EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2-methyl-6-ethoxypyrazine
2-ethoxy-6-methylpyrazine

Supplier Sponsors

CAS Number: 53163-97-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:258-402-9
FDA UNII: D47RK4A68R
Nikkaji Web:J295.902J
MDL:MFCD07787591
XlogP3:1.80 (est)
Molecular Weight:138.16990000
Formula:C7 H10 N2 O
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FEMA Number:3569 2-ethoxy-6-methylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 191.00 to 193.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.708000 mmHg @ 25.00 °C. (est)
Flash Point: 155.00 °F. TCC ( 68.33 °C. )
logP (o/w): 1.703 (est)
Soluble in:
 alcohol
 water
 water, 1824 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Type: nutty
nutty roasted
Odor Description:at 0.10 % in propylene glycol. nutty roasted
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-ethoxy-6-methylpyrazine 95%
Jalor-Chem
For experimental / research use only.
2-Ethoxy-6-methylpyrazine
Parchem
2-methyl-6-ethoxypyrazine
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-Methyl-6-ethoxypyrazine
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for 2-methyl-6-ethoxypyrazine usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 11
Click here to view publication 11
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -0.50000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: -2.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.50000
fruit ices: --
gelatins / puddings: -3.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):53163-97-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :104421
National Institute of Allergy and Infectious Diseases:Data
2-ethoxy-6-methylpyrazine
Chemidplus:0053163976
 
References:
 2-ethoxy-6-methylpyrazine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:53163-97-6
Pubchem (cid):104421
Pubchem (sid):135060443
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB40144
FooDB:FDB019841
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
For Odor
No odor group found for these
sulfuryl octanoate
FL/FR
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
valeraldehyde propylene glycol acetal
FL/FR
animal
animal
costus valerolactone
FR
balsamic
2-
acetyl furan
FL/FR
iso
amyl cinnamate
FL/FR
amyl cinnamate
FL/FR
amyl phenyl acetate
FL/FR
butyl cinnamate
FL/FR
prenyl benzoate
FL/FR
propyl benzoate
FL/FR
terpinyl cinnamate
FL/FR
bready
coffee furanone
FL/FR
buttery
acetyl propionyl
FL/FR
3,4-
hexane dione
FL/FR
camphoreous
bornyl isobutyrate
FL/FR
butyrophenone
FL/FR
caramellic
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
fenugreek oleoresin
FL/FR
cheesy
2-
heptanone
FL/FR
chocolate
iso
amyl phenyl acetate
FL/FR
iso
butyl phenyl acetate
FL/FR
chocolate pyrazine A
FL/FR
cocoa hexenal
FL/FR
cocoa oleoresin
FL/FR
cocoa pentenal
FL/FR
2,5-
dimethyl pyrazine
FL/FR
2,6-
dimethyl pyrazine
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
2-
methoxypyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
cocoa
2-iso
butyl-3,5-(and 3,6)-dimethyl pyrazine
FL/FR
2-
methyl butyraldehyde
FL/FR
coconut
alpha-
angelica lactone
FL/FR
coconut decanone methyl
FR
coconut naphthalenone
FL/FR
delta-
decalactone
FL/FR
delta-2-
dodecenolactone
FL/FR
delta-
heptalactone
FL/FR
gamma-
heptalactone
FL/FR
delta-
nonalactone
FL/FR
