nopol
10-hydroxymethylene-2-pinene
 
Notes:
None found
  • Berjé
    • Berje Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Flavor Ingredients
      Fragrance Ingredients
      Functional Ingredients
      Happening at Berje
      Product(s):
      Nopol
       
  • Moellhausen
    • Moellhausen S.P.A.
      THE CHEMISTRY OF EMOTIONS
      Innovation and commitment in the name of excellence.
      After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. My personal history is inextricably bound to that of the company, and I continue to dedicate all my energy to it along with our partners and collaborators who have supported us thus far with dedication, passion, love, and experience. Continuous investments and a professionalism aimed at achieving the highest levels of performance in service and quality, along with that same dedication, passion, love, and experience, have together enabled us to reach the absolute avant-garde level that characterizes Moellhausen today, recognized worldwide for its modernity, innovation, creativity, and respect for the environment and the safety and rights of those who work with us. As President and CEO of the company for 32 years, I offer a well-deserved thank you to all of our numerous customers, suppliers, employees, and company friends for helping to sustain our unstoppable and honorable growth. And it is with the support of all of our stakeholders that we will confidently continue to pursue our commitment to further advancing the excellence that our industry demands.
      Voice: +39 039.685.6262
      Fax: +39 039.685.6263
      Linkedin
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      Sustainability is at the foundation of a
      Pervasive technology and total control
      Product(s):
      126250 nopol
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      14-84000 NOPOL, Kosher
       
  • SRS Aromatics
    • SRS Aromatics Ltd
      For over 25 years
      Bringing flavour and fragrance into your world.
      As suppliers / distributors of ingredients to the fragrance and flavour industries, our goal is to provide high quality materials at competitive prices with an exceptional level of service. Established in 1984, SRS Aromatics Ltd is an independent family owned business which has become very well-respected within the fragrance and flavour industry as a reliable and trustworthy partner. Over the years this has allowed the company to develop strong relationships with many global manufacturers; several of whom we represent in the UK. A core aim of our business is to work extremely closely with both our suppliers and customers to maximise service levels with minimum disruption to supply.
      Email: Info
      Email: Sales
      Voice: +44 (0) 1284 704076
      Fax: +44 (0) 1284 760819
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      Product(s):
      NOPOL
       
  • Vigon International
    • Vigon International, Inc.
      Passion for Simplicity
      Manufacturer and supplier of high quality flavor and fragrance ingredients.
      The growth and success of Vigon is due in large part to a unique corporate concept that Vigon has developed and established within the industry: Creative Partnerships. This partnership concept has been and continues to be the foundation and guiding principle for all of Vigon's activities.
      US Email: Sales
      US Voice: 570-476-6300
      US Fax: 570-476-1110
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      Products List: View
      Product(s):
      503559 Nopol
       
Synonyms   Articles   Notes   Search
2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol (Click)
CAS Number: 128-50-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 204-890-3
FDA UNII: XK8HU7WJQC
Nikkaji Web: J21.520A
XlogP3-AA: 2.10 (est)
Molecular Weight: 166.26366000
Formula: C11 H18 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: Racemate (EFFA, 2010a).
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 986  10-hydroxymethylene-2-pinene
Flavis Number: 02.141 (Old)
DG SANTE Food Flavourings: 02.141  2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethan-1-ol
FEMA Number: 3938
FDA Mainterm: 10-HYDROXYMETHYLENE-2-PINENE
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.96500 to 0.97300 @  25.00 °C.
Pounds per Gallon - (est).: 8.030 to  8.096
Refractive Index: 1.49000 to 1.50000 @  20.00 °C.
Boiling Point: 110.50 °C. @ 10.00 mm Hg
Boiling Point: 230.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.009000 mm/Hg @ 25.00 °C. (est)
Flash Point: 210.00 °F. TCC ( 98.89 °C. )
logP (o/w): 3.152 (est)
Soluble in:
 alcohol
 paraffin oil, cloudy
 water, 318.1 mg/L @ 25 °C (est)
Insoluble in:
 water
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: balsamic
Odor Strength: medium
 sweet  balsamic  citrus  pine  herbal  
Odor Description:
at 100.00 %. 
sweet balsamic citrus pine herbal
Luebke, William tgsc, (1987)
Substantivity: 32 Hour(s)
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Berjé
Nopol
Happening at Berje
DRT Terpenes
NOPOL
≥ 99%
Flowersynth
NOPOL
Moellhausen
nopol
Odor: characteristic, soft woody (pine note)
Penta International
NOPOL, Kosher
Reincke & Fichtner
Nopol
SRS Aromatics
NOPOL
Takasago
Nopol
≥98% as Nopol
Odor: Very mild, woody-camphoraceous
Use: Used in fragrances and compositions. Gives a clean note for soaps and detergents.
The Fragrance Museum
Ungerer & Company
Nopol
Vigon International
Nopol
Synonyms   Articles   Notes   Search   Top
Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  890 mg/kg
Study acceptable, but substance name given as Nopol. It has not been possible to confirm that this is the same substance.
(Moreno, 1977u)

intramuscular-mouse LD50  500 mg/kg
Journal of Scientific and Industrial Research, Section C: Biological Sciences. Vol. 21, Pg. 342, 1962.

