toluene
mono-methyl benzene
 
Notes:
a widely used industrial solvent. Isol. from distilled tolu balsam (Myroxylon balsamum). Minor constit. of lime oil (Citrus aurantifolia) Toluene, formerly known as toluol, is a clear, water-insoluble liquid with the typical smell of paint thinners. It is an aromatic hydrocarbon that is widely used as an industrial feedstock and as a solvent. (Wikipedia)
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toluene (Click)
CAS Number: 108-88-3Picture of molecule
ECHA EINECS - REACH Pre-Reg: 203-625-9
FDA UNII: 3FPU23BG52
Nikkaji Web: J2.868A
Beilstein Number: 0635760
MDL: MFCD00008512
XlogP3: 2.70 (est)
Molecular Weight: 92.14076000
Formula: C7 H8
NMR Predictor: Predict (works with chrome or firefox)
Category: extraction solvents
 
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JECFA Food Additive: Toluene
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.86500 @  25.00 °C.
Melting Point: -95.00 to  -94.00 °C. @ 760.00 mm Hg
Boiling Point: 110.00 to  111.00 °C. @ 760.00 mm Hg
Boiling Point: 36.00 to  37.00 °C. @ 50.00 mm Hg
Vapor Pressure: 27.712000 mm/Hg @ 25.00 °C. (est)
Vapor Density: 3.2 ( Air = 1 )
Flash Point: 39.00 °F. TCC ( 3.89 °C. )
logP (o/w): 2.730
Soluble in:
 alcohol
 water, 573.1 mg/L @ 25 °C (est)
 water, 526 mg/L @ 25 °C (exp)
Insoluble in:
 water
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Organoleptic Properties:
Odor Description:
at 10.00 %. 
sweet
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
solvents
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Suppliers:
Chevron Phillips
Toluene, Reference Fuel Grade
Covalent Chemical
Toluene
EMD Millipore
For experimental / research use only.
Toluene
Kraft Chemical
Toluene
LyondellBasell Industries
TOLUENE
Sigma-Aldrich
For experimental / research use only.
Toluene anhydrous, 99.8%
Silver Fern Chemical
Toluene
Odor: characteristic
Use: Toluene has many uses including fuels and gasoline, solvents for paints and coatings, resins, rubbers, oils, adhesives, and as a heat transfer fluid.
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Safety Information:
European information :
Most important hazard(s):
Xn - Harmful.
R 11 - Highly flammable.
R 20 - Harmful by inhalation.
R 38 - Irritating to skin.
R 48 - Danger of serious damage to health by prolonged exposure.
R 63 - Possible risk of harm to the unborn child.
R 65 - Harmful: may cause lung damage if swallowed.
R 67 - Vapours may cause frowsiness and dizziness.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37 - Wear suitable protective clothing and gloves.
S 46 - If swallowed, seek medical advice immediately and show this container or label.
S 62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  636 mg/kg
Neurotoxicology. Vol. 2, Pg. 567, 1981.

intravenous-rat LD50  1960 mg/kg
Medicina del Lavoro. Industrial Medicine. Vol. 54, Pg. 486, 1963.

intraperitoneal-rat LD50  1332 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.

intraperitoneal-guinea pig LD50  500 mg/kg
Neurotoxicology. Vol. 2, Pg. 567, 1981.

oral-human LDLo  50 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 883, 1980.

oral-mammal (species unspecified) LD50  4000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.

intraperitoneal-mammal (species unspecified) LDLo  1750 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
American Journal of Hygiene. Vol. 7, Pg. 276, 1927.

oral-man LDLo  719 uL/kg
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: OTHER CHANGES CARDIAC: OTHER CHANGES
Forensic Science International. Vol. 41, Pg. 255, 1989.

intraperitoneal-mouse LD50  59 mg/kg
Neurotoxicology. Vol. 2, Pg. 567, 1981.

unreported-mouse LD50  2000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(12), Pg. 64, 1980.

intravenous-rabbit LDLo  130 mg/kg
Haematologica. Vol. 58, Pg. 491, 1973.

unreported-rat LD50  6900 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(12), Pg. 64, 1980.

Dermal Toxicity:
skin-rabbit LD50 14100 ul/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.

subcutaneous-frog LDLo 920 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 130, Pg. 250, 1928.

subcutaneous-mouse LD50 2250 mg/kg
Neurotoxicology. Vol. 8, Pg. 237, 1987.

