EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

decanoic acid, 1,2,3-propanetriyl ester

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CAS Number: 621-71-6Picture of molecule3D/inchi
Other(deleted CASRN):17263-37-5
ECHA EINECS - REACH Pre-Reg:210-702-0
Nikkaji Web:J95.465I
Beilstein Number:1717683
XlogP3-AA:12.20 (est)
Molecular Weight:554.85234000
Formula:C33 H62 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:emollients, solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 578.59 °C. @ 760.00 mm Hg (est)
Flash Point: 452.00 °F. TCC ( 233.30 °C. ) (est)
logP (o/w): 12.444 (est)
Soluble in:
 water, 1.334e-008 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: fragrance
skin conditioning
skin conditioning - emollient
Captex 1000
BOC Sciences
For experimental / research use only.
ASTM D6584 Tricaprin Solution, Internal Standard #2 95%
For experimental / research use only.
Santa Cruz Biotechnology
For experimental / research use only.
Glyceryl tridecanoate
Sigma-Aldrich: Sigma
For experimental / research use only.
Glyceryl tridecanoate ≥99% (GC)
For experimental / research use only.
Tricaprin >98.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 > 10000 mg/kg
Acta Physiologica Scandinavica. Vol. 40, Pg. 338, 1957.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
emollients, solvents
Recommendation for tricaprin usage levels up to:
 not for fragrance use.
Recommendation for tricaprin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):621-71-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :69310
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
2,3-di(decanoyloxy)propyl decanoate
RTECS:HE0100000 for cas# 621-71-6
 2,3-di(decanoyloxy)propyl decanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:621-71-6
Pubchem (cid):69310
Pubchem (sid):135027244
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Metabolomics Database:Search
HMDB (The Human Metabolome Database):HMDB00548
Export Tariff Code:2915.90.5050
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 capric acid triglyceride
 captex 1000
 decanoic acid, 1,2,3-propanetriyl ester
 decanoin, tri-
 dynasan 110
 glycerin tricaprate
 glycerol tricaprate
 glycerol tricaprin
 glycerol tridecanoate
 glycerol tris(decanoate)
 glyceryl tridecanoate
 propane-1,2,3-triyl tridecanoate
1,2,3-propanetriyl tridecanoate
1,2,3-propanol tridecanoate
 tricapric glyceride


