EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

tert-amyl alcohol

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CAS Number: 75-85-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-908-9
FDA UNII: 69C393R11Z
Nikkaji Web:J4.164E
Beilstein Number:1361351
CoE Number:515
XlogP3:0.90 (est)
Molecular Weight:88.14984000
Formula:C5 H12 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
DG SANTE Food Flavourings:02.041 2-methylbutan-2-ol
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.80500 to 0.81300 @ 25.00 °C.
Pounds per Gallon - (est).: 6.698 to 6.765
Refractive Index:1.40200 to 1.40800 @ 20.00 °C.
Melting Point: -9.00 to -8.00 °C. @ 760.00 mm Hg
Boiling Point: 102.00 to 103.00 °C. @ 760.00 mm Hg
Boiling Point: 19.00 to 20.00 °C. @ 10.00 mm Hg
Vapor Pressure:16.800000 mmHg @ 25.00 °C.
Vapor Density:3.0 ( Air = 1 )
Flash Point: 70.00 °F. TCC ( 21.11 °C. )
logP (o/w): 0.890
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 water, 1.10E+05 mg/L @ 25 °C (exp)
Similar Items:note
amyl alcohol
isoamyl alcohol
neoamyl alcohol
sec-amyl alcohol
sec-isoamyl alcohol
Organoleptic Properties:
Odor Description:pungent
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
tert-Amyl Alcohol
Penta International
Santa Cruz Biotechnology
For experimental / research use only.
2-Methyl-2-butanol ≥97%
For experimental / research use only.
2-Methyl-2-butanol anhydrous, ≥99%
For experimental / research use only.
tert-Amyl Alcohol >98.0%(GC)
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 20 - Harmful by inhalation.
R 37/38 - Irritating to respiratory system and skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 23 - Do not breath vapour.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1000 mg/kg
(Schaffarzick & Brown, 1952)

oral-rat LD50 1000 - 2000 mg/kg
(Dow Chemical Company, 1982b)

gavage-rabbit LD50 [sex: M,F] 2027 mg/kg
(Munch, 1972)

parenteral-frog LDLo 4000 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 50, Pg. 296, 1935.

unreported-man LDLo 441 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

intravenous-mouse LD50 610 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 135, Pg. 330, 1962.

intraperitoneal-mouse LDLo 2000 mg/kg
Skandinavisches Archiv fuer Physiologie. Vol. 79, Pg. 258, 1938.

oral-mouse LDLo 2500 mg/kg
"Narkoseversuche mit Hoheren Alkoholen und Stickstoffderivaten, Dissertation," Leube, F., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.

oral-rabbit LD50 2028 mg/kg
Industrial Medicine and Surgery. Vol. 41, Pg. 31, 1972.

oral-rat LD50 1000 mg/kg
Science. Vol. 116, Pg. 663, 1952.

intraperitoneal-rat LDLo 1530 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 1, 1945.

Dermal Toxicity:
subcutaneous-mouse LD50 2100 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 161, 1955.

subcutaneous-rat LDLo 1400 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 49, Pg. 36, 1933.

Inhalation Toxicity:
inhalation-rat LCLo 5700 ppm/6H
National Technical Information Service. Vol. OTS0536478

Safety in Use Information:
flavoring agents
Recommendation for tert-amyl alcohol usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 2.70 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3900 (μg/person/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 7.0000035.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 5.0000025.00000
Edible ices, including sherbet and sorbet (03.0): 10.0000050.00000
Processed fruit (04.1): 7.0000035.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000025.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 20.00000100.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 18 (FGE.18): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical group 6
View page or View pdf

Flavouring Group Evaluation 18, Revision 1 (FGE. 18 Rev1)[1] : Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 90 (FGE.90): Consideration of Aliphatic, acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances evaluated by JECFA (68th meeting)FGE.18Rev1 (2009)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 18, Revision 2 (FGE.18Rev2): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8.
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 18, Revision 3 (FGE.18Rev3): Aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols, aromatic tertiary alcohols and their esters from chemical groups 6 and 8.
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):75-85-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6405
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
EPA/NOAA CAMEO:hazardous materials
RTECS:SC0175000 for cas# 75-85-4
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:75-85-4
Pubchem (cid):6405
Pubchem (sid):134971220
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
KEGG (GenomeNet):D02931
HMDB (The Human Metabolome Database):HMDB33772
Export Tariff Code:2905.15.0000
VCF-Online:VCF Volatile Compounds in Food
grades: technical; cp; nf.
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 apple plant
Search Trop Picture
 cherimoya - up to 0.1 mg/kg
Search Trop Picture
 chicken - 0.0007 mg/kg
Search PMC Picture
 loquat fruit - up to 0.1 mg/kg
Search Trop Picture
 passion fruit - up to 0.01 mg/kg
Search Trop Picture
 pepper bell pepper fruit
Search Trop Picture
 rum - 0.2 mg/kg
Search PMC Picture
 sapodilla fruit - 0.00002 mg/kg
Search Trop Picture
 strawberry wild strawberry fruit
Search Trop Picture
tert-N-amyl alcohol
 butan-2-ol, 2-methyl-
 dimethyl ethyl carbinol
 dimethylethyl carbinol
 ethyl dimethyl carbinol
2-methyl butan-2-ol
tert-pentyl alcohol


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PubMed:Modification of flavonoid using lipase in non-conventional media: effect of the water content.
Isol. from strawberry aroma
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