EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hexyl myristate
tetradecanoic acid, hexyl ester

Supplier Sponsors

CAS Number: 42231-99-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:255-722-0
Nikkaji Web:J278.361D
XlogP3-AA:8.70 (est)
Molecular Weight:312.53720000
Formula:C20 H40 O2
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
FLAVIS Number:09.582 (Old)
DG SANTE Food Flavourings:09.582 hexyl tetradecanoate
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 359.00 to 362.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000019 mmHg @ 25.00 °C. (est)
Flash Point: 349.00 °F. TCC ( 176.11 °C. )
logP (o/w): 8.937 (est)
Soluble in:
 alcohol
 water, 0.0003691 mg/L @ 25 °C (est)
Insoluble in:
 water
Similar Items:note
isoamyl myristate
butyl myristate
isobutyl myristate
ethyl myristate
2-methyl butyl myristate
methyl myristate
isopropyl myristate
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Tetradecanoic acid,hexyl ester
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the Chemical Sources Association
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
Recommendation for hexyl myristate usage levels up to:
  25.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.61 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
 
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 2, Revision 1 (FGE.02) : Branched- and straight-chain aliphatic saturated primary alcohols and related esters of primary alcohols and straight-chain carboxylic acids and one straight-chain aldehyde from chemical groups 1 and 2 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

EPI System: View
EPA Substance Registry Services (TSCA):42231-99-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :170623
National Institute of Allergy and Infectious Diseases:Data
hexyl tetradecanoate
Chemidplus:0042231992
 
References:
 hexyl tetradecanoate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):170623
Pubchem (sid):135125880
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 hexyl tetradecanoate
 tetradecanoic acid hexyl ester
 tetradecanoic acid, hexyl ester
 

Articles:

PubMed:Bioassay-guided chemical study of the anti-inflammatory effect of Senna villosa (Miller) H.S. Irwin & Barneby (Leguminosae) in TPA-induced ear edema.
PubMed:Differential involvement of signaling pathways in the regulation of growth hormone release by somatostatin and growth hormone-releasing hormone in orange-spotted grouper (Epinephelus coioides).
PubMed:Activation of phospholipase-Cγ and protein kinase C signal pathways helps the survival of spinal motoneurons injured by root avulsion.
PubMed:Sulfhydryl modification induces calcium entry through IP₃-sensitive store-operated pathway in activation-dependent human neutrophils.
PubMed:Role for protein kinase C in controlling Aplysia bag cell neuron excitability.
PubMed:Roles of phospholipase D in phorbol myristate acetate-stimulated neutrophil respiratory burst.
PubMed:Protein kinase C-mediated inhibition of recombinant T-type Cav3.2 channels by neurokinin 1 receptors.
PubMed:Effect of thimerosal on Ca(2+) movement and viability in human oral cancer cells.
PubMed:Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.
PubMed:Volatile signals during pregnancy: a possible chemical basis for mother-infant recognition.
PubMed:Determination of volatile compounds in cider spirits by gas chromatography with direct injection.
PubMed:Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE).
PubMed:Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells.
PubMed:Calcium signaling in human airway goblet cells following purinergic activation.
PubMed:Adenosine A1 receptor-mediated inhibition of myocardial norepinephrine release involves neither phospholipase C nor protein kinase C but does involve adenylyl cyclase.
PubMed:Norepinephrine-induced changes in gene expression of phospholipase C in cardiomyocytes.
PubMed:Equol and para-ethyl-phenol stimulate prostaglandin F(2alpha) secretion in bovine corpus luteum: intracellular mechanisms of action.
PubMed:Contribution of lipid mediators to the regulation of phosphatidylcholine synthesis by angiotensin.
PubMed:Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C.
PubMed:Role of protein kinase C in the monocyte-derived macrophage-mediated biodegradation of polycarbonate-based polyurethanes.
PubMed:PKC alpha depletion in RAW264.7 macrophages following microbial/IFNgamma stimulation is PC-PLC-mediated.
PubMed:Interaction between adenosine A 2B-receptors and alpha2-adrenoceptors on the modulation of noradrenaline release in the rat vas deferens: possible involvement of a group 2 adenylyl cyclase isoform.
PubMed:Nonylphenol-induced Ca2+ elevation and Ca2+-independent cell death in human osteosarcoma cells.
PubMed:Stimulation of intracellular Ca2+ elevation in neutrophils by thiol-oxidizing phenylarsine oxide.
PubMed:Linker-based bio-compatible microemulsions.
PubMed:Stimulation of cellular free Ca2+ elevation and inhibition of store-operated Ca2+ entry by kazinol B in neutrophils.
PubMed:Effect of carvedilol on Ca2+ movement and cytotoxicity in human MG63 osteosarcoma cells.
PubMed:Suppression of receptor-mediated Ca2+ mobilization and functional leukocyte responses by hyperforin.
PubMed:Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans.
PubMed:Effects of methyl p-hydroxybenzoate (methyl paraben) on Ca2+ concentration and histamine release in rat peritoneal mast cells.
PubMed:Distinct regulation of expressed calcium channels 2.3 in Xenopus oocytes by direct or indirect activation of protein kinase C.
PubMed:Investigation of the cellular mechanism of inhibition of formyl-methionyl-leucyl-phenylalanine-induced superoxide anion generation in rat neutrophils by 2-benzyloxybenzaldehyde.
PubMed:[Enhancing effects of ion-pair complexes on skin permeation of cromolyn in vitro].
PubMed:Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells.
PubMed:Activation of angiotensin II type I receptor promotes protein kinase C translocation and cell proliferation in human cultured breast epithelial cells.
PubMed:Modulation of volume-sensitive chloride current by noradrenaline in rabbit portal vein myocytes.
PubMed:Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.
PubMed:Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells.
PubMed:Local anesthetic effects on priming and activation of human neutrophils.
PubMed:beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells.
PubMed:Effect of the antianginal drug bepridil on intracellular Ca2+ release and extracellular Ca2+ influx in human neutrophils.
PubMed:Nutritional lipid emulsions modulate cellular signaling and activation of human neutrophils.
PubMed:Characterization of intracellular calcium oscillations induced by extracellular nucleotides in HEp-2 cells.
PubMed:Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.
PubMed:The effects of aliphatic (n-nonane), naphtenic (1,2, 4-trimethylcyclohexane), and aromatic (1,2,4-trimethylbenzene) hydrocarbons on respiratory burst in human neutrophil granulocytes.
PubMed:fMLP-induced arachidonic acid release in db-cAMP-differentiated HL-60 cells is independent of phosphatidylinositol-4, 5-bisphosphate-specific phospholipase C activation and cytosolic phospholipase A(2) activation.
PubMed:Nitric oxide activates PKCalpha and inhibits Na+-K+-ATPase in opossum kidney cells.
PubMed:Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases.
PubMed:The phospholipase C inhibitor U73122 inhibits phorbol ester-induced platelet activation.
PubMed:Noradrenaline stimulates the production of prostaglandin f2alpha in cultured bovine endometrial cells.
PubMed:Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells.
PubMed:Pharmacology of [3H]-pyrilamine binding and of the histamine-induced inositol phosphates generation, intracellular Ca2+ -mobilization and cytokine release from human corneal epithelial cells.
PubMed:A potential role of Ras-mediated signal transduction for the enhancement of depolarization-induced Ca2+ responses in hippocampal neurons by basic fibroblast growth factor.
PubMed:Bradykinin-evoked Ca2+ mobilization in Madin Darby canine kidney cells.
PubMed:Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.
PubMed:Molecular mechanism(s) of action of norepinephrine on the expression of the angiotensinogen gene in opossum kidney cells.
PubMed:U73122 blocked the cGMP-induced calcium release in sea urchin eggs.
PubMed:Modulation of mechanically induced calcium waves in hippocampal astroglial cells. Inhibitory effects of alpha 1-adrenergic stimulation.
PubMed:Contribution of phospholipase C-beta3 phosphorylation to the rapid attenuation of opioid-activated phosphoinositide response.
PubMed:Activity-dependent regulation of [Ca2+]i in avian cochlear nucleus neurons: roles of protein kinases A and C and relation to cell death.
PubMed:Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase-1 release from human corneal epithelial cells.
PubMed:Proliferation of adult rat hepatocytes in primary cultures induced by platelet-derived growth factor is potentiated by phenylephrine.
PubMed:Protein kinase C mediates P2U purinergic receptor inhibition of K+ channel in apical membrane of strial marginal cells.
PubMed:P2U purinergic receptor inhibits apical IsK/KvLQT1 channel via protein kinase C in vestibular dark cells.
PubMed:Bradykinin- and thrombin-induced increases in endothelial permeability occur independently of phospholipase C but require protein kinase C activation.
PubMed:Potentiation by thyroxine of interferon-gamma-induced antiviral state requires PKA and PKC activities.
PubMed:Human neutrophil secondary granule exocytosis is independent of protein kinase activation and is modified by calmodulin activity.
PubMed:U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions.
PubMed:Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: the role of a wortmannin-sensitive signaling pathway.
PubMed:Pseudo-ternary phase diagrams of lecithin-based microemulsions: influence of monoalkylphosphates.
PubMed:Activation of protein kinase C stimulates cAMP phosphodiesterase in rat renal collecting tubule.
PubMed:Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase requires protein kinase C activation.
PubMed:Increased voltage-dependent calcium influx produced by alpha 1B-adrenergic receptor activation in rat medullary thyroid carcinoma 6-23 cells.
PubMed:A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid hormone-stimulated signaling pathways in rat osteosarcoma cells.
PubMed:Sequential activation of phospholipase-C and -D in agonist-stimulated gonadotrophs.
PubMed:Studies of in vitro skin permeation and retention of a leukotriene antagonist from topical vehicles with a hairless guinea pig model.
PubMed:Enhancing effect of pyrrolidone derivatives on transdermal penetration of 5-fluorouracil, triamcinolone acetonide, indomethacin, and flurbiprofen.
PubMed:Human growth hormone-stimulated growth of human cultured lymphocytes (IM-9) and its inhibition by phorbol diesters through down-regulation of the hormone receptors. Possible involvement of phosphorylation of a 55,000 molecular weight protein associated with the receptor in the down-regulation.
PubMed:Occurrence of cytochrome P-450 with prostaglandin omega-hydroxylase activity in rabbit placental microsomes.
PubMed:Multiple forms of cytochrome P-450 in kidney cortex microsomes of rabbits treated with 3-methylcholanthrene.
PubMed:Effect of cytochrome b5 on fatty acid omega- and (omega-1)-hydroxylation catalyzed by partially purified cytochrome P-450 from rabbit kidney cortex microsomes.
PubMed:Fatty acid omega and (omega-1)-Hydroxylation in rabbit intestinal mucosa microsomes.
 
Notes:
None found
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