oral-rat LD50  890 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 879, 1979.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 879, 1979.

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for nopol usage levels up to:
  8.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 33.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
Click here to view publication 19
 average usual ppmaverage maximum ppm
baked goods: 2.000003.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 2.000003.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 1.000002.00000
fruit ices: --
gelatins / puddings: 2.000004.00000
granulated sugar: --
gravies: --
hard candy: 4.000005.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 1.500003.00000
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 12 (FGE.12); Primary saturated or unsaturated alicyclic alcohol, aldehyde, and esters from chemical group 7 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Primary saturated or unsaturated alicyclic alcohol, aldehyde, and esters from chemical group 7 - Flavouring Group Evaluation 12, Revision 1 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 73, (FGE.73)[1] - Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohol, aldehyde and esters evaluated by EFSA in FGE.12 (2005) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 73, Revision 1 (FGE.73Rev1): Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohol, aldehyde, and esters evaluated by EFSA in FGE.12Rev2 (2011)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 73, Revision 2 (FGE.73Rev2): Consideration of alicyclic primary alcohols, aldehydes, acids and related esters evaluated by JECFA (59th meeting) structurally related to primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters evaluated by EFSA in FGE.12Rev3 (2012)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 73, Revision 3 (FGE.73Rev3): Consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting) structurally related to primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters evaluated by EFSA in FGE.12Rev4 (2013)
View page or View pdf
EPI System: View
EPA Substance Registry Services (TSCA): 128-50-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 31408
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol
Chemidplus: 0000128507
Synonyms   Articles   Notes   Search   Top
References:
 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 128-50-7
Pubchem (cid): 31408
Pubchem (sid): 134974754
Pherobase: View
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB001291
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
aldehydic
 pinoacetaldehydeFR
amber
 ambroxideFL/FR
laevo-bornyl acetateFL/FR
 bornyl acetateFL/FR
isobornyl benzoate 
 cypress absoluteFR
 gurjun balsamFR
(Z)-pinaneFR
red spruce oilFR
camphoreous
 bornyl isobutyrateFL/FR
 camphor tree bark oilFL/FR
 fencholFL/FR
 hinoki leaf oilFR
earthy
scotch pine needle oilFL/FR
scotch pine needle oil estoniaFL/FR
scotch pine needle oil yugoslaviaFL/FR
(E+Z)-2,4,8-trimethyl-3,7-nonadien-2-olFL/FR
fir needle
 abies amabilis oil canadaFR
floral
 bursera graveolens wood oilFL/FR
gamma-damasconeFR
 verdyl acetateFR
fruity
 bisaboleneFL/FR
herbal
3-allyl-1-methyl-2-oxabicyclo(2.2.2)octane 
 bornyl salicylateFR
 bursera graveolens wood 
 cardamom liquid resinFR
1,4-cineoleFL/FR
 dihydroterpinyl acetateFL/FR
 herbal specialtyFR
 herbal undecanoneFR
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
 hyssop oilFL/FR
 myrtenolFL/FR
 nopyl acetateFR
beta-pineneFL/FR
alpha-pineneFL/FR
laevo-beta-pineneFL/FR
L-(-)-alpha-pineneFL/FR
 pinocarveolFL/FR
 sage oleoresinFL/FR
 terpineol acetateFL/FR
 terpinoleneFL/FR
 tricyclo(5.2.1.02,6)dec-3-enyl acetateFR
pine
 pine oil 85FR
 plectranthus glandulosus hook f. leaf oil cameroon 
spicy
 tea tree oilFR
terpenic
laevo-limoneneFL/FR
 pinus nigra twig leaf oilFR
woody
isobornyl isovalerateFL/FR
 cedarwood oil port orfordFR
3,7-dimethyl-1-octene 
(E+Z)-4,8-dimethyl-3,7-nonadien-2-olFL/FR
 juniper berry oil terpenesFR
isolongifolene epoxideFR
 myrtenyl formateFL/FR
 myrtenyl isobutyrate 
 nopyl aldehydeFR
 sabineneFL/FR
 tetrahydromugolFR
(Z)-woody amyleneFR
 
