(Z)-ambrettolide
(Z)-omega-6-hexadecenlactone

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  CODE139974 CODE139974
  Product(s):
  123-69-3 Musk Ambrette

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  CODE139974 CODE139974
  Product(s):
  3XA00034 Ambrettolide
  5XU07617 Ambrettolide 10% in DPG

Name: (7Z)-17-oxacycloheptadec-7-en-1-one CAS Number: 123-69-3 3D/inchi Other(deleted CASRN): 17598-28-6 ECHA EINECS - REACH Pre-Reg: 204-644-5 FDA UNII: 095I377U8F Nikkaji Web: J10.068D XlogP3-AA: 5.50 (est) Molecular Weight: 252.39756000 Formula: C16 H28 O2 NMR Predictor: Predict (works with chrome, Edge or firefox) EFSA/JECFA Comments: CASrn in Register refers to the Z-isomer. Stereoisomeric composition to be specified. Category:flavor and fragrance agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Perfumer and Flavorist: Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search DG SANTE Food Flavourings: 10.059 hexadec-7-en-16-olide   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Specific Gravity: 0.95500 to 0.96100 @ 25.00 °C. Pounds per Gallon - (est).: 7.947 to 7.996 Refractive Index: 1.48200 to 1.48800 @ 20.00 °C. Boiling Point: 398.00 to 399.00 °C. @ 760.00 mm Hg Flash Point: 334.00 °F. TCC ( 167.78 °C. ) logP (o/w): 5.516 (est) Soluble in:   alcohol   water, 0.5925 mg/L @ 25 °C (est) Insoluble in:   water Similar Items:note ambrettolide isoambrettolide 12-norambrienolide   Organoleptic Properties: Odor Type: musk musty animal musk ambrette Odor Description:at 100.00 %. musty animal musk ambrette Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: perfuming agents   Suppliers: BOC Sciences For experimental / research use only. Musk Ambrette PerfumersWorld Ambrettolide 10% in DPG PerfumersWorld Ambrettolide Odor: natural-musk ambrette-seed floral-musk sweet Perfumery Laboratory AMBRETHTOLID IFF 20% DPG (AMBRETTOLIDE IFF 20% DPG) Odor: The aroma of an ambrette, natural, floral, sweet   Safety Information:   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-mouse LDLo 1600 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985. oral-rat LD50 339 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1513, 1980. Dermal Toxicity: skin-rabbit LD50 > 5000 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985. skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 13, Pg. 707, 1975. Inhalation Toxicity: Not determined   Safety in Use Information: Category: flavor and fragrance agents RIFM Fragrance Material Safety Assessment: Search IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice   Maximised Survey-derived Daily Intakes (MSDI-EU): 1.90 (μg/capita/day) Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day) Threshold of Concern: 1800 (μg/person/day) Structure Class: I   Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.   average usage mg/kg maximum usage mg/kg Dairy products, excluding products of category 02.0 (01.0): 7.00000 35.00000 Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.00000 25.00000 Edible ices, including sherbet and sorbet (03.0): 10.00000 50.00000 Processed fruit (04.1): 7.00000 35.00000 Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): - - Confectionery (05.0): 10.00000 50.00000 Chewing gum (05.3): - - Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.00000 25.00000 Bakery wares (07.0): 10.00000 50.00000 Meat and meat products, including poultry and game (08.0): 2.00000 10.00000 Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.00000 10.00000 Eggs and egg products (10.0): - - Sweeteners, including honey (11.0): - - Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.00000 25.00000 Foodstuffs intended for particular nutritional uses (13.0): 10.00000 50.00000 Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.00000 25.00000 Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.00000 50.00000 Ready-to-eat savouries (15.0): 20.00000 100.00000 Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.00000 25.00000   Safety References: European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... European Food Safety Authority (EFSA) reference(s): Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 View page or View pdf EPI System: View AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):123-69-3 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :5365703 National Institute of Allergy and Infectious Diseases:Data WGK Germany:2 (7Z)-17-oxacycloheptadec-7-en-1-one Chemidplus:0000123693   References:   (7Z)-17-oxacycloheptadec-7-en-1-one NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 123-69-3 Pubchem (cid): 5365703 Pubchem (sid): 134974739   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements HMDB (The Human Metabolome Database): HMDB31086 FooDB: FDB003091 Typical G.C. ChemSpider: View   Potential Blenders and core components note For Odor No odor group found for these methyl carbitol CS acidic acidic cyclohexyl acetic acid FL/FR alcoholic propyl alcohol FL/FR amber amber furan FR ambergris naphthol FR alpha- ambrinol FL/FR ambrinol FR angelica root oil FL/FR angelica seed oil CO2 extract FL/FR cistus ladaniferus absolute resin FL/FR cistus ladaniferus resin FR labdanum absolute FL/FR animal animal carbolactone FR animal specialty FR iso butyl quinoline FR iso butyl quinoline FR civet absolute FL/FR costus valerolactone FR para- cresyl caprylate FL/FR para- cresyl isobutyrate FL/FR para- cresyl phenyl acetate FL/FR indolall FR indole FL/FR indoletal FR para- methyl tetrahydroquinoline FL/FR musk indenofuran FR piperidine FL/FR procavia capensis excrete absolute FR skatole FL/FR 1-oxa spiro-4,7-dodecane FR balsamic iso amyl cinnamate FL/FR amyl phenyl acetate FL/FR iso bornyl formate FL/FR iso butyl benzoate FL/FR guaiyl butyrate FR myrrh absolute FL/FR opoponax oil (balsamodendron kafal) FL/FR opoponax resinoid (balsamodendron kafal) FR propyl cinnamate FL/FR chocolate iso amyl phenyl acetate FL/FR 2,4,5- trimethyl thiazole FL/FR citrus methyl heptenone FL/FR cocoa 2-iso butyl-3,5-(and 3,6)-dimethyl pyrazine FL/FR 2- methyl butyraldehyde FL/FR coffee 1- hydroxy-2-butanone FL/FR earthy 2- ethyl fenchol FL/FR geosmin FL/FR muscogene FR 1- octen-3-one FL/FR ethereal propyl valerate FL/FR fatty hexyl pivalate FR delta- juniper lactone FL/FR 4- methyl octanoic acid FL/FR floral citronellol FL/FR para- cresyl acetate FL/FR cyclamen aldehyde FL/FR dimethyl anthranilate FL/FR dimethyl octanol FL/FR linalool oxide (furanoid) FL/FR 2- methyl-4-phenyl butanal FL/FR phenethyl butyrate FL/FR (E)-2,5,9- trimethyl-4,9-decadien-1-al FR fruity cyclohexyl acetate FL/FR 2- ethyl butyl acetate FL/FR hexyl propionate FL/FR linalyl hexanoate FL/FR tetrahydrofurfuryl butyrate FL/FR fungal hydroxymethyl hexyl ethyl ketone FL/FR green 2-sec- butyl-3-methoxypyrazine FL/FR 1- heptanol FL/FR hexanal dimethyl acetal FL/FR (Z)-4- hexen-1-ol FL/FR styralyl acetate FL/FR valerian rhizome oil CO2 extract china FL/FR herbal petitgrain heptane FR valerian rhizome oil FL/FR honey phenethyl furoate FL/FR leathery castoreum absolute FL/FR marine marine pyridine FR minty ethyl benzoate FL/FR mossy oakmoss absolute FL/FR musk iso ambrettolide FL/FR (3alpha,5alpha)- androst-16-en-3-ol FR (Z)- civet decenone FL/FR ethylene brassylate FL/FR ethylene dodecanoate FR exaltone (Firmenich) FR juniper lactone FL/FR (E)-3- methyl-5-cyclotetradecen-1-one FR delta- muscenone FR dextro,laevo- muscone FL/FR musk ambrette CS musk ambrette replacer FR musk cyclopentenyl propionate FR musk dimethyl indane FL/FR musk lactone FR musk nonane FR (Z)- musk pentane FR musk propanoate FR omega- pentadecalactone FL/FR musty 2- acetyl pyrrole FL/FR 3- acetyl-2,5-dimethyl furan FL/FR cocoa butenal FL/FR 3- ethyl phenol FL/FR hazelnut pyrazine FL/FR menthofuran FL/FR ketoiso phorone FL/FR tetrahydrogeranyl acetone FL/FR nutty 4,5- dimethyl-2-ethyl-3-thiazoline FL/FR 2- ethyl pyrazine FL/FR filbert pyrazine FL/FR 2- methyl thio-3,5 or 6-methyl pyrazine FL/FR nutty quinoxaline FL/FR 2,3,5,6- tetramethyl pyrazine FL/FR 2,3,5- trimethyl pyrazine FL/FR vinyl sulfurol FL/FR phenolic 2,3- xylenol FL/FR spicy 4- carvomenthenol FL/FR cassia bark oleoresin FL/FR ginger oleoresin FL/FR (E,E)- piperine FL/FR sulfurous cassis pentanone FL/FR tobacco para- cresyl isovalerate FL/FR vanilla ortho- dimethyl hydroquinone FL/FR waxy octyl 2-methyl butyrate FL/FR woody cedarwood oil china FR para- menth-3-en-1-ol FL/FR spikenard oil FL/FR For Flavor No flavor group found