EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

perilla alcohol
p-mentha-1,8-dien-7-ol

Supplier Sponsors

Fragrance Demo Formulas
Name:(4-prop-1-en-2-yl-1-cyclohexenyl)methanol
CAS Number: 536-59-4Picture of molecule3D/inchi
Other(deleted CASRN):1406-56-0
ECHA EINECS - REACH Pre-Reg:208-639-9
FDA UNII: 319R5C7293
Nikkaji Web:J11.581I
CoE Number:2024
XlogP3-AA:2.10 (est)
Molecular Weight:152.23672000
Formula:C10 H16 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
EFSA/JECFA Comments:
Racemate
Category: cosmetic, flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Flavoring:974 p-mentha-1,8-dien-7-ol
DG SANTE Food Flavourings:02.060 p-mentha-1,8-dien-7-ol
FEMA Number:2664 p-mentha-1,8-dien-7-ol
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):536-59-4 ; P-MENTHA-1,8-DIEN-7-OL
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95600 to 0.96300 @ 25.00 °C.
Pounds per Gallon - (est).: 7.955 to 8.013
Refractive Index:1.49500 to 1.50500 @ 20.00 °C.
Boiling Point: 119.00 to 121.00 °C. @ 11.00 mm Hg
Boiling Point: 92.00 to 93.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.006000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 3.170
Soluble in:
 alcohol
 water, 471 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: green
Odor Strength:medium
Substantivity:269 hour(s) at 100.00 %
green cumin spicy aromatic woody cardamom floral waxy violet
Odor Description:at 100.00 %. green cumin spicy aromatic woody cardamom floral waxy violet
Luebke, William tgsc, (2021)
Odor sample from: CA Aromatics Company Inc.
sweet woody aromatic spicy cardamom green cumin orange peel green waxy floral
Odor Description:at 1.00 %. sweet , woody, aromatic spicy cardamom and green cumin like with dried orange peel and green waxy floral nuances
Mosciano, Gerard, (2009)
Flavor Type: woody
woody aromatic cumin spicy green cardamom waxy floral oily earthy
Taste Description: woody aromatic cumin spicy green cardamom waxy floral oily earthy
Luebke, William tgsc, (2021)
sweet woody aromatic spicy cardamom green cumin orange peel green waxy floral
Taste Description: at 25.00 ppm. sweet , woody, aromatic spicy cardamom and green cumin like with dried orange peel and green waxy floral nuances
Mosciano, Gerard, (2009)
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
antioxidants
fragrance
perfuming agents
skin protecting agents
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Perillyl Alcohol XXXXXXXXXXXXXXXXXXXXXXXXpercnt 98%
BOC Sciences
For experimental / research use only.
Dihydrocuminyl alcohol >98%
Citrus and Allied Essences
Perilla Alcohol
Market Report
De Monchy Aromatics
dihydro cuminyl alcohol
Foreverest Resources
Perillyl Alcohol
Indukern F&F
PERILLA ALCOHOL
Odor: GREEN, HERBAL
Jiangyin Healthway
Perillyl Alcohol
New functional food ingredients
Lluch Essence
PERILLA ALCOHOL
Nippon Terpene Chemicals
l-Perillyl alcohol 85% up
Penta International
PERILLA ALCOHOL
Reincke & Fichtner
p-Mentha-1,8-dien-7-ol
Synerzine
Perillyl Alcohol
 
Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
4 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50 2100 mg/kg
Food and Cosmetics Toxicology. Vol. 19, Pg. 253, 1981.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 19, Pg. 253, 1981.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
maximum skin levels for fine fragrances:
  0.1700 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2006)
Recommendation for perilla alcohol usage levels up to:
  4.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics:
  0.0200 %
Dermal Systemic Exposure in Cosmetic Products:
 0.0005 mg/kg/day (IFRA, 2006)
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.34 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 1.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 1500 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 10.0000050.00000
beverages(nonalcoholic): 0.500001.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.500001.00000