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
gamma-
octalactone
FL/FR
delta-
octalactone
FL/FR
propyl octanoate
FL/FR
tetrahydrojasmone
FR
delta-
undecalactone
FL/FR
wine lactone
FL/FR
corn chip
popcorn pyrimidine
FL/FR
coumarinic
coumane
FL/FR
phthalide
FL/FR
tonka bean resinoid
FR
creamy
creamy lactone
FL/FR
earthy
2-
ethyl-3-methoxypyrazine
FL/FR
nutty pyrazine
FL/FR
ethereal
iso
propyl formate
FL/FR
fatty
coconut absolute
FL/FR
lauric acid
FL/FR
fermented
3-
methyl-1-pentanol
FL/FR
valeraldehyde
FL/FR
floral
alpha-
amyl cinnamyl acetate
FL/FR
amyl salicylate
FL/FR
boronia butenal
FR
para-
cresyl laurate
FL/FR
dihydrojasmone lactone
FL/FR
ethyl phenyl acetate
FL/FR
heliotropin
FL/FR
hexenyl cyclopentanone
FR
jasmin lactone (IFF)
FL/FR
2-
pentyl cyclopentanone
FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
fruity
allyl 2-ethyl butyrate
FL/FR
amyl heptanoate
FL/FR
iso
amyl nonanoate
FL/FR
iso
amyl octanoate
FL/FR
butyl 2-methyl butyrate
FL/FR
gamma-
decalactone
FL/FR
4-
hydroxybenzyl alcohol
FL/FR
methyl (Z)-5-octenoate
FL/FR
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
nonyl isovalerate
FL/FR
iso
propyl octanoate
FL/FR
tropical thiazole
FL/FR
green
alpha-
decalactone
FL/FR
2-
heptyl furan
FL/FR
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
phenyl acetaldehyde
FL/FR
herbal
saffron pyranone
FR
gamma-
valerolactone
FL/FR
honey
butyl phenyl acetate
FL/FR
phenyl acetic acid
FL/FR
medicinal
meta-
dimethyl hydroquinone
FL/FR
milky
laevo-
glutamine
CS
musty
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
cocoa butenal
FL/FR
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
naphthyl
para-
methyl anisole
FL/FR
ortho-
methyl anisole
FL/FR
nutty
3-
acetyl pyridine
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2-
ethyl pyrazine
FL/FR
2-
ethyl-4-methyl thiazole
FL/FR
filbert heptenone
FL/FR
filbert pyrazine
FL/FR
2,6-
lutidine
FL/FR
maraniol
CS
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2-
methyl-3-pentenoic acid
FL/FR
2-
methyl-3-propyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty quinoxaline
FL/FR
shoyu pyrazine
FL/FR
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
acetyl pyrazine
FL/FR
2-
acetyl thiazole
FL/FR
roasted
fenugreek resinoid
FL/FR
soapy
ethyl undecanoate
FL/FR
spicy
3-(2-
furyl) acrolein
FL/FR
mace absolute
FL/FR
mace oil
FL/FR
mace oleoresin
FL/FR
methyl heptadienone
FL/FR
nutmeg oil
FL/FR
nutmeg oil CO2 extract
FL/FR
nutmeg oil terpeneless
FL/FR
nutmeg oleoresin
FL/FR
sulfurous
furfuryl thioacetate
FL/FR
terpenic
cassis bud oil
FL/FR
tobacco
veltonal (Bedoukian)
FR
tonka
6-
amyl-alpha-pyrone
FL/FR
gamma-
hexalactone
FL/FR
7-
methyl coumarin
CS
mint lactone
FL/FR
tonka bean absolute
FR
whiskey lactone
FL/FR
tropical
delta-
dodecalactone
FL/FR
glyceryl 5-hydroxydecanoate
FL/FR
glyceryl 5-hydroxydodecanoate
FL/FR
vanilla
ethyl vanillin isobutyrate
FL/FR
vanillin
FL/FR
vanillyl isobutyrate
FL/FR
waxy
butyl laurate
FL/FR
1-
dodecanol
FL/FR
methyl laurate
FL/FR
myristyl alcohol
FL/FR
phenethyl octanoate
FL/FR
2-
tridecanone
FL/FR
undecanoic acid
FL/FR
woody
cedrenyl acetate
FR
2-
methoxy-4-vinyl phenol
FL/FR
sandalwood oil
FL/FR
For Flavor
No flavor group found for these
acetyl acetaldehyde dimethyl acetal
FL
amyl phenyl acetate
FL/FR
bornyl isobutyrate
FL/FR
butyl cinnamate
FL/FR
2-iso