for these acetyl acetaldehyde dimethyl acetal FL amyl phenyl acetate FL/FR 2-iso butyl-3,5-(and 3,6)-dimethyl pyrazine FL/FR cyclohexyl methyl pyrazine FL 2,5- diethyl thiazole FL 2,6- dimethoxy-4-vinyl phenol FL ortho- dimethyl hydroquinone FL/FR furfuryl hexanoate FL geosmin FL/FR hexanal dimethyl acetal FL/FR hexyl propionate FL/FR hydroxymethyl hexyl ethyl ketone FL/FR linalool oxide (furanoid) FL/FR linalyl hexanoate FL/FR para- menth-3-en-1-ol FL/FR methyl 2-hydroxy-4-methyl valerate FL 4- methyl cyclohexanone FL para- methyl tetrahydroquinoline FL/FR tris( methyl thio) methane FL 2- methyl-4-phenyl butanal FL/FR 2- pentyl-1-buten-3-one FL phenethyl furoate FL/FR piperidine FL/FR propyl valerate FL/FR skatole FL/FR spikenard oil FL/FR alcoholic alcoholic propyl alcohol FL/FR amber alpha- ambrinol FL/FR cistus ladaniferus absolute resin FL/FR labdanum absolute FL/FR animal civet absolute FL/FR para- cresyl caprylate FL/FR indole FL/FR aromatic para- cresyl acetate FL/FR para- cresyl isobutyrate FL/FR balsamic myrrh absolute FL/FR opoponax oil (balsamodendron kafal) FL/FR brown 1- hydroxy-2-butanone FL/FR burnt furfuryl alcohol FL citrus ketoiso phorone FL/FR tetrahydrogeranyl acetone FL/FR cooling 4- carvomenthenol FL/FR earthy 2- ethyl fenchol FL/FR 1- octen-3-one FL/FR fatty dimethyl octanol FL/FR delta- juniper lactone FL/FR 4- methyl octanoic acid FL/FR (E)-2- octenoic acid FL floral iso amyl cinnamate FL/FR iso amyl phenyl acetate FL/FR citronellol FL/FR fruity iso butyl benzoate FL/FR dimethyl anthranilate FL/FR 2- ethyl butyl acetate FL/FR 2,4- hexadien-1-ol FL phenethyl butyrate FL/FR propyl cinnamate FL/FR styralyl acetate FL/FR tetrahydrofurfuryl butyrate FL/FR valerian rhizome oil FL/FR valerian rhizome oil CO2 extract china FL/FR fusel 2- methyl butyraldehyde FL/FR green angelica root oil FL/FR cassis pentanone FL/FR cocoa butenal FL/FR cyclamen aldehyde FL/FR (Z)-4- hexen-1-ol FL/FR methyl heptenone FL/FR oakmoss absolute FL/FR herbal angelica seed oil CO2 extract FL/FR 5- hydroxymethyl furfural FL leathery castoreum absolute FL/FR medicinal ethyl benzoate FL/FR musk iso ambrettolide FL/FR (Z)- civet decenone FL/FR ethylene brassylate FL/FR juniper lactone FL/FR dextro,laevo- muscone FL/FR musk dimethyl indane FL/FR musty 2- ethoxythiazole FL hazelnut pyrazine FL/FR menthofuran FL/FR 2,3,5- trimethyl pyrazine FL/FR nutty 2- acetyl pyrrole FL/FR 3- acetyl-2,5-dimethyl furan FL/FR 4,5- dimethyl-2-ethyl-3-thiazoline FL/FR 2- ethyl pyrazine FL/FR filbert pyrazine FL/FR 2- methyl thio-3,5 or 6-methyl pyrazine FL/FR nutty quinoxaline FL/FR peanut oxazole FL 2,3,5,6- tetramethyl pyrazine FL/FR 2,4,5- trimethyl thiazole FL/FR vinyl sulfurol FL/FR phenolic para- cresyl isovalerate FL/FR para- cresyl phenyl acetate FL/FR 3- ethyl phenol FL/FR 2,3- xylenol FL/FR roasted ethyl 3-(furfuryl thio) propionate FL solvent cyclohexyl acetate FL/FR 1- heptanol FL/FR sour 3- methyl valeric acid FL spicy cassia bark oleoresin FL/FR ginger oleoresin FL/FR (E,E)- piperine FL/FR sulfurous methyl 2-(methyl thio) butyrate FL methyl thiomethyl butyrate FL sweet cyclohexyl acetic acid FL/FR vanilla omega- pentadecalactone FL/FR vegetable 2-sec- butyl-3-methoxypyrazine FL/FR waxy octyl 2-methyl butyrate FL/FR woody iso bornyl formate FL/FR   Potential Uses: FR amber FR ambergris FR ambreine FR ambrette oil replacer FL/FR angelica FR animal FR castoreum FL/FR cistus FR civet FR costus   fecal   fur   hair FR heather FR labdanum FR leather FR leather russian leather FR mastic oil replacer FR musk FR myrrh FR opoponax FR spikenard oil replacer FL/FR valerian FR vetiver   Occurrence (nature, food, other):note   not found in nature   abelmoschus moschatus seed oil @ 7.80% Data GC Search Trop Picture   Synonyms: (Z)- ambrettolide   ambrettolide LG (7Z)-17-oxa cycloheptadec-7-en-1-one (8Z)-oxa cycloheptadec-8-en-2-one (Z)-oxa cycloheptadec-8-en-2-one   hexadec-7-en-16-olide (Z)-omega-6- hexadecenlactone (Z)-16- hydroxy-7-hexadecenoic acid lactone   Articles:   None found yet. Try the PubMed Search.

Notes: pure essence from secretion of preputial follicles of moschus moschiferus l.. Once used in fruit flavouring; its use has been discontinued due to its toxic nature