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EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

butyroin
5-hydroxy-4-octanone

Supplier Sponsors

BOC Sciences

Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
Email:	Marketing
US Email:	Marketing
Email:	Sales
US Email:	Sales
Voice: 1-631-485-4226
Fax: 1-631-614-7828
US Voice: 1-631-485-4226
US Fax: 1-631-614-7828
Europe	44-203-286-1088
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Product(s):
496-77-5 5-Hydroxy-4-octanone

Penta International Corporation

Chemistry innovation
At Penta, our products and services help businesses do business better.
For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
US Email:	Technical Services
US Email:	Sales
US Voice: (973) 740-2300
US Fax: (973) 740-1839
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Product(s):
08-67000 5-HYDROXY-4-OCTANONE

Soda Aromatic Co., Ltd.

Depth of Experience
We guarantees product safety and quality.
Our international sales department is happy to design the most suitable flavor & fragrance for specific uses of processed food, cosmetics, and fragrance manufactures all over the world, specializing in Asia.Let us help you with your flavor & fragrance needs.
Email:	Info
Email:	Sales
Voice: +81-3-5645-7347
Fax: +81-3-3664-5204
Fragrance Creation
Flavor Creation
Ingredient Development
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Product(s):
110224015 Butyroin

TCI AMERICA

Moving Your Chemistry Forward
We continuously strive to advance our technology.
With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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Voice: 1-800-423-8616
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GSC102778104023 GSC102778104023
Product(s):
B0971 Butyroin >96.0%(GC)
SDS

Name:	5-hydroxyoctan-4-one
CAS Number:	496-77-5	3D/inchi
ECHA EINECS - REACH Pre-Reg:	207-830-4
FDA UNII:	WG070EDJ4X
Nikkaji Web:	J6.098D
MDL:	MFCD00021928
CoE Number:	2045
XlogP3-AA:	1.40 (est)
Molecular Weight:	144.21392000
Formula:	C8 H16 O2
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
JECFA evaluated 5-hydroxy-4-octanone (CASrn as in Register). CASrn in Register refers to the racemate.

Category: flavoring agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
JECFA Food Flavoring:	416 5-hydroxy-4-octanone
DG SANTE Food Flavourings:	07.065 5-hydroxyoctan-4-one
FEMA Number:	2587 5-hydroxy-4-octanone
FDA:	No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):	496-77-5 ; 5-HYDROXY-4-OCTANONE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants.

Physical Properties:

Appearance:	yellow clear liquid (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Specific Gravity:	0.92000 to 0.92300 @ 20.00 °C.
Pounds per Gallon - (est).:	7.664 to 7.689
Specific Gravity:	0.90700 to 0.92300 @ 20.00 °C.
Pounds per Gallon - est.:	7.556 to 7.689
Refractive Index:	1.43100 to 1.43300 @ 20.00 °C.
Refractive Index:	1.42600 to 1.43200 @ 20.00 °C.
Boiling Point:	80.00 to 82.00 °C. @ 10.00 mm Hg
Boiling Point:	182.00 °C. @ 760.00 mm Hg
Vapor Pressure:	0.172000 mmHg @ 25.00 °C. (est)
Flash Point:	175.00 °F. TCC ( 79.44 °C. )
logP (o/w):	1.739 (est)
Soluble in:
	alcohol
	water, very slightly
	water, 1.119e+004 mg/L @ 25 °C (est)
Insoluble in:
	water

Organoleptic Properties:

Odor Type: buttery

sweet pungent buttery nutty

Odor Description:at 1.00 % in dipropylene glycol. sweet pungent buttery nut

Flavor Type: buttery

buttery

Taste Description: buttery

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

5-Hydroxy-4-octanone

Frinton Laboratories

For experimental / research use only.

For experimental / research use only.

Butyroin >96.0%(GC)

sds

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
flavoring agents
Recommendation for butyroin usage levels up to:
	not for fragrance use.

Maximised Survey-derived Daily Intakes (MSDI-EU):		0.012 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
		average usual ppm	average maximum ppm
baked goods:		-	7.80000
beverages(nonalcoholic):		0.50000	5.00000
beverages(alcoholic):		-	-
breakfast cereal:		-	-
cheese:		-	-
chewing gum:		-	-
condiments / relishes:		-	-
confectionery froastings:		-	-
egg products:		-	-
fats / oils:		-	-
fish products:		-	-
frozen dairy:		1.00000	20.00000
fruit ices:		1.00000	20.00000
gelatins / puddings:		-	-
granulated sugar:		-	-
gravies:		-	-
hard candy:		-	10.00000
imitation dairy:		-	-
instant coffee / tea:		-	-
jams / jellies:		-	-
meat products:		-	-
milk products:		-	-
nut products:		-	-
other grains:		-	-
poultry:		-	-
processed fruits:		-	-
processed vegetables:		-	-
reconstituted vegetables:		-	-
seasonings / flavors:		-	-
snack foods:		-	-
soft candy:		-	-
soups:		-	-
sugar substitutes:		-	-
sweet sauces:		-	-

Safety References:

European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 11 (FGE.11): Aliphatic dialcohols, diketones, and hydroxyketones from chemical group 10 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 11, Revision 1 (FGE.11Rev1) - Aliphatic dialcohols, diketones, and hydroxyketones from chemical group 10 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :219794

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

5-hydroxyoctan-4-one

Chemidplus:0000496775

References:

	5-hydroxyoctan-4-one
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	496-77-5
Pubchem (cid):	219794
Pubchem (sid):	135296180

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
HMDB (The Human Metabolome Database):	Search
FooDB:	FDB008108
Export Tariff Code:	2914.40.9000
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View