fruit ices: 0.500001.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -20.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 5.0000010.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 5.0000010.00000
Processed fruit (04.1): 5.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 5.0000025.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000010.00000
Bakery wares (07.0): 8.0000050.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): --
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 1.000005.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 0.500001.00000
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 2.0000010.00000
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Flavouring Group Evaluation 208 Revision 1 (FGE.208Rev1): Consideration of genotoxicity data on representatives for 10 alicyclic aldehydes with the a,ß-unsaturation in ring / side-chain and precursors from chemical subgroup 2.2 of
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 208 Revision 2 (FGE.208Rev2): Consideration of genotoxicity data on alicyclic aldehydes with a,ß-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 73, Revision 4 (FGE.73Rev4): consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th and 63rd meeting) structurally related to primary saturated or unsaturated alicyclic alcohols, aldehydes, acids and esters evaluated by EFSA in FGE.12Rev5
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 208 Revision 3 (FGE.208Rev3): consideration of genotoxicity data on alicyclic aldehydes with a,ß-unsaturation in ring/side-chain and precursors from chemical subgroup 2.2 of FGE.19
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 73, Revision 5 (FGE.73Rev5): consideration of alicyclic alcohols, aldehydes, acids and related esters evaluated by JECFA (59th, 63rd and 86th meeting) and structurally related to substances evaluated in FGE.12Rev5
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):536-59-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10819
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
(4-prop-1-en-2-yl-1-cyclohexenyl)methanol
Chemidplus:0000536594
RTECS:OS8395000 for cas# 536-59-4
 
References:
 (4-prop-1-en-2-yl-1-cyclohexenyl)methanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:536-59-4
Pubchem (cid):10819
Pubchem (sid):134977617
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C02452
HMDB (The Human Metabolome Database):HMDB03634
FooDB:FDB014925
Export Tariff Code:2906.10
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
aldehydic
citronellyl oxyacetaldehyde
FL/FR
lily pentanal
FR
muguet undecadienal
FR
nonanal (aldehyde C-9)
FL/FR
animal
para-
cresyl isobutyrate
FL/FR
para-
cresyl phenyl acetate
FL/FR
anise
star
anise oil CO2 extract
FL/FR
aromatic
aromatic woody citrus floral fragrance
FR
balsamic
benzoin absolute replacer
FL/FR
linalyl cinnamate
FL/FR
myrrh oil CO2 extract
FL/FR
opoponax absolute (balsamodendron kafal)
FL/FR
citrus
benzyl anthranilate
FR
citrus ocimenol
FR
(Z)-4-
decenal
FL/FR
lemon oil replacer
FR
myrmac aldehyde
FR
bitter
orange peel oil brazil
FL/FR
tetrahydromyrcenol
FR
earthy
octyl phenyl acetate
FL/FR
floral
alpha-
amyl cinnamaldehyde dimethyl acetal
FL/FR
bois de rose oil brazil
FL/FR
alpha-
butyl cinnamaldehyde
FL/FR
citronellyl ethoxalate
FR
coranol (Firmenich)
FR
cumin carbinol
FR
cyclamen aldehyde / methyl anthranilate schiff's base
FR
cyclamen homoaldehyde
FR
cyclohexyl ethyl alcohol
FL/FR
cyclohexyl propanol
FR
2-
decalinol
FR
dihydrolinalool
FL/FR
3,6-
dimethyl-3-octanol
FL/FR
ethyl linalool
FR
ethyl linalyl acetal
FR
ethyl linalyl acetate
FR
ethyl linalyl ether
FL/FR
(E,E)-
farnesol
FL/FR
floral butanal
FR
floral pyranol
FR
freesia acetate
FR
gardenia decalone
FR
hawthorn ethanol
FR
ho leaf oil
FR
ho wood oil
FR
hydroxycitronellal
FL/FR
hydroxycitronellal / methyl anthranilate schiff's base
FR
hydroxycitronellal diethyl acetal
FL/FR
hydroxycitronellal dimethyl acetal
FL/FR
hydroxycitronellol
FL/FR
jasimia
FR
lavender oil
FL/FR
lavender oil replacer
FR
leerall
FR
leerall / methyl anthranilate schiff's base
FR
lily propanol
FR
lilyall
FR
lilyall / methyl anthranilate schiff's base
FR
laevo-
linalool
FL/FR
dextro-
linalool
FL/FR
linalool
FL/FR
linalool oxide
FL/FR
linalyl anthranilate
FL/FR
linalyl benzoate
FL/FR
linalyl propionate
FL/FR
magnolia cyclohexanol
FR
magnolia decadienal
FR
methoxycitronellal
FR
2-
methyl octanal
FL/FR
muguet butanal
FR
muguet butanol
FR
muguet carbaldehyde
FR
muguet carbinol
FL/FR
muguet carboxaldehyde
FR
muguet ethanol
FR
muguet nitrile
FR
muguet octadienol
FR
muguet propanol
FR
muguet shiseol
FL/FR
phenyl glycol diacetate
FR
alpha-
terpinyl anthranilate
FL/FR
tetrahydrolinalool
FL/FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil CO2 extract
FL/FR
ylang ylang flower oil I
FL/FR
ylang ylang flower oil II
FL/FR
ylang ylang flower oil III
FL/FR
herbal
apium graveolens seed oil
FL/FR
carrot seed oil (daucus carota ssp. gummifer hook. fil.) spain
FR
carrot seed oil (daucus carota ssp. maximus (desf.) ball)
FR
wild
carrot seed oil terpeneless
FL/FR
celery ketone
FL/FR
celery seed oil replacer
FR
celery specialty
FR
dimethyl benzyl carbinyl formate
FL/FR
laurus nobilis leaf oil
FL/FR
lavender fragrance
FR
lavender specialty
FR
patchouli oil terpenes
FR
laevo-
perillaldehyde
FL/FR
licorice
licorice fragrance
FR
marine
ozone propanal
FR
spicy
allspice berry absolute
FL/FR
cardamom seed oil CO2 extract
FL/FR
cinnamon bark absolute
FL/FR
cinnamon bark oil (cinnamomum zeylanicum) india
FL/FR
cinnamon bark oil ceylon
FL/FR
cinnamon leaf oil ceylon
FL/FR
clove bud absolute
FL/FR
clove bud oil
FL/FR
clove bud oil replacer
FR
clove fragrance
FR
clove leaf oil
FL/FR
clove stem oil
FL/FR
cubeb oil
FL/FR
laurel leaf oil replacer
FR
mace fragrance
FR
mace oil
FL/FR
nutmeg oil replacer
FR
nutmeg oleoresin
FL/FR
pepper tree berry oil
FL/FR
terpenic
hinoki oil replacer
FR
vanilla
vanillylidene acetone
FL/FR
woody
agarwood oil (aetoxylon sympetalum)
FR
cedarleaf oil replacer
FR
cedarwood oil western red
FR
louro brasileiro wood oil
FR
thuja occidentalis leaf oil
FL/FR
For Flavor
No flavor group found for these
alpha-
amyl cinnamaldehyde dimethyl acetal
FL/FR
dimethyl benzyl carbinyl formate
FL/FR
ethyl linalyl ether
FL/FR
(E,E)-
farnesol
FL/FR
dextro-
linalool
FL/FR
2-
methyl octanal
FL/FR
octyl phenyl acetate
FL/FR
alpha-
terpinyl anthranilate
FL/FR
alpha-
butyl cinnamaldehyde
FL/FR
aldehydic
aldehydic
nonanal (aldehyde C-9)
FL/FR
anise
star
anise oil CO2 extract
FL/FR
aromatic
para-
cresyl isobutyrate
FL/FR
laevo-
perillaldehyde
FL/FR
balsamic
benzoin absolute replacer
FL/FR
myrrh oil CO2 extract
FL/FR
opoponax absolute (balsamodendron kafal)
FL/FR
vanillylidene acetone
FL/FR
citrus
citronellyl oxyacetaldehyde
FL/FR
(Z)-4-
decenal
FL/FR
linalool
FL/FR
laevo-
linalool
FL/FR
floral
bois de rose oil brazil
FL/FR
dihydrolinalool
FL/FR
linalyl anthranilate
FL/FR
muguet carbinol
FL/FR
muguet shiseol
FL/FR
tetrahydrolinalool
FL/FR
ylang ylang flower oil
FL/FR
ylang ylang flower oil CO2 extract
FL/FR
ylang ylang flower oil I
FL/FR
ylang ylang flower oil II
FL/FR
ylang ylang flower oil III
FL/FR
fruity
linalyl benzoate
FL/FR
linalyl cinnamate
FL/FR
bitter
orange peel oil brazil
FL/FR
green
celery ketone
FL/FR
cyclohexyl ethyl alcohol
FL/FR
linalool oxide
FL/FR
herbal
apium graveolens seed oil
FL/FR
cardamom distillates
FL
wild
carrot seed oil terpeneless
FL/FR
celery flavor
FL
celery seed oil distillates
FL
3,6-
dimethyl-3-octanol
FL/FR
laurus nobilis leaf oil
FL/FR
lavender oil
FL/FR
linalyl propionate
FL/FR
melon
hydroxycitronellal diethyl acetal
FL/FR
phenolic
para-
cresyl phenyl acetate
FL/FR
powdery
hydroxycitronellol
FL/FR
solvent
methyl phenyl sulfide
FL
spicy
allspice berry absolute
FL/FR
cardamom seed oil CO2 extract
FL/FR
cinnamon bark absolute
FL/FR
cinnamon bark oil (cinnamomum zeylanicum) india
FL/FR
cinnamon bark oil ceylon
FL/FR
cinnamon leaf oil ceylon
FL/FR
clove bud absolute
FL/FR
clove bud oil
FL/FR
clove flavor
FL
clove leaf oil
FL/FR
clove stem oil
FL/FR
cubeb oil
FL/FR
mace flavor
FL
mace oil
FL/FR
nutmeg oleoresin
FL/FR
pepper tree berry oil
FL/FR
waxy
hydroxycitronellal
FL/FR
hydroxycitronellal dimethyl acetal
FL/FR
woody
thuja occidentalis leaf oil
FL/FR
 
Potential Uses:
FRbergamot
FL/FRcaraway seed
FRcardamom oil replacer
FRcranberry
FRcumin oil replacer
FRgingergrass
FRhop
FRhuckleberry
FRlavandin
FRroot beer
FRspearmint
FRvanilla
 
Occurrence (nature, food, other):note
 amomum testaceum ridl. fruit oil malaysia @ 1.70%
Data GC Search Trop Picture
 angelica root oil @ 0.10%
Data GC Search Trop Picture
 bay laurel leaf
Search Trop Picture
 bergamot plant wild
Search Trop Picture
 caraway oil
Search Trop Picture
 caraway plant
Search Trop Picture
 caraway seed oil @ 0.10%
Data GC Search Trop Picture
 chamomile sweet false chamomile plant
Search Trop Picture
 ginger rhizome
Search Trop Picture
 gingergrass
Search Trop Picture
 lavandin
Search PMC Picture
 mandarin oil uruguay @ 0.02-0.03%
Data GC Search Trop Picture
 orange peel oil bitter china @ 0.01%
Data GC Search Trop Picture
 perilla
Search Trop Picture
 rose oil otto bulgaria @ 0.05%
Data GC Search Trop Picture
 savin
Search Trop Picture
 savory winter savory plant
Search Trop Picture
 spearmint leaf
Search Trop Picture
 spearmint oil
Search Trop Picture
 turmeric root oil hydrodistilled @ 0.17%
Data GC Search Trop Picture
 wormseed oil spain @ 0.15%
Data GC Search Trop Picture
 
Synonyms:
 cyclohex-1-ene-1-methanol, 4-(1-methylethenyl)-
1-cyclohexene-1-methanol, 4-(1-methylethenyl)
 dihydro cuminyl alcohol
 hydrocumin alcohol
1-hydroxymethyl-4-isopropenyl-1-cyclohexene
p-mentha-1,8-dien-7-ol
para-mentha-1,8-dien-7-ol
 menthadien-7-carbinol
1,8-p-menthadien-7-ol
4-(1-methyl ethenyl)-1-cyclohexene-1-methanol
[4-(1-methylethenyl)-1-cyclohexen-1-yl]methanol
4-(1-methylethenyl)-1-cyclohexene-1-methanol
 perillic alcohol
 perillol
(4-prop-1-en-2-yl-1-cyclohexenyl)methanol
[4-(prop-1-en-2-yl)cyclohex-1-en-1-yl]methanol
4-isopropenyl cyclohex-1-en-1-yl methanol
4-isopropenyl cyclohex-1-ene-1-methanol
4-isopropenyl cyclohex-1-enyl methanol
(4-isopropenyl-1-cyclohexen-1-yl)methanol
4-isopropenyl-1-cyclohexene carbinol
4-isopropenyl-1-cyclohexenecarbinol
4-isopropenyl-1-cyclohexenyl methanol
4-isopropenyl-cyclohex-1-ene-1-methanol
4-isopropenyl-cyclohex-1-enylmethanol
4-isopropenylcyclohex-1-en-1-ylmethanol
4-isopropenylcyclohex-1-enyl methanol
4-isopropenylcyclohex-1-enylmethanol
 

Articles:

US Patents:3,993,604 - Alicyclic compounds, their use and process for preparing same
PubMed:Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives.
PubMed:Gene discovery for enzymes involved in limonene modification or utilization by the mountain pine beetle-associated pathogen Grosmannia clavigera.
PubMed:Influence of culture conditions on the biotransformation of (+)-limonene by Aspergillus niger.
PubMed:A Novel Temozolomide-Perillyl Alcohol Conjugate Exhibits Superior Activity against Breast Cancer Cells In Vitro and Intracranial Triple-Negative Tumor Growth In Vivo.
PubMed:A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option.
PubMed:Long-term outcome in patients with recurrent malignant glioma treated with Perillyl alcohol inhalation.
PubMed:Perillyl alcohol suppresses antigen-induced immune responses in the lung.
PubMed:Chemical composition and mosquito repellency of essential oil of Conyza newii propagated in different geographical locations of Kenya.
PubMed:Intranasal administration of perillyl alcohol activates peripheral and bronchus-associated immune system in vivo.
PubMed:Chemoprevention gene therapy (CGT) of pancreatic cancer using perillyl alcohol and a novel chimeric serotype cancer terminator virus.
PubMed:Skin repair properties of d-Limonene and perillyl alcohol in murine models.
