EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 541-02-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-764-9
Nikkaji Web:J120.964G
Beilstein Number:1800166
Molecular Weight:370.77160000
Formula:C10 H30 O5 Si5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Appearance:colorless to pale yellow clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95930 @ 20.00 °C.
Refractive Index:1.39820 @ 20.00 °C.
Melting Point: -38.00 °C. @ 760.00 mm Hg
Boiling Point: 210.00 °C. @ 760.00 mm Hg
Boiling Point: 209.00 to 210.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.200000 mmHg @ 25.00 °C.
Flash Point: 204.00 °F. TCC ( 95.60 °C. ) (est)
logP (o/w): 5.200
Soluble in:
 water, 0.017 mg/L @ 25 °C (exp)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
skin conditioning - emollient
BOC Sciences
For experimental / research use only.
Decamethylcyclopentasiloxane >99.0%(GC)
Odor: characteristic
Use: A cyclic volatile methylsiloxane (cVMS) used in cosmetic and personal care products. Used in dermal exposure and inh
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
Indis NV
For experimental / research use only.
Cyclopentasiloxane (D5)
LanCos SI25
Sigma-Aldrich: Aldrich
For experimental / research use only.
Decamethylcyclopentasiloxane 97%
Siltech CF-955
Odor: characteristic
Use: Siltech®CF-955 is an excellent carrier for oils and greases and for active ingredients. Siltech®CF-955 can also be used as to clean various substrates where removal of greases, silicone fluids or waxes is important. Leaves a soft, silky feel in cosmetic formulations.
Universal Preserv-A-Chem Inc.
Cyclopentasiloxane; Dimethiconol
Odor: characteristic
Use: ABIL OSW 5 is also suitable as a conditioner that improves the structure of treated damaged hair after repeated permanent waving or oxidative dyeing.
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: Used for excellent spreading, fast evaporation leaving no residue or build-up, leaves a unique soft feel and lubricity; non-greasy feel, non-occlusive and non-irritating. Used in conditioners, hair sprays, face wash, body wash, make-up, sun care, antiperspirants, and deodorants.
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 24134 mg/kg
National Technical Information Service. Vol. OTS0572801

Dermal Toxicity:
skin-rabbit LD50 > 16 mL/kg
Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974.

Inhalation Toxicity:
inhalation-rat LC > 2700 mg/m3/4H
National Technical Information Service. Vol. OTS0572802

Safety in Use Information:
cosmetic agents
Recommendation for cyclopentasiloxane usage levels up to:
 not for fragrance use.
Recommendation for cyclopentasiloxane flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):541-02-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10913
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
RTECS:GY5945200 for cas# 541-02-6
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:541-02-6
Pubchem (cid):10913
Pubchem (sid):134975748
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
the combination of octamethylcyclotetrasiloxane, d4, with decamethylcyclopentasiloxane, d5, is commonly referred to as cyclomethicone which has a wide range of applications as a formulation aid in personal care products.[klykken pc et al; drug chem toxicol 22 (4): 655-77 (1999)] pubmed abstract
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 cyclopentasiloxane, 2,2,4,4,6,6,8,8,10,10-decamethyl-
 decamethyl cyclopentasiloxane
 dow corning 345
 silicon SF 1202
 union carbide 7158 silicone fluid


