EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

isobutyl methyl anthranilate
isobutyl N-methylanthranilate

Supplier Sponsors

CAS Number: 65505-24-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:265-798-7
FDA UNII:IO2PZH1T3A
Nikkaji Web:J307.422F
CoE Number:649
XlogP3-AA:3.60 (est)
Molecular Weight:207.27289000
Formula:C12 H17 N O2
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:1548 isobutyl N-methylanthranilate
FLAVIS Number:09.769 (Old)
DG SANTE Food Flavourings:09.769 isobutyl N-methylanthranilate
FEMA Number:4149 isobutyl N-methylanthranilate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: ISOBUTYL N-METHYLANTHRANILATE
 
Physical Properties:
Appearance:pale yellow solid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 70.00 °C. @ 760.00 mm Hg
Boiling Point: 296.00 to 297.00 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure:0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: 272.00 °F. TCC ( 133.33 °C. )
logP (o/w): 4.078 (est)
Soluble in:
 alcohol
 water, very slightly
 water, 10.15 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: fruity
Odor Strength:medium
fruity grapefruit grape
Odor Description:at 100.00 %. fruity grapefruit grape
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
isoButyl 2-(methylamino)benzoate 95%
Jalor-Chem
For experimental / research use only.
IsoButyl 2-(methylamino)benzoate
Parchem
isobutyl methyl anthranilate
PCAS
isoButyl Methyl Anthranilate
Penta International
isoBUTYL-N-METHYL ANTHRANILATE
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
IFRA Critical Effect: Potential of nitrosamine formation
IFRA fragrance material specification:
 The material has been identified for having the potential of forming nitrosamines in nitrosating systems. Downstream users therefore have to be notified of the presence of the material and its potential to be able to consider adequate protective measures.
IFRA: View Standard
Recommendation for isobutyl methyl anthranilate usage levels up to:
  3.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.06 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.09 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 2300 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
 average usual ppmaverage maximum ppm
baked goods: 10.0000050.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: 5.0000025.00000
cheese: 7.0000035.00000
chewing gum: --
condiments / relishes: 2.0000025.00000
confectionery froastings: 10.0000050.00000
egg products: --
fats / oils: 5.0000025.00000
fish products: 2.0000010.00000
frozen dairy: 7.0000035.00000
fruit ices: 10.0000050.00000
gelatins / puddings: --
granulated sugar: --
gravies: 5.0000025.00000
hard candy: --
imitation dairy: 7.0000035.00000
instant coffee / tea: --
jams / jellies: --
meat products: 5.0000025.00000
milk products: 7.0000035.00000
nut products: --
other grains: 5.0000025.00000
poultry: 2.0000010.00000
processed fruits: 7.0000035.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 5.0000025.00000
snack foods: 20.00000100.00000
soft candy: --
soups: 5.0000025.00000
sugar substitutes: --
sweet sauces: 5.0000025.00000
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 84, (FGE.84)[1] - Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):65505-24-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :522171
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-methylpropyl 2-(methylamino)benzoate
Chemidplus:0065505240
 
References:
 2-methylpropyl 2-(methylamino)benzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:65505-24-0
Pubchem (cid):522171
Pubchem (sid):135267700
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
HMDB (The Human Metabolome Database):HMDB37697
FooDB:FDB016825
Export Tariff Code:2922.49.3800
ChemSpider:View
 
