Widely distributed in foodstuffs in trace amts., presumably as bacterial decarboxylation prod. of proline. Present in bread, milk, cheese, carrots, celery stalks, beer, spirits, coffee, caviar and fatty fish. Flavouring agent Pyrrolidine is a clear liquid with an unpleasant odor that is ammoniacal, fishy, shellfish-like and seaweed-like. Pyrrolidine is found naturally in the leaves of tobacco and carrot. The pyrrolidine ring structure is present in numerous natural alkaloids such as nicotine and hygrine. It is found in many pharmaceutical drugs such as procyclidine and bepridil. It also forms the basis for the racetam compounds (e.g. piracetam, aniracetam). A pyrrolidine ring is the central structure of the amino acids proline and hydroxyproline. (Wikipedia)
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      10426 Pyrrolidine
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      W1650 pyrrolidine
  • DeLong Chemicals America
    • DeLong Chemicals America
      Custom Manufacturing
      Supplier of aroma chemicals, pharmaceutical and specialty chemical intermediates.
      DeLong Chemicals America, LLC is an extension of Shijiazhuang Lida Chemical Co, Ltd to North America, a leading supplier and manufacturer of aroma chemicals, serving the industries of food, tobacco and perfume, while also providing intermediates, custom synthesis and custom manufacturing for pharmaceutical and specialty chemical industries.
      US Email: Customer Service
      US Email: Sales
      US Voice: (203) 271-9017
      New products
      9851 Tetrahydro pyrrole, Kosher
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Natural Food Colour
      New functional food ingredients
      HL0187 tetrahydro pyrrole
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      H0100 TETRAHYDRO PYRROLE, Kosher
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      16-92700 PYRROLIDINE, Kosher
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
      Certified Food Grade Products
      W352316 Pyrrolidine, ≥99%, FG
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      H0100 Tetrahydro Pyrrole
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
      US Fax: 888-520-1075
      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
      P0576 Pyrrolidine >98.0%(GC)
  • Treatt
    • Treatt PLC
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
Synonyms   Articles   Notes   Search
pyrrolidine (Click)
CAS Number: 123-75-1Picture of molecule
ECHA EINECS - REACH Pre-Reg: 204-648-7
Nikkaji Web: J2.931I
Beilstein Number: 0102395
MDL: MFCD00005249
CoE Number: 10491
XlogP3: 0.50 (est)
Molecular Weight: 71.12273000
Formula: C4 H9 N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1609  pyrrolidine
Flavis Number: 14.064 (Old)
DG SANTE Food Flavourings: 14.064  pyrrolidine
FEMA Number: 3523  pyrrolidine
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.84700 to 0.85300 @  25.00 °C.
Pounds per Gallon - (est).: 7.048 to  7.098
Refractive Index: 1.44000 to 1.44600 @  20.00 °C.
Melting Point: -57.80 °C. @ 760.00 mm Hg
Boiling Point: 87.00 to  88.00 °C. @ 760.00 mm Hg
Vapor Pressure: 58.582001 mm/Hg @ 25.00 °C. (est)
Vapor Density: 2.45 ( Air = 1 )
Flash Point: 37.00 °F. TCC ( 2.78 °C. )
logP (o/w): 0.460
Soluble in:
 water, 1.00E+06 mg/L @ 20 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: ammoniacal
Odor Strength: very high ,
recommend smelling in a 0.10 % solution or less
 ammoniacal  animal  eggy  
Odor Description:
at 0.10 % in propylene glycol. 
ammoniacal animal egg amine
 ammoniacal  fishy  shellfish  seaweed  
Odor Description:
Ammonia, fishy, shellfish and seaweed-like
Mosciano, Gerard P&F 20, No. 2, 37, (1995)
 ammoniacal  fishy  ammoniacal  seaweed  shellfish  
Taste Description:
at 50.00 ppm.  
Ammonia and fishy amine-like with seaweed and shellfish nuances
Mosciano, Gerard P&F 20, No. 2, 37, (1995)
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Anhui Suzhou Jinli Aromatic Chemicals
Odor: fish, Amine
Pyrrolidine pure
Beijing Lys Chemicals
CTC Organics
DeLong Chemicals America
Tetrahydro pyrrole, Kosher
EMD Millipore
For experimental / research use only.
Jiangyin Healthway
tetrahydro pyrrole
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
Tetrahydro pyrrole, Kosherk
M&U International
Penta International
Pyrrolidine, ≥99%, FG
Certified Food Grade Products
Sigma-Aldrich: Aldrich
For experimental / research use only.
Pyrrolidine ≥99%
Sunaux International
Tetrahydro Pyrrole
For experimental / research use only.
Pyrrolidine >98.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
Tetrahydro Pyrrole
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 11 - Highly flammable.
R 20/22 - Harmful by inhalation and if swallowed.
R 35 - Causes severe burns.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 28 - After contact with skin, wash immediately with plenty of water.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  300 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.

