ortho-cresol
o-cresol
 
Notes:
Flavouring ingredient
  • Advanced Biotech
  • H. Interdonati, Inc.
    • H. Interdonati, Inc.
      Innovative products
      Because your flavors and fragrances are only as good as their source "Since 1952"
      H. Interdonati, Inc. began in 1952 with the tradition of delivering quality pharmaceuticals and fine chemical ingredients at competitive prices. The mission was simple: To provide the most reliable, personal service in the industry.
      Email: Info
      US Email: Info
      Email: Sales
      US Email: Andrew Interdonati (Sales)
      Voice: 800 367-6617
      Fax: 631 367-6626
      Featured Products
      Product(s):
      o-Creosol Natural, Kosher
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      News
      Product(s):
      N0120 NAT.O-CRESOL, Kosher
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      03-52600 o-CRESOL, Kosher
      03-52650 o-CRESOL, NATURAL, Kosher
       
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
      US Email: Sales
      US Voice: 800-244-1173
      US Fax: 800-368-4661
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      Certified Food Grade Products
      Product(s):
      W348007 o-Cresol, ≥99%
      SDS
       
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      Sales0512-57995626
      Sales0512-57570299
      News
      Product(s):
      N0132 nat.o-Cresol
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
      US Fax: 888-520-1075
      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
      Facebook
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      Product(s):
      C0402 o-Cresol >99.0%(GC)
       
Synonyms   Articles   Notes   Search
    Flavor Demo Formulas
2-methylphenol (Click)
CAS Number: 95-48-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 202-423-8
FDA UNII: YW84DH5I7U
Nikkaji Web: J1.176B
Beilstein Number: 0506917
MDL: MFCD00002226
CoE Number: 618
XlogP3: 2.00 (est)
Molecular Weight: 108.13996000
Formula: C7 H8 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: food contact resinous and polymeric coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 691  o-cresol
Flavis Number: 04.027 (Old)
DG SANTE Food Flavourings: 04.027  2-methylphenol
DG SANTE Food Contact Materials: 2-methylphenol
FEMA Number: 3480  o-cresol
FDA Mainterm: O-CRESOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2410 Phenolic resins in molded articles.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white solid (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.04600 to 1.05100 @  25.00 °C.
Pounds per Gallon - (est).: 8.704 to  8.745
Refractive Index: 1.54800 to 1.55900 @  20.00 °C.
Melting Point: 30.00 to  34.00 °C. @ 760.00 mm Hg
Boiling Point: 191.00 to  192.00 °C. @ 760.00 mm Hg
Boiling Point: 110.00 to  111.00 °C. @ 50.00 mm Hg
Vapor Pressure: 0.030000 mm/Hg @ 20.00 °C.
Vapor Density: 3.72 ( Air = 1 )
Flash Point: 178.00 °F. TCC ( 81.11 °C. )
logP (o/w): 1.950
Soluble in:
 alcohol
 water, 9066 mg/L @ 25 °C (est)
 water, 2.59E+04 mg/L @ 25 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: phenolic
Odor Strength: high ,
recommend smelling in a 0.01 % solution or less
 musty  phenolic  medicinal  
Odor Description:
at 0.01 % in dipropylene glycol. 
musty phenolic
Luebke, William tgsc, (1995)
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Aceto
o-Cresol
Advanced Biotech
ORTHO CRESOL NATURAL
Aurochemicals
ortho-CRESOL, Natural
EMD Millipore
For experimental / research use only.
o-Cresol
H. Interdonati, Inc.
o-Creosol Natural, Kosher
Featured Products
M&U International
NAT.O-CRESOL, Kosher
Penta International
o-CRESOL, Kosher
Penta International
o-CRESOL, NATURAL, Kosher
SABIC Innovative Plastics
ortho-cresol (2-methylphenol)
Santa Cruz Biotechnology
For experimental / research use only.
2-Methylphenol
Sigma-Aldrich
o-Cresol, ≥99%
Odor: musty; medicinal
Certified Food Grade Products
Sunaux International
nat.o-Cresol
TCI AMERICA
For experimental / research use only.
o-Cresol >99.0%(GC)
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 24/25 - Toxic in contact with skin and if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  121 mg/kg
(E.I. du Pont de Nemours & Company, 1969b)

oral-mouse LD50  344 mg/kg
(E.I. du Pont de Nemours & Company, 1969b)

gavage-rat LD50  [sex: M,F] 300 mg/kg
(Bailey, 1983)

gavage-rat LD50  [sex: M,F] 530 mg/kg
Substance administered as a 2 % or 5 % aqueous solution.
(Deichmann & Witherup

gavage-rat LD50  [sex: M,F] 540 mg/kg
Substance administered as a 10 % aqueous solution.
(Deichmann & Witherup

gavage-rat LD50  [sex: M,F] 340 mg/kg
Substance administered as a 20 % aqueous solution.
(Deichmann & Witherup

gavage-rat LD50  [sex: F] 400 mg/kg
(Berman et al., 1995)

oral-rat LD50  121 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH LUNGS, THORAX, OR RESPIRATION: DYSPNEA
IBIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 4-5/1969

oral-rabbit LDLo  940 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

intravenous-rabbit LDLo  180 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

intraperitoneal-mouse LDLo  200 mg/kg
Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952.

