EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ortho-cresol
o-cresol

Supplier Sponsors

Flavor Demo Formulas
Name:2-methylphenol
CAS Number: 95-48-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-423-8
FDA UNII:YW84DH5I7U
Nikkaji Web:J1.176B
Beilstein Number:0506917
MDL:MFCD00002226
CoE Number:618
XlogP3:2.00 (est)
Molecular Weight:108.13996000
Formula:C7 H8 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food contact resinous and polymeric coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:691 o-cresol
FLAVIS Number:04.027 (Old)
DG SANTE Food Flavourings:04.027 2-methylphenol
DG SANTE Food Contact Materials:2-methylphenol
FEMA Number:3480 o-cresol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: O-CRESOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2410 Phenolic resins in molded articles.
 
Physical Properties:
Appearance:white solid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.04600 to 1.05100 @ 25.00 °C.
Pounds per Gallon - (est).: 8.704 to 8.745
Refractive Index:1.54800 to 1.55900 @ 20.00 °C.
Melting Point: 30.00 to 34.00 °C. @ 760.00 mm Hg
Boiling Point: 191.00 to 192.00 °C. @ 760.00 mm Hg
Boiling Point: 110.00 to 111.00 °C. @ 50.00 mm Hg
Vapor Pressure:0.030000 mm/Hg @ 20.00 °C.
Vapor Density:3.72 ( Air = 1 )
Flash Point: 178.00 °F. TCC ( 81.11 °C. )
logP (o/w): 1.950
Soluble in:
 alcohol
 water, 9066 mg/L @ 25 °C (est)
 water, 2.59E+04 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: phenolic
Odor Strength:high ,
recommend smelling in a 0.01 % solution or less
Substantivity:41 hour(s) at 100.00 %
musty phenolic plastic medicinal herbal leathery
Odor Description:at 0.01 % in dipropylene glycol. musty phenolic plastic medicinal herbal leathery
Luebke, William tgsc, (1995)
Odor sample from: Sigma-Aldrich
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
perfuming agents
 
Suppliers:
Aceto
o-Cresol
Advanced Biotech
ORTHO CRESOL NATURAL
Aurochemicals
ortho-CRESOL, Natural
EMD Millipore
For experimental / research use only.
o-Cresol
H. Interdonati, Inc.
o-Creosol Natural, Kosher
Featured Products
M&U International
NAT.O-CRESOL, Kosher
Penta International
o-CRESOL, Kosher
Penta International
o-CRESOL, NATURAL, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
2-Methylphenol
Sigma-Aldrich
o-Cresol, ≥99%
Odor: musty; medicinal
Certified Food Grade Products
Sunaux International
nat.o-Cresol
Synerzine
o-Cresol
TCI AMERICA
For experimental / research use only.
o-Cresol >99.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 24/25 - Toxic in contact with skin and if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 121 mg/kg
(E.I. du Pont de Nemours & Company, 1969b)

oral-mouse LD50 344 mg/kg
(E.I. du Pont de Nemours & Company, 1969b)

gavage-rat LD50 [sex: M,F] 300 mg/kg
(Bailey, 1983)

gavage-rat LD50 [sex: M,F] 530 mg/kg
Substance administered as a 2 % or 5 % aqueous solution.
(Deichmann & Witherup

gavage-rat LD50 [sex: M,F] 540 mg/kg
Substance administered as a 10 % aqueous solution.
(Deichmann & Witherup

gavage-rat LD50 [sex: M,F] 340 mg/kg
Substance administered as a 20 % aqueous solution.
(Deichmann & Witherup

gavage-rat LD50 [sex: F] 400 mg/kg
(Berman et al., 1995)

oral-rat LD50 121 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH LUNGS, THORAX, OR RESPIRATION: DYSPNEA
IBIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 4-5/1969

oral-rabbit LDLo 940 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

intravenous-rabbit LDLo 180 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

intraperitoneal-mouse LDLo 200 mg/kg
Revue Belge de Pathologie et de Medecine Experimentale. Vol. 22, Pg. 1, 1952.

oral-mouse LD50 344 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

intraperitoneal-guinea pig LDLo 720 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

Dermal Toxicity:
skin-rabbit LD50 890 mg/kg
Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977.

skin-rat LD50 620 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 58, 1974.

subcutaneous-rat LDLo 65 mg/kg
SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-rabbit LDLo 450 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

subcutaneous-mouse LDLo 410 mg/kg
Zeitschrift fuer Hygiene und Infektionskrankheiten. Vol. 64, Pg. 113, 1909.

subcutaneous-guinea pig LDLo 35 mg/kg
BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-frog LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1361, 1935.

subcutaneous-cat LDLo 55 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 80, Pg. 233, 1944.