Inhalation Toxicity:
inhalation-rat LC50 49000 mg/m3/4H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 23, 1988.

inhalation-rabbit LC50 55000 ppm/40M
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 69, 1944.

inhalation-guinea pig LCLo 1600 ppm
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: IRRITABILITY
Journal of Industrial Hygiene. Vol. 10, Pg. 261, 1928.

inhalation-human TCLo 200 ppm
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE BEHAVIORAL: ANTIPSYCHOTIC BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
JAMA, Journal of the American Medical Association. Vol. 123, Pg. 1106, 1943.

inhalation-mammal (species unspecified) LC50 30000 mg/m3
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(10), Pg. 25, 1988.

inhalation-man TCLo 100 ppm
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
Work, Environment, Health. Vol. 9, Pg. 131, 1972.

inhalation-mouse LC50 400 ppm/24H
Neurotoxicology. Vol. 2, Pg. 567, 1981.

inhalation-rabbit LCLo 55000 ppm/40M
Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 69, 1944.

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Safety in Use Information:
Category: extraction solvents
IFRA Critical Effect: Liver toxicity
IFRA fragrance material specification:
 The level of toluene has to be kept as low as practicable and should never exceed 100 ppm in the fragrance compound.
IFRA: View Standard
Recommendation for toluene usage levels up to:
 PROHIBITED: Should not be used as a fragrance ingredient.
 
Recommendation for toluene flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ECHA (ESR): View
EPA-Iris: IRIS
ClinicalTrials.gov: search
Daily Med: search
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
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Carcinogenic Potency Database: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 108-88-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 1140
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WISER: UN 1294
WGK Germany: 2
 toluene
Chemidplus: 0000108883
EPA/NOAA CAMEO: hazardous materials
RTECS: 108-88-3
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References:
 toluene
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 108-88-3
Pubchem (cid): 1140
Pubchem (sid): 134973333
Flavornet: 108-88-3
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
UM BBD: Search
KEGG (GenomeNet): C01455
HMDB (The Human Metabolome Database): HMDB34168
FooDB: FDB012454
Export Tariff Code: 2902.30.0000
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VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•research, reagent, nitration - all 99.8+%; industrial: contains 94+%, with 5% xylene and small amounts of benzene and nonaromatic hydrocarbons; 90120: less pure than industrial. •grades: research 99.99%; pure 99.98% •grades: 1st degree nitration; 2nd degree commercial; 90% solvent •grade: (usually defined in terms of boiling ranges) pure, commercial, straw-colored, nitration, scintilation, industrial.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 solvents 
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Occurrence (nature, food, other): note
 allspice plant
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 apricot fruit
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 bay laurel leaf
Search Trop  Picture
 cayenne fruit
Search Trop  Picture
 chu-lan tree
Search Trop  Picture
 coriander leaf
Search Trop  Picture
 dianthus arenarius
Search Trop  Picture
 dill shoot oil
Search Trop  Picture
 dill weed oil cuba @ trace%
Data  GC  Search Trop  Picture
 dill weed oil reunion @ 0.20%
Data  GC  Search Trop  Picture
 eriotheca longitubulosa
Search Trop  Picture
 guava fruit
Search Trop  Picture
 kiwi fruit
Search Trop  Picture
 kohlrabi stem
Search Trop  Picture
 lavender oil spike spain @ 0.003%
Data  GC  Search Trop  Picture
 mushroom giant puffball mushroom
Search  PMC Picture
 myroxylon balsamum
Search Trop  Picture
 osmanthus absolute @ trace%
Data  GC  Search Trop  Picture
 papaya fruit
Search Trop  Picture
 parsley leaf
Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 petitgrain sweet oil @ 0.08%
Data  GC  Search  Picture
 rosemary plant
Search Trop  Picture
 spearmint oil
Search Trop  Picture
 walnut black walnut fruit
Search Trop  Picture
 walnut black walnut oil
Search Trop  Picture
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Synonyms:
 methacide
 methyl benzene
mono-methyl benzene
 methyl benzol
 phenyl methane
 tolu-sol
 toluene [UN1294] [Flammable liquid]
 toluol
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