feverfew flower oil
fever few flower oil (tanacetum parthenium)
Used for inflammation of the skin, calming of nervousness, treatment of meteorism and colics, and for prevention of migraines. an aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. it contains tannins, volatile oils (oils, essential), and sesquiterpene lactones, especially parthenolide.
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Name: tanacetum parthenium flower oil
CAS Number: 89997-65-9 
ECHA EC Number: 289-701-2
Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Food Chemicals Codex Listed: No
Soluble in:
Insoluble in:
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Organoleptic Properties:
Odor Strength: medium
Odor Description:
at 100.00 %. 
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Cosmetic Information:
None found
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
IFRA Critical Effect: Sensitization
contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only)
benzyl alcohol Max. Found: trace to <0.10 % and Reason: Sensitization
eugenol Max. Found: <0.20 % and Reason: Sensitization
(E)-2-hexen-1-al Max. Found: trace to <0.10 % and Reason: Sensitization
Recommendation for feverfew flower oil usage levels up to:
 not for fragrance use.
Recommendation for feverfew flower oil flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med: search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 tanacetum parthenium flower oil
Chemidplus: 0089997659
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 tanacetum parthenium flower oil
Pubchem (sid): 135359261
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Other Information:
Export Tariff Code: 3301.29.6000
MedlinePlusSupp: View
 Typical G.C.
Wikipedia: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
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 aphanostephus pinulensis flower oil
 chrysanthemum parthenium flower oil
 fever few flower oil (tanacetum parthenium)
 matricaria parthenium flower oil
 pyrethrum parthenium flower oil
 tanacetum parthenium flower oil
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PubMed: Chrysanthemum morifolium extract attenuates high-fat milk-induced fatty liver through peroxisome proliferator-activated receptor α-mediated mechanism in mice.
PubMed: [Effect of water and nitrogen fertilizer coupling on yield and growth of genuine medicinal materials Chuzhou Chrysanthemum morifolium].
PubMed: Identification of chrysanthemum (Chrysanthemum morifolium) self-incompatibility.
PubMed: An arabinogalactan from flowers of Chrysanthemum morifolium: structural and bioactivity studies.
PubMed: [Comparative study on four major active compounds of Sanvitalia procumbens and Chrysanthemum morifolium cv 'Hangju' and 'Gongju'].
PubMed: An integrated approach utilising chemometrics and GC/MS for classification of chamomile flowers, essential oils and commercial products.
PubMed: Rapid genetic and epigenetic alterations under intergeneric genomic shock in newly synthesized Chrysanthemum morifolium x Leucanthemum paludosum hybrids (Asteraceae).
PubMed: Factors affecting quantity of pollen dispersal of spray cut chrysanthemum (Chrysanthemum morifolium).
PubMed: Proteomic changes in the base of chrysanthemum cuttings during adventitious root formation.
PubMed: Genetic mapping of quantitative trait loci underlying flowering time in chrysanthemum (Chrysanthemum morifolium).
PubMed: Study on the effects of sulfur fumigation on chemical constituents and antioxidant activity of Chrysanthemum morifolium cv. Hang-ju.
PubMed: Quantitative determination of phenolic compounds by UHPLC-UV-MS and use of partial least-square discriminant analysis to differentiate chemo-types of Chamomile/Chrysanthemum flower heads.
PubMed: Environmentally friendly ionic liquid-in-water microemulsions for extraction of hydrophilic and lipophilic components from Flos Chrysanthemi.
PubMed: Genetic engineering of novel bluer-colored chrysanthemums produced by accumulation of delphinidin-based anthocyanins.
PubMed: Chrysanthemum expressing a linalool synthase gene 'smells good', but 'tastes bad' to western flower thrips.
PubMed: Inhibition of c-Kit signaling by diosmetin isolated from Chrysanthemum morifolium.
PubMed: Green synthesis of silver nanoparticles by Chrysanthemum morifolium Ramat. extract and their application in clinical ultrasound gel.
PubMed: The promoter of the carotenoid cleavage dioxygenase 4a-5 gene of Chrysanthemum morifolium (CmCCD4a-5) drives petal-specific transcription of a conjugated gene in the developing flower.
PubMed: [Study on the pollen viability and stigma receptivity of Chrysanthemum morifolium 'Fubaiju'].