butyl-3,5-(and 3,6)-dimethyl pyrazine
FL/FR
2(4)-iso
butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine
FL
butyramide
FL
butyrophenone
FL/FR
chocolate pyrazine A
FL/FR
coconut naphthalenone
FL/FR
coumane
FL/FR
cyclohexyl methyl pyrazine
FL
alpha-
decalactone
FL/FR
2,5-
diethyl thiazole
FL
2,5-
diethyl-4-methyl thiazole
FL
6,7-
dihydro-2,3-dimethyl-5H-cyclopentapyrazine
FL
dimethyl benzofuranone
FL
dimethyl dihydrocyclopentapyrazine
FL
2,5-
dimethyl thiazole
FL
4,5-
dimethyl-2-ethyl thiazole
FL
delta-2-
dodecenolactone
FL/FR
ethyl 2-hydroxy-2-methyl butyrate
FL/FR
2-
ethyl-3-methoxypyrazine
FL/FR
(Z+E)-5-
ethyl-4-methyl-2-(2-butyl) thiazoline
FL
(Z+E)-5-
ethyl-4-methyl-2-(2-methyl propyl) thiazoline
FL
3-(2-
furyl) acrolein
FL/FR
(E,E)-2,4-
heptadien-1-ol
FL
2-
hexyl-5 or 6-keto-1,4-dioxane
FL
jasmin lactone (IFF)
FL/FR
lauric acid
FL/FR
2-
methoxypyrazine
FL/FR
methyl 2-(methyl thio) acetate
FL
2-
methyl-3-(methyl thio) pyrazine
FL/FR
2-
methyl-3-ethoxypyrazine
FL/FR
2-
methyl-3-pentenoic acid
FL/FR
myristyl alcohol
FL/FR
nonyl isovalerate
FL/FR
peanut dithiazine
FL
prenyl benzoate
FL/FR
propyl octanoate
FL/FR
2-
propyl pyridine
FL
para-
salicylic acid
FL
sulfuryl butyrate
FL/FR
sulfuryl decanoate
FL/FR
sulfuryl hexanoate
FL/FR
sulfuryl isobutyrate
FL/FR
(R)-
tonka furanone
FL
valeraldehyde propylene glycol acetal
FL/FR
wine lactone
FL/FR
5-
acetyl-2,3-dihydro-1,4-thiazine
FL
sulfuryl formate
FL
sulfuryl octanoate
FL/FR
sulfuryl propionate
FL/FR
valeraldehyde dibutyl acetal
FL/FR
alliaceous
alliaceous
dicyclohexyl disulfide
FL
2-
methyl thioacetaldehyde
FL
tropical thiazole
FL/FR
aromatic
amyl salicylate
FL/FR
balsamic
amyl cinnamate
FL/FR
bitter
methyl ethoxypyrazine
FL
bready
2-
propionyl thiazole
FL
brown
fenugreek oleoresin
FL/FR
burnt
2-
methyl quinoxaline
FL
buttery
butyroin
FL
3,4-
hexane dione
FL/FR
camphoreous
ortho-
methyl anisole
FL/FR
caramellic
fenugreek resinoid
FL/FR
cheesy
2-
heptanone
FL/FR
chemical
meta-
dimethyl hydroquinone
FL/FR
cherry
heliotropin
FL/FR
chocolate
cocoa oleoresin
FL/FR
cocoa propanal
FL
cocoa
iso
butyl phenyl acetate
FL/FR
butyraldehyde
FL
cocoa hexenal
FL/FR
2-
methyl furan
FL
coconut
delta-
decalactone
FL/FR
(R)-
massoia lactone
FL
6-
methyl coumarin
FL
gamma-
nonalactone (aldehyde C-18 (so-called))
FL/FR
delta-
octalactone
FL/FR
coffee
difurfuryl ether
FL
2-
ethyl-4-methyl thiazole
FL/FR
2-iso
propyl pyrazine
FL
corn chip
2-
acetyl thiazole
FL/FR
2-
acetyl-2-thiazoline
FL
popcorn pyrimidine
FL/FR
coumarinic
phthalide
FL/FR
creamy
6-
amyl-alpha-pyrone
FL/FR
alpha-
angelica lactone
FL/FR
creamy lactone
FL/FR
5,5-
dibutyl dihydrofuran-2(3H)-one
FL
delta-
dodecalactone
FL/FR
glyceryl 5-hydroxydecanoate
FL/FR
glyceryl 5-hydroxydodecanoate
FL/FR
gamma-
hexalactone
FL/FR
mint lactone
FL/FR
delta-
nonalactone
FL/FR
delta-
undecalactone
FL/FR
dairy
methyl (Z)-5-octenoate
FL/FR
earthy
alpha-
amyl cinnamyl acetate
FL/FR
2-
methyl-3-propyl pyrazine
FL/FR
ethereal
allyl 2-ethyl butyrate
FL/FR
fatty
coconut absolute
FL/FR
(E,E)-2,4-
decadienal
FL
2-
heptyl furan
FL/FR
(E,E)-2,4-
nonadienal
FL
2-
tridecanone
FL/FR
fishy
4,5-
dimethyl thiazole
FL
floral
iso
amyl cinnamate
FL/FR
iso
amyl phenyl acetate
FL/FR
cocoa pentenal
FL/FR
phenyl acetic acid
FL/FR
fruity
amyl heptanoate
FL/FR
iso
amyl octanoate
FL/FR
