sodium ferulate
sodium 3-methoxy-4-hydroxycinnamate
 
Notes:
Flavouring ingredient with a sweet clovery, phenolic odour Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis. It is found in the root of Angelica sinensis. It is considered safe and effective.
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      Product(s):
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sodium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate (Click)
CAS Number: 24276-84-4Picture of molecule
FDA UNII: OIS7F1IRQK
Molecular Weight: 217.17626928
Formula: C10 H10 O4 Na
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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JECFA Food Flavoring: 2014  sodium 3-methoxy-4-hydroxycinnamate
FEMA Number: 3812  sodium 3-methoxy-4-hydroxycinnamate
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Physical Properties:
Appearance: pale yellow powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 371.00 to  372.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.000003 mm/Hg @ 25.00 °C. (est)
Flash Point: 302.00 °F. TCC ( 150.00 °C. )
logP (o/w): 1.641 (est)
Soluble in:
 alcohol
 water
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor Type: spicy
Odor Strength: medium
 sweet  spicy  clove  phenolic  
Odor Description:
at 100.00 %. 
sweet clove phenolic
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
BOC Sciences
For experimental / research use only.
Sodium Ferulate
Matrix Scientific
For experimental / research use only.
Sodium 3-(4-hydroxy-3-methoxyphenyl)acrylate, 95+%
Parchem
sodium ferulate
Penta International
SODIUM FERULATE, Kosher
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for sodium ferulate usage levels up to:
 not for fragrance use.
 
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 17
Click here to view publication 17
 average usual ppmaverage maximum ppm
baked goods: 100.00000100.00000
beverages(nonalcoholic): 400.00000400.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: 100.00000100.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: 2000.000002000.00000
sweet sauces: 300.00000300.00000
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Safety References:
EPI System: View
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 23669636
National Institute of Allergy and Infectious Diseases: Data
 sodium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
Chemidplus: 0024276844
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References:
 sodium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 23669636
Pubchem (sid): 135283346
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB019993
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
FAO: Sodium 3-methoxy-4-hydroxycinnamate
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 cinnamic acid, 4-hydroxy-3-methoxy-, monosodium salt
 ferulic acid sodium salt
3-(4-hydroxy-3-methoxyphenyl) propenoic acid sodium salt
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid monosodium salt
(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid, sodium salt
2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, monosodium salt
2-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, sodium salt, (2E)- (1:1)
 sodium (2E)-3-(4-hydroxy-3-methoxyphenyl)acrylate
 sodium (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
 sodium (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
monosodium 3-(4-hydroxy-3-methoxyphenyl)-2-propenoate
 sodium 3-methoxy-4-hydroxycinnamate
monosodium 4-hydroxy-3-methoxycinnamate
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Articles:
PubMed: Sodium Ferulate Prevents Daunorubicin - Induced Apoptosis in H9c2 Cells via Inhibition of the ERKs Pathway.
PubMed: [Sodium Ferulate Attenuates Oxidative Stress Induced Inflammation via Suppressing NALP3 and NF-κB Signal Pathway].
PubMed: [Sodium ferulate protects against daunorubicin-induced cardiotoxicity in juvenile rats].
PubMed: The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury.
PubMed: Sodium Ferulate Reduces Portal Pressure Through Inhibition of RhoA/Rho-Kinase and Activation of Endothelial Nitric Oxide Synthase in Cirrhotic Rats.
PubMed: HMGB1 Silencing Potentiates the Anti-inflammatory Effects of Sodium Ferulate in ox-LDL-Stimulated Vascular Smooth Muscle Cells.
PubMed: Angelica sinensis and osteoarthritis: a natural therapeutic link?
PubMed: Sodium ferulate lowers portal pressure in rats with secondary biliary cirrhosis through the RhoA/Rho-kinase signaling pathway: a preliminary study.
PubMed: Effect of sodium ferulate on delayed rectifier K(+) currents in PC12 cells.
PubMed: Protective effects of the combination of sodium ferulate and oxymatrine on cecal ligation and puncture-induced sepsis in mice.
PubMed: Sodium ferulate inhibits neointimal hyperplasia in rat balloon injury model.
PubMed: The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice.
PubMed: [Protective effect of sodium ferulate magnetic nanoparticle in septic kidney injury rats].
PubMed: Sodium ferulate protects against daunorubicin-induced cardiotoxicity by inhibition of mitochondrial apoptosis in juvenile rats.
PubMed: Exogenous and endogenous therapeutic effects of combination Sodium Ferulate and bone marrow stromal cells (BMSCs) treatment enhance neurogenesis after rat focal cerebral ischemia.
