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triethyl amine

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CAS Number: 121-44-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-469-4
Nikkaji Web:J2.485F
Beilstein Number:0605283
CoE Number:10496
XlogP3:1.40 (est)
Molecular Weight:101.19255000
Formula:C6 H15 N
NMR Predictor:Predict (works with chrome or firefox)
Category:food contact substances for use only as components of articles intended for repeated use
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:1611 triethylamine
FLAVIS Number:11.023 (Old)
DG SANTE Food Flavourings:11.023 triethylamine
FEMA Number:4246 triethylamine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):121-44-8 ; TRIETHYLAMINE
FDA Regulation:
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.

Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1580 Polycarbonate resins.

Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Surfaces
Sec. 177.1585 Polyestercarbonate resins.
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.72400 to 0.73000 @ 25.00 °C.
Pounds per Gallon - (est).: 6.024 to 6.074
Refractive Index:1.39500 to 1.40100 @ 20.00 °C.
Melting Point:-115.00 °C. @ 760.00 mm Hg
Boiling Point: 88.80 to 89.00 °C. @ 760.00 mm Hg
Vapor Pressure:56.054001 mmHg @ 25.00 °C. (est)
Vapor Density:3.5 ( Air = 1 )
Flash Point: 20.00 °F. TCC ( -6.67 °C. )
logP (o/w): 1.450
Soluble in:
 water, 6.826e+004 mg/L @ 25 °C (est)
 water, 7.37E+04 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor Type: fishy
Odor Strength:high ,
recommend smelling in a 0.01 % solution or less
ammoniacal fishy
Odor Description:at 0.01 % in propylene glycol. ammoniacal fishy
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
Charkit Chemical
Eastman Chemical
EMD Millipore
For experimental / research use only.
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
Triethylamine, ≥99.5%
Certified Food Grade Products
Silver Fern Chemical
Odor: characteristic
Use: Triethylamine is mainly used in the production of quaternary ammonium compounds for textile auxiliaries and quaternary ammonium salts of dyes. It is also a catalyst and acid neutralizer for condensation reactions and is useful as an intermediate for manufacturing medicines, pesticides and other chemicals.
Taminco (Eastman)
For experimental / research use only.
Triethylamine >99.0%(GC)(T)
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
C - Corrosive.
R 12 - Extremely flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 35 - Causes severe burns.
S 03 - Keep in cool place.
S 16 - Keep away from sources of ignition - No Smoking.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 29 - Do not empty into drains.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 460 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

intraperitoneal-rat LD50 75 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

oral-mouse LD50 546 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

intraperitoneal-mouse LD50 405 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

gavage-rat LD50 [sex: M] < 182.30 mg/kg
(Myers & Ballantyne, 1997)

intraperitoneal-mouse LD50 405 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.

oral-mouse LD50 546 mg/kg
Hygiene and Sanitation Vol. 30(7-9), Pg. 351, 1965.

intraperitoneal-rat LDLo 75 mg/kg
Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968.

Dermal Toxicity:
skin-rabbit LD50 570 ul/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

Inhalation Toxicity:
inhalation-guinea pig LCLo 1000 ppm/4H
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 2, 1948.

inhalation-human TCLo 6500 ug/m3/4H
Occupational and Environmental Medicine. Vol. 56, Pg. 1, 1999.

inhalation-human TCLo 12 mg/m3/11W-C
International Archives of Occupational and Environmental Health. Vol. 57, Pg. 297, 1986.

inhalation-human TCLo 20 mg/m3/8H
Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 4, Pg. 45, 1990.

inhalation-mammal (species unspecified) LC50 6000 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

inhalation-mouse LC50 6000 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 56, 1965.

inhalation-rat LCLo 1000 ppm/4H
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

Safety in Use Information:
Category: food contact substances for use only as components of articles intended for repeated use
Recommendation for triethyl amine usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.073 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.90 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 340 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
 average usual ppmaverage maximum ppm
baked goods: 2.0000010.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: 0.200001.00000
cheese: 0.400002.00000
chewing gum: --
condiments / relishes: 0.100000.50000
confectionery froastings: 1.000005.00000
egg products: --
fats / oils: 0.100000.50000
fish products: 0.200001.00000
frozen dairy: 0.400002.00000
fruit ices: 0.400002.00000
gelatins / puddings: --
granulated sugar: --
gravies: 0.100000.50000
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 0.200001.00000
milk products: 0.400002.00000
nut products: --
other grains: 0.200001.00000
poultry: 0.200001.00000
processed fruits: 0.400002.00000
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 0.100000.50000
snack foods: 1.000005.00000
soft candy: --
soups: 0.100000.50000
sugar substitutes: --
sweet sauces: --
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.400002.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.100000.50000
Edible ices, including sherbet and sorbet (03.0): 0.400002.00000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.100000.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.200001.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): --
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 1.000005.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.200001.00000
Safety References:
European Food Safety Athority(efsa):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf

Flavouring Group Evaluation 45 (FGE.45)[1]: One tertiary amine from chemical group 28
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):121-44-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8471
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
EPA/NOAA CAMEO:hazardous materials
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:121-44-8
Pubchem (cid):8471
Pubchem (sid):134975714
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C14691
HMDB (The Human Metabolome Database):HMDB32539
Export Tariff Code:2921.19.1100
Household Products:Search
RSC Learn Chemistry:View
purity: 98.5% min
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
(diethyl amino) ethane
N,N-diethyl ethanamine
 ethanamine, N,N-diethyl-


Info:aliphatic and aromatic amines and amides derivatives
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Used as a food additive [EAFUS]
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