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octamethyl cyclotetrasiloxane
cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-

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CAS Number: 556-67-2Picture of molecule3D/inchi
Other(deleted CASRN):104986-37-0
ECHA EINECS - REACH Pre-Reg:209-136-7
Nikkaji Web:J428F
Beilstein Number:1787074
Molecular Weight:296.61728000
Formula:C8 H24 O4 Si4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.95600 @ 25.00 °C.
Refractive Index:1.39600 @ 20.00 °C.
Melting Point: 17.50 °C. @ 760.00 mm Hg
Boiling Point: 175.80 °C. @ 760.00 mm Hg
Vapor Pressure:1.600000 mmHg @ 25.00 °C. (est)
Flash Point: 140.00 °F. TCC ( 60.00 °C. )
logP (o/w): 5.100
Soluble in:
 water, 0.005 mg/L @ 25 °C (exp)
 water, 0.06124 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
skin conditioning - emollient
Santa Cruz Biotechnology
For experimental / research use only.
Octamethylcyclotetrasiloxane 98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Octamethyl Cyclotetrasiloxane 98%
For experimental / research use only.
Octamethylcyclotetrasiloxane >98.0%(GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1540 mg/kg
National Technical Information Service. Vol. OTS0538262

Dermal Toxicity:
skin-rabbit LD50 794 uL/kg
National Technical Information Service. Vol. OTS0538262

skin-rat LD50 1770 mg/kg
National Technical Information Service. Vol. OTS0538262

Inhalation Toxicity:
inhalation-rat LC50 36000 mg/m3/4H
National Technical Information Service. Vol. OTS0557551

Safety in Use Information:
cosmetic agents
Recommendation for octamethyl cyclotetrasiloxane usage levels up to:
 not for fragrance use.
Recommendation for octamethyl cyclotetrasiloxane flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):556-67-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :11169
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:556-67-2
Pubchem (cid):11169
Pubchem (sid):134976880
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Metabolomics Database:Search
UM BBD:Search
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2931.90.9010
the combination of octamethylcyclotetrasiloxane, d4, with decamethylcyclopentasiloxane, d5, is commonly referred to as cyclomethicone which has a wide range of applications as a formulation aid in personal care products.[klykken pc et al; drug chem toxicol 22 (4): 655-77 (1999)] pubmed abstract
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl-
 cyclotetrasiloxane, octamethyl-
 union carbide 7207
 volasil 244