For Flavor
 
No flavor group found for these
 ambroxideFL/FR
laevo-bornyl acetateFL/FR
isobornyl benzoate 
 bornyl isobutyrateFL/FR
 bursera graveolens wood 
 bursera graveolens wood oilFL/FR
 dihydroterpinyl acetateFL/FR
3,7-dimethyl-1-octene 
(E+Z)-4,8-dimethyl-3,7-nonadien-2-olFL/FR
laevo-limoneneFL/FR
 myrtenyl formateFL/FR
 myrtenyl isobutyrate 
scotch pine needle oilFL/FR
scotch pine needle oil estoniaFL/FR
scotch pine needle oil yugoslaviaFL/FR
laevo-beta-pineneFL/FR
L-(-)-alpha-pineneFL/FR
 plectranthus glandulosus hook f. leaf oil cameroon 
 terpineol acetateFL/FR
(E+Z)-2,4,8-trimethyl-3,7-nonadien-2-olFL/FR
camphoreous
 bornyl acetateFL/FR
 camphor tree bark oilFL/FR
 fencholFL/FR
6-hydroxydihydrotheaspirane (mixture of isomers)FL/FR
 pinocarveolFL/FR
citrus
 bisaboleneFL/FR
cooling
1,4-cineoleFL/FR
herbal
3-allyl-1-methyl-2-oxabicyclo(2.2.2)octane 
 hyssop oilFL/FR
 sage oleoresinFL/FR
minty
 myrtenolFL/FR
pine
beta-pineneFL/FR
woody
isobornyl isovalerateFL/FR
alpha-pineneFL/FR
 sabineneFL/FR
 terpinoleneFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 alpine bouquet 
 balsamFR
 citrusFR
 fir 
 green grassFR
 herbalFR
 pineFR
 woodyFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 carrot root
Search Trop  Picture
 orange bigarade oil @ 0.36%
Data  GC  Search  Picture
 rosemary plant
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 bicyclo(3.1.1)hept-2-ene-2-ethanol, 6,6-dimethyl-
 bicyclo[3.1.1]hept-2-ene-2-ethanol, 6,6-dimethyl-
2-(6,6-dimethyl bicyclo(3.1.1)hept-2-en-2-yl) ethan-1-ol
6,6-dimethyl-2-hydroxyethyl-6,6-dimethyl bicyclo(3,1,1)hept-2-ene bicyclo(3.1.1)hept-2-ene-2-ethanol
6,6-dimethyl-2-norpinene-2-ethanol
6,6-dimethylbicyclo-(3.1.1)-2-heptene-2-ethanol
2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethan-1-ol
2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol
6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-ethanol
2-hydroxyethyl-6,6-dimethyl-bicyclo[3,1,1]-hept-2-ene
10-hydroxymethylene-2-pinene
homomyrtenol
2-norpinene-2-ethanol, 6,6-dimethyl-
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Superior performance of metal-organic frameworks over zeolites as solid acid catalysts in the Prins reaction: green synthesis of nopol.
PubMed: On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal.
PubMed: Microbial transformation of (-)-nopol benzyl ether: direct dihydroxylation of benzene ring.
PubMed: Transition metal-substituted Dawson anions as chemo- and regio-selective oxygen transfer catalysts for H2O2 in the epoxidation of allylic alcohols.
PubMed: Antioxidant responses and reactive oxygen species generation in different body regions of the estuarine polychaeta Laeonereis acuta (Nereididae).
PubMed: Analysis of the essential oil composition of eight Anthemis species from Greece.
PubMed: Mesoporous iron phosphate as an active, selective and recyclable catalyst for the synthesis of nopol by Prins condensation.
PubMed: Synthesis of nopol over MCM-41 catalysts.
PubMed: Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.
PubMed: Enzymatic synthesis of structural analogs of PAF-acether by phospholipase D-catalysed transphosphatidylation.
PubMed: Glucuronidation of 2-arylpropionic acids pirprofen, flurbiprofen, and ibuprofen by liver microsomes.
PubMed: Differential action of thyroid hormones and chemically related compounds on the activity of UDP-glucuronosyltransferases and cytochrome P-450 isozymes in rat liver.
PubMed: Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver.
PubMed: Properties of human hepatic UDP-glucuronosyltransferases. Relationship to other inducible enzymes in patients with cholestasis.
PubMed: [On a new local anesthetic. Homomyrtenol and diethylaminoethanol ether].
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