Potential Blenders and core components note
For Odor
aldehydic
tridecanal
FL/FR
citrus
benzyl anthranilate
FR
curacao peel oil
FL/FR
dimethyl octenone
FR
2,4-
dimethyl-3-cyclohexene-1-methanyl acetate
FR
grapefruit indene
FR
grapefruit mercaptan
FL/FR
grapefruit nitrile
FR
grapefruit oil c.p. california
FL/FR
grapefruit oil CO2 extract (citrus paradisi macf. var. falvedo)
FL/FR
grapefruit oil terpeneless
FL/FR
grapefruit pentanol
FR
lime oil distilled terpeneless
FL/FR
5-
mercapto-5-methyl-3-hexanone
FL/FR
myrmac aldehyde
FR
(+)-
nootkatone
FL/FR
petitgrain mandarin oil replacer
FL/FR
rhubafuran
FR
alpha-
terpinyl methyl ether
FL/FR
(±)-2,4,8-
trimethyl-7-nonen-2-ol
FL/FR
valencene
FL/FR
ethereal
2-
methyl valeraldehyde
FL/FR
floral
cassis oxime 10%
FR
2,4-
dimethyl cyclohexyl methyl acetate
FR
ethyl anthranilate
FL/FR
gardenia amide
FR
gardenia decalone
FR
gardenia pentyl acetate
FR
magnolia indene
FR
neryl acetate
FL/FR
peony acetonitrile
FR
petitgrain mandarin oil
FL/FR
fruity
butyl anthranilate
FL/FR
iso
butyl anthranilate
FL/FR
cyclohexyl anthranilate
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
grape butyrate
FL/FR
grapefruit acetal
FR
(Z)-3-
hexen-1-yl anthranilate
FL/FR
methyl anthranilate
FL/FR
methyl formyl anthranilate
FL/FR
herbal
6-
acetoxydihydrotheaspirane
FL/FR
3-
octyl acetate
FL/FR
sulfurous
ethyl 3-mercaptopropionate
FL/FR
grapefruit menthane
FL/FR
For Flavor
No flavor group found for these
6-
acetoxydihydrotheaspirane
FL/FR
curacao peel oil
FL/FR
dihydronootkatone
FL
ethyl 3-mercaptopropionate
FL/FR
4-
mercapto-4-methyl-2-pentanol
FL
5-
mercapto-5-methyl-3-hexanone
FL/FR
methyl formyl anthranilate
FL/FR
citrus
citrus
grapefruit mercaptan
FL/FR
grapefruit oil c.p. california
FL/FR
grapefruit oil CO2 extract (citrus paradisi macf. var. falvedo)
FL/FR
grapefruit oil terpeneless
FL/FR
lime oil distilled terpeneless
FL/FR
(+)-
nootkatone
FL/FR
petitgrain mandarin oil
FL/FR
petitgrain mandarin oil replacer
FL/FR
(±)-2,4,8-
trimethyl-7-nonen-2-ol
FL/FR
valencene
FL/FR
earthy
(±)-2-
mercapto-5-methylheptan-4-one
FL
fatty
(E,E)-2,4-
dodecadienal
FL
floral
(Z)-3-
hexen-1-yl anthranilate
FL/FR
neryl acetate
FL/FR
fruity
butyl anthranilate
FL/FR
iso
butyl anthranilate
FL/FR
cyclohexyl anthranilate
FL/FR
ethyl 3-hydroxyhexanoate
FL/FR
ethyl anthranilate
FL/FR
furfuryl butyrate
FL
methyl anthranilate
FL/FR
green
grape butyrate
FL/FR
3-
octyl acetate
FL/FR
sulfurous
grapefruit menthane
FL/FR
vegetable
2-
methyl valeraldehyde
FL/FR
waxy
tridecanal
FL/FR
woody
alpha-
terpinyl methyl ether
FL/FR
 
Potential Uses:
FRfruit
FRgrape
FRgrapefruit
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzoic acid, 2-(methylamino)-, 2-methylpropyl ester
isobutyl 2-(methyl amino) benzoate
isobutyl 2-(methylamino)benzoate
isobutyl 2-N-methylaminobenzoate
isobutyl methyl aminobenzoate
isobutyl methyl anthranilate
isobutyl N-methyl anthranilate
isobutyl N-methylanthranilate
2-methyl propyl 2-(methyl amino) benzoate
2-methyl propyl 2-N-methyl aminobenzoate
2-methylpropyl 2-(methylamino)benzoate
2-methylpropyl 2-methylaminobenzoate
2-methylpropyl 2-N-methylaminobenzoate
2-methylpropyl N-methyl-2-aminobenzoate
 
 
Notes:
Possible flavour ingredient; reported in food additive surveys
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