PubMed: Interspecies difference of luteolin and apigenin after oral administration of Chrysanthemum morifolium extract and prediction of human pharmacokinetics.
PubMed: An isoform of eukaryotic initiation factor 4E from Chrysanthemum morifolium interacts with Chrysanthemum virus B coat protein.
PubMed: [Comparison of botanical characteristics of cultivated Chrysanthemum morifolium cv. 'Hangju' of different origins].
PubMed: Flowering retardation by high temperature in chrysanthemums: involvement of FLOWERING LOCUS T-like 3 gene repression.
PubMed: Comparative evaluation of cultivars of Chrysanthemum morifolium flowers by HPLC-DAD-ESI/MS analysis and antiallergic assay.
PubMed: Altered expression of CmNRRa changes flowering time of Chrysanthemum morifolium.
PubMed: [Relationship between seedling grade and plant growth, yield and quality of medicinal Chrysanthemum morifolium].
PubMed: Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats.
PubMed: Influences of four different light-emitting diode lights on flowering and polyphenol variations in the leaves of chrysanthemum (Chrysanthemum morifolium).
PubMed: Day light quality affects the night-break response in the short-day plant chrysanthemum, suggesting differential phytochrome-mediated regulation of flowering.
PubMed: [Rapid identification system for seedlings of medicinal Chrysanthemum morifolium].
PubMed: [Simultaneous determination of 6 active components in Chrysanthemum morifolium by HPLC].
PubMed: Global detection and analysis of volatile components from sun-dried and sulfur-fumigated herbal medicine by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry.
PubMed: Increased exposure of vitamin A by Chrysanthemum morifolium Ramat extract in rat was not via induction of CYP1A1, CYP1A2, and CYP2B1.
PubMed: [Effects of different cropping system and fertilization on functional diversity in soil microbial community of Chrysanthemum morifolium].
PubMed: [Study on hydroxyproline tolerance of different cultivars of Chrysanthemum morifolium in vitro].
PubMed: Improved cryopreservation of chrysanthemum (Chrysanthemum morifolium) using droplet-vitrification.
PubMed: Facile synthesis of acacetin-7-O-β-D-galactopyranoside.
PubMed: [Study on salt stress tolerance of Chrysanthemum morifolium 'Hangbaiju' and 'Huangju' and F1 seedlings].
PubMed: [Active ingredients and efficacies of Ganoderma lucidum cultivated on non-medicinal parts of Chinese medicinal herbs].
PubMed: [Numerical analysis of morphological variation of germplasm resources of Chrysanthemum morifolium for medicine].
PubMed: [Effect of PEG stress on plantlets of Chrysanthemum morifolium induced by endophytic botrytis sp. (C1) and Chaetomium globosum (C4)].
PubMed: [Comparative analysis on the configuration of vegetative organs of medicinal Chrysanthemum from different original locations and species].
PubMed: [Manufacturing process and quality control of total flavonoid from Chrysanthemum morifolium and Sophora japonica and its quality control].
PubMed: Ethanol Extract of the Flower Chrysanthemum morifolium Augments Pentobarbital-Induced Sleep Behaviors: Involvement of Cl Channel Activation.
PubMed: [Effects of phosphate fertilizer on active ingredients and antioxidant activities of Chrysanthemum morifolium].
PubMed: Host plant effects on development and reproduction of the glassy-winged sharpshooter, Homalodisca vitripennis (Homoptera: Cicadellidae).
PubMed: Relative contribution of small and large intestine to deglycosylation and absorption of flavonoids from Chrysanthemun morifolium extract.
PubMed: Toxicity study of ethanolic extract of Chrysanthemum morifolium in rats.
PubMed: [Correlation of main physiological characteristics and active components in cultivars of medicinal Chrysanthemum morifolium].
PubMed: [Effects of soil factors on active component content of Chrysanthemum morifolium].
PubMed: [The effect of different endophytic fungi on Chrysanthemum morifolium output and quality].
PubMed: [Effects of light intensity on physiological and biochemical characteristics of Chrysanthemum morifolium at vegetative stage].
PubMed: Antioxidant action of a Chrysanthemum morifolium extract protects rat brain against ischemia and reperfusion injury.
PubMed: Effect of a variety of Chinese herbs and an herb-containing dentifrice on volatile sulfur compounds associated with halitosis: An in vitro analysis.