PubMed: Genetic Variants of Pregnane X Receptor (PXR) and CYP2B6 Affect the Induction of Bupropion Hydroxylation by Sodium Ferulate.
PubMed: Synchronous fluorescence determination of ferulic acid with Ce(IV) and sodium tripolyphosphate.
PubMed: Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro'--authors' reply.
PubMed: Response to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro'.
PubMed: Effects of sodium ferulate on preventing steroid-induced femoral head osteonecrosis in rabbits.
PubMed: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro.
PubMed: The effects of sodium ferulate on the pharmacokinetics of bupropion and its active metabolite in healthy men.
PubMed: Cardioprotective effect of sodium ferulate in diabetic rats.
PubMed: Hypnic headache responsive to sodium ferulate in 2 new cases.
PubMed: Sodium Ferulate combined with bone marrow stromal cell treatment ameliorating rat brain ischemic injury after stroke.
PubMed: Protective effect of sodium ferulate on acetaldehyde-treated precision-cut rat liver slices.
PubMed: The effects of the combination of sodium ferulate and oxymatrine on lipopolysaccharide-induced acute lung injury in mice.
PubMed: Enhancement of placental antioxidative function and P-gp expression by sodium ferulate mediated its protective effect on rat IUGR induced by prenatal tobacco/alcohol exposure.
PubMed: The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells.
PubMed: P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine.
PubMed: The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischaemia in C57 BL/6J mice.
PubMed: The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine.
PubMed: [Effect of Ligusticum and its two main components on muscle atrophy in a hind limb unloaded rat model].
PubMed: [Systematic review on sodium ferulate for treatment of diabetic nephropathy].
PubMed: Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats.
PubMed: [Sodium ferulate treatment and interventional mechanism reverse erectile dysfunction in streptozotocin-induced diabetic rats].
PubMed: Sodium ferulate modified gene expression profile of oxidized low-density lipoprotein-stimulated human umbilical vein endothelial cells.
PubMed: Mannose 6-phosphate-modified bovine serum albumin nanoparticles for controlled and targeted delivery of sodium ferulate for treatment of hepatic fibrosis.
PubMed: Effects of sodium ferulate on human osteoarthritic chondrocytes and osteoarthritis in rats.
PubMed: [Clinical study on sodium ferulate for intracerebral hemorrhage in early stage].
PubMed: Sodium ferulate attenuates anoxia/reoxygenation-induced calcium overload in neonatal rat cardiomyocytes by NO/cGMP/PKG pathway.
PubMed: Endothelium-independent vasorelaxant effect of sodium ferulate on rat thoracic aorta.
PubMed: Neuroprotective effect of sodium ferulate and signal transduction mechanisms in the aged rat hippocampus.
PubMed: [Effect of sodium ferulate on hemodynamics in hepatic cirrhosis patients with portal hypertension].
PubMed: Role of sodium ferulate in the nociceptive sensory facilitation of neuropathic pain injury mediated by P2X(3) receptor.
PubMed: Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
PubMed: Neuroprotection by sodium ferulate against glutamate-induced apoptosis is mediated by ERK and PI3 kinase pathways.
PubMed: Study on effect and mechanism of sodium ferulate in preventing and treating ozone induced lung injury in mice.
PubMed: Preparation and characterization of sodium ferulate entrapped bovine serum albumin nanoparticles for liver targeting.
PubMed: Protection against oxidative stress in diabetic rats by wheat bran feruloyl oligosaccharides.
PubMed: Effect of sodium ferulate on fluidity and morphology of cell membrane in ozone induced lung injury.
PubMed: A novel controlled porosity osmotic pump system for sodium ferulate.
PubMed: [Preliminary study on effects of sodium ferulate in treating diabetic nephropathy].
PubMed: High-performance liquid chromatography-electrospray ionization mass spectrometry determination of sodium ferulate in human plasma.
PubMed: Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus.
PubMed: Development of a gradient reversed-phase HPLC method for the determination of sodium ferulate in beagle dog plasma.
PubMed: In vitro controlled release of sodium ferulate from Compritol 888 ATO-based matrix tablets.
PubMed: [Cardioprotective effects of sodium ferulate mediated by nitric oxide on ischemia-reperfusion injured myocardium: experiment with isolated rat hearts].
PubMed: Potent protection of ferulic acid against excitotoxic effects of maternal intragastric administration of monosodium glutamate at a late stage of pregnancy on developing mouse fetal brain.
