EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cynara scolymus leaf extract
extract of the leaves of the artichoke, cynara scolymus l., compositae

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Name:cynara scolymus leaf extract
CAS Number: 84012-14-6
ECHA EC Number:281-659-3
Category:cosmetic agents, dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Flavor Type: green
green artichoke vegetable leafy earthy
Taste Description: green artichoke
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
AuNutra® Industries
Artichoke Leaf P.E.
Bio-Botanica®
Artichoke Leaf Cynara Scolymus (Artichoke) Leaf Extract
Changsha Organic Herb
Artichoke leaf extract
ECSA Chemicals
ARTICHOKE LEAF DRY EXTRACT >2% CYNARINE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ICHIMARU PHARCOS
Biobenefity
Odor: characteristic
Use: Artichoke Leaf Extract contains rich Cynaropycrine and inhibit NF-kB; which is relative to inhibition of skin aging.
Naturex
Artichoke Leaf Extract
NAT activ®
Silab
MENOFIT®
The youth ingredient dedicated to menopausal skin
Xi'an Greena Biotech
Artichoke Extract
Odor: characteristic
Use: Artichoke, Cynara cardunculus, one of the oldest medicinal plant used as a remedy,dating back to 4th century B.C.While it has traditionally been used to stimulate the kidneys,a digestive aid and increase bile production in the liver.Today,artichoke leaf Extract is commonly used to treat gastrointestinal disorders, and help regulate blood cholesterol levels. Artichoke extract is actually made from the leaves of the artichoke plant.The leaves contain active ingredients,including flavonoids,bitter substances and three essential groups consisting of caffeeolyquinic acid(CCS).
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 1000 mg/kg
Indian Journal of Experimental Biology. Vol. 9, Pg. 91, 1971.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents, dietary supplements
Recommendation for cynara scolymus leaf extract usage levels up to:
 not for fragrance use.
 
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-a-tocopheryl hydrogen succinate, riboflavin and inositol hexanicotinate in Limicol® and reduction of blood LDL-cholesterol concentrations pursuant to Article 14 of Regulation (EC) No 1924/2006
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Daily Med:search
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EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
cynara scolymus leaf extract
Chemidplus:0084012146
 
References:
 cynara scolymus leaf extract
Pubchem (sid):135312255
 
Other Information:
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
alliaceous
dibutyl sulfide
FL/FR
dipropyl disulfide
FL/FR
caramellic
2-iso
butyl-3-methyl pyrazine
FL/FR
chocolate
2,4,5-
trimethyl thiazole
FL/FR
citrus
methyl heptenone
FL/FR
(E)-2-
tetradecenal
FL/FR
coumarinic
phthalide
FL/FR
ethereal
2-
methyl valeraldehyde
FL/FR
floral
hexahydrofarnesyl acetone
FL/FR
(Z)-
rose oxide
FL/FR
fruity
butyl 2-decenoate
FL/FR
ethyl 2-ethyl acetoacetate
FL/FR
(E)-2-
nonen-1-yl acetate
FL/FR
green
acetaldehyde butyl phenethyl acetal
FL/FR
acetaldehyde dipropyl acetal
FL/FR
iso
butyl methyl ketone
FL/FR
2-iso
butyl thiazole
FL/FR
cortex pyridine
FL/FR
galbanum decatriene
FL/FR
geranium thiazole
FL/FR
green ether
FL/FR
(Z)-2-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl (E)-2-hexenoate
FL/FR
(Z)-3-
hexen-1-yl octanoate
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
(Z)-
leaf acetal
FL/FR
methyl heptine carbonate
FL/FR
nerol oxide
FL/FR
(Z,Z)-3,6-
nonadien-1-ol
FL/FR
1-
penten-3-ol
FL/FR
herbal
3-
butylidene phthalide
FL/FR
2-
pentyl acetate
FL/FR
musty
cocoa butenal
FL/FR
sulfurous
3-(
methyl thio) hexanol
FL/FR
woody
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
yeasty
2-
octen-4-one
FL/FR
For Flavor
alliaceous
allyl thiopropionate
FL
dipropyl disulfide
FL/FR
avocado
guacamole flavor
FL
celery
3-
butylidene phthalide
FL/FR
coumarinic
phthalide
FL/FR
dairy
2-
pentyl acetate
FL/FR
earthy
asparagus flavor
FL
fruity
butyl 2-decenoate
FL/FR
ethyl 2-ethyl acetoacetate
FL/FR
2,4-
hexadien-1-ol
FL
(Z)-3-
hexen-1-yl (E)-2-hexenoate
FL/FR
jackfruit flavor
FL
green
acetaldehyde butyl phenethyl acetal
FL/FR
acetaldehyde dipropyl acetal
FL/FR
artichoke flavor
FL
avocado flavor
FL
iso
butyl methyl ketone
FL/FR
2-iso
butyl thiazole
FL/FR
2-iso
butyl-3-methyl pyrazine
FL/FR
cactus flavor
FL
cocoa butenal
FL/FR
cortex pyridine
FL/FR
dibutyl sulfide
FL/FR
dihydroxyacetophenone (mixed isomers)
FL
alpha-
farnesene
FL/FR
alpha-
farnesene isomer
FL/FR
galbanum decatriene
FL/FR
geranium thiazole
FL/FR
green ether
FL/FR
hexahydrofarnesyl acetone
FL/FR
(Z)-2-
hexen-1-ol
FL/FR
(Z)-3-
hexen-1-yl octanoate
FL/FR
(Z)-3-
hexen-1-yl tiglate
FL/FR
2-
hexyl pyridine
FL
horseradish oil
FL
(Z)-
leaf acetal
FL/FR
methyl heptenone
FL/FR
methyl heptine carbonate
FL/FR
4-
methyl thiazole
FL
nerol oxide
FL/FR
4-
penten-1-yl acetate
FL
1-
penten-3-ol
FL/FR
(Z)-
rose oxide
FL/FR
squash flavor
FL
metallic
3-(
methyl thio) hexanol
FL/FR
nutty
2,4,5-
trimethyl thiazole
FL/FR
radish
horseradish flavor
FL
sulfurous
broccoli flavor
FL
vegetable
2-
methyl valeraldehyde
FL/FR
2-
octen-4-one
FL/FR
waxy
(Z,Z)-3,6-
nonadien-1-ol
FL/FR
(E)-2-
nonen-1-yl acetate
FL/FR
(E)-2-
tetradecenal
FL/FR
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cynara scolymus leaf
Search Trop Picture
 
Synonyms:
 artichoke leaf extract
 artichoke leaf extract, 5% cynarin
 artichoke leaf P.E.
 biobenefity
 extract of the leaves of the artichoke, cynara scolymus l., compositae
 menofit
 

Articles:

PubMed:Use of artichoke (Cynara scolymus) flower extract as a substitute for bovine rennet in the manufacture of Gouda-type cheese: characterization of aspartic proteases.
PubMed:Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells.
PubMed:Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat.
PubMed:Lanthanide-IMAC enrichment of carbohydrates and polyols.
PubMed:Cynara Scolymus Leaf Extract Stimulates Adipogenesis in 3T3-L1 Preadipocytes and Suppresses Hepatic Glucose Output in H4IIE Hepatocytes.
PubMed:Extensive characterisation of bioactive phenolic constituents from globe artichoke (Cynara scolymus L.) by HPLC-DAD-ESI-QTOF-MS.
PubMed:Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells.
PubMed:Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat.
PubMed:Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads.
PubMed:Artichoke leaf extract for treating hypercholesterolaemia.
PubMed:Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial.
PubMed:[Artichoke--untapped potential of herbal medicine in the treatment of atherosclerosis and liver diseases].
PubMed:[Development and validation of method for the determination of cynarin, luteolin in plasma].
PubMed:In vivo genotoxicity evaluation of an artichoke (Cynara scolymus L.) aqueous extract.
PubMed:Artichoke induces genetic toxicity in the cytokinesis-block micronucleus (CBMN) cytome assay.
PubMed:Separation and identification of phenolic compounds in canned artichoke by LC/DAD/ESI-MS using core-shell C18 column: a comparative study.
PubMed:Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B.
PubMed:Effect of zeolite nano-materials and artichoke (Cynara scolymus L.) leaf extract on increase in urinary clearance of systematically absorbed nicotine.
PubMed:Development of an automated method for Folin-Ciocalteu total phenolic assay in artichoke extracts.
PubMed:Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on operant self-administration of a chocolate-flavoured beverage in rats.
PubMed:Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells.
PubMed:Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
PubMed:Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats.
PubMed:Extracts of edible and medicinal plants in inhibition of growth, adherence, and cytotoxin production of Campylobacter jejuni and Campylobacter coli.
PubMed:Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters.
PubMed:Appetite Control and Glycaemia Reduction in Overweight Subjects treated with a Combination of Two Highly Standardized Extracts from Phaseolus vulgaris and Cynara scolymus.
PubMed:Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats.
PubMed:Antiproliferative, protective and antioxidant effects of artichoke, dandelion, turmeric and rosemary extracts and their formulation.
PubMed:Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells.
PubMed:[Phytotherapy with a mixture of dry extracts with hepato-protective effects containing artichoke leaves in the management of functional dyspepsia symptoms].
PubMed:Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
PubMed:Effects of artichoke leaf extract on acute gastric mucosal injury in rats.
PubMed:The effect of artichoke (Cynara scolymus L.) extract on respiratory chain system activity in rat liver mitochondria.
PubMed:Artichoke leaf extract for treating hypercholesterolaemia.
PubMed:Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet.
PubMed:Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet.
PubMed:Artichoke leave extract for chronic hepatitis C - a pilot study.
PubMed:The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells.
PubMed:Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress.
PubMed:The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers.
PubMed:Effect of two artichoke extracts (36_U and 36_EB) on rat ileum (with respect to bowel syndrome) and the peristaltic threshold.
PubMed:Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial.
PubMed:Effect of artichoke extract (Cynara scolymus L.) on palmitic-1-14C acid oxidation in rats.
PubMed:Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application.
PubMed:Effects of artichoke extract supplementation on gonads of cadmium-treated rats.
PubMed:Clinical uses of artichoke leaf extract.
PubMed:Research on biomodulatory effect of natural compounds.
PubMed:Tabletted microspheres containing Cynara scolymus (var. Spinoso sardo) extract for the preparation of controlled release nutraceutical matrices.
PubMed:Time-resolved spectral studies of blue-green fluorescence of artichoke (Cynara cardunculus L. Var. Scolymus) leaves: identification of chlorogenic acid as one of the major fluorophores and age-mediated changes.
PubMed:Choleretic effects of yarrow (Achillea millefolium s.l.) in the isolated perfused rat liver.
PubMed:Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans.
PubMed:Antifungal activity of Cynara scolymus L. extracts.
PubMed:Purification of cynarases from artichoke (Cynara scolymus L.): enzymatic properties of cynarase A.
PubMed:Purification and characterization of a milk-clotting aspartic proteinase from globe artichoke (Cynara scolymus L.).
PubMed:Experimental mycotoxicosis in chickens induced by ochratoxin A and penicillic acid and intervention with natural plant extracts.
PubMed:Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.
PubMed:Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis.
PubMed:Flavonoids from artichoke (Cynara scolymus L.) up-regulate endothelial-type nitric-oxide synthase gene expression in human endothelial cells.
PubMed:Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial.
PubMed:Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial.
PubMed:Validated method for the determination of six metabolites derived from artichoke leaf extract in human plasma by high-performance liquid chromatography-coulometric-array detection.
PubMed:Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.
PubMed:Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus).
PubMed:Efficacy of different Cynara scolymus preparations on liver complaints.
PubMed:Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats.
PubMed:Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action.
PubMed:Protective properties of artichoke (Cynara scolymus) against oxidative stress induced in cultured endothelial cells and monocytes.
PubMed:Artichoke (Cynara scolymus L.) byproducts as a potential source of health-promoting antioxidant phenolics.
PubMed:Electrospray characterization of selected medicinal plant extracts.
PubMed:Artichoke leaf extract - Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts.
PubMed:[Action of an extract of artichoke (Cynara scolymus) on cholesterolesterase in vitro].
 
Notes:
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