aesculus hippocastanum bark extract
extract of the bark of the horse chestnut, aesculus hippocastanum l., hippocastanaceae
 
Notes:
None found
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Name: aesculus hippocastanum l. bark extract
CAS Number: 8053-39-2 
ECHA EC Number: 232-497-7
Category: astringent, skin conditioning
 
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Physical Properties:
Assay: 50.00 to 100.00 % 
Food Chemicals Codex Listed: No
Similar Items: note
aesculus hippocastanum flower water
aesculus hippocastanum seed extract
aesculus hippocastanum triterpene saponins mixture extract
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: astringents
skin conditioning
tonic
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  2150 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.

oral-rat LD50  833 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.

intravenous-rat LD50  1450 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

intraperitoneal-rat LD50  13750 mg/kg
Drugs in Japan Vol. 6, Pg. 399, 1982.

oral-rabbit LD50  1530 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.

intravenous-rabbit LD50  400 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

intravenous-rabbit LD50  30 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

oral-mouse LD50  990 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.

oral-mouse LD50  164 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

oral-guinea pig LD50  1120 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.

intravenous-guinea pig LD50  37 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

intravenous-guinea pig LD50  940 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

intraperitoneal-mouse LD50  6700 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

intraperitoneal-mouse LD50  55 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 45, 1980.

intravenous-mouse LD50  14400 ug/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

intravenous-mouse LD50  1377 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

intraperitoneal-rat LD50  10100 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

intravenous-rat LD50  62500 ug/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.

oral-rat LD50  833 mg/kg
Yakkyoku. Pharmacy. Vol. 33, Pg. 335, 1982.

Dermal Toxicity:
subcutaneous-rat LD50 150 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

subcutaneous-mouse LD50 38500 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: astringent, skin conditioning
Recommendation for aesculus hippocastanum bark extract usage levels up to:
 not for fragrance use.
 
Recommendation for aesculus hippocastanum bark extract flavor usage levels up to:
 not for flavor use.
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Safety References:
ClinicalTrials.gov: search
Daily Med: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 aesculus hippocastanum l. bark extract
Chemidplus: 0008053392
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References:
 aesculus hippocastanum l. bark extract
Pubchem (sid): 135344704
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Other Information:
MedlinePlusSupp: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 astringents 
 skin conditioning 
 tonic 
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Occurrence (nature, food, other): note
 chestnut horse-chestnut
Search Trop  Picture
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Synonyms:
horse chestnut aesculus glabra bark extract
horse chestnut bark extract
 extract of the bark of the horse chestnut, aesculus hippocastanum l., hippocastanaceae
 hippocastanum vulgare bark extract
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Articles:
PubMed: Plant extracts inhibit ADP-induced platelet activation in humans: their potential therapeutic role as ADP antagonists.
PubMed: Characterisation of the antioxidant effects of Aesculus hippocastanum L. bark extract on the basis of radical scavenging activity, the chemiluminescence of human neutrophil bursts and lipoperoxidation assay.
PubMed: Inhibition of viral RNA synthesis in canine distemper virus infection by proanthocyanidin A2.
PubMed: An attempt to control Cameraria ohridella using an attract-and-kill technique.
PubMed: Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications.
PubMed: Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study.
PubMed: Antifeedants and feeding stimulants in bark extracts of ten woody non-host species of the pine weevil, Hylobius abietis.
PubMed: Modulation of activity of the adipocyte aquaglyceroporin channel by plant extracts.
PubMed: Differences in salt sensitivity of four deciduous tree species to soil or airborne salt.
PubMed: Effects of proanthocyanidin on normal and reinnervated rat muscle.
PubMed: Steroidal constituents and anti-inflammatory activity of the horse chestnut (Aesculus hippocastanum L.) bark.
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