oral-guinea pig LDLo  250 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.

oral-mouse LD50  450 mg/kg
Bollettino Chimico Farmaceutico. Vol. 103, Pg. 414, 1964.

intraperitoneal-mouse LD50  420 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946.

oral-rabbit LDLo  250 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.

oral-mammal (species unspecified) LD50  250 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.

intravenous-mouse LD50  56 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06769

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-mouse LC50 1300 mg/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.

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Safety in Use Information:
Category: flavoring agents
Recommendation for pyrrolidine usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 2.00 (μg/capita/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 10
Click here to view publication 10
 average usual ppmaverage maximum ppm
baked goods: -2.00000
beverages(nonalcoholic): -0.50000
beverages(alcoholic): --
breakfast cereal: -1.50000
cheese: --
chewing gum: -6.00000
condiments / relishes: --
confectionery froastings: -3.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: -0.50000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Safety and efficacy of pyridine and pyrrole derivatives belonging to chemical group 28 when used as flavourings for all animal species
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 123-75-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 31268
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1922
WGK Germany: 2
Chemidplus: 0000123751
EPA/NOAA CAMEO: hazardous materials
RTECS: 123-75-1
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 123-75-1
Pubchem (cid): 31268
Pubchem (sid): 134974741
Flavornet: 123-75-1
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB31641
FooDB: FDB008290
Export Tariff Code: 2933.99.9700
Haz-Map: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
grades: 95% min purity
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
For Odor
 tangerine acetateFR
grosso lavandin oilFL/FR
 seaweed absolute (fucus vesiculosus et serratus)FL/FR
 treemoss absoluteFR
para-anisyl formateFL/FR
For Flavor
No flavor group found for these
 amyl amineFL
isobutyl amineFL
(±)-sec-butyl amineFL
 butyl amineFL
 ethyl amineFL
 hexyl amineFL
2-methyl butyl amineFL
isopentylidene isopentyl amineFL
 phenethyl amineFL
 propionyl pyrroline 1% in vegatable oil triglycerideFL
isopropyl amineFL
 seaweed absolute (fucus vesiculosus et serratus)FL/FR
(R)-N,N,alpha-trimethyl benzyl amineFL
(R)-N,N,alpha-trimethyl benzyl amineFL
 tripropyl amineFL
 tripropyl amineFL
2-methyl piperidineFL
4,5-dimethyl thiazoleFL
grosso lavandin oilFL/FR
para-anisyl formateFL/FR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 apple pericarp
Search Trop  Picture
 barley seed
Search Trop  Picture
Search  Picture
 carrot plant
Search Trop  Picture
Search  Picture
 celery plant
Search Trop  Picture
 celery stem
Search Trop  Picture
 cheese camembert cheese
Search  Picture
 cheese limburger cheese
Search  Picture
 cheese tilsit cheese
Search  Picture
Search  Picture
 corn seed
Search Trop  Picture
 grape fruit juice
Search Trop  Picture
 peanut roasted peanut
Search  Picture
 pepper bell pepper fruit
Search Trop  Picture
 pepper black pepper seed
Search Trop  Picture
 poppy opium poppy latex
Search Trop  Picture
Search Trop  Picture
 spinach leaf
Search Trop  Picture
Search  Picture
 wine red wine
Search  Picture
 wine white wine
Search  Picture
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 pyrrole, tetrahydro-
 pyrrolidine pure
 tetrahydro pyrrole
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