PubMed: [Absorption and distribution of nitrogen, phosphorus and potassium in Chrysanthemum morifolium].
PubMed: Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells.
PubMed: Chlororespiration and tolerance to drought, heat and high illumination.
PubMed: In vitro conservation and cryopreservation of ornamental plants.
PubMed: Chrysanthemum morifolium Ramat. reduces the oxidized LDL-induced expression of intercellular adhesion molecule-1 and E-selectin in human umbilical vein endothelial cells.
PubMed: [Characteristics of accumulation and distribution of nitrogen, phosphorus, potassium, calcium and magnesium in Chrysanthemum morifolium].
PubMed: [Effects of waterlogging stress on physiological and biochemical characteristics of medicinal Chrysanthemum morifolium during seedling stage].
PubMed: [Effects of two controlled-release fertilizers with different proportions of N, P and K on the nutrient uptake and growth of Chrysanthemum morifolium Ramat].
PubMed: [Effects of light intensity on growth and photosynthetic characteristics of Chrysanthemum morifolium].
PubMed: [Comparative study on eight trace elements in twelve flower medicines].
PubMed: Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity.
PubMed: [Antiarrhythmic effect of ethyl acetate extract from Chrysanthemum Morifolium Ramat on rats].
PubMed: Identification of volatile compounds in Chrysanthemum morifolium by microwave distillation solid-phase microextraction coupled with GC/MS.
PubMed: Nondestructive, stereological estimation of canopy surface area.
PubMed: [Comparative study on botanical morphologic character of different cultivated types medicinal Chrysanthemum morifolium].
PubMed: [Antagonism of total flavonoids from Chrysanthemum morifolium against lead induced oxidative injury in mice].
PubMed: [Characterization of chemical components of essential oil from flowers of Chrysanthemum morifolium produced in Anhui province].
PubMed: Susceptibility of chrysanthemum and Paris daisy varieties to several isolates of Fusarium oxysporum f. sp. chrysanthemi.
PubMed: Involvement of the ethylene response pathway in dormancy induction in chrysanthemum.
PubMed: [Study on dynamic accumulation of flavone in various Chrysanthemum morifolium for medicine].
PubMed: [Characterization of chemical components of essential oil from cupitulum of Chrysanthemum morifolium cultivated in Tongxiang city].
PubMed: [Study on quality of flavone in various cultivars of Chrysanthemum morifolium for medicine].
PubMed: [Studies on chemical constituents in Huangjuhua (flowers of Chrysanthemum morifolium)].
PubMed: [Effects of stem numbers per ground area on the quality of standard cut Chrysanthemum morifolium in greenhouse: simulation model].
PubMed: Characteristic thickened cell walls of the bracts of the 'eternal flower' Helichrysum bracteatum.
PubMed: Susceptibility of gerbera and chrysanthemum varieties (Gerbera jamesoni and Chrysanthemum morifolium) to Fusarium oxysporum f.sp. chrysanthemi.
PubMed: [Comparative study on leaf ultrastructure in varieties of Chrysanthemum morifolium].
PubMed: [Effects of climate factors on quality of Chrysanthemum morifolium originated from Wenxian county].
PubMed: Experience-induced habituation and preference towards non-host plant odors in ovipositing females of a moth.
PubMed: [Determination of trace elements in new food sources by flame atomic absorption spectrophotometry].
PubMed: High frequency shoot regeneration from petal explants of Chrysanthemum morifolium Ramat. in vitro.
PubMed: [Effects of transplanting date and density on appearance quality of greenhouse single-flower cut chrysanthemum].
PubMed: [GC-MS analysis of essential oil from Xiaoboju processed by aeration-desiccation and sulfur-burnin fumigation].
PubMed: [Comparative study on inner quality of various Chrysanthemum morifolium cultivated in Tongxiang city].
PubMed: [GC-MS analysis of essential oil from anthodiums of Chrysanthemum morifolium processed by microwave-airflow and steam calefaction].
PubMed: [Study on dynamic accumulation of secondary metabolites content and isoenzyme activity during blossoming stages in Chrysanthemum morifolium originating from Wenxian county].
PubMed: Development of NaCl-tolerant line in Chrysanthemum morifolium Ramat. through shoot organogenesis of selected callus line.
PubMed: Effect of different extracting methods on quality of Chrysanthemum Morifolium Ramat. Infusion.