PubMed:Anti-stress effects of d-limonene and its metabolite perillyl alcohol.
PubMed:Influence of GSTM1 and GSTT1 polymorphisms on the survival rate of patients with malignant glioma under perillyl alcohol-based therapy.
PubMed:eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase.
PubMed:Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production.
PubMed:Perillyl alcohol as a protective modulator against rat hepatocarcinogenesis via amelioration of oxidative damage and cell proliferation.
PubMed:Double reduction of cyclic aromatic sulfonamides: synthesis of (+)-mesembrine and (+)-mesembranol.
PubMed:4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K(+)-ATPase and Ras oncogene activity in cancer cells.
PubMed:Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin.
PubMed:Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL.
PubMed:Perillyl alcohol causes G1 arrest through p15(INK4b) and p21(WAF1/Cip1) induction.
PubMed:Perillyl alcohol for the treatment of temozolomide-resistant gliomas.
PubMed:The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells.
PubMed:Chemoprevention of hepatocarcinogenesis with dietary isoprenic derivatives: cellular and molecular aspects.
PubMed:Growth-inhibiting effects of Paeonia lactiflora root steam distillate constituents and structurally related compounds on human intestinal bacteria.
PubMed:Analysis of EGF+61A>G polymorphism and EGF serum levels in Brazilian glioma patients treated with perillyl alcohol-based therapy.
PubMed:Microbial hydroxylation of S-(-)-perillyl alcohol by Fusarium heterosporium.
PubMed:Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activities.
PubMed:Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.
PubMed:Anticancer efficacy of perillyl alcohol-bearing PLGA microparticles.
PubMed:Influence of the active compounds of Perilla frutescens leaves on lipid membranes.
PubMed:Nonmelanoma skin cancer chemoprevention.
PubMed:An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.
PubMed:Cell physiology rather than enzyme kinetics can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization.
PubMed:Evaluation of the antioxidant and antiproliferative potential of bioflavors.
PubMed:Prevention of transplant coronary artery disease by prenylation inhibitors.
PubMed:Mechanism of statin-induced contractile dysfunction in rat cultured skeletal myofibers.
PubMed:Perillyl alcohol protects against ethanol induced acute liver injury in Wistar rats by inhibiting oxidative stress, NFκ-B activation and proinflammatory cytokine production.
PubMed:Chemo-resistant protein expression pattern of glioblastoma cells (A172) to perillyl alcohol.
PubMed:Nonsurgical innovations in the treatment of nonmelanoma skin cancer.
PubMed:The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor.
PubMed:Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma.
PubMed:Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids.
PubMed:The promise of natural products for blocking early events in skin carcinogenesis.
PubMed:A phase 2a study of topical perillyl alcohol cream for chemoprevention of skin cancer.
PubMed:Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol.
PubMed:(1S,2R,4S)-1-[(Benzyl-amino)-meth-yl]-4-(prop-1-en-2-yl)cyclo-hexane-1,2-diol.
PubMed:Pharmacotherapy of actinic keratosis.
PubMed:Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of lewis lung carcinoma.
PubMed:Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin.
PubMed:Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system.
PubMed:Possible contribution of beta-glycosidases and caspases in the cytotoxicity of novel glycoconjugates in colon cancer cells.
PubMed:[Natural compounds in chemoprevention of esophageal squamous cell tumors--experimental studies].
PubMed:Components of lemon essential oil attenuate dementia induced by scopolamine.
PubMed:GO Explorer: A gene-ontology tool to aid in the interpretation of shotgun proteomics data.
PubMed:Anti-thrombin as a prognostic biomarker candidate for patients with recurrent glioblastoma multiform under treatment with perillyl alcohol.
PubMed:Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis.
PubMed:Correlation of tumor topography and peritumoral edema of recurrent malignant gliomas with therapeutic response to intranasal administration of perillyl alcohol.
PubMed:Gateways to clinical trials.
PubMed:High-performance liquid chromatographic and pharmacokinetic analyses of an intravenous submicron emulsion of perillyl alcohol in rats.
PubMed:Sensitive determination of monoterpene alcohols in urine by HPLC-FLD combined with ESI-MS detection after online-solid phase extraction of the monoterpene-coumarincarbamate derivates.
PubMed:Mechanism of in vitro pancreatic cancer cell growth inhibition by melanoma differentiation-associated gene-7/interleukin-24 and perillyl alcohol.
PubMed:Ras pathway activation in gliomas: a strategic target for intranasal administration of perillyl alcohol.
PubMed:Chemoprevention by perillyl alcohol coupled with viral gene therapy reduces pancreatic cancer pathogenesis.
PubMed:Fragrance material review on p-mentha-1,8-dien-7-ol.
