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valeriana officinalis rhizome extract
extract of the rhizomes of the valerian, valeriana officinalis l., valerianaceae

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Name:valeriana officinalis l. rhizome extract
CAS Number: 8057-49-6
ECHA EC Number:232-501-7
Wisconsin Invasive Non-native plant species
Category:cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FEMA Number:3099 valerian rhizome extract
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: VALERIAN ROOT, EXTRACT (VALERIANA OFFICINALIS L.)
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.510 Natural flavoring substances and natural substances used in conjunction with flavors.
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor Type: fruity
Odor Strength:medium
valerian root
Odor Description:at 100.00 %. valerian root
Flavor Type: fruity
valerian root
Taste Description: valerian root
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Bristol Botanicals
Valerian root fluid extract Valeriana officinalis 1:1 45%
Changsha Organic Herb
valerian extract
Horner International
Valerian Fluid Extract
Horner International
Valerian Spray-Dried Powder Extract
Liberty Natural Products
VALERIAN 4:1 EXT. POWDER USA
Xi'an Greena Biotech
Valerian Extract
Odor: characteristic
Use: Valerian is well known for its sedative qualities and its ability to relax the central nervous system and anti-anxiety capabilities.Valerian has been used in Unani, Ayurvedic, and traditional Chinese Medicinal for centuries.Valerian has been used for its sedative properties many years in France, Germany,and Switzerland.The valerian root contains compounds including valeric acid, valeranone,hydroxy valerenic acid,valerianine,valepoitriate,maali alcohol,isovaltrate,patchouli alcohol and other active ingredients.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mammal (species unspecified) LD50 975 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988.

oral-mammal (species unspecified) LD50 2250 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988.

intraperitoneal-mouse LD50 3300 mg/kg
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Journal of Pharmaceutical Sciences. Vol. 50, Pg. 240, 1961.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
Wisconsin Invasive Non-native plant species
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -69.00000
beverages(nonalcoholic): -25.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -24.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -35.00000
fruit ices: -35.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -65.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
NLM Hazardous Substances Data Bank:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
valeriana officinalis l. rhizome extract
Chemidplus:0008057496
 
References:
 valeriana officinalis l. rhizome extract
Pubchem (sid):135331255
 
Other Information:
FDA Everything Added to Food in the United States (EAFUS):View
MedlinePlusSupp:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
balsamic
valerian rhizome absolute
FL/FR
valeriana wallichii root oil
FR
fruity
valerian rhizome essence
FL/FR
valeriana officinalis rhizome tincture
FL/FR
valeriana officinalis rhizome/root extract
FL/FR
valeriana officinalis root extract
FL/FR
green
3-
hexenyl isovalerate
FL/FR
valerian rhizome oil CO2 extract china
FL/FR
herbal
(-)-
bornyl isovalerate
FL/FR
white
cognac oil
FL/FR
hop absolute
FL/FR
valerian rhizome oil
FL/FR
valerian rhizome oil china
FL/FR
woody
iso
bornyl isovalerate
FL/FR
spikenard oil
FL/FR
spikenard oil CO2 extract
FL/FR
For Flavor
No flavor group found for these
(-)-
bornyl isovalerate
FL/FR
menthyl valerate
FL
spikenard oil
FL/FR
spikenard oil CO2 extract
FL/FR
fruity
fruity
valerian rhizome absolute
FL/FR
valerian rhizome distillates
FL
valerian rhizome essence
FL/FR
valerian rhizome oil
FL/FR
valerian rhizome oil china
FL/FR
valerian rhizome oil CO2 extract china
FL/FR
valeriana officinalis rhizome tincture
FL/FR
valeriana officinalis rhizome/root extract
FL/FR
valeriana officinalis root extract
FL/FR
fusel
white
cognac oil
FL/FR
green
3-
hexenyl isovalerate
FL/FR
herbal
hop absolute
FL/FR
woody
iso
bornyl isovalerate
FL/FR
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 valerian rhizome
Search Trop Picture
 
Synonyms:
 extract of the rhizomes of the valerian, valeriana officinalis l., valerianaceae
 valerian fluid extract
 valerian rhizome extract
 valerian root extract (so called)
 valerian spray-dried powder extract
 

Articles:

PubMed:Antioxidant effect and study of bioactive components of Valeriana sisymbriifolia and Nardostachys jatamansii in comparison to Valeriana officinalis.
PubMed:Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei.
PubMed:Antidepressant effect of Valeriana wallichii patchouli alcohol chemotype in mice: Behavioural and biochemical evidence.
PubMed:Valeriana jatamansi partially reverses liver cirrhosis and tissue hyperproliferative response in rat.
PubMed:Chemical analysis and biological activity of the essential oils of two valerianaceous species from China: Nardostachys chinensis and Valeriana officinalis.
PubMed:Vasorelaxant effect of Valeriana edulis ssp. procera (Valerianaceae) and its mode of action as calcium channel blocker.
PubMed:Terpenoid content of Valeriana wallichii extracts and antidepressant-like response profiles.
PubMed:Root colonization by symbiotic arbuscular mycorrhizal fungi increases sesquiterpenic acid concentrations in Valeriana officinalis L.
PubMed:Transport of a GABAA receptor modulator and its derivatives from Valeriana officinalis L. s. l. across an in vitro cell culture model of the blood-brain barrier.
PubMed:[Studies on chemical constituents of Valeriana officinalis].
PubMed:[Study on quality specification of Rhizoma et Radix Valeriana Jatamansi].
PubMed:Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice.
PubMed:Antispasmodic and blood pressure lowering effects of Valeriana wallichii are mediated through K+ channel activation.
PubMed:Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia.
 
Notes:
None found
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