PubMed:Trophic transfer of methyl siloxanes in the marine food web from coastal area of northern china.
PubMed:Nanorheology by atomic force microscopy.
PubMed:Regeneration of siloxane-exhausted activated carbon by advanced oxidation processes.
PubMed:Occurrence of cyclic and linear siloxanes in indoor air from Albany, New York, USA, and its implications for inhalation exposure.
PubMed:Fate of anthropogenic cyclic volatile methylsiloxanes in a wastewater treatment plant.
PubMed:Aggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment.
PubMed:Measurement of cyclic volatile methylsiloxanes in the aquatic environment using low-density polyethylene passive sampling devices using an in-field calibration study--challenges and guidance.
PubMed:Comment on "Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments".
PubMed:Organophosphate flame retardants and organosiloxanes in predatory freshwater fish from locations across Canada.
PubMed:Solvation force simulations in atomic force microscopy.
PubMed:Determination of soil-water sorption coefficients of volatile methylsiloxanes.
PubMed:Siloxanes removal from biogas by a lab-scale biotrickling filter inoculated with Pseudomonas aeruginosa S240.
PubMed:Biogas upgrading: optimal activated carbon properties for siloxane removal.
PubMed:Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry.
PubMed:Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic cod.
PubMed:Absorption of a linear (L2) and a cyclic (D4) siloxane using different oils: application to biogas treatment.
PubMed:Relevance of an organic solvent for absorption of siloxanes.
PubMed:Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada.
PubMed:Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout.
PubMed:Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment.
PubMed:Improving the efficiency of quantitative (1)H NMR: an innovative external standard-internal reference approach.
PubMed:Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments.
PubMed:Atomic force microscopy of confined liquids using the thermal bending fluctuations of the cantilever.
PubMed:Composition and source identification of deposits forming in landfill gas (LFG) engines and effect of activated carbon treatment on deposit composition.
PubMed:Adsorption characteristics of siloxanes in landfill gas by the adsorption equilibrium test.
PubMed:Pharmacodynamic models: parameterizing the hill equation, Michaelis-Menten, the logistic curve, and relationships among these models.
PubMed:Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation.
PubMed:Calibration and application of a passive air sampler (XAD-PAS) for volatile methyl siloxanes.
PubMed:Selected ion flow tube studies of several siloxanes.
PubMed:Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model.
PubMed:Fathead minnow (Pimephales promelas) embryo to adult exposure to decamethylcyclopentasiloxane (D5).
PubMed:Mechanism of diffusion slowdown in confined liquids.
PubMed:Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry.
PubMed:Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment.
PubMed:Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).
PubMed:Determination of the dietary biomagnification of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane with the rainbow trout (Oncorhynchus mykiss).
PubMed:Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air.
PubMed:Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China.
PubMed:Cyclic volatile methylsiloxanes in fish from the Baltic Sea.
PubMed:Junge relationships in measurement data for cyclic siloxanes in air.
PubMed:Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada.
PubMed:Comprehensive mass flow analysis of Swedish sludge contaminants.
PubMed:High refractive index polysiloxane as injectable, in situ curable accommodating intraocular lens.
PubMed:Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants.
PubMed:Food web accumulation of cyclic siloxanes in Lake Mjøsa, Norway.
PubMed:Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol.
PubMed:A surprise from 1954: siloxane equilibration is a simple, robust, and obvious polymer self-healing mechanism.
PubMed:Quantitative force and dissipation measurements in liquids using piezo-excited atomic force microscopy: a unifying theory.
PubMed:Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program.
PubMed:Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary.
PubMed:Confinement-dependent damping in a layered liquid.
PubMed:Unraveling the properties of octamethylcyclotetrasiloxane under nanoscale confinement: atomistic view of the liquidlike state from molecular dynamics simulation.
PubMed:Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China.
PubMed:Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method.
PubMed:Nonlinear rheology of a nanoconfined simple fluid.
PubMed:Volatile siloxanes in the European arctic: assessment of sources and spatial distribution.
PubMed:High-resolution friction force microscopy under electrochemical control.
PubMed:Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures.
PubMed:Do epitaxy and temperature affect oscillatory solvation forces?
PubMed:Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses.
PubMed:Dissipation and oscillatory solvation forces in confined liquids studied by small-amplitude atomic force spectroscopy.
PubMed:Quantitative analysis of volatile methylsiloxanes in waste-to-energy landfill biogases using direct APCI-MS/MS.
PubMed:Siloxane treatment by adsorption into porous materials.
PubMed:Direct analysis of volatile methylsiloxanes in gaseous matrixes using atmospheric pressure chemical ionization-tandem mass spectrometry.
PubMed:Effect of ozone and relative humidity on the heterogeneous uptake of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane on model mineral dust aerosol components.
PubMed:Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.
PubMed:Temperature dependence of solvation forces as measured in atomic force microscopy.