PubMed: Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract.
PubMed: Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS.
PubMed: Carotenoid cleavage dioxygenase (CmCCD4a) contributes to white color formation in chrysanthemum petals.
PubMed: Non-host plant extracts reduce oviposition of Plutella xylostella (Lepidoptera: Plutellidae) and enhance parasitism by its parasitoid Cotesia plutellae (Hymenoptera: Braconidae).
PubMed: Development of NaCl-tolerant strain in Chrysanthemum morifolium Ramat. through in vitro mutagenesis.
PubMed: Two acidic polysaccharides from the flowers of Chrysanthemum morifolium.
PubMed: [GC-MS analysis of essential oil of the flower of the Chrysanthemum morifolium by the different processing methods].
PubMed: [RAPD analysis for genetic diversity of Chrysanthemum morifolium].
PubMed: [Comparative study on internal quality of various Chrysanthemum morifolium].
PubMed: [Study on the extraction and purification for total flavonoids in Lonicera japonica Thunb. and Chrysanthemum morifolium Tzvel].
PubMed: Determination and assay validation of luteolin and apigenin in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC.
PubMed: Identification of new dicaffeoylquinic acids from Chrysanthemum morifolium and their antioxidant activities.
PubMed: [Analysis of volatile components from the flowers of Chrysanthemum morifolium by GC-MS with solid-phase microextraction].
PubMed: Simultaneous determination of luteolin and apigenin in dog plasma by RP-HPLC.
PubMed: [Studies on the technology of directly inducing regenerated plantlet from leaf of Chrysanthemum morifolium].
PubMed: [Comparative study on physiological and biochemical mechanism between virus-free seedling and common seedling in Chrysanthemum morifolium from Anhui].
PubMed: [Study on ultrasonic extraction techniques of flavonoids in Chrysanthemum morifolium].
PubMed: [Studies on petal tissue culture of the traditional Chinese medicine Chrysanthemum morifolium].
PubMed: Antitubercular activity of triterpenoids from Asteraceae flowers.
PubMed: [Selection of sodium chloride tolerant mutants in Chrysanthemum morifolium in Anhui].
PubMed: [Study on extraction technology for extract and flavonoids in Chrysanthemum morifolium by orthogonal design].
PubMed: [Advances in the study on chemical constituents of Chrysanthemum morifolium Ramat].
PubMed: Chrysanthemum morifolium attenuated the reduction of contraction of isolated rat heart and cardiomyocytes induced by ischemia/reperfusion.
PubMed: A flavanone and two phenolic acids from Chrysanthemum morifolium with phytotoxic and insect growth regulating activity.
PubMed: Biological effect of irradiated chitosan on plants in vitro.
PubMed: [Comparative study on pesticide and heavy metal residuals of four cultivars of Chrysanthemum morifolium].
PubMed: [Salt-tolerance evaluation of seedlings of medicinal Chrysanthemum morifolium cultivar].
PubMed: [Studies on callus induced from leaves and plantlets regeneration of the traditional Chinese medicine Chrysanthemum morifolium].
PubMed: [Study on the soil fertility changes in planting base to develop the special fertilizer for cultivation of Chrysanthemum morifolium].
PubMed: [Study on selective breeding of medicinal Chrysanthemum morifolium].
PubMed: [Determination of luteolin and luteolin-7-beta-D-glucoside in Chrysanthemum morfolium Ramat. from different collection time by RP-HPLC].
PubMed: A new anti-HIV flavonoid glucuronide from Chrysanthemum morifolium.
PubMed: Antimutagenic activity of flavonoids from Chrysanthemum morifolium.
PubMed: Using the expolinear growth equation for modelling crop growth in year-round cut chrysanthemum.
PubMed: Isobutylamides of unsaturated fatty acids from Chrysanthemum morifolium associated with host-plant resistance against the western flower thrips.
PubMed: Cryopreservation of Chrysanthemum morifolium (Dendranthema grandiflora Ramat.) using different approaches.
PubMed: [Comparative study on internal quality of four cultivars of Chrysanthemum morifolium].
PubMed: [Studies on the chemical constituents from Chrysanthemum morifolium Ramat].
PubMed: [Study on stem-tip tissue culture of the traditional Chinese medicine Chrysanthemum morifolium].