PubMed:Discovery of new biocatalysts for the glycosylation of terpenoid scaffolds.
PubMed:Synthesis of phosphatidylated-monoterpene alcohols catalyzed by phospholipase D and their antiproliferative effects on human cancer cells.
PubMed:Biphenylalkylacetylhydroquinone ethers suppress the proliferation of murine B16 melanoma cells.
PubMed:A pilot study of perillyl alcohol in pancreatic cancer.
PubMed:Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma.
PubMed:Phase 1 study of topical perillyl alcohol cream for chemoprevention of skin cancer.
PubMed:Anti-inflammatory senescence actives 5203-L molecule to promote healthy aging and prolongation of lifespan.
PubMed:Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas.
PubMed:Perillyl Alcohol Protects Against Fe-NTA-Induced Nephrotoxicity and Early Tumor Promotional Events in Rat Experimental Model.
PubMed:Cloning of four genes involved in limonene hydroxylation from Enterobacter cowanii 6L.
PubMed:Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells.
PubMed:Phase II trial of daily oral perillyl alcohol (NSC 641066) in treatment-refractory metastatic breast cancer.
PubMed:Rab-small GTPases are involved in fluvastatin and pravastatin-induced vacuolation in rat skeletal myofibers.
PubMed:Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BP1 phosphorylation as well as eIF4E/eIF4G interactions in human tumor cells.
PubMed:Anaplastic oligodendroglioma responding favorably to intranasal delivery of perillyl alcohol: a case report and literature review.
PubMed:Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells.
PubMed:Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549.
PubMed:In vitro induction of apoptosis in U937 cells by perillyl alcohol with sensitization by pentoxifylline: increased BCL-2 and BAX protein expression.
PubMed:Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis.
PubMed:Evaluation of characteristic aroma compounds of Citrus natsudaidai Hayata (Natsudaidai) cold-pressed peel oil.
PubMed:Terpenoids as plant antioxidants.
PubMed:Perillyl alcohol induces c-Myc-dependent apoptosis in Bcr/Abl-transformed leukemia cells.
PubMed:Recent advances in the molecular genetics of malignant gliomas disclose targets for antitumor agent perillyl alcohol.
PubMed:Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells.
PubMed:Perillyl alcohol inhibits a calcium-dependent constitutive nuclear factor-kappaB pathway.
PubMed:Gateways to clinical trials.
PubMed:Regio- and stereoselective fungal oxyfunctionalisation of limonenes.
PubMed:Perillyl alcohol inhibits the expression and function of the androgen receptor in human prostate cancer cells.
PubMed:Protein and m-RNA expression of farnesyl-transferases, RhoA and RhoB in rat liver hepatocytes: action of perillyl alcohol and vitamin A in vivo.
PubMed:CaaX-prenyltransferases are essential for expression of genes involvedin the early stages of monoterpenoid biosynthetic pathway in Catharanthus roseus cells.
PubMed:Fumigant toxicity of the essential oils of some African plants against Anopheles gambiae sensu stricto.
PubMed:Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida.
PubMed:Perillyl alcohol induces apoptosis in human glioblastoma multiforme cells.
PubMed:Cancer preventive role of selected dietary factors.
PubMed:Effect of D-limonene on immune response in BALB/c mice with lymphoma.
PubMed:An HPLC method for quantitation of perillyl alcohol in a topical pharmaceutical cream formulation.
PubMed:A novel psychrotrophic fungus, Mortierella minutissima, for D-limonene biotransformation.
PubMed:Sle1ab mediates the aberrant activation of STAT3 and Ras-ERK signaling pathways in B lymphocytes.
PubMed:Species differences in the metabolism of (+)- and (-)-limonenes and their metabolites, carveols and carvones, by cytochrome P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits, dogs, monkeys, and humans.
PubMed:Clinical trials in cancer prevention: current results and perspectives for the future.
PubMed:A pilot surrogate end point biomarker trial of perillyl alcohol in breast neoplasia.
PubMed:R-(+)-perillyl alcohol-induced cell cycle changes, altered actin cytoskeleton, and decreased ras and p34(cdc2) expression in colonic adenocarcinoma SW480 cells.
PubMed:Monoterpenes enhanced the sensitivity of head and neck cancer cells to radiation treatment in vitro.
PubMed:Repellency of essential oils of some Kenyan plants against Anopheles gambiae.
PubMed:Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.
PubMed:Perillyl alcohol is an angiogenesis inhibitor.
PubMed:A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days.
PubMed:Effects of POH in combination with STI571 on the proliferation and apoptosis of K562 cells.
PubMed:Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test.
PubMed:Gateways to clinical trials.