butyl 2-methyl butyrate
FL/FR
cassis bud oil
FL/FR
gamma-
decalactone
FL/FR
2,4-
hexadien-1-ol
FL
4-
hydroxybenzyl alcohol
FL/FR
methyl valerate
FL/FR
3-
methyl-2-butenal
FL/FR
phenethyl octanoate
FL/FR
2-
phenyl propionaldehyde dimethyl acetal
FL/FR
propyl benzoate
FL/FR
iso
propyl formate
FL/FR
iso
propyl octanoate
FL/FR
terpinyl cinnamate
FL/FR
fusel
2-
methyl butyraldehyde
FL/FR
green
cocoa butenal
FL/FR
dihydroxyacetophenone (mixed isomers)
FL
2,5-
dimethyl thiophene
FL
2-
ethyl butyraldehyde
FL
methyl heptadienone
FL/FR
4-
methyl thiazole
FL
2-
methyl-5-isopropyl pyrazine
FL
(E,Z)-2,6-
nonadien-1-yl acetate
FL/FR
2-
vinyl pyrazine
FL
herbal
massoia bark oil
FL
honey
butyl phenyl acetate
FL/FR
ethyl phenyl acetate
FL/FR
phenyl acetaldehyde
FL/FR
lactonic
delta-
heptalactone
FL/FR
gamma-
heptalactone
FL/FR
gamma-
octalactone
FL/FR
meaty
2,6-
dimethyl pyrazine
FL/FR
musty
2,5-
dimethyl pyrazine
FL/FR
2-
ethoxythiazole
FL
hazelnut pyrazine
FL/FR
menthofuran
FL/FR
shoyu pyrazine
FL/FR
2,3,5-
trimethyl pyrazine
FL/FR
naphthyl
para-
methyl anisole
FL/FR
nutty
2-
acetyl furan
FL/FR
3-
acetyl pyridine
FL/FR
2-
acetyl pyrrole
FL/FR
3-
acetyl-2,5-dimethyl furan
FL/FR
2-
acetyl-3-ethyl pyrazine
FL/FR
2-
acetyl-3-methyl pyrazine
FL/FR
2-
acetyl-3,5-dimethyl pyrazine
FL/FR
2-
acetyl-3,5(or 6)-dimethyl pyrazine
FL/FR
2-
acetyl-5-methyl furan
FL/FR
3,5-
cocoa pyrazine
FL/FR
3,6-
cocoa pyrazine
FL/FR
coffee furanone
FL/FR
3,5-
diethyl-2-methyl pyrazine
FL
2,5-
diethyl-3-methyl pyrazine
FL
2,3-
dimethyl pyrazine
FL/FR
4,5-
dimethyl-2-ethyl-3-thiazoline
FL/FR
2,4-
dimethyl-5-vinyl thiazole
FL
2-
ethyl pyrazine
FL/FR
1-
ethyl-2-acetyl pyrrole
FL
filbert heptenone
FL/FR
filbert pyrazine
FL/FR
european
hazelnut oleoresin
FL
2,6-
lutidine
FL/FR
2-
methoxy-3-methyl pyrazine
FL/FR
2-
methyl pyrazine
FL/FR
5-
methyl quinoxaline
FL/FR
2-
methyl thio-3,5 or 6-methyl pyrazine
FL/FR
nutty cyclohexenone
FL/FR
nutty pyrazine
FL/FR
nutty quinoxaline
FL/FR
nutty thiazole
FL
peanut oxazole
FL
2,3,5,6-
tetramethyl pyrazine
FL/FR
2,4,5-
trimethyl thiazole
FL/FR
vinyl sulfurol
FL/FR
popcorn
2-
propionyl-2-thiazoline
FL
roasted
2-
acetyl pyrazine
FL/FR
furfuryl thioacetate
FL/FR
smoky
2-
methoxy-4-vinyl phenol
FL/FR
soapy
1-
dodecanol
FL/FR
spicy
mace absolute
FL/FR
mace oil
FL/FR
mace oleoresin
FL/FR
nutmeg oil
FL/FR
nutmeg oil CO2 extract
FL/FR
nutmeg oil terpeneless
FL/FR
nutmeg oleoresin
FL/FR
toasted
acetyl propionyl
FL/FR
tonka
gamma-
valerolactone
FL/FR
vanilla
ethyl vanillin isobutyrate
FL/FR
vanillin
FL/FR
vanillyl isobutyrate
FL/FR
waxy
butyl laurate
FL/FR
para-
cresyl laurate
FL/FR
dihydrojasmone lactone
FL/FR
ethyl undecanoate
FL/FR
methyl laurate
FL/FR
undecanoic acid
FL/FR
whiskey
3-
methyl-1-pentanol
FL/FR
winey
iso
amyl nonanoate
FL/FR
5-
ethyl-2-methyl pyridine
FL
valeraldehyde
FL/FR
woody
sandalwood oil
FL/FR
whiskey lactone
FL/FR
 
Potential Uses:
FLalmond toasted almond
FRearth
FLhazelnut
FLnut
FLpineapple
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
6-ethoxy-2-methyl pyrazine
2-ethoxy-6-methyl pyrazine
2-ethoxy-6-methylpyrazine
 pyrazine, 2-ethoxy-6-methyl-
 pyrazine, 6-ethoxy-2-methyl
 
 
Notes:
Flavouring ingredient with roast taste and pineapple odour. Component of FEMA 3569, together with its regioisomers
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