EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 540-97-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-762-8
Nikkaji Web:J120.965E
Molecular Weight:444.92592000
Formula:C12 H36 O6 Si6
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96720 @ 25.00 °C.
Refractive Index:1.40150 @ 20.00 °C.
Melting Point: -3.00 °C. @ 760.00 mm Hg
Boiling Point: 245.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.022500 mmHg @ 25.00 °C. (est)
Flash Point: 256.00 °F. TCC ( 124.40 °C. ) (est)
Soluble in:
 water, 0.005007 mg/L @ 25 °C (est)
 water, 0.0051 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
skin conditioning - emollient
BOC Sciences
For experimental / research use only.
Odor: characteristic
Use: A cyclic volatile methylsiloxane (cVMS) used in cosmetic and personal care products. Used in dermal exposure
Sigma-Aldrich: Aldrich
For experimental / research use only.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 50000 mg/kg
National Technical Information Service. Vol. OTS0572798

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for cyclohexasiloxane usage levels up to:
 not for fragrance use.
Recommendation for cyclohexasiloxane flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):540-97-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10911
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:540-97-6
Pubchem (cid):10911
Pubchem (sid):134975746
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
typically including dodecamethylcyclohexasiloxane (d6) with a general formula of (-si(ch3)2o-)x in a cyclic configuration, where x is generally less than 8, and more commonly x is 3-7. this formulation is commonly used in cosmetics.
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-
 cyclohexasiloxane, dodecamethyl-
 dodecamethyl cyclohexasiloxane


PubMed:Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada.
PubMed:Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout.
PubMed:Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment.
PubMed:Water-in-oil emulsions prepared by peptide-silicone hybrid polymers as active interfacial modifier: effects of silicone oil species on dispersion stability of emulsions.
PubMed:Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation.
PubMed:Concentrations in ambient air and emissions of cyclic volatile methylsiloxanes in Zurich, Switzerland.
PubMed:Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model.
PubMed:Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry.
PubMed:Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment.
PubMed:Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).
PubMed:Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air.
PubMed:Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China.
PubMed:Cyclic volatile methylsiloxanes in fish from the Baltic Sea.
PubMed:Junge relationships in measurement data for cyclic siloxanes in air.
PubMed:Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada.
PubMed:Chemical fate, latitudinal distribution and long-range transport of cyclic volatile methylsiloxanes in the global environment: a modeling assessment.
PubMed:Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants.
PubMed:Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol.
PubMed:Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
PubMed:Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program.
PubMed:Measuring chemical emissions from wet products--development of a new measurement technique.
PubMed:Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary.
PubMed:Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China.
PubMed:Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method.
PubMed:Determination of cyclic and linear siloxanes in soil samples by ultrasonic-assisted extraction and gas chromatography-mass spectrometry.
PubMed:Volatile siloxanes in the European arctic: assessment of sources and spatial distribution.
PubMed:Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures.
PubMed:Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.
PubMed:Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products.
PubMed:Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.
PubMed:[Residual chemicals in silicone rubber products for food contact use].
PubMed:Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.
PubMed:Cyclosiloxanes produce fatal liver and lung damage in mice.
PubMed:Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.
None found
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