Inhalation Toxicity:
inhalation-rat LC50 > 1220 mg/m3/1H
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 4-5/1969

inhalation-mouse LC50 179 mg/m3/2H
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 40, 1982.

 
Safety in Use Information:
Category: food contact resinous and polymeric coatings
Recommendation for ortho-cresol usage levels up to:
  0.0100 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 250.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.10 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 10
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: -0.50000
cheese: --
chewing gum: --
condiments / relishes: -0.50000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: -0.50000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -0.50000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: -0.50000
snack foods: --
soft candy: --
soups: -0.50000
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species
View page or View pdf

EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):95-48-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :335
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3455
WGK Germany:2
2-methylphenol
Chemidplus:0000095487
EPA/NOAA CAMEO:hazardous materials
RTECS:95-48-7
 
References:
 2-methylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:95-48-7
Pubchem (cid):335
Pubchem (sid):134971878
Flavornet:95-48-7
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C01542
HMDB (The Human Metabolome Database):HMDB02055
FooDB:FDB008785
YMDB (Yeast Metabolome Database):YMDB01457
Export Tariff Code:2907.12.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
Wikipedia2:View2
RSC Learn Chemistry:View
Formulations/Preparations:
•grades: according to freezing point: 25, 29, 30, 30.5 deg c ... •pure cresol is a mixture of ortho-, meta- and para- isomers. crude cresol (commercial cresol) is a mixture of aromatic cmpd containing about 20% of o-cresol, 40% of m-cresol, and 30% of p-cresol with small amount of phenol and xylenols.
 
Potential Blenders and core components note
For Odor
herbal
ajowan seed oil
FL/FR
2,10-
epoxypinane
FR
matricaria chamomilla flower oil
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
red
thyme oil spain
FL/FR
thymol
FL/FR
leathery
2-tert-
butyl-6-methyl phenol
FR
medicinal
2,6-
xylenol
FL/FR
phenolic
meta-
cresol
FR
2-
propyl phenol
FL/FR
4-
vinyl phenol
FL/FR
spicy
4-
methyl guaiacol
FL/FR
For Flavor
No flavor group found for these
2-
propyl phenol
FL/FR
burnt
burnt
2,6-
xylenol
FL/FR
herbal
ajowan seed oil
FL/FR
matricaria chamomilla flower oil
FL/FR
white
thyme oil
FL/FR
thyme oil (thymus zygis gracillis) spain
FL/FR
red
thyme oil spain
FL/FR
phenolic
thymol
FL/FR
4-
vinyl phenol
FL/FR
vanilla
4-
methyl guaiacol
FL/FR
 
Potential Uses:
FRacacia
 antimicrobial agents
FRcastoreum
 
Occurrence (nature, food, other):note
 asparagus shoot
Search Trop Picture
 castoreum
Search PMC Picture
 cherry sour cherry plant
Search Trop Picture
 coffee arabica coffee bean
Search Trop Picture
 coffee bean
Search Trop Picture
 lavender oil spike spain @ 0.016%
Data GC Search Trop Picture
 mustard white mustard
Search Trop Picture
 pepper bell pepper fruit
Search Trop Picture
 peppermint leaf
Search Trop Picture
 tarragon plant
Search Trop Picture
 tea leaf
Search Trop Picture
 tomato fruit
Search Trop Picture
 
Synonyms:
2-cresol
nat.o-cresol
o-cresol
o-cresol, natural
o-cresylic acid
ortho-cresylic acid
2-hydroxy-1-methylbenzene
1-hydroxy-2-methylbenzene
2-hydroxytoluene
o-hydroxytoluene
ortho-hydroxytoluene
2-methyl phenol
o-methyl phenol
ortho-methyl phenol
1-methyl-2-hydroxybenzene
2-methylphenol
o-methylphenol
 

Articles:

PubMed:Contribution of several volatile phenols and their glycoconjugates to smoke-related sensory properties of red wine.
PubMed:Interaction of phenol, o-cresol, and p-cresol with a clay-rich soil sample.
PubMed:Characterisation of volatile compounds in a smoke flavouring from rice husk.
PubMed:Cloud-point extraction and reversed-phase high performance liquid chromatography for analysis of phenolic compounds and their antioxidant activity in Thai local wines.
PubMed:Contribution of several volatile phenols and their glycoconjugates to smoke-related sensory properties of red wine.
PubMed:Retention and extractability of phenol, cresol, and dichlorophenol exposed to two surface soils in the presence of horseradish peroxidase enzyme.
PubMed:Purification and characterization of a peroxidase isozyme from Indian turnip roots.
 
Notes:
Flavouring ingredient
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