EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

butyl methyl ketone
methyl butyl ketone

Supplier Sponsors

CAS Number: 591-78-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-731-1
FDA UNII:6QDY60NH6N
Nikkaji Web:J3.303K
Beilstein Number:1737676
MDL:MFCD00009482
CoE Number:11776
XlogP3:1.40 (est)
Molecular Weight:100.16084000
Formula:C6 H12 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -55.50 °C. @ 760.00 mm Hg
Boiling Point: 127.60 °C. @ 760.00 mm Hg
Vapor Pressure:11.600000 mm/Hg @ 25.00 °C.
Flash Point: 95.00 °F. TCC ( 35.00 °C. )
logP (o/w): 1.380
Soluble in:
 alcohol
 water, 17500 mg/L @ 20 °C (exp)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: fruity
Odor Strength:high ,
recommend smelling in a 1.00 % solution or less
fruity fungal meaty buttery
Odor Description:at 1.00 % in dipropylene glycol. fruity fungal meaty buttery
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: not used anymore
 
Suppliers:
Beijing Lys Chemicals
2-Hexanone
Inoue Perfumery
BUTYL METHYL KETONE
Penta International
2-HEXANONE
Sigma-Aldrich
For experimental / research use only.
2-Hexanone purum, ≥96.0% (GC)
Synerzine
2-Hexanone
TCI AMERICA
For experimental / research use only.
Butyl Methyl Ketone >98.0%(GC)
WholeChem
2-Hexanone
 
Safety Information:
European information :
Most important hazard(s):
T - Toxic.
R 10 - Flammable.
R 48/23 - Toxic: danger of serious damage to health by prolonged exposure through inhalation.
R 62 - Possible risk of impaired fertility.
R 67 - Vapours may cause frowsiness and dizziness.
S 02 - Keep out of the reach of children.
S 07/09 - Keep container tightly closed and in well-ventilated place.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2590 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.

oral-mouse LD50 2430 mg/kg
Toxicology Letters. Vol. 30, Pg. 13, 1986.

unreported-guinea pig LD50 914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

oral-guinea pig LDLo 914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

unreported-rat LD50 914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

intraperitoneal-rat LDLo 914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

Dermal Toxicity:
skin-rabbit LD50 4800 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.

Inhalation Toxicity:
inhalation-rat LC50 8000 ppm/4H
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.

inhalation-human TCLo 1000 ppm
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: HEADACHE GASTROINTESTINAL: NAUSEA OR VOMITING
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.

 
Safety in Use Information:
Category: flavoring agents
Recommendation for butyl methyl ketone usage levels up to:
 not for fragrance use.
 
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):591-78-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11583
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WISER:UN 1224
WGK Germany:1
hexan-2-one
Chemidplus:0000591786
EPA/NOAA CAMEO:hazardous materials
RTECS:591-78-6
 
References:
 hexan-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:591-78-6
Pubchem (cid):11583
Pubchem (sid):134977464
Flavornet:591-78-6
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB05842
FooDB:FDB008079
Export Tariff Code:2914.19.0000
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Formulations/Preparations:
•grade: technical •commercial grades of mnbk vary in purity from 70 to 96%; the more dilute grades include predominantly methyl isobutyl ketone (mibk).
 
Potential Blenders and core components note
For Odor
alcoholic
fusel oil
FL/FR
chemical
iso
butyl formate
FL/FR
ethereal
acetal
FL/FR
butyl acetate
FL/FR
ethyl acetate
FL/FR
ethyl pyruvate
FL/FR
iso
propyl acetate
FL/FR
propyl valerate
FL/FR
iso
valeraldehyde propylene glycol acetal
FL/FR
floral
nonan-3-yl acetate
FL/FR
fruity
acetaldehyde diisoamyl acetal
FL/FR
amyl acetate
FL/FR
amyl formate
FL/FR
amyl heptanoate
FL/FR
benzyl methyl ether
FL/FR
iso
butyl acetate
FL/FR
iso
butyl isobutyrate
FL/FR
iso
butyl valerate
FL/FR
2-
ethyl butyl acetate
FL/FR
ethyl propionate
FL/FR
geranyl ethyl ether
FL/FR
methyl 2-methyl butyrate
FL/FR
methyl butyrate
FL/FR
methyl hexanoate
FL/FR
methyl isobutyrate
FL/FR
iso
propyl propionate
FL/FR
strawberry furanone butyrate
FL/FR
green
cognac heptanone
FL/FR
3-
heptanone
FL/FR
3-
hepten-2-one
FL/FR
(Z)-2-
penten-1-ol
FL/FR
For Flavor
No flavor group found for these
acetaldehyde diisoamyl acetal
FL/FR
ethyl 2-methyl-2-(methyl thio) propionate
FL
geranyl ethyl ether
FL/FR
2-
heptenoic acid
FL
2-
methyl butyl isobutyrate
FL
2-
methyl butyl propionate
FL
S-(
methyl thio) hexanoate
FL
nonan-3-yl acetate
FL/FR
propyl valerate
FL/FR
citrus
citrus
cognac heptanone
FL/FR
creamy
3-
hepten-2-one
FL/FR
ethereal
butyl acetate
FL/FR
ethyl acetate
FL/FR
methyl isobutyrate
FL/FR
iso
propyl acetate
FL/FR
fruity
amyl acetate
FL/FR
amyl formate
FL/FR
amyl heptanoate
FL/FR
benzyl methyl ether
FL/FR
iso
butyl acetate
FL/FR
iso
butyl isobutyrate
FL/FR
iso
butyl valerate
FL/FR
2-
ethyl butyl acetate
FL/FR
ethyl propionate
FL/FR
2-
furyl pentyl ketone
FL
fusel oil
FL/FR
methyl 2-methyl butyrate
FL/FR
2-
methyl allyl butyrate
FL
methyl hexanoate
FL/FR
iso
propyl propionate
FL/FR
strawberry furanone butyrate
FL/FR
iso
valeraldehyde propylene glycol acetal
FL/FR
fusel
methyl butyrate
FL/FR
green
2-
ethyl butyraldehyde
FL
(Z)-2-
penten-1-ol
FL/FR
ketonic
3-
heptanone
FL/FR
nutty
acetal
FL/FR
rummy
iso
butyl formate
FL/FR
ethyl pyruvate
FL/FR
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 clove bud oil @ 0.05%
Data GC Search Trop Picture
 clove fruit
Search Trop Picture
 clove leaf oil @ 0.03%
Data GC Search Trop Picture
 clove oil
Search Trop Picture
 clove stem oil india @ 0.05%
Data GC Search Trop Picture
 corn husk oil
Search Trop Picture
 corn seed oil
Search Trop Picture
 hyssop shoot
Search Trop Picture
 pepper bell pepper fruit
Search Trop Picture
 plumcot fruit
Search PMC Picture
 
Synonyms:
N-butyl methyl ketone
 butylmethyl ketone
 hexan-2-one
2-oxohexane
2-hexanone
 ketone, butyl methyl
 MBK
 methyl butyl ketone
 methyl N-butyl ketone
 methylbutyl ketone
 propyl acetone
 propylacetone
 

Articles:

PubMed:Volatile Organic Compounds during Inflammation and Sepsis in Rats: A Potential Breath Test Using Ion-mobility Spectrometry.
PubMed:Reaction rate constants of H-abstraction by OH from large ketones: measurements and site-specific rate rules.
PubMed:Binding of carbonyl flavours to canola, pea and wheat proteins using GC/MS approach.
PubMed:Salivary microbiota and metabolome associated with celiac disease.
PubMed:Combined IR/NIR and density functional theory calculations analysis of the solvent effects on frequencies and intensities of the fundamental and overtones of the C ═ O stretching vibrations of acetone and 2-hexanone.
PubMed:Development of an electrospray-(63)Ni-differential ion mobility spectrometer for the analysis of aqueous samples.
PubMed:[Biomonitoring of exposure to chemical products in environmental and workplace toxicology].
PubMed:Furry pet allergens, fungal DNA and microbial volatile organic compounds (MVOCs) in the commercial aircraft cabin environment.
PubMed:Brushed block copolymer micelles with pH-sensitive pendant groups for controlled drug delivery.
PubMed:Can volatile organic metabolites be used to simultaneously assess microbial and mite contamination level in cereal grains and coffee beans?
PubMed:Mass and Ion Transport in Ketones and Ketone Electrolytes: Comparison with Acetate Systems.
PubMed:An endophytic Nodulisporium sp. from Central America producing volatile organic compounds with both biological and fuel potential.
PubMed:Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS).
PubMed:Blending synthetic pheromones of cerambycid beetles to develop trap lures that simultaneously attract multiple species.
PubMed:Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice.
PubMed:Bioactivity of short-chain aliphatic ketones against adults of the granary weevil, Sitophilus granarius (L.).
PubMed:Simplification of a complex microbial antilisterial consortium to evaluate the contribution of its flora in uncooked pressed cheese.
PubMed:Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example.
PubMed:Improved synthesis of three methyl-branched pheromone components produced by the female lichen moth.
PubMed:Thermodynamic properties of hyperbranched polymer, Boltorn U3000, using inverse gas chromatography.
PubMed:Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831.
PubMed:Quantification of volatile compounds in goat milk Jack cheese using static headspace gas chromatography.
PubMed:High-pressure ion mobility spectrometry.
PubMed:Biocatalytical production of (5S)-hydroxy-2-hexanone.
PubMed:Extraction and spectrophotometric determination of cobalt(II) with isonitroso-5-methyl-2-hexanone.
PubMed:Headspace solid phase microextraction/gas chromatography-mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: a new tool to detect dog contamination by visceral leishmaniasis.
PubMed:Airborne concentrations of volatile organic compounds in neonatal incubators.
PubMed:Aroma barrier properties of sodium caseinate-based films.
PubMed:Microbial volatile organic compounds in the air of moldy and mold-free indoor environments.
PubMed:Acid-catalyzed isomerization and decomposition of ketone-2,4-dinitrophenylhydrazones.
PubMed:Evaluation of lipid oxidation and oxidative products as affected by pork meat cut, packaging method, and storage time during frozen storage (-10 degrees C).
PubMed:Kinetic analysis of volatile formation in milk subjected to pressure-assisted thermal treatments.
PubMed:Rate constants for the reaction of cl with a series of C4 to C6 ketones using the relative rate method.
PubMed:[Identification of volatiles from field cotton plant under different induction treatments].
PubMed:Purification and characterization of alcohol dehydrogenase reducing N-benzyl-3-pyrrolidinone from Geotrichum capitatum.
PubMed:Pulsed laser photolysis vacuum UV laser-induced fluorescence kinetic study of the gas-phase reactions of Cl(2P3/2) atoms with C3-C6 ketones.
PubMed:Ozone artifacts and carbonyl measurements using Tenax GR, Tenax TA, Carbopack B, and Carbopack X adsorbents.
PubMed:Solid-phase microextraction: investigation of the metabolism of substances that may be abused by inhalation.
PubMed:Quantitative determination of thermally derived off-flavor compounds in milk using solid-phase microextraction and gas chromatography.
PubMed:Degradation characteristics of methyl ethyl ketone by Pseudomonas sp. KT-3 in liquid culture and biofilter.
PubMed:Capture of female Hylotrupes bajulus as influenced by trap type and pheromone blend.
PubMed:1,4-hydroxycarbonyl products of the OH radical initiated reactions of C5-C8 n-alkanes in the presence of NO.
PubMed:Enhancement of attraction and trap catches of the old-house borer, Hylotrupes bajulus (Coleoptera: Cerambycidae), by combination of male sex pheromone and monoterpenes.
PubMed:Tropospheric reaction of OH with selected linear ketones: kinetic studies between 228 and 405 K.
PubMed:Microwave-assisted derivatization of 2,5-hexanedione in urine: evaluation using GC-MS and GC-ECD.
PubMed:Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
PubMed:Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D.
PubMed:The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase.
PubMed:Migration of volatile degradation products into ozonated water from plastic packaging materials.
PubMed:Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry.
PubMed:Synthesis, structural characterization and antimicrobial studies of hydrazone derivatives of 3-hydroxyimino-5-methyl-2-hexanone.
PubMed:Evaluation of 2,5-hexanedione in urine of workers exposed to n-hexane in Brazilian shoe factories.
PubMed:Synthesis and antimicrobial activity of 3-hydroxyimino-5-methyl-2-hexanone(HIMH) and its dioxime derivative.
PubMed:Aromatic as well as aliphatic hydrocarbon solvent axonopathy.
PubMed:Determination of unique microbial volatile organic compounds produced by five Aspergillus species commonly found in problem buildings.
PubMed:Detection and quantification of ochratoxin A and deoxynivalenol in barley grains by GC-MS and electronic nose.
PubMed:The generalization of an olfactory-based conditioned response reveals unique but overlapping odour representations in the moth Manduca sexta.
PubMed:Aroma compounds-proteins interaction using headspace techniques.
PubMed:Evaluation of individual components of plum odor as potential attractants for adult plum curculios.
PubMed:Positional effect of solute functional group among positional isomers in hydroxyl group-solvent and carbonyl group-solvent specific interactions in menthanol--water mixed solvents monitored by high-performance liquid chromatography.
PubMed:Ruthenium complex-catalyzed anti-Markovnikov hydration of terminal alkynes.
PubMed:Regulated workplace ketones and their interference in the PFBHA method for aldehydes.
PubMed:Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration.
PubMed:Effect of aeration during cell growth on ketone reactions by immobilized yeast.
PubMed:NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123.
PubMed:Determination of free and glucuronated hexane metabolites without prior hydrolysis by liquid- and gas-chromatography coupled with mass spectrometry.
PubMed:Evidence for an inducible nucleotide-dependent acetone carboxylase in Rhodococcus rhodochrous B276.
PubMed:Water activity control: a way to improve the efficiency of continuous lipase esterification.
PubMed:Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 2. Glucuronide-conjugated metabolites in untreated urine samples by electrospray ionization.
PubMed:Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 1. 2,5-hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization.
PubMed:Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?
PubMed:Method for the simultaneous quantification of n-hexane metabolites: application to n-hexane metabolism determination.
PubMed:Toxic effects of hexane derivatives on cultured rat Schwann cells.
PubMed:In vitro quantitative structure-activity relationship assessment of pyrrole adducts production by gamma-diketone-forming neurotoxic solvents.
PubMed:Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat.
PubMed:Structure, stereochemistry, and thermal isomerization of the male sex pheromone of the longhorn beetle Anaglyptus subfasciatus.
PubMed:Induction of chromosome loss in yeast by combined treatment with neurotoxic hexacarbons and monoketones.
PubMed:Sensory irritation and pulmonary irritation of n-methyl ketones: receptor activation mechanisms and relationships with threshold limit values.
PubMed:A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats.
PubMed:A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat. Effects of chemicals of varied structure.
PubMed:Compounds affecting mosquito oviposition: structure-activity relationships and concentration effects.
PubMed:Immunochemical detection of cytochrome P450 isozymes induced in rat liver by n-hexane, 2-hexanone and acetonyl acetone.
PubMed:Gonadotoxic effects of 2-hexanone and 1,2-dibromo-3-chloropropane on the enzymatic activity of rat testicular 17 alpha-hydroxylase/C17,20-lyase.
PubMed:Evidence for the involvement of organelles in the mechanism of ketone-potentiated chloroform-induced hepatotoxicity.
PubMed:The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro.
PubMed:Induction of chromosome loss by mixtures of organic solvents including neurotoxins.
PubMed:Induction of cytochromes P450IIE1 and P450IIB1 by secondary ketones and the role of P450IIE1 in chloroform metabolism.
PubMed:Synthesis and pheromonal activity of 6,10,13-trimethyl-1-tetradecanol for predatory stink bug,Stiretrus anchorago (Heteroptera: Pentatomidae).
PubMed:Cytoskeletal changes induced in vitro by 2,5-hexanedione: an immunocytochemical study.
PubMed:Volatile methyl ketone seed-germination inhibitors fromAmaranthus palmeri S. Wats. Residues.
PubMed:The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man.
PubMed:The role of biotransformation-detoxication in acetone-, 2-butanone-, and 2-hexanone-potentiated chloroform-induced hepatotoxicity.
PubMed:Disposition, pharmacokinetics, and metabolism of a dermal dose of [14C]2,5-hexanedione in hens.
PubMed:4,5-Dihydroxy-2-hexanone: a new metabolite of N-hexane and of 2,5-hexanedione in rat urine.
PubMed:Modifications in rat hepatobiliary function following treatment with acetone, 2-butanone, 2-hexanone, mirex, or chlordecone and subsequently exposed to chloroform.
PubMed:Renal and hepatic interactions between 2-hexanone and carbon tetrachloride in F-344 rats.
PubMed:Impairment of human polymorphonuclear leukocyte chemotaxis by 2,5-hexanedione.
PubMed:Methodological investigations on the determination of n-hexane metabolites in urine.
PubMed:Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography.
PubMed:The joint neurotoxic action of inhaled methyl butyl ketone vapor and dermally applied O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens: potentiating effect.
PubMed:Role of intrarenal biotransformation in chloroform-induced nephrotoxicity in rats.
PubMed:Temporal analysis of rat liver injury following potentiation of carbon tetrachloride hepatotoxicity with ketonic or ketogenic compounds.
PubMed:Dose-response relationships in ketone-induced potentiation of chloroform hepato- and nephrotoxicity.
PubMed:Nephrotoxic interactions between ketonic solvents and halogenated aliphatic chemicals.
PubMed:An electrophysiological study of 2-hexanone and 2,5-hexanedione neurotoxicity in rats.
PubMed:Mechanisms in 2-hexanone potentiation of chloroform hepatotoxicity.
PubMed:Anaesthetic action of esters and ketones: evidence for an interaction with the sodium channel protein in squid axons.
PubMed:2-hexanone potentiation of [14C]chloroform hepatotoxicity: covalent interaction of a reactive intermediate with rat liver phospholipid.
PubMed:In vitro effect of n-hexane and its metabolites on selected enzymes in glycolysis, pentose phosphate pathway and citric acid cycle.
PubMed:Relationship between the carbon skeleton length of ketonic solvents and potentiation of chloroform-induced hepatotoxicity in rats.
PubMed:Ultrastructural studies of the dying-back process. VI. Examination of nerve fibers undergoing giant axonal degeneration in organotypic culture.
PubMed:[An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane].
PubMed:Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens.
PubMed:Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione.
PubMed:Microbial Oxidation of Gaseous Hydrocarbons: Production of Methylketones from Corresponding n-Alkanes by Methane-Utilizing Bacteria.
PubMed:Clinical epidemiology of occupational neurotoxic disease.
PubMed:Microbial production of methyl ketones. Purification and properties of a secondary alcohol dehydrogenase from yeast.
PubMed:Oxidation of secondary alcohols to methyl ketones by yeasts.
PubMed:Simultaneous determination of n-hexane, 2-hexanone and 2,5-hexanedione in biological tissues by gas chromatography mass spectrometry.
PubMed:Peripheral nervous system in a case of canine giant axonal neuropathy.
PubMed:The effect of 2-hexanone and 2-hexanone metabolites on pupillomotor activity and growth.
PubMed:Toxicity and metabolism of methyl n-butyl ketone.
PubMed:2-hexanone. (Methylbutyl ketone, MBK).
PubMed:2-Hexanone (methyl-n-butyl ketone, n-butyl methyl ketone, propyl acetone).
 
Notes:
an industrial solvent which causes nervous system degeneration. mbk is an acronym often used to refer to it. Present in hop oil (Humulus lupulus), potato (Solanum tuberosum) and groundnuts (Arachis hypogaea) 2-Oxohexane is a volatile organic compound. 2-Oxohexane is occasionally found as a volatile component of normal human biofluids. 2-Oxohexane is an hexacarbon solvent; Hexan-2-one is the organic compound with the formula C4H9COCH3. This colorless to pale yellow liquid has a sharp odor. It is a ketone and often known either as MBK (methyl butyl ketone) or 2-hexanone. It dissolves very easily in water, and can evaporate easily into the air as a vapor. Hexan-2-one was used in the past in paint and paint thinner, to make other chemical substances, and to dissolve oils and waxes.; the neurotoxicity of hexacarbon solvents has become apparent and an extensive literature has already developed as a result of the clinical and epidemiological implications of the human disease. The main neurological disorders associated with chronic volatile substance are peripheral neuropathy, cerebellar disease, chronic encephalopathy and dementia. Apart from peripheral neuropathy, the clinical features are non-specific, evidence for solvent-related toxicity is in most cases circumstantial and there is no clear dose/response relationship. (PMID: 5556886, 6278344, 2550357)
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