EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ammonium glycyrrhizate
glycyrrhizic acid ammoniated

Sponsors

Name:(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
CAS Number: 53956-04-0Picture of molecule3D/inchi
Other:1407-03-0
ECHA EINECS - REACH Pre-Reg:258-887-7
FDA UNII:3VRD35U26C
Beilstein Number:3897076
MDL:MFCD00167400
CoE Number:2221
Molecular Weight:839.97425000
Formula:C42 H65 N O16
NMR Predictor:Predict (works with chrome or firefox)
Category:licorice and licorice derivatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1408 Ammoniated Glycyrrhizin View-review
184.1408 Licorice, Glycyrrhiza, and Ammoniated Glycyrrhizin View-review
FLAVIS Number:16.060 (Old)
DG SANTE Food Flavourings:16.060 glycyrrhizic acid ammoniated
FEMA Number:2528 glycyrrhizic acid ammoniated
FDA Mainterm: GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1408 Licorice and licorice derivatives.
 
Physical Properties:
Appearance:pale yellow to amber brown solid (est)
Assay: 75.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 209.00 to 215.00 °C. @ 760.00 mm Hg
Boiling Point: 971.00 to 972.00 °C. @ 760.00 mm Hg
Flash Point: 550.00 °F. TCC ( 287.78 °C. )
logP (o/w): 4.637 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:refrigerate in tightly sealed containers.
Soluble in:
 water, 5.355 mg/L @ 25 °C (est)
Similar Items:note
glycyrrhizin
glycyrrhizic acid
 
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. bland
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
skin conditioning
 
Suppliers:
Aceto
Glycyrrhizinate Monoammonium
Aromiens International
Ammonium Glycyrrhizate
Augustus Oils
Ammonium Glycyrrhizate
Services
BOC Sciences
For experimental / research use only.
Glycyrrhizic acid ammonium salt
Charkit Chemical
MONOAMMONIUM GLYCYRRHIZINATE
Coompo
For experimental / research use only.
Glycyrrhizic Acid Ammonium Salt from Plants ≥96%
Odor: characteristic
Use: Glycyrrhizic acid ammonium salt is active against viruses. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.
ExtraSynthese
For experimental / research use only.
Glycyrrhizin ammoniacal
M&U International
NAT.AMMONIUM GLYCYRRHIZATE
Nacalai USA
For experimental / research use only.
Glycyrrhizic Acid Monoammonium Salt n-Hydrate
O'Laughlin Industries
MAGOLIN, Ammonium glycyrrhizinate 18%
Penta International
AMMONIATED GLYCYRRHIZIN FCC, Kosher
Penta International
AMMONIATED GLYCYRRHIZIN FCC, NATURAL, Kosher
Sabinsa Corporation
MonoAmmonium Glycyrrhizinate
TCI AMERICA
For experimental / research use only.
Monoammonium Glycyrrhizinate Hydrate >75.0%(LC)
 
Safety Information:
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 10000 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

intraperitoneal-rat LD50 > 300 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

oral-mouse LD50 9818 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

intravenous-mouse LD50 540 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

intraperitoneal-mouse LDLo 1000 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: licorice and licorice derivatives
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 130.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 90 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 210000 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -51.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 5.0000062.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): -40.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): -91.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): -1512.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): -45.00000
Bakery wares (07.0): -61.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): -300.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): -100.00000
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): -50.00000
Foodstuffs intended for particular nutritional uses (13.0): -60.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): -200.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): -200.00000
Ready-to-eat savouries (15.0): -150.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): -79.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 36, (FGE.36) - Two triterpene glycosides from the priority list - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Scientific Opinion on the safety and efficacy of glycyrrhizic acid ammoniated (chemical group 30, miscellaneous substances) when used as a flavouring for all animal species
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):53956-04-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :62074
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
Chemidplus:0053956040
RTECS:LZ6500000 for cas# 53956-04-0
 
References:
 (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:53956-04-0
Pubchem (cid):62074
Pubchem (sid):135021079
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
KEGG (GenomeNet):C18610
HMDB (The Human Metabolome Database):HMDB29844
FooDB:FDB001061
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
For Odor
anise
anise oleoresin
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
star
anise seed oil terpeneless
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
anisic
dihydroanethol
FL/FR
estragole
FL/FR
ethyl para-anisate
FL/FR
ocimum basilicum herb oil egypt
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
caramellic
caramel pentadione
FL/FR
cyclotene
FL/FR
fruity
iso
butyl 2-butenoate
FL/FR
(E,E)-
ethyl sorbate
FL/FR
hexanal propylene glycol acetal
FL/FR
licorice
(E)-
anethol
FL/FR
glycyrrhiza glabra root extract
FL/FR
minty
carvone
FL/FR
musk
omega-
pentadecalactone
FL/FR
musty
2-
acetyl pyrrole
FL/FR
powdery
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
For Flavor
No flavor group found for these
carvone
FL/FR
fleabane oil (erigeron canadensis)
FL
anise
anise
(E)-
anethol
FL/FR
anise oleoresin
FL/FR
anise seed oil
FL/FR
star
anise seed oil china
FL/FR
anise seed oil colombia
FL/FR
star
anise seed oil spain
FL/FR
star
anise seed oil terpeneless
FL/FR
ethyl para-anisate
FL/FR
sweet
fennel absolute
FL/FR
sweet
fennel oleoresin
FL/FR
anisic
ocimum basilicum herb oil egypt
FL/FR
caramellic
caramel pentadione
FL/FR
cyclotene
FL/FR
fruity
para-
anisyl acetate
FL/FR
para-
anisyl alcohol
FL/FR
ethyl 3-oxohexanoate
FL
(E,E)-
ethyl sorbate
FL/FR
furfuryl isovalerate
FL
hexanal propylene glycol acetal
FL/FR
(E,E)-
methyl sorbate
FL
green
iso
butyl 2-butenoate
FL/FR
herbal
dihydroanethol
FL/FR
ocimum basilicum leaf oil CO2 extract
FL/FR
licorice
2-
butyl-3-methyl pyrazine
FL
estragole
FL/FR
glycyrrhiza glabra root extract
FL/FR
glycyrrhiza glabra root extract powder
FL
nutty
2-
acetyl pyrrole
FL/FR
sweet
neo
hesperidin dihydrochalcone
FL
vanilla
omega-
pentadecalactone
FL/FR
 
Potential Uses:
 biological additives
 skin conditioning
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 AMGZ
 ammoniated glycyrrhizin
 ammoniated glycyrrhizin FCC
 ammoniated glycyrrhizin FCC, natural
monoammonium glycyrrhizate
 ammonium glycyrrhizinate
monoammonium glycyrrhizinate
monoammonium glycyrrhizinate hydrate
 glycamil
 glycyrram
 glycyrrhizic acid ammoniated
 glycyrrhizic acid ammonium salt
 glycyrrhizic acid monoammonium salt
 glycyrrhizic acid, ammonium salt
 glycyrrhizic acid, monoammonium salt
 glycyrrhizin ammoniated
 glycyrrhizin, ammoniated
 glycyrrhizinate monoammonium
 glycyrrhizinic acid ammonium salt
 glycyrrhizinic acid, ammonium salt (1:1)
 olean-12-en-30-oic acid, 3-[(2-O-β-D-glucopyranuronosyl-a-D-glucopyranuronosyl)oxy]-11-oxo-, ammonium salt, (3β)-
 

Articles:

Google Patents:Sucrose-ammoniated glycyrrhizin sweetening agent
US Patents:8,007,849 - Unsaturated cyclic and acyclic carbamates exhibiting taste and flavor enhancement effect in flavor compositions
PubMed:[About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs].
PubMed:Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
PubMed:Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum Arabic in rodent germ cells.
PubMed:Time required to achieve homogeneity in swine feed mixtures.
PubMed:Production of experimental hypertension and cardiovascularrenal lesions with licorice and ammoniated glycyrrhizin.
PubMed:Desoxycorticosterone-mimetic action of ammoniated glycyrrhizin in rats.
 
Notes:
Nonnutritive sweetener and flavour enhancer
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