ammonium glycyrrhizate
glycyrrhizic acid ammoniated
 
Notes:
Nonnutritive sweetener and flavour enhancer
  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements. Augustus has invested in modern, well equipped laboratories to provide unparalleled control of quality, and a development environment that continues to produce innovative ranges of natural ingredients. The strength of the company is built on both its comprehensive knowledge base, and extensive stocks of raw materials for both fragrance and flavour use. To complement its range of conventional and Organic Essential Oils and Aroma Chemicals, Augustus also offers a steadily increasing range of its own, UK manufactured Natural Extracts, Absolutes, Resinoids and Natural Chemicals. These again are fully tested and certificated, and very tightly quality controlled. Augustus is committed to promoting the use of natural ingredients, wherever the potential lies and to provide an environment of support and trust to both our customers and suppliers.
      Email: Enquiries
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      Voice: +44 (0)1420 590555
      Fax: +44 (0)1420 592420
      Services
      Product(s):
      Ammonium Glycyrrhizate
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
      Email: Sales
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      Fax: 203-299-1355
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      Product(s):
      MONOAMMONIUM GLYCYRRHIZINATE
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      News
      Product(s):
      N0160 NAT.AMMONIUM GLYCYRRHIZATE
       
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
      Manufacturer of Aroma
      Leading the Flavor and Fragrance Industry since 1980.
      O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets.
      Email: Sales
      US Email: Joe Schreiber
      Voice: (852) 2527-1031
      Fax: (852) 2529-0231
      US Voice: (973) 376-4600
      US Fax: (973) 376-4630
      Product(s):
      774-2304 MAGOLIN, Ammonium glycyrrhizinate 18%
       
  • Penta International
Synonyms   Articles   Notes   Search
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14 (Click)
CAS Number: 53956-04-0Picture of molecule
Other: 1407-03-0
ECHA EINECS - REACH Pre-Reg: 258-887-7
FDA UNII: 3VRD35U26C
Beilstein Number: 3897076
MDL: MFCD00167400
CoE Number: 2221
Molecular Weight: 839.97425000
Formula: C42 H65 N O16
NMR Predictor: Predict (works with chrome or firefox)
Category: licorice and licorice derivatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1408 Ammoniated Glycyrrhizin View-review
184.1408 Licorice, Glycyrrhiza, and Ammoniated Glycyrrhizin View-review
Flavis Number: 16.060 (Old)
DG SANTE Food Flavourings: 16.060  glycyrrhizic acid ammoniated
FEMA Number: 2528  glycyrrhizic acid ammoniated
FDA Mainterm: GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1408 Licorice and licorice derivatives.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: pale yellow to amber brown solid (est)
Assay: 75.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 209.00 to  215.00 °C. @ 760.00 mm Hg
Boiling Point: 971.00 to  972.00 °C. @ 760.00 mm Hg
Flash Point: 550.00 °F. TCC ( 287.78 °C. )
logP (o/w): 4.637 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: refrigerate in tightly sealed containers.
Soluble in:
 water, 5.355 mg/L @ 25 °C (est)
Similar Items: note
glycyrrhizin
glycyrrhizic acid
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Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
bland
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
skin conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
Aceto
Glycyrrhizinate Monoammonium
Augustus Oils
Ammonium Glycyrrhizate
Services
Charkit Chemical
MONOAMMONIUM GLYCYRRHIZINATE
Coompo
For experimental / research use only.
Glycyrrhizic Acid Ammonium Salt from Plants ≥96%
Odor: characteristic
Use: Glycyrrhizic acid ammonium salt is active against viruses. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.
ExtraSynthese
For experimental / research use only.
Glycyrrhizin ammoniacal
M&U International
NAT.AMMONIUM GLYCYRRHIZATE
Nacalai USA
For experimental / research use only.
Glycyrrhizic Acid Monoammonium Salt n-Hydrate
O'Laughlin Industries
MAGOLIN, Ammonium glycyrrhizinate 18%
Penta International
AMMONIATED GLYCYRRHIZIN FCC, Kosher
Penta International
AMMONIATED GLYCYRRHIZIN FCC, NATURAL, Kosher
Sabinsa Corporation
MonoAmmonium Glycyrrhizinate
TCI AMERICA
For experimental / research use only.
Monoammonium Glycyrrhizinate Hydrate >75.0%(LC)
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Safety Information:
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  > 10000 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

intraperitoneal-rat LD50  > 300 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

oral-mouse LD50  9818 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

intravenous-mouse LD50  540 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

intraperitoneal-mouse LDLo  1000 mg/kg
Yaoxue Tongbao. Bulletin of Pharmacology. Vol. 22, Pg. 449, 1987.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: licorice and licorice derivatives
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 130.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 90 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 210000 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -5.00000
beverages(nonalcoholic): -51.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 5.0000062.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): -40.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): -91.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): -1512.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): -45.00000
Bakery wares (07.0): -61.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): -300.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): -100.00000
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): -50.00000
Foodstuffs intended for particular nutritional uses (13.0): -60.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): -200.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): -200.00000
Ready-to-eat savouries (15.0): -150.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): -79.00000
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 29 (FGE29)[1] - Substance from the priority list: Vinylbenzene from chemical group 31 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 36, (FGE.36) - Two triterpene glycosides from the priority list - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Scientific Opinion on the safety and efficacy of glycyrrhizic acid ammoniated (chemical group 30, miscellaneous substances) when used as a flavouring for all animal species
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 49, Revision 1 (FGE.49Rev1): xanthine alkaloids from the priority list
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 53956-04-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 62074
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
Chemidplus: 0053956040
RTECS: LZ6500000 for cas# 53956-04-0
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References:
 (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 53956-04-0
Pubchem (cid): 62074
Pubchem (sid): 135021079
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
KEGG (GenomeNet): C18610
HMDB (The Human Metabolome Database): HMDB29844
FooDB: FDB001061
FDA Listing of Food Additive Status: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
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Potential Blenders and core components note
 
For Odor
anise
 anise oleoresinFL/FR
 anise seed oilFL/FR
star anise seed oil chinaFL/FR
 anise seed oil colombiaFL/FR
star anise seed oil spainFL/FR
star anise seed oil terpenelessFL/FR
sweet fennel absoluteFL/FR
sweet fennel oleoresinFL/FR
anisic
 dihydroanetholFL/FR
 estragoleFL/FR
 ethyl para-anisateFL/FR
 ocimum basilicum herb oil egyptFL/FR
 ocimum basilicum leaf oil CO2 extractFL/FR
caramellic
 caramel pentadioneFL/FR
 cycloteneFL/FR
fruity
isobutyl 2-butenoateFL/FR
(E,E)-ethyl sorbateFL/FR
 hexanal propylene glycol acetalFL/FR
licorice
(E)-anetholFL/FR
 glycyrrhiza glabra root extractFL/FR
minty
 carvoneFL/FR
musk
omega-pentadecalactoneFL/FR
musty
2-acetyl pyrroleFL/FR
powdery
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 
For Flavor
 
No flavor group found for these
 carvoneFL/FR
 fleabane oil (erigeron canadensis)FL
omega-pentadecalactoneFL/FR
anise
(E)-anetholFL/FR
 anise oleoresinFL/FR
 anise seed oilFL/FR
star anise seed oil chinaFL/FR
 anise seed oil colombiaFL/FR
star anise seed oil spainFL/FR
star anise seed oil terpenelessFL/FR
 ethyl para-anisateFL/FR
sweet fennel absoluteFL/FR
sweet fennel oleoresinFL/FR
anisic
 ocimum basilicum herb oil egyptFL/FR
caramellic
 caramel pentadioneFL/FR
 cycloteneFL/FR
fruity
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 ethyl 3-oxohexanoateFL
(E,E)-ethyl sorbateFL/FR
 furfuryl isovalerateFL
 hexanal propylene glycol acetalFL/FR
(E,E)-methyl sorbateFL
green
isobutyl 2-butenoateFL/FR
herbal
 dihydroanetholFL/FR
 ocimum basilicum leaf oil CO2 extractFL/FR
licorice
2-butyl-3-methyl pyrazineFL
 estragoleFL/FR
 glycyrrhiza glabra root extractFL/FR
 glycyrrhiza glabra root extract powderFL
nutty
2-acetyl pyrroleFL/FR
sweet
neohesperidin dihydrochalconeFL
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 biological additives 
 skin conditioning 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 AMGZ
 ammoniated glycyrrhizin
 ammoniated glycyrrhizin FCC
 ammoniated glycyrrhizin FCC, natural
monoammonium glycyrrhizate
 ammonium glycyrrhizinate
monoammonium glycyrrhizinate
monoammonium glycyrrhizinate hydrate
 glycamil
 glycyrram
 glycyrrhizic acid ammoniated
 glycyrrhizic acid ammonium salt
 glycyrrhizic acid monoammonium salt
 glycyrrhizic acid, ammonium salt
 glycyrrhizic acid, monoammonium salt
 glycyrrhizin ammoniated
 glycyrrhizin, ammoniated
 glycyrrhizinate monoammonium
 glycyrrhizinic acid ammonium salt
 glycyrrhizinic acid, ammonium salt (1:1)
 olean-12-en-30-oic acid, 3-[(2-O-β-D-glucopyranuronosyl-a-D-glucopyranuronosyl)oxy]-11-oxo-, ammonium salt, (3β)-
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Articles:
Google Patents: Sucrose-ammoniated glycyrrhizin sweetening agent
US Patents: 8,007,849 - Unsaturated cyclic and acyclic carbamates exhibiting taste and flavor enhancement effect in flavor compositions
PubMed: [About flavouring substances and flavouring preparations regulation in the field of manufacturing of flavourings and foodstuffs].
PubMed: Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.
PubMed: Tests for mutagenic effects of ammoniated glycyrrhizin, butylated hydroxytoluene, and gum Arabic in rodent germ cells.
PubMed: Time required to achieve homogeneity in swine feed mixtures.
PubMed: Production of experimental hypertension and cardiovascularrenal lesions with licorice and ammoniated glycyrrhizin.
PubMed: Desoxycorticosterone-mimetic action of ammoniated glycyrrhizin in rats.
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