capscaisin
nonanoyl 4-hydroxy-3-methoxybenzylamide
 
Notes:
has effect on sensory neurons. Alkaloid from Capsicum spp. Flavouring ingredient Nonivamide is an organic compound and a capsaicinoid. It is an amide of pelargonic acid and vanillylamine. It is present in chili peppers, but is commonly manufactured synthetically. It is more heat-stable than capsaicin.
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
      Email: Info
      Email: Carl Sheeley
      Email: Customer Service
      Voice: +1 (414) 744 3993
      Fax: +1 (414) 744 7111
      News
      Product(s):
      NONIVAMIDE (KOSHER)
      NONIVAMIDE 10 WT% SOLUTION IN BENZYL ALCOHOL
      NONIVAMIDE (NON-KOSHER)
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      News
      Product(s):
      10482 8-Methyl-N-vanillyl-trans-B-nonenamide
       
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      Resources
      History
      Product(s):
      W149 nonanoyl 4-hydroxy-3-methoxy benzylamide
       
  • FCI SAS
    • FCI SAS
      Inspired by Nature
      At FCI customer service is not a department it’s an attitude.
      Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly.
      Email: Info
      Email: Philippe Faucher
      Voice: +33 (0)1 34 25 58 10
      Fax: + 33 1 34 25 58 18
      News
      Product(s):
      13135 NONIVAMIDE
       
  • Frutarom
    • Frutarom Ltd
      Discover Our Passion
      Your preferred partner for flavour and fragrance success.
      At Frutarom, we take pride in our expertise and knowledge of Flavour & Fragrance Ingredients and our thorough understanding of the needs of Flavourists, Perfumers and Food Technologists. Working closely with our customers we have a strong track record of providing unique solutions to fulfil requirements.
      US Email: Info- USA
      Email: Info - UK
      Voice: +44 (0) 1429 863 222
      US Voice: +1 513 870 4900
      Products List: View
      Product(s):
      C0005-0 CAPSCAISIN 10% VEGETABLE OIL
       
  • Indukern F&F
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      103329 Nonivamide?Pelargonic acid vanillylamide?
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      News
      Product(s):
      A0439 NONIVAMIDE
       
  • Penta International
Synonyms   Articles   Notes   Search
N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide (Click)
CAS Number: 2444-46-4Picture of molecule
Other: 497080-86-1
ECHA EINECS - REACH Pre-Reg: 219-484-1
FDA UNII: S846B891OR
Nikkaji Web: J7.575B
Beilstein Number: 2144300
MDL: MFCD00017286
CoE Number: 590
XlogP3-AA: 4.20 (est)
Molecular Weight: 293.40679000
Formula: C17 H27 N O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1599  nonanoyl 4-hydroxy-3-methoxybenzylamide
Flavis Number: 16.006 (Old)
DG SANTE Food Flavourings: 16.006  nonanoyl 4-hydroxy-3-methoxybenzylamide
FEMA Number: 2787  nonanoyl 4-hydroxy-3-methoxybenzylamide
FDA Mainterm: NONANOYL 4-HYDROXY-3-METHOXYBENZYLAMIDE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white to pale brown crystalline powder (est)
Assay: 96.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.94600 @  20.00 °C.
Refractive Index: 1.45200 @  20.00 °C.
Melting Point: 124.00 to  128.00 °C. @ 760.00 mm Hg
Boiling Point: 492.00 to  493.00 °C. @ 760.00 mm Hg (est)
Acid Value: 1.00 max. KOH/g
Flash Point: 485.00 °F. TCC ( 251.80 °C. ) (est)
logP (o/w): 3.202 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: refrigerate in tightly sealed containers.
Soluble in:
 alcohol
 dipropylene glycol
 water, slightly
 water, 7.716 mg/L @ 25 °C (est)
Insoluble in:
 water
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
bland odorless
 pungent  spicy  
Taste Description:
pungent burning
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Apiscent Labs
NONIVAMIDE (KOSHER)
Odor: Mild, warm-herbaceous
Apiscent Labs
NONIVAMIDE (NON-KOSHER)
Apiscent Labs
NONIVAMIDE 10 WT% SOLUTION IN BENZYL ALCOHOL
Beijing Lys Chemicals
8-Methyl-N-vanillyl-trans-B-nonenamide
Changsha Organic Herb
Red Chilli Peppers Extract
CTC Organics
nonanoyl 4-hydroxy-3-methoxy benzylamide
FCI SAS
NONIVAMIDE
Odor: Mild, warm-herbaceous
Flavor: Burning, pungent
Frutarom
CAPSCAISIN 10% VEGETABLE OIL
Indukern F&F
CAPSAICIN SYNTHETIC
Odor: ALMOST ODORLESS, HERBAL
CROP CALENDAR
Jiangyin Healthway
Nonivamide?Pelargonic acid vanillylamide?
New functional food ingredients
M&U International
NONIVAMIDE
Nacalai USA
For experimental / research use only.
N-Vanillylnonanamide
Penta International
N-NONANOYL VANILLYLAMIDE CONGEALED LIQUID, Kosher
Penta International
N-NONANOYL VANILLYLAMIDE POWDER, Kosher
Sigma-Aldrich: Sigma
For experimental / research use only.
N-Vanillylnonanamide
TCI AMERICA
For experimental / research use only.
N-Vanillylnonanamide [=Capsaicin (Synthetic)] >96.0%(N)
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 25 - Toxic if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50  8 mg/kg
Journal of Medicinal Chemistry. Vol. 36, Pg. 2595, 1993.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavoring agents
Recommendation for capscaisin usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 6.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.07 (μg/capita/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -10.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -10.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -10.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): --
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): --
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): 10.00000300.00000
Confectionery (05.0): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): --
Bakery wares (07.0): --
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): --
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): --
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 40: An aromatic derivative of 2-hydroxy-propionamide. Chemical group 16
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 2444-46-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 2998
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 2811
WGK Germany: 3
 N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
Chemidplus: 0002444464
RTECS: RA5955000 for cas# 2444-46-4
Synonyms   Articles   Notes   Search   Top
References:
 N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 2444-46-4
Pubchem (cid): 2998
Pubchem (sid): 134981769
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): D08282
HMDB (The Human Metabolome Database): HMDB29846
FooDB: FDB001066
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
amber
 angelica seed oilFL/FR
 angelica seed oil CO2 extractFL/FR
anisic
bitter fennel seed oil spainFR
balsamic
 amyris wood oilFL/FR
 copaiba balsam oilFL/FR
 hemlock western oil (tsuga heterophylla) canadaFR
 tolu balsam oilFL/FR
floral
alpha-bisabololFL/FR
herbal
 canarium luzonicum gumFL/FR
 canarium luzonicum oilFL/FR
 elemi resinoidFL/FR
spicy
 agarospirolFR
 atractylis root oilFR
4-carvomenthenolFL/FR
 croton eluteria bark oilFL/FR
 ethyl vinyl ketoneFL/FR
 grains of paradise oilFL/FR
 myrceneFL/FR
black pepper absoluteFL/FR
 pepper hexanoneFR
black pepper oilFL/FR
black pepper oleoresinFL/FR
 pepper tree berry oilFL/FR
(E,E)-piperineFL/FR
 zvoulimba leaf oilFR
terpenic
 juniperus communis fruit oilFL/FR
laevo-limoneneFL/FR
woody
 guaiacwood oil 20% in gurjun balsam oilFR
alpha-guaieneFL/FR
 methyl vetivateFR
 sugi wood oilFR
 
For Flavor
 
No flavor group found for these
alpha-bisabololFL/FR
 capsicum oleoresinFL
 grains of paradise oilFL/FR
alpha-guaieneFL/FR
laevo-limoneneFL/FR
(E,E)-piperineFL/FR
amber
 angelica seed oilFL/FR
balsamic
 copaiba balsam oilFL/FR
 tolu balsam oilFL/FR
cooling
4-carvomenthenolFL/FR
green
 canarium luzonicum gumFL/FR
 canarium luzonicum oilFL/FR
 elemi resinoidFL/FR
herbal
 angelica seed oil CO2 extractFL/FR
spicy
 chipotle chili oleoresinFL
 croton eluteria bark oilFL/FR
 cubeb oleoresinFL
 ethyl vinyl ketoneFL/FR
 jalapeno oleoresinFL
black pepper absoluteFL/FR
black pepper oilFL/FR
black pepper oleoresinFL/FR
white pepper oleoresinFL
 pepper tree berry oilFL/FR
terpenic
 juniperus communis fruit oilFL/FR
woody
 amyris wood oilFL/FR
 myrceneFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 cayenne fruit
Search Trop  Picture
 chili pepper
Search  Picture
 pepper bell pepper fruit
Search Trop  Picture
 pepper bell pepper sap
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
pseudocapsaicin
 capsaicin synthetic
 capscaisin
 capscaisin 10% vegetable oil
N-[(4-hydroxy-3-methoxy-phenyl)methyl]nonanamide
N-4-hydroxy-3-methoxybenzyl nonanamide
N-(4-hydroxy-3-methoxybenzyl)nonanamide
N-((4-hydroxy-3-methoxyphenyl)methyl) nonanamide
N-((hydroxy-3-methoxyphenyl)methyl)4-nonanamide
N-((4-hydroxy-3-methoxyphenyl)methyl)nonanamide
N-[(4-hydroxy-3-methoxyphenyl)methyl]nonanamide
 hydroxymethoxybenzyl pelargonamide
8-methyl-N-vanillyl-trans-b-nonenamide
 nonanamide, N-((4-hydroxy-3-methoxyphenyl)methyl)-
 nonanamide, N-[ (4-hydroxy-3-methoxyphenyl)methyl]-
 nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-
 nonanamide, N-vanillyl-
 nonanoic acid 4-hydroxy-3-methoxy-benzylamide
 nonanoic acid vanillylamide
 nonanoyl 4-hydroxy-3-methoxy benzylamide
 nonanoyl 4-hydroxy-3-methoxybenzyl amide
 nonanoyl 4-hydroxy-3-methoxybenzylamide
N-nonanoyl vanillyl amide
N-nonanoyl vanillylamide congealed liquid
N-nonanoyl vanillylamide powder
 nonivamide
 nonivamide (non-kosher)
 nonivamide 10 wt% solution in benzyl alcohol
 nonoyl vanillylamide
 nonylic acid vanillylamide
 nonylvanylamide
 pelargonic acid vanillyl amide
 pelargonic acid vanillylamide
 pelargonic acid, vanillylamide
 pelargonyl vanillilamide
 pelargonyl vanillyl amide
 pelargonyl vanillylamide
 vanillyl pelargonic amide
 vanillyl-N-nonyl amide
 vanillyl-N-nonylamide
N-vanillylnonamide
N-vanillylnonanamide
N-vanillylnonanoamide
N-vanillylpelargonamide
Synonyms   Articles   Notes   Search   Top
Articles:
Info: aliphatic and aromatic amines and amides
PubMed: The capsaicin analog nonivamide decreases total energy intake from a standardized breakfast and enhances plasma serotonin levels in moderately overweight men after administered in an oral glucose tolerance test: A randomized, crossover trial.
PubMed: Oil-in-Oil-Emulsions with Enhanced Substantivity for the Treatment of Chronic Skin Diseases.
PubMed: Evaluation of changes in the haemoglobin of skin and muscle tissue of the calf, as induced by topical application of a nonivamide/nicoboxil cream.
PubMed: In vitro studies on release and skin permeation of nonivamide from novel oil-in-oil-emulsions.
PubMed: Nonivamide, a capsaicin analog, increases dopamine and serotonin release in SH-SY5Y cells via a TRPV1-independent pathway.
PubMed: In vitro skin permeation and penetration of nonivamide from novel film-forming emulsions.
PubMed: [A novel method for the identification of illegal cooking oil (1): detection of three capsaicinoids with liquid chromatography-mass spectrometry].
PubMed: Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum.
PubMed: Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.
PubMed: Comparison of the effects of pelargonic acid vanillylamide and capsaicin on human vanilloid receptors.
PubMed: New film forming emulsions containing Eudragit® NE and/or RS 30D for sustained dermal delivery of nonivamide.
PubMed: Determination and pharmacokinetics of [6]-gingerol in mouse plasma by liquid chromatography-tandem mass spectrometry.
PubMed: Novel penetration enhancers for skin applications: a review.
PubMed: Contributions of TRPV1, endovanilloids, and endoplasmic reticulum stress in lung cell death in vitro and lung injury.
PubMed: Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity.
PubMed: Molecular dynamics at ambient and elevated pressure of the amorphous pharmaceutical: nonivamide (pelargonic acid vanillylamide).
PubMed: Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists.
PubMed: Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation.
PubMed: A comparison of pretreatment with a topical combination of nonivamide and nicoboxil and surgical delay in a random pattern skin flap model.
PubMed: Neuroprotective effects of glyceryl nonivamide against microglia-like cells and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y human dopaminergic neuroblastoma cells.
PubMed: Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles.
PubMed: Evaluation of ketoprofen formulations via penetration rate and irritation in vivo study.
PubMed: Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells.
PubMed: Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.
PubMed: Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry.
PubMed: Assessment of pepper spray product potency in Asian and Caucasian forearm skin using transepidermal water loss, skin temperature and reflectance colorimetry.
PubMed: Electrically-assisted skin permeation of two synthetic capsaicin derivatives, sodium nonivamide acetate and sodium nonivamide propionate, via rate-controlling polyethylene membranes.
PubMed: TRPV1 antagonists elevate cell surface populations of receptor protein and exacerbate TRPV1-mediated toxicities in human lung epithelial cells.
PubMed: The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.
PubMed: Local heating of human skin by millimeter waves: effect of blood flow.
PubMed: Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
PubMed: Improved dorsal random-pattern skin flap survival in rats with a topically applied combination of nonivamide and nicoboxil.
PubMed: Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells.
PubMed: Determination of capsaicin, nonivamide, and dihydrocapsaicin in blood and tissue by liquid chromatography-tandem mass spectrometry.
PubMed: In vitro topical application and in vivo pharmacodynamic evaluation of nonivamide hydrogels using Wistar rat as an animal model.
PubMed: Transdermal iontophoresis of sodium nonivamide acetate. V. Combined effect of physical enhancement methods.
PubMed: Prevention of cerebral vasospasm by a capsaicin derivative, glyceryl nonivamide, in an experimental model of subarachnoid hemorrhage.
PubMed: In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels.
PubMed: Evaluation of percutaneous absorption and skin irritation of ketoprofen through rat skin: in vitro and in vivo study.
PubMed: Quantitative analysis of capsaicinoids in fresh peppers, oleoresin capsicum and pepper spray products.
PubMed: Determination of capsaicin, dihydrocapsaicin, and nonivamide in self-defense weapons by liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry.
PubMed: Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin.
PubMed: The transepidermal oxygen flux from the environment is in balance with the capillary oxygen supply.
PubMed: Nitrated nonivamide displaying a drawback of proton's role in capsaicin-associated sensory and neuronal activities.
PubMed: The effect of the base on the kinetics of action of the capsaicinoid nonivamide: evaluation with a hyperemic test.
PubMed: Transdermal delivery of sodium nonivamide propionate by iontophoresis.
PubMed: Selective block by glyceryl nonivamide of inwardly rectifying K+ current in rat anterior pituitary GH3 cells.
PubMed: A possible role of nitric oxide formation in the vasodilatation of rabbit ear artery induced by a topically applied Capsaicin analogue.
PubMed: The responses of rat trigeminal ganglion neurons to capsaicin and two nonpungent vanilloid receptor agonists, olvanil and glyceryl nonamide.
PubMed: Glyceryl nonivamide: a capsaicin derivative with cardiac calcitonin gene-related peptide releasing, K+ channel opening and vasorelaxant properties.
PubMed: Glyceryl nonivamide, a nonpungent analogue of capsaicin, enhances substance P release and renal function in rats.
PubMed: Development and evaluation of transdermal patches of nonivamide and sodium nonivamide acetate.
PubMed: Capsinolol: the first beta-adrenoceptor blocker with an associated calcitonin gene-related peptide releasing activity in the heart.
PubMed: Multiple sensory and functional effects of non-phenolic aminodimethylene nonivamide: an approach to capsaicin antagonist.
PubMed: Sodium nonivamide acetate: a non-pungently antinociceptive capsaicin derivative with unusual anti-inflammatory properties.
PubMed: In vitro effect of penetration enhancers on sodium nonivamide acetate in rat skin.
PubMed: Metabolism of capsaicinoids: evidence for aliphatic hydroxylation and its pharmacological implications.
PubMed: Autonomic and sensory cardiovascular activities of nonivamide: intrathecal administration of clonidine.
PubMed: Desensitizing mechanism of capsaicin and nonanoyl vanillylamide on the vascular nociceptive response in the guinea pig.
PubMed: Capsaicin: identification, nomenclature, and pharmacotherapy.
PubMed: Cardiovascular interactions of nonivamide, glyceryl nonivamide, capsaicin analogues, and substance P antagonist in rats.
PubMed: Cardiovascular effects of nonivamide succinate.
PubMed: [The effect of nonanoyl vanillylamide on the chemically-induced nociception].
PubMed: Studies on the hypothermic response of capsaicin and its analogue in mice.
PubMed: Comparison of nonivamide and capsaicin with regard to their pharmacokinetics and effects on sensory neurons.
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