PubMed: Differentiation of human bone marrow stromal cells into neural-like cells induced by sodium ferulate in vitro.
PubMed: Neuroprotective effect of sodium ferulate on transient focal cerebral ischemia by weakening activation of postsynaptic density-95 in rats.
PubMed: Effect of sodium ferulate on human colonic anion secretion and the underlying signaling mechanism.
PubMed: Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus.
PubMed: Pharmacological actions of sodium ferulate in cardiovascular system.
PubMed: [Preliminary clinical observation on effect of soduim ferulate in treating diabetic nephropathy].
PubMed: [Study on the pharmacological mechanism of sodium ferulate for anti-asthmatic effect in guinea pigs].
PubMed: [Mechanisms of sodium ferulate inhibition of collagen synthesis in hepatic stellate cells].
PubMed: [Description of the release of sodium ferulate from hydroxypropyl methylcellulose based matrix tablets in vitro].
PubMed: [Protective effect and mechanism of pharmacologic preconditioning induced by sodium ferulate on primary cultured myocardial cell injury by anoxia/reoxygenation].
PubMed: [Renal protective effect and its mechanism of sodium ferulate in diabetic rats].
PubMed: Sodium ferulate inhibits atherosclerogenesis in hyperlipidemia rabbits.
PubMed: [Antagonistic effect of sodium ferulate on glycerol-induced renal oxidative injury in mice].
PubMed: [Effect of sodium ferulate on activation of extracellular signal regulated kinase after cerebral ischemia/reperfusion injury in rats].
PubMed: Ameliorative effects of sodium ferulate on experimental colitis and their mechanisms in rats.
PubMed: [Effect of sodium ferulate on leucocyte spontaneous activation and surface adhesion molecule expression in arteriosclerosis obliterans patients].
PubMed: Influence of Angelicae sinensis extract on lipid accumulation in rabbit aortic smooth muscle cells induced by oxidized LDL.
PubMed: [Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL].
PubMed: [The effect of antioxidant sodium ferulate on human lymphocytes apoptosis induced by H2O2].
PubMed: [Antagonizing effect of sodium ferulate on the changes of hepatic antioxidative function induced by ethanol in mice].
PubMed: [Mechanism of inhibitory action of sodium ferulate on liver lipid peroxidation in mice].
PubMed: Effects of tetramethylpyrazine phosphate and sodium ferulate alone or in combination on hemodynamics in anesthetized dog.
PubMed: [Sodium ferulate alleviates prednisolone induced liver toxicity in mice].
PubMed: [Protective effect of sodium ferulate on damage of the rat liver mitochondria induced by oxygen free radicals].
PubMed: [Sodium ferulate alleviated paracetamol-induced liver toxicity in mice].
PubMed: [Effects of paracetamol on glutathione S-transferase activity in mice].
PubMed: Effect of hydroxyl radical on Na(+)-K(+)-ATPase activity of the brain microsomal membranes.
PubMed: [The influence of sodium ferulate on hypotensive effect and urinary excretion of TXB2 after captopril in essential hypertensive patients].
PubMed: [Protection of biomembrane fatty acids by antioxidants studied with gas chromatography].
PubMed: [Scavenging effects of sodium ferulate and 18 beta-glycyrrhetic acid on oxygen free radicals].
PubMed: [Effect of sodium ferulate on arachidonic acid metabolism].
PubMed: [Effect of sodium ferulate on C14-arachidonic acid metabolism in rabbit platelets].
PubMed: [Experimental study on the effect of sodium ferulate in protecting acute oxygen intoxication and lipid peroxidation].
PubMed: [Sodium ferulate is an inhibitor of thromboxane A2 synthetase].
PubMed: [Effects of sodium ferulate on platelet aggregation and platelet thromboxane A2 in patients with coronary heart disease].
PubMed: [Hemospasia therapy and sodium ferulate intravenous dripping in the treatment of cor pulmonale].
PubMed: [Effect of sodium ferulate on malondialdehyde production from the platelets of rats].
PubMed: [The effect of sodium ferulate on complement-activated hemolysis].
PubMed: [The effect of sodium ferulate on lipid peroxidation of the erythrocyte membrane].
PubMed: [Effects of sodium ferulate combined with acetylsalicylic acid on rat platelet aggregation and on modulation of PGI2-TXA2 balance].
PubMed: [Studies on mechanism of the antiplatelet effect of sodium ferulate--effect on TXA2/PGI2 balance].
PubMed: [Antithrombotic effect of sodium ferulate in rats (author's transl)].
PubMed: Effect of sodium glycolate and sodium ferulate on renal functions in dog.
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