PubMed:Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.
PubMed:Protein engineering of Bacillus thermocatenulatus lipase via deletion of the α5 helix.
PubMed:Liquid extraction surface analysis (LESA) of hydrophobic TLC plates coupled to chip-based nanoelectrospray high-resolution mass spectrometry.
PubMed:Charge-mediated topical delivery of plasmid DNA with cationic lipid nanoparticles to the skin.
PubMed:A cold-adapted and organic solvent-tolerant lipase from a psychrotrophic bacterium Pseudomonas sp. strain YY31: identification, cloning, and characterization.
PubMed:Long-term stable cationic solid lipid nanoparticles for the enhanced intracellular delivery of SMAD3 antisense oligonucleotides in activated murine macrophages.
PubMed:Evolution of fat crystal network microstructure followed by NMR.
PubMed:Evaluation of a mucoadhesive lipid-based bioerodable tablet compared with Biotène mouthwash for dry mouth relief--a pilot study.
PubMed:Fatty acid selectivity of lipases during acidolysis reaction between oleic acid and monoacid triacylglycerols.
PubMed:Solid lipid nanoparticles as delivery systems for bromocriptine.
PubMed:Novel cationic solid lipid nanoparticles enhanced p53 gene transfer to lung cancer cells.
PubMed:Isolation of lipase producing Bacillus sp. from olive mill wastewater and improving its enzyme activity.
PubMed:A novel organic solvent tolerant lipase from Bacillus sphaericus 205y: extracellular expression of a novel OST-lipase gene.
PubMed:Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides.
PubMed:Inhibitory effect of lysophosphatidylcholine on pancreatic lipase-mediated hydrolysis in lipid emulsion.
PubMed:Enzymatic synthesis of medium-chain triglycerides in a solvent-free system.
PubMed:Effect of additives on the release of a model protein from PLGA microspheres.
PubMed:A supercritical fluid-based coating technology. 2: solubility considerations.
PubMed:Formulation parameters determining the physicochemical characteristics of solid lipid nanoparticles loaded with all-trans retinoic acid.
PubMed:Effect of tricaprin on the physical characteristics and in vitro release of etoposide from PLGA microspheres.
PubMed:Process development for production of medium chain triglycerides using immobilized lipase in a solvent-free system.
PubMed:Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length.
PubMed:Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.
PubMed:Effect of additives on stability of etoposide in PLGA microspheres.
PubMed:Structure of mono-acid even-numbered beta-triacylglycerols.
PubMed:Tricaproin, tricaprin and trilaurin are utilized more efficiently than tricaprylin by carp (Cyprinus carpio L.) larvae.
PubMed:Preexercise medium-chain triglyceride ingestion does not alter muscle glycogen use during exercise.
PubMed:A novel frameshift mutation in exon 6 (the site of Asn 291) of the lipoprotein lipase gene in type I hyperlipidemia.
PubMed:Physical behavior of lipase substrates.
PubMed:An improved GLC method for a rapid, simultaneous analysis of both medium chain fatty acids and medium chain triglycerides in plasma.
PubMed:Plasma ketone levels in neonatal calves fed medium chain triglycerides in milk.
PubMed:A study on the values computed by dieticians and chemical analysis of fats, cholesterol, and P/S ratio in food.
PubMed:Type I hyperlipoproteinemia caused by lipoprotein lipase defect in lipid-interface recognition was relieved by administration of medium-chain triglyceride.
PubMed:Medium-chain triacylglycerols enhance release of cholecystokinin in chicks.
PubMed:Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats.
PubMed:The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat.
PubMed:Effect of triglyceride on small intestinal absorption of cefoxitin in rats.
PubMed:Hepatic triacylglycerol lipase in circulating blood of normal and tumor-bearing mice and its hydrolysis of very-low-density lipoprotein and synthetic acylglycerols.
PubMed:Effects of dietary triglycerides on serum and liver lipids and sterol excretion of rats.
PubMed:Substrate specificities of lipases from corn and other seeds.
PubMed:[Effect of short- or medium-chain fatty acids on cholesterol dynamics in the rat].
PubMed:Purification and properties of lipase from Rhizopus japonicus.
PubMed:Histological effects of lipids on the liver and spleen of mice.
PubMed:Effects of simple lipids on macrophages in vitro.
PubMed:Lipase from Pseudomonas fragi. II. Properties of the Enzyme.
Used in dietary food products TG(10:0/10:0/10:0) or tricapric glyceride is a tridecanoic acid triglyceride or medium chain triglyceride. Triglycerides (TGs) are also known as triacylglycerols or triacylglycerides, meaning that they are glycerides in which the glycerol is esterified with three fatty acid groups (i.e. fatty acid tri-esters of glycerol). TGs may be divided into three general types with respect to their acyl substituents. They are simple or monoacid if they contain only one type of fatty acid, diacid if they contain two types of fatty acids and triacid if three different acyl groups. Chain lengths of the fatty acids in naturally occurring triglycerides can be of varying lengths and saturations but 16, 18 and 20 carbons are the most common. TG(10:0/10:0/10:0), in particular, consists of one chain of decanoic acid at the C-1 position, one chain of decanoic acid at the C-2 position and one chain of decanoic acid acid at the C-3 position. TGs are the main constituent of vegetable oil and animal fats. TGs are major components of very low density lipoprotein (VLDL) and chylomicrons, play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice the energy (9 kcal/g) of carbohydrates and proteins. In the intestine, triglycerides are split into glycerol and fatty acids (this process is called lipolysis) with the help of lipases and bile secretions, which can then move into blood vessels. The triglycerides are rebuilt in the blood from their fragments and become constituents of lipoproteins, which deliver the fatty acids to and from fat cells among other functions. Various tissues can release the free fatty acids and take them up as a source of energy. Fat cells can synthesize and store triglycerides. When the body requires fatty acids as an energy source, the hormone glucagon signals the breakdown of the triglycerides by hormone-sensitive lipase to release free fatty acids. As the brain cannot utilize fatty acids as an energy source, the glycerol component of triglycerides can be converted into glucose for brain fuel when it is broken down. (,; ; TAGs can serve as fatty acid stores in all cells, but primarily in adipocytes of adipose tissue. The major building block for the synthesis of triacylglycerides, in non-adipose tissue, is glycerol. Adipocytes lack glycerol kinase and so must use another route to TAG synthesis. Specifically, dihydroxyacetone phosphate (DHAP), which is produced during glycolysis, is the precursor for TAG synthesis in adipose tissue. DHAP can also serve as a TAG precursor in non-adipose tissues, but does so to a much lesser extent than glycerol. The use of DHAP for the TAG backbone depends on whether the synthesis of the TAGs occurs in the mitochondria and ER or the ER and the peroxisomes. The ER/mitochondria pathway requires the action of glycerol-3-phosphate dehydrogenase to convert DHAP to glycerol-3-phosphate. Glycerol-3-phosphate acyltransferase then esterifies a fatty acid to glycerol-3-phosphate thereby generating lysophosphatidic acid. The ER/peroxisome reaction pathway uses the peroxisomal enzyme DHAP acyltransferase to acylate DHAP to acyl-DHAP which is then reduced by acyl-DHAP reductase. The fatty acids that are incorporated into TAGs are activated to acyl-CoAs through the action of acyl-CoA synthetases. Two molecules of acyl-CoA are esterified to glycerol-3-phosphate to yield 1,2-diacylglycerol phosphate (also known as phosphatidic acid). The phosphate is then removed by phosphatidic acid phosphatase (PAP1), to generate 1,2-diacylglycerol. This diacylglycerol serves as the substrate for addition of the third fatty acid to make TAG. Intestinal monoacylglycerols, derived from dietary fats, can also serve as substrates for the synthesis of 1,2-diacylglycerols.
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