EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

diethyl amine
2,2'-diethylamine

Sponsors

CAS Number: 109-89-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-716-3
FDA UNII:B035PIS86W
Nikkaji Web:J807I
Beilstein Number:0605268
MDL:MFCD00009032
CoE Number:10470
XlogP3:0.60 (est)
Molecular Weight:73.13867000
Formula:C4 H11 N
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm: Diethylamine
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.70400 to 0.70800 @ 20.00 °C.
Pounds per Gallon - (est).: 5.865 to 5.898
Refractive Index:1.38300 to 1.38700 @ 20.00 °C.
Melting Point: -5.00 to -4.50 °C. @ 760.00 mm Hg
Boiling Point: 55.00 to 58.00 °C. @ 760.00 mm Hg
Vapor Pressure:237.000000 mm/Hg @ 25.00 °C.
Vapor Density:2.5 ( Air = 1 )
Flash Point: -18.00 °F. TCC ( -27.78 °C. )
logP (o/w): 0.580
Soluble in:
 water, 4.369e+005 mg/L @ 25 °C (est)
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: ammoniacal
fishy ammoniacal
Odor Description:at 0.10 % in dipropylene glycol. fishy ammoniacal
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: buffering agents
masking agents
perfuming agents
 
Suppliers:
BASF
Diethylamine
Capot Chemical
Diethylamine
Eastman Chemical
Diethylamine
EMD Millipore
For experimental / research use only.
Diethylamine
Penta International
DIETHYLAMINE
Santa Cruz Biotechnology
For experimental / research use only.
Diethylamine ≥99%
Sarchem Laboratories
For experimental / research use only.
Diethylamine
Sigma-Aldrich
For experimental / research use only.
Diethylamine ≥99.5%
Silver Fern Chemical
Diethylamine
Odor: characteristic
Use: Diethylamine is used as a corrosion inhibitor and in the production of rubber, textiles, resins, electroplating, dyes and pharmaceuticals. It is also commonly found in many pesticides.
Taminco (Eastman)
diethylamine
TCI AMERICA
For experimental / research use only.
Diethylamine >99.0%(GC)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
F - Highly flammable.
R 11 - Highly flammable.
R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R 35 - Causes severe burns.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 03/09 - Keep in cool, well-ventilated place.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 540 mg/kg
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

intraperitoneal-rat LDLo 50 mg/kg
Farmakologiya i Toksikologiya Vol. 31, Pg. 238, 1968.

oral-mouse LD50 500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: SLEEP
Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.

intraperitoneal-mouse LD50 585 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977.

Dermal Toxicity:
skin-rabbit LD50 820 ul/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

Inhalation Toxicity:
inhalation-rat LC50 4000 ppm/4H
Archives of Environmental Health. Vol. 1, Pg. 343, 1960.

inhalation-rabbit LC50 20 gm/m3
"Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960Vol. -

inhalation-mammal (species unspecified) LC50 5000 mg/m3
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 80, 1975.

inhalation-mouse LCLo 3000 mg/m3/2H
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LIVER: FATTY LIVER DEGERATION BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 20(4), Pg. 28, 1955.

inhalation-rabbit LCLo 20000 mg/m3
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LIVER: FATTY LIVER DEGERATION LUNGS, THORAX, OR RESPIRATION: EMPHYSEMA
"Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960Vol. -, Pg. 176, 1960.

 
Safety in Use Information:
Category: indirect food additives: adhesives and components of coatings
Recommendation for diethyl amine usage levels up to:
 not for fragrance use.
 
Recommendation for diethyl amine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):109-89-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8021
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1154
WGK Germany:1
N-ethylethanamine
Chemidplus:0000109897
EPA/NOAA CAMEO:hazardous materials
RTECS:HZ8750000 for cas# 109-89-7
 
References:
 N-ethylethanamine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:109-89-7
Pubchem (cid):8021
Pubchem (sid):134974008
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
UM BBD:Search
HMDB (The Human Metabolome Database):Search
FooDB:FDB005767
Export Tariff Code:2921.19.1100
Haz-Map:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•98.5% minimum purity •grade of purity: technical: 99%
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 buffering agents
 
Occurrence (nature, food, other):note
 apple fruit
Search Trop Picture
 arum dioscoridis
Search Trop Picture
 barley seed
Search Trop Picture
 corn seed
Search Trop Picture
 dragonwort
Search Trop Picture
 grape fruit juice
Search Trop Picture
 spinach leaf
Search Trop Picture
 
Synonyms:
 diethylamine
2,2'-diethylamine
 diethylamine [UN1154] [Flammable liquid]
N-ethylethanamine
 

Articles:

PubMed:Systematic analysis of the ability of Nitric Oxide donors to dislodge biofilms formed by Salmonella enterica and Escherichia coli O157:H7.
PubMed:[Determination of enantiomeric impurity of timolol maleate in bulk substances and eye drops].
PubMed:Gas chromatography-mass spectrometry assessment of amines in Port wine and grape juice after fast chloroformate extraction/derivatization.
PubMed:Microwave-assisted extraction and determination of cyanuric acid residue in pet food samples by liquid chromatography-tandem mass spectrometry.
PubMed:Determination of melamine and its analogues in egg by gas chromatography-tandem mass spectrometry using an isotope dilution technique.
PubMed:Chiral stationary phases for separation of intermedine and lycopsamine enantiomers from Symphytum uplandicum.
PubMed:Determination of sulfonamides in swine muscle after salting-out assisted liquid extraction with acetonitrile coupled with back-extraction by a water/acetonitrile/dichloromethane ternary component system prior to high-performance liquid chromatography.
PubMed:[Determination of melamine and cyanuric acid in milk by gas chromatography-mass spectrometry].
PubMed:Simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry.
PubMed:Simultaneous determination of azaperone and azaperol in animal tissues by HPLC with confirmation by electrospray ionization mass spectrometry.
PubMed:Diagnostic determination of melamine and related compounds in kidney tissue by liquid chromatography/tