hop cone oil
volatile oil obtained from the freshly dried membranous cones of the female plants of the hops, humulus lupulus l., cannabidaceae
tsca definition 2008: extractives and their physically modified derivatives. humulus lupulus, moraceae.
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Name: humulus lupulus l. cone oil
CAS Number: 8007-04-3 
Also Contains: humulus lupulus cone extract
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Perfumer and Flavorist: Search
Google Patents: Search
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PubMed: Search
NCBI: Search
FEMA Number: 2580  hop cone oil
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Physical Properties:
Food Chemicals Codex Listed: No
Soluble in:
Insoluble in:
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Organoleptic Properties:
Odor Type: herbal
Odor Description:
Taste Description:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
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Payand Betrand
Hop Cone Oil Hungary
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  3500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 79, 1967.

oral-rat LD50  2700 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 17, Pg. 79, 1967.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -2.90000
beverages(nonalcoholic): -1.70000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -2.20000
condiments / relishes: 20.0000035.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.70000
fruit ices: -1.70000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -2.50000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
EPI System: View
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 8007-04-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 humulus lupulus l. cone oil
Chemidplus: 0008007043
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 humulus lupulus l. cone oil
Canada Domestic Sub. List: 8007-04-3
Pubchem (sid): 135306977
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Other Information:
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
Search Trop  Picture
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 hop cone oil
 humulus lupulus cone oil
 volatile oil obtained from the freshly dried membranous cones of the female plants of the hops, humulus lupulus l., cannabidaceae
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PubMed: Quantitative genetic parameters for yield, plant growth and cone chemical traits in hop (Humulus lupulus L.).
PubMed: Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties.
PubMed: Quantitative trait loci in hop (Humulus lupulus L.) reveal complex genetic architecture underlying variation in sex, yield and cone chemistry.
PubMed: Increase in cone biomass and terpenophenolics in hops ( Humulus lupulus L.) by treatment with prohexadione-calcium.
PubMed: The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets.
PubMed: Varietal characterization of hop (Humulus lupulus L.) by GC-MS analysis of hop cone extracts.
PubMed: Capillary zone electrophoresis method for determination of bitter (alpha- and beta-) acids in hop (Humulus lupulus L.) cone extracts.
PubMed: Effects of powdery mildew fungicide programs on twospotted spider mite (Acari: Tetranychidae), hop aphid (Hemiptera: Aphididae), and their natural enemies in hop yards.
PubMed: DNA sequence and expression variation of hop (Humulus lupulus) valerophenone synthase (VPS), a key gene in bitter acid biosynthesis.
PubMed: Gold binding by native and chemically modified hops biomasses.
PubMed: Efficient extraction of high-quality total RNA from various hop tissues (Humulus lupulus L.).
PubMed: Comparative chemical attributes of native North American hop, Humulus lupulus var. lupuloides E. Small.
PubMed: Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones.
PubMed: [The influence of gibberellic acid on the flower and cone development in hop (Humulus lupulus L.)].
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