PubMed:Drainage of a nanoconfined simple fluid: rate effects on squeeze-out dynamics.
PubMed:Biological removal of siloxanes from landfill and digester gases: opportunities and challenges.
PubMed:A mechanistic study of cyclic siloxane pyrolyses at low pressures.
PubMed:Flow injection potentiometric determination of paraquat in formulations and biological samples.
PubMed:[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa].
PubMed:Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans.
PubMed:Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures?
PubMed:Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products.
PubMed:Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies.
PubMed:Effect of tip size on force measurement in atomic force microscopy.
PubMed:In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5).
PubMed:Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humans.
PubMed:Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)).
PubMed:Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats.
PubMed:Surface melting of octamethylcyclotetrasiloxane confined in controlled pore glasses: curvature effects observed by 1H NMR.
PubMed:An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens.
PubMed:A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation.
PubMed:Recent progress in the determination of solid surface tensions from contact angles.
PubMed:In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes.
PubMed:NMR cryoporometry with octamethylcyclotetrasiloxane as a probe liquid. Accessing large pores.
PubMed:Effect of octamethylcyclotetrasiloxane on methylation of bismuth by Methanosarcina barkeri.
PubMed:Density functional theory calculation of (29)Si NMR chemical shifts of organosiloxanes.
PubMed:Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy.
PubMed:Oscillatory dissipation of a simple confined liquid.
PubMed:Discrete solvation layering in confined binary liquids.
PubMed:Interpretation of contact angle measurements on two different fluoropolymers for the determination of solid surface tension.
PubMed:How confined lubricants diffuse during shear.
PubMed:Contact angle measurements with liquids consisting of bulky molecules.
PubMed:Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha.
PubMed:The measurement of conformational stability of proteins adsorbed on siloxanes.
PubMed:Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise.
PubMed:PBPK modeling advances understanding of D4 pharmacokinetics.
PubMed:Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.
PubMed:Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models.
PubMed:Further comments on the bioavailability of D4.
PubMed:Bioavailability of D4 after inhalation and implantation exposure to silicones.
PubMed:Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model.
PubMed:Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane.
PubMed:The effect of cyclic swelling (octamethylcyclotetrasiloxane) on the physical properties of silicone breast implant shells.
PubMed:Effect of interfacial liquid structuring on the coherence length in nanolubrication.
PubMed:Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats.
PubMed:Study of the advancing and receding contact angles: liquid sorption as a cause of contact angle hysteresis.
PubMed:Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation.
PubMed:The transport of octamethylcyclotetrasiloxane (D4) and polydimethylsiloxane (PDMS) in lightly cross-linked silicone rubber.
PubMed:Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay.
PubMed:Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.
PubMed:Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.
PubMed:Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.
PubMed:Permeation of substituted silanes and siloxanes through selected gloves and protective clothing.
PubMed:Genetic toxicity evaluation of octamethylcyclotetrasiloxane.
PubMed:Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes.
PubMed:Disposition of radioactivity in fischer 344 rats after single and multiple inhalation exposure to [(14)C]Octamethylcyclotetrasiloxane ([(14)C]D(4)).
PubMed:Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats.
PubMed:Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine.
PubMed:Microbial degradation of octamethylcyclotetrasiloxane.
PubMed:Cyclosiloxanes produce fatal liver and lung damage in mice.
PubMed:Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects.
PubMed:Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor.
PubMed:Protein denaturation induced by cyclic silicone.
PubMed:Drug microencapsulation by PLA/PLGA coacervation in the light of thermodynamics. 2. Parameters determining microsphere formation.
PubMed:Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study.
PubMed:Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.
PubMed:Extraction of octamethylcyclotetrasiloxane and its metabolites from biological matrices.
PubMed:Force-distance curves by AFM. A powerful technique for studying surface interactions.
PubMed:Silicone gel and octamethylcyclotetrasiloxane (D4) enhances antibody production to bovine serum albumin in mice.
PubMed:Cytotoxicity and membrane damage in vitro by inclusion complexes between gamma-cyclodextrin and siloxanes.
PubMed:Silicone gel and octamethylcyclotetrasiloxane potentiate antibody production to bovine serum albumin in mice.
PubMed:The adjuvancy of silicones: dependency on compartmentalization.
PubMed:Induction of type II collagen arthritis in the DA rat using silicone gels and oils as adjuvant.
PubMed:The effect of molecular weight and gel preparation on humoral adjuvancy of silicone oils and silicone gels.
PubMed:Octamethylcyclotetrasiloxane in aquatic sediments: toxicity and risk assessment.
PubMed:Ocular toxicity of low-molecular-weight components of silicone and fluorosilicone oils.
PubMed:Use of plasma polymerization for preparing silicone-coated membranes for possible use in blood oxygenators.
None found
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