PubMed:Determination of soil-water sorption coefficients of volatile methyl siloxanes.
PubMed:Sensitive Method for Quantification of Octamethylcyclotetrasiloxane (D4) and Decamethylcyclopentasiloxane (D5) in End-Exhaled Air by Thermal Desorption Gas Chromatography Mass Spectrometry.
PubMed:Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic cod.
PubMed:Emissions of decamethylcyclopentasiloxane from Chicago.
PubMed:Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada.
PubMed:Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout.
PubMed:Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment.
PubMed:Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments.
PubMed:Compound allergy to a lipophilic gel containing vitamin E acetate and cyclopentasiloxane.
PubMed:Water-in-oil emulsions prepared by peptide-silicone hybrid polymers as active interfacial modifier: effects of silicone oil species on dispersion stability of emulsions.
PubMed:Composition and source identification of deposits forming in landfill gas (LFG) engines and effect of activated carbon treatment on deposit composition.
PubMed:Adsorption characteristics of siloxanes in landfill gas by the adsorption equilibrium test.
PubMed:Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation.
PubMed:Calibration and application of a passive air sampler (XAD-PAS) for volatile methyl siloxanes.
PubMed:Concentrations in ambient air and emissions of cyclic volatile methylsiloxanes in Zurich, Switzerland.
PubMed:Selected ion flow tube studies of several siloxanes.
PubMed:VOC contamination in hospital, from stationary sampling of a large panel of compounds, in view of healthcare workers and patients exposure assessment.
PubMed:Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model.
PubMed:Decamethylcyclopentasiloxane (D5) spiked sediment: bioaccumulation and toxicity to the benthic invertebrate Hyalella azteca.
PubMed:Fathead minnow (Pimephales promelas) embryo to adult exposure to decamethylcyclopentasiloxane (D5).
PubMed:Bioaccumulation of decamethylcyclopentasiloxane in perch in Swedish lakes.
PubMed:Occurrence of linear and cyclic volatile methylsiloxanes in wastewater, surface water and sediments from Catalonia.
PubMed:Uncertainty analysis using a fugacity-based multimedia mass-balance model: application of the updated EQC model to decamethylcyclopentasiloxane (D5).
PubMed:Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry.
PubMed:Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment.
PubMed:Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).
PubMed:Determination of the dietary biomagnification of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane with the rainbow trout (Oncorhynchus mykiss).
PubMed:Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air.
PubMed:Accounting for intended use application in characterizing the contributions of cyclopentasiloxane (D5) to aquatic loadings following personal care product use: antiperspirants, skin care products and hair care products.
PubMed:Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China.
PubMed:Cyclic volatile methylsiloxanes in fish from the Baltic Sea.
PubMed:Simulated use and wash-off release of decamethylcyclopentasiloxane used in anti-perspirants.
PubMed:Junge relationships in measurement data for cyclic siloxanes in air.
PubMed:Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada.
PubMed:Characterization of low-k dielectric SiCOH films deposited with decamethylcyclopentasiloxane and cyclohexane.
PubMed:Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants.
PubMed:Food web accumulation of cyclic siloxanes in Lake Mjøsa, Norway.
PubMed:Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol.
PubMed:Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
PubMed:An updated state of the science EQC model for evaluating chemical fate in the environment: application to D5 (decamethylcyclopentasiloxane).
PubMed:Ecotoxicity of siloxane D5 in soil.
PubMed:A study of pyrolysis of polymethylsiloxanes by Fourier transform infrared.
PubMed:Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program.
PubMed:Volatile organic compounds in small- and medium-sized commercial buildings in California.
PubMed:Measuring chemical emissions from wet products--development of a new measurement technique.
PubMed:Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary.
PubMed:BETR global--a geographically-explicit global-scale multimedia contaminant fate model.
PubMed:Determination of decamethylcyclopentasiloxane in river and estuarine sediments in the UK.
PubMed:Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China.
PubMed:Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method.
PubMed:Determination of cyclic and linear siloxanes in soil samples by ultrasonic-assisted extraction and gas chromatography-mass spectrometry.
PubMed:Volatile siloxanes in the European arctic: assessment of sources and spatial distribution.
PubMed:Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures.
PubMed:Concentrations and fate of decamethylcyclopentasiloxane (D(5)) in the atmosphere.
PubMed:Dynamic multi-phase partitioning of decamethylcyclopentasiloxane (D5) in river water.
PubMed:Determination of decamethylcyclopentasiloxane in air using commercial solid phase extraction cartridges.
PubMed:Active interfacial modifier: stabilization mechanism of water in silicone oil emulsions by peptide-silicone hybrid polymers.
PubMed:Study on penetration of titanium dioxide (TiO(2)) nanoparticles into intact and damaged skin in vitro.
PubMed:Quantitative analysis of volatile methylsiloxanes in waste-to-energy landfill biogases using direct APCI-MS/MS.
PubMed:Modelling concentrations of decamethylcyclopentasiloxane in two UK rivers using LF2000-WQX.
PubMed:Direct analysis of volatile methylsiloxanes in gaseous matrixes using atmospheric pressure chemical ionization-tandem mass spectrometry.
PubMed:Effect of ozone and relative humidity on the heterogeneous uptake of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane on model mineral dust aerosol components.
PubMed:Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.
PubMed:Effect of Aldrich humic acid on water-atmosphere transfer of decamethylcyclopentasiloxane.
PubMed:A mechanistic study of cyclic siloxane pyrolyses at low pressures.
PubMed:Determination of decamethylcyclopentasiloxane in river water and final effluent by headspace gas chromatography/mass spectrometry.
PubMed:[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa].
PubMed:Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.
PubMed:Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
PubMed:Protective effect of conditioning agents on Afro-ethnic hair chemically treated with thioglycolate-based straightening emulsion.
PubMed:Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products.
PubMed:Disposition of decamethylcyclopentasiloxane in Fischer 344 rats following single or repeated inhalation exposure to 14C-decamethylcyclopentasiloxane (14C-D5).
PubMed:In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).
PubMed:Fabrication of spatially periodic double roughness structures by directional viscous fingering and spinodal dewetting for water-repellent surfaces.
PubMed:Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).
PubMed:Recent progress in the determination of solid surface tensions from contact angles.
PubMed:In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes.
PubMed:A two-generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation.
PubMed:Novel anhydrous emulsions: formulation as controlled release vehicles.
PubMed:Interpretation of contact angle measurements on two different fluoropolymers for the determination of solid surface tension.
PubMed:Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.
PubMed:Highly activated, silicone entrapped, lipase.
PubMed:Beyond rheology modification: hydrophilically modified silicone elastomers provide new benefits.
PubMed:The measurement of conformational stability of proteins adsorbed on siloxanes.
PubMed:Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.
PubMed:Metabolites of hexamethyldisiloxane and decamethylcyclopentasiloxane in Fischer 344 rat urine--a comparison of a linear and a cyclic siloxane.
PubMed:Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.
PubMed:Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes.
PubMed:Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats.
PubMed:Induction of hepatic xenobiotic metabolizing enzymes in female Fischer-344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5).
PubMed:Cyclosiloxanes produce fatal liver and lung damage in mice.
PubMed:Inhalation toxicology of decamethylcyclopentasiloxane (D5) following a 3-month nose-only exposure in Fischer 344 rats.
PubMed:Toxicology and humoral immunity assessment of decamethylcyclopentasiloxane (D5) following a 1-month whole body inhalation exposure in Fischer 344 rats.
PubMed:Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.
None found
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