on licorice flavonoid oil (LFO).
PubMed: Artocarpus lakoocha heartwood extract as a novel cosmetic ingredient: evaluation of the in vitro anti-tyrosinase and in vivo skin whitening activities.
PubMed: 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats.
PubMed: Fungal contamination of raw materials of some herbal drugs and recommendation of Cinnamomum camphora oil as herbal fungitoxicant.
PubMed: Less-known botanical cosmeceuticals.
PubMed: Botanical ingredients in cosmeceuticals.
PubMed: Absorption of dietary licorice isoflavan glabridin to blood circulation in rats.
PubMed: Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update.
PubMed: Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans.
PubMed: Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice.
PubMed: Treatment of rosacea with herbal ingredients.
PubMed: Antifungal activity of plant extracts against Arthrinium sacchari and Chaetomium funicola.
PubMed: Identification of chemicals, possibly originating from misuse of refillable PET bottles, responsible for consumer complaints about off-odours in water and soft drinks.
PubMed: Volatile components and key odorants of fennel (Foeniculum vulgare Mill.) and thyme (Thymus vulgaris L.) oil extracts obtained by simultaneous distillation-extraction and supercritical fluid extraction.
PubMed: The antioxidative activity of traditional Japanese herbs.
PubMed: Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice.
PubMed: Complementary and alternative interventions in asthma, allergy, and immunology.
PubMed: Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society.
PubMed: Herbal bioactivation: the good, the bad and the ugly.
PubMed: Ability of cold-tolerant plants to grow in hydrocarbon-contaminated soil.
PubMed: The effect of glycyrrhizin on the release rate and skin penetration of diclofenac sodium from topical formulations.
PubMed: Potential interactions between alternative therapies and warfarin.
PubMed: Contact allergy due to oil-soluble licorice extracts in cosmetic products.
PubMed: Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions.
PubMed: Increased sodium appetite and thirst in rat induced by the ingredients of liquorice, glycyrrhizic acid and glycyrrhetinic acid.
PubMed: Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants.
PubMed: [Von Siebold's prescriptions (2)].
PubMed: Processing of nux vomica. VII. Antinociceptive effects of crude alkaloids from the processed and unprocessed seeds of Strychnos nux-vomica in mice.
PubMed: [Anti-promoting and anti-mutagenic actions of G9315].
PubMed: Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts.
PubMed: Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo(a)pyrene.
PubMed: [Effect of glycyrrhetinic acid on DNA damage and unscheduled DNA synthesis induced by benzo (a) pyrene].
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