PubMed:Using patients as their own controls for cost evaluation of phase I clinical trials.
PubMed:Perillyl alcohol inhibits human breast cancer cell growth in vitro and in vivo.
PubMed:Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects.
PubMed:Transformation of terpenes using a Picea abies suspension culture.
PubMed:Development of a perillyl alcohol topical cream formulation.
PubMed:Effect of antiproliferative agents on vascular function in normal and in vitro balloon-injured porcine coronary arteries.
PubMed:Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer.
PubMed:Gateways to clinical trials.
PubMed:Anti-leukemia effect of perillyl alcohol in Bcr/Abl-transformed cells indirectly inhibits signaling through Mek in a Ras- and Raf-independent fashion.
PubMed:Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia.
PubMed:Studies with cytotoxic agents suggest that apoptosis is not a major determinant of clonogenic death in neuroblastoma cells.
PubMed:Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro.
PubMed:Phase I trial of perillyl alcohol administered four times daily continuously.
PubMed:Skin cancer chemoprevention: strategies to save our skin.
PubMed:Perillyl alcohol mediated radiosensitization via augmentation of the Fas pathway in prostate cancer cells.
PubMed:In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometry.
PubMed:Perillyl alcohol as a radio-/chemosensitizer in malignant glioma.
PubMed:Phase II trial of perillyl alcohol in patients with metastatic colorectal cancer.
PubMed:Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis.
PubMed:Biotransformation of limonene by bacteria, fungi, yeasts, and plants.
PubMed:A phase I trial of perillyl alcohol in patients with advanced solid tumors.
PubMed:Monoterpene regulation of Ras and Ras-related protein expression.
PubMed:Mechanism-based in vitro screening of potential cancer chemopreventive agents.
PubMed:Micronutrients in cancer chemoprevention.
PubMed:Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis biomarkers in pancreatic cancer chemoprevention.
PubMed:Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme a reductase synthesis at the post-transcriptional level.
PubMed:Perillyl Alcohol Inhibits Breast Cell Migration without Affecting Cell Adhesion.
PubMed:Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model.
PubMed:Sensitive biomonitoring of monoterpene exposure by gas chromatographic-mass spectrometric measurement of hydroxy terpenes in urine.
PubMed:Monoterpenes inhibit proliferation of human colon cancer cells by modulating cell cycle-related protein expression.
PubMed:Phase I study of perillyl alcohol in patients with refractory malignancies.
PubMed:A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group Study E2E96.
PubMed:Effects of perillyl alcohol on melanoma in the TPras mouse model.
PubMed:Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.
PubMed:Weight-loss drugs and supplements: are there safer alternatives?
PubMed:Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.
PubMed:Sex differences in the metabolism of (+)- and (-)-limonene enantiomers to carveol and perillyl alcohol derivatives by cytochrome p450 enzymes in rat liver microsomes.
PubMed:Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol.
PubMed:Biotransformation of limonene by Pseudomonas putida.
PubMed:Chemopreventive efficacy of promising farnesyltransferase inhibitors.
PubMed:Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note.
PubMed:Phase I pharmacokinetic trial of perillyl alcohol (NSC 641066) in patients with refractory solid malignancies.
PubMed:Cytotoxicity and biotransformation of the anticancer drug perillyl alcohol in PC12 cells and in the rat.
PubMed:The state-of-the-art in chemoprevention of skin cancer.
PubMed:Cloning and expression of the limonene hydroxylase of Bacillus stearothermophilus BR388 and utilization in two-phase limonene conversions.
PubMed:Perillyl alcohol inhibits TCR-mediated [Ca(2+)](i) signaling, alters cell shape and motility, and induces apoptosis in T lymphocytes.
PubMed:Prenylation inhibitors to treat proliferative renal disease.
PubMed:Correlation of chemopreventive efficacy data from the human epidermal cell assay with in vivo data.
PubMed:Progress in cancer chemoprevention: development of diet-derived chemopreventive agents.
PubMed:Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day.
PubMed:Perillyl alcohol, an inhibitor of geranylgeranyl transferase, induces apoptosis of immortalized human vascular smooth muscle cells in vitro.
PubMed:Progress in cancer chemoprevention.
PubMed:Drug development in prostate cancer.
PubMed:Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines.
PubMed:Induction of AP-1 activity by perillyl alcohol in breast cancer cells.
PubMed:Enhancement of sterol synthesis by the monoterpene perillyl alcohol is unaffected by competitive 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.
PubMed:Gas chromatographic-mass spectrometric analysis of perillyl alcohol and metabolites in plasma.
PubMed:Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene.
PubMed:Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors.
PubMed:Activation of the transforming growth factor beta signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol.
PubMed:Prevention and therapy of cancer by dietary monoterpenes.