PubMed: The promoter-terminator of chrysanthemum rbcS1 directs very high expression levels in plants.
PubMed: [Effect of Chrysanthemum morifolium Ramat on apoptosis of bovine aortic smooth muscle cells]
PubMed: [A preliminary study on tissue culture of stem apex of Chrysanthemum morifolium].
PubMed: [Determination of chlorogenic acid in chrysanthemum morifolium Ramat.flower].
PubMed: Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.
PubMed: Constituents of compositae plants. 2. Triterpene diols, triols, and their 3-o-fatty acid esters from edible chrysanthemum flower extract and their anti-inflammatory effects.
PubMed: Isolation and complete NMR assignment of the numbing principle from Chrysanthemum morifolium.
PubMed: High genome-wide mutation rates in vegetatively propagated bermudagrass.
PubMed: Tomato spotted wilt virus in ornamental plants, vegetables and weeds in the Czech Republic.
PubMed: Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents.
PubMed: Inhibitory effect of heliantriol C; a component of edible Chrysanthemum, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
PubMed: Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects.
PubMed: [Effect of alcohol extracts of Chrysanthemum morifolium on Plasmodium falciparum in vitro].
PubMed: [Inhibition of the development of Plasmodium yoelii in exoerythrocytic stage in rodents (rats) with Chrysanthemum morifolium].
PubMed: Biolistic transformation of chrysanthemum with the nucleocapsid gene of tomato spotted wilt virus.
PubMed: Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.
PubMed: Erwinia chrysanthemi EC16 Produces a Second Set of Plant-Inducible Pectate Lyase Isozymes.
PubMed: [A prospective clinical study on reversion of 200 precancerous patients with hua-sheng-ping].
PubMed: Studies on aldose reductase inhibitors from natural products. IV. Constituents and aldose reductase inhibitory effect of Chrysanthemum morifolium, Bixa orellana and Ipomoea batatas.
PubMed: Characterization of an Unusual New Agrobacterium tumefaciens Strain from Chrysanthemum morifolium Ram.
PubMed: Rapid mass propagation of Chrysanthemum morifolium by callus derived from stem and leaf explants.
PubMed: Efficient, direct plant regeneration from stem segments of chrysanthemum (Chrysanthemum morifolium Ramat. cv. Royal Purple).
PubMed: Contact dermatitis from chrysanthemums in India.
PubMed: Airborne contact dermatitis from Compositae plants in northern India.
PubMed: [Chrysanthemum morifolium in the treatment of hypertension].
PubMed: [Contact eczema caused by Chrysanthemum morifolium Ramat].
PubMed: Preliminary observation of 131Cs distribution in experimental acute myocardial infarction and coronary insufficiency treated with root of salvia miltiorrhiza, flower of Chrysanthemum morifolium and Chrysanthemum indicum.
PubMed: [Studies on the components of Chrysanthemum morifolium Ramat. var. sinense Makino forma esculentum Makino. II. Components of one of brands "Mottenohoka" (author's transl)].
PubMed: Alantolactone sensitivity in chrysanthemum contact dermatitis.
PubMed: [Studies on the components of the petals of Chrysanthemum morifolium Ramat. var. sinense Makino forma esculentum Makino (author's transl)].
PubMed: Self compatibility in garden Chrysanthemum: occurrence, inheritance and breeding potential.
PubMed: A quantitative description of inhibition of stem growth in vegetative lateral shoots of Chrysanthemum morifolium by N-dimethylaminosuccinamic acid (daminozide).
PubMed: Genetic studies of self incompatibility in the garden chrysanthemum, Chrysanthemum morifolium ramat.
PubMed: Flowering of Chrysanthemum under non-inductive long days by gibberellins and N(6)-benzyladenine.
PubMed: Measuring Osmotic Pressure of Sap within Live Cells by Means of a Visual Melting Point Apparatus.
PubMed: Photoreactions Controlling Flowering of Chrysanthemum morifolium (Ramat. and Hemfl.) Illuminated with Fluorescent Lamps.
PubMed: Effect of Meloidogyne incognita, M. hapla, and M. javanica on the Severity of Fusarium Wilt of Chrysanthemum.
PubMed: Presence and possible mode of action of a proteinaceous gonadotropin-like growth regulating factor in plant systems.
PubMed: Flower Induction in Japanese Chrysanthemums with Gibberellic Acid.
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