EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cycloionone
6,7,8,8a-tetrahydro-2,5,5,8a-tetramethyl-(5H)-1-benzopyran

Sponsors

CAS Number: 5552-30-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:226-916-2
FDA UNII:9Q35X5W89M
Nikkaji Web:J225.012H
CoE Number:13165
XlogP3-AA:3.40 (est)
Molecular Weight:192.30160000
Formula:C13 H20 O
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:1239 cycloionone
FLAVIS Number:13.165 (Old)
DG SANTE Food Flavourings:13.165 6,7,8,8a-tetrahydro-2,5,5,8a-tetramethyl-(5H)-1-benzopyran
FEMA Number:3822 cycloionone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: CYCLOIONONE
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 96.70 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95000 to 0.95500 @ 25.00 °C.
Pounds per Gallon - (est).: 7.905 to 7.947
Refractive Index:1.49900 to 1.50500 @ 20.00 °C.
Boiling Point: 240.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.016000 mm/Hg @ 25.00 °C. (est)
Flash Point: 226.00 °F. TCC ( 107.78 °C. )
logP (o/w): 3.462 (est)
Soluble in:
 alcohol
 water, 9.006 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: woody
Odor Strength:medium
woody cedarwood raspberry orris rooty
Odor Description:at 100.00 %. woody cedarwood raspberry orris root
Flavor Type: woody
">woody cedarwood fruity floral raspberry orris
Taste Description: woody cedarwood fruity floral raspberry orris
Odor and/or flavor descriptions from others (if found).
Symrise
Cycloionone
Taste Description:woody, cedarwood, raspberry, orris root
Useful in: fruity red, fruity yellow, fruity tropical, sweet others.
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
6,7,8,8a-tetrahydro-2,5,5,8a-tetramethyl-5H-1-benzopyran
Parchem
cycloionone
Symrise
Cycloionone
Flavor: woody, cedarwood, raspberry, orris root
Useful in: fruity red, fruity yellow, fruity tropical, sweet others.
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavoring agents
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.14 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 2.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 18
 average usual ppmaverage maximum ppm
baked goods: 10.0000030.00000
beverages(nonalcoholic): 0.100001.00000
beverages(alcoholic): 0.500005.00000
breakfast cereal: --
cheese: --
chewing gum: 10.0000050.00000
condiments / relishes: --
confectionery froastings: 0.500005.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.500005.00000
fruit ices: 0.200002.00000
gelatins / puddings: 0.200005.00000
granulated sugar: --
gravies: --
hard candy: 1.0000010.00000
imitation dairy: --
instant coffee / tea: 0.100001.00000
jams / jellies: 0.500005.00000
meat products: --
milk products: 0.500005.00000
nut products: --
other grains: --
poultry: --
processed fruits: 0.500005.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 0.500005.00000
soups: --
sugar substitutes: --
sweet sauces: 0.500005.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 59 (FGE.59): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 33 (FGE.33)[1] - Six Tetrahydrofuran Derivatives from Chemical Groups 13, 14, 16 and 26 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 59, Revision 1 (FGE.59Rev1): Consideration of aliphatic and aromatic ethers evaluated by JECFA (61st meeting and 63rd meeting) structurally related to aliphatic, alicyclic and aromatic ethers including anisole derivatives evaluated by EFSA in FGE.23 Rev2 (2010)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):5552-30-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :110664
National Institute of Allergy and Infectious Diseases:Data
2,5,5,8a-tetramethyl-7,8-dihydro-6H-chromene
Chemidplus:0005552307
 
References:
 2,5,5,8a-tetramethyl-7,8-dihydro-6H-chromene
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):110664
Pubchem (sid):135068367
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB36144
FooDB:FDB014995
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
amber
amber decane
FR
ambermax 50 (Givaudan)
FR
balsamic
benzyl cinnamate
FL/FR
cedar forest fragrance
FR
hemlock western oil (tsuga heterophylla) canada
FR
3-
phenyl propyl acetate
FL/FR
floral
citronellyl anthranilate
FL/FR
(E)-
geranyl acetone
FL/FR
beta-
ionyl acetate
FL/FR
alpha-
irone
FL/FR
iso
jasmone
FL/FR
iso
jasmone
FL/FR
(Z)-
methyl epi-jasmonate
FL/FR
alpha-iso
methyl ionone (70% min.)
FL/FR
alpha-iso
methyl ionone (80% min.)
FL/FR
methyl jasmonate
FL/FR
mimosa absolute
FL/FR
mimosa absolute france
FL/FR
mimosa absolute india
FL/FR
(E)-
nerolidol
FL/FR
neryl isovalerate
FL/FR
bitter
orangeflower absolute morocco
FL/FR
osmanthus concrete
FL/FR
papaya isobutyrate
FL/FR
phenethyl butyrate
FL/FR
phenethyl hexanoate
FL/FR
rose butanoate
FL/FR
fruity
bisabolene
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
beta-
ionyl ethyl ether
FR
linalyl isobutyrate
FL/FR
neryl propionate
FL/FR
vanilla carboxylate
FL/FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
leafy acetal
FL/FR
neryl butyrate
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
herbal
hop oil
FL/FR
(1S,5R)-
myrtenyl acetate
FL/FR
tricyclo(5.2.1.02,6)dec-3-enyl acetate
FR
rooty
vetiveryl propionate
FR
spicy
anona squamosa leaf oil
FR
machilus kusanoi leaf oil
FR
woody
amber decatriene
FR
ambrene acetal
FR
amyris acetate
FR
caryophyllene alcohol acetate
FR
cedar cyclododecatriene
FR
cedarwood oil alcohols
FL/FR
cedarwood oil himalaya
FR
cedarwood oil terpenes
FL/FR
cedarwood oil texas
FR
cedarwood oil virginia
FR
cedarwood oil white
FR
cedrela wood oil
FR
cedrene
FR
alpha-
cedrene
FL/FR
cedrenyl acetate
FR
cedrol
FL/FR
cedryl acetate
FL/FR
4-(3,3-
dimethyl bicyclo(2.2.1)hept-2-yl)-2-oxabicyclo(2.2.2)octane
FR
alpha-
ethyl-2,2,6-trimethyl cyclohexane propanol
FR
juniperus deppeana wood oil
FR
juniperus mexicana extract
FR
methyl cedryl ketone replacer
FR
sandal pentanol
FR
sclareolide
FL/FR
sugi wood oil
FR
thujopsis dolabrata wood oil
FR
violet propanol
FR
woody acetate
FR
woody dodecane
FR
For Flavor
No flavor group found for these
cedarwood oil alcohols
FL/FR
alpha-
cedrene
FL/FR
aromatic
aromatic
leafy acetal
FL/FR
balsamic
3-
phenyl propyl acetate
FL/FR
citrus
bisabolene
FL/FR
floral
(E)-
geranyl acetone
FL/FR
linalyl isobutyrate
FL/FR
(Z)-
methyl epi-jasmonate
FL/FR
alpha-iso
methyl ionone (70% min.)
FL/FR
alpha-iso
methyl ionone (80% min.)
FL/FR
methyl jasmonate
FL/FR
bitter
orangeflower absolute morocco
FL/FR
fruity
citronellyl anthranilate
FL/FR
ethyl methyl-para-tolyl glycidate
FL/FR
neryl isovalerate
FL/FR
osmanthus concrete
FL/FR
phenethyl butyrate
FL/FR
rose butanoate
FL/FR
vanilla carboxylate
FL/FR
green
acetaldehyde ethyl phenethyl acetal
FL/FR
iso
jasmone
FL/FR
iso
jasmone
FL/FR
(E)-
nerolidol
FL/FR
neryl butyrate
FL/FR
neryl propionate
FL/FR
papaya isobutyrate
FL/FR
phenyl acetaldehyde dimethyl acetal
FL/FR
herbal
hop oil
FL/FR
nutty
2-
acetyl-1-methyl pyrrole
FL
spicy
benzyl cinnamate
FL/FR
waxy
mimosa absolute
FL/FR
mimosa absolute france
FL/FR
mimosa absolute india
FL/FR
phenethyl hexanoate
FL/FR
woody
cedarwood oil terpenes
FL/FR
cedrol
FL/FR
cedryl acetate
FL/FR
beta-
ionyl acetate
FL/FR
alpha-
irone
FL/FR
(1S,5R)-
myrtenyl acetate
FL/FR
sclareolide
FL/FR
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 champaca concrete @ 0.20%
Data GC Search Trop Picture
 cognac
Search PMC Picture
 passion fruit
Search Trop Picture
 
Synonyms:
5H-1-benzopyran, 6,7,8,8a-tetrahydro-2,5,5,8a-tetramethyl-
5H-benzopyran, 6,7,8,8a-tetrahydro-2,5,8a-tetramethyl-
 cyclic-b-ionone
 cyclic-beta-ionone
6,7,8,8a-tetrahydro-2,5,5,8a-tetramethyl-(5H)-1-benzopyran
2,5,5,8a-tetramethyl-6,7,8,8a-tetrahydro-1(5H)-1-benzopyran
2,5,5,8a-tetramethyl-6,7,8,8a-tetrahydro-5H-1-benzopyran
2,5,5,8a-tetramethyl-6,7,8,8a-tetrahydro-5H-chromene
2,5,5,8a-tetramethyl-7,8-dihydro-6H-chromene
 
 
Notes:
Present in cognac. Food flavouring ingredient
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