oral-mouse LD50  344 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

intraperitoneal-guinea pig LDLo  720 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

Dermal Toxicity:
skin-rabbit LD50 890 mg/kg
Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977.

skin-rat LD50 620 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

subcutaneous-rat LDLo 65 mg/kg
SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-rabbit LDLo 450 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

subcutaneous-mouse LDLo 410 mg/kg
Zeitschrift fuer Hygiene und Infektionskrankheiten. Vol. 64, Pg. 113, 1909.

subcutaneous-guinea pig LDLo 35 mg/kg
BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-frog LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

subcutaneous-cat LDLo 55 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

Inhalation Toxicity:
inhalation-rat LC50 > 1220 mg/m3/1H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 4-5/1969

inhalation-mouse LC50 179 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 40, 1982.

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Safety in Use Information:
Category: food contact resinous and polymeric coatings
Recommendation for ortho-cresol usage levels up to:
  0.0100 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 250.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 10
Click here to view publication 10
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: -0.50000
cheese: --
chewing gum: --
condiments / relishes: -0.50000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -0.50000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -0.50000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: -0.50000
snack foods: --
soft candy: --
soups: -0.50000
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf
Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species
View page or View pdf
EPI System: View
EPA-Iris: IRIS
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 95-48-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 335
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 3455
WGK Germany: 2
 2-methylphenol
Chemidplus: 0000095487
EPA/NOAA CAMEO: hazardous materials
RTECS: 95-48-7
Synonyms   Articles   Notes   Search   Top
References:
 2-methylphenol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 95-48-7
Pubchem (cid): 335
Pubchem (sid): 134971878
Flavornet: 95-48-7
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C01542
HMDB (The Human Metabolome Database): HMDB02055
FooDB: FDB008785
YMDB (Yeast Metabolome Database): YMDB01457
Export Tariff Code: 2907.12.0000
FDA Listing of Food Additive Status: View
Haz-Map: View
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
Wikipedia2: View2
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
Formulations/Preparations:
•grades: according to freezing point: 25, 29, 30, 30.5 deg c ... •pure cresol is a mixture of ortho-, meta- and para- isomers. crude cresol (commercial cresol) is a mixture of aromatic cmpd containing about 20% of o-cresol, 40% of m-cresol, and 30% of p-cresol with small amount of phenol and xylenols.
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
herbal
 ajowan seed oilFL/FR
2,10-epoxypinaneFR
 matricaria chamomilla flower oilFL/FR
white thyme oilFL/FR
 thyme oil (thymus zygis gracillis) spainFL/FR
red thyme oil spainFL/FR
 thymolFL/FR
leathery
2-tert-butyl-6-methyl phenolFR
medicinal
2,6-xylenolFL/FR
phenolic
meta-cresolFR
2-propyl phenolFL/FR
4-vinyl phenolFL/FR
spicy
4-methyl guaiacolFL/FR
 
For Flavor
 
No flavor group found for these
2-propyl phenolFL/FR
burnt
2,6-xylenolFL/FR
herbal
 ajowan seed oilFL/FR
 matricaria chamomilla flower oilFL/FR
white thyme oilFL/FR
 thyme oil (thymus zygis gracillis) spainFL/FR
red thyme oil spainFL/FR
phenolic
 thymolFL/FR
4-vinyl phenolFL/FR
vanilla
4-methyl guaiacolFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 acacia cassie farnesianaFR
 antimicrobial agents 
 castoreumFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 asparagus shoot
Search Trop  Picture
 castoreum
Search  Picture
 cherry sour cherry plant
Search Trop  Picture
 coffee arabica coffee bean
Search Trop  Picture
 coffee bean
Search Trop  Picture
 lavender oil spike spain @ 0.016%
Data  GC  Search Trop  Picture
 mustard white mustard
Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 peppermint leaf
Search Trop  Picture
 tarragon plant
Search Trop  Picture
 tea leaf
Search Trop  Picture
 tomato fruit
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
2-cresol
nat.o-cresol
o-cresol
o-cresol, natural
o-cresylic acid
ortho-cresylic acid
2-hydroxy-1-methylbenzene
1-hydroxy-2-methylbenzene
2-hydroxytoluene
o-hydroxytoluene
ortho-hydroxytoluene
2-methyl phenol
o-methyl phenol
ortho-methyl phenol
1-methyl-2-hydroxybenzene
2-methylphenol
o-methylphenol
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Contribution of several volatile phenols and their glycoconjugates to smoke-related sensory properties of red wine.
PubMed: Interaction of phenol, o-cresol, and p-cresol with a clay-rich soil sample.
PubMed: Characterisation of volatile compounds in a smoke flavouring from rice husk.
PubMed: Cloud-point extraction and reversed-phase high performance liquid chromatography for analysis of phenolic compounds and their antioxidant activity in Thai local wines.
PubMed: Contribution of several volatile phenols and their glycoconjugates to smoke-related sensory properties of red wine.
PubMed: Retention and extractability of phenol, cresol, and dichlorophenol exposed to two surface soils in the presence of horseradish peroxidase enzyme.
PubMed: Purification and characterization of a peroxidase isozyme from Indian turnip roots.
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