PubMed:Inhibition of protein prenylation by metabolites of limonene.
PubMed:Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4.
PubMed:Perillyl alcohol: applications in oncology.
PubMed:Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines.
PubMed:Modulation of small G protein isoprenylation by anticancer monoterpenes in in situ mammary gland epithelial cells.
PubMed:Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells.
PubMed:Phase I clinical trial of perillyl alcohol administered daily.
PubMed:Monoterpenes in breast cancer chemoprevention.
PubMed:Inhibitory effects of perillyl alcohol on UVB-induced murine skin cancer and AP-1 transactivation.
PubMed:Quantification of carvone, cineole, perillaldehyde, perillyl alcohol and sobrerol by isocratic high-performance liquid chromatography.
PubMed:Clinical trials referral resource. Clinical trials with perillyl alcohol.
PubMed:Lysophosphatidic acid stimulates phospholipase D activity and cell proliferation in PC-3 human prostate cancer cells.
PubMed:Modulation of RAS expression in human malignant cells by dietary supplements.
PubMed:Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocarcinoma relative to untransformed ductal epithelial cells.
PubMed:Inhibition of type I and type II geranylgeranyl-protein transferases by the monoterpene perillyl alcohol in NIH3T3 cells.
PubMed:Total Synthesis of the Enantiomer of the Furanocembrane Rubifolide.
PubMed:Cancer chemoprevention and therapy by monoterpenes.
PubMed:Composition and antimalarial activity in vitro of the essential oil of Tetradenia riparia.
PubMed:Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo.
PubMed:Oral monoterpene therapy (perillyl alcohol) reduces vein graft intimal hyperplasia.
PubMed:Production of alpha-terpineol from Escherichia coli cells expressing thermostable limonene hydratase.
PubMed:Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol.
PubMed:Chemoprevention of colon carcinogenesis by dietary perillyl alcohol.
PubMed:Analysis of perillic acid in plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
PubMed:Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
PubMed:Prevention of mammary preneoplastic transformation by naturally-occurring tumor inhibitors.
PubMed:Inhibition of metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by limonene.
PubMed:Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.
PubMed:Chemoprevention of breast cancer.
PubMed:Clinical development plan: l-perillyl alcohol.
PubMed:Strategy and planning for chemopreventive drug development: clinical development plans II.
PubMed:New agents for cancer chemoprevention.
PubMed:Monoterpenes as regulators of malignant cell proliferation.
PubMed:Antitumorigenic effects of limonene and perillyl alcohol against pancreatic and breast cancer.
PubMed:Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo.
PubMed:Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents.
PubMed:Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol.
PubMed:Induction of differentiation in neuro-2A cells by the monoterpene perillyl alcohol.
PubMed:Promoting apoptosis.
PubMed:Differential effects of monoterpenes and lovastatin on RAS processing.
PubMed:Pharmacokinetics of active drug metabolites after oral administration of perillyl alcohol, an investigational antineoplastic agent, to the dog.
PubMed:Isoprenylation of proteins in the protozoan Giardia lamblia.
PubMed:The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol.
PubMed:Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol.
PubMed:Prevention and therapy of mammary cancer by monoterpenes.
PubMed:The chemoprevention of cancer by mevalonate-derived constituents of fruits and vegetables.
PubMed:Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation.
PubMed:Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association.
PubMed:Prenylated proteins and lymphocyte proliferation: inhibition by d-limonene related monoterpenes.
PubMed:Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol.
PubMed:Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene.
PubMed:[Constituents of essential oils from leaves, stems, and fruits of Perilla frutescens (L.) Britt].
PubMed:Monoterpene biosynthesis: specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint (Mentha spicata), and perilla (Perilla frutescens) leaves.
PubMed:Benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II from Acinetobacter calcoaceticus. Substrate specificities and inhibition studies.
PubMed:Metabolism of alpha-terpineol by Pseudomonas incognita.
PubMed:Monographs on fragrance raw materials.
PubMed:Microbiological transformations of terpenes. XIV. Purification & properties of perillyl alcohol dehydrogenase.
PubMed:Perillyl alcohol dehydrogenase from a soil pseudomonad.
 
Notes:
inhibits geranylgeranyl transferase. Perillyl alcohol is a monoterpene isolated from the essential oils of lavendin, peppermint, spearmint, cherries, celery seeds, and several other plants. In animal studies it has been shown to regress pancreatic, mammary, and liver tumors, to exhibit possible application as a chemopreventative agent for colon, skin, and lung cancer, and as a chemotherapeutic agent for neuroblastoma, and prostate and colon cancer.(PMID: 9855569) [HMDB] Occurs in a variety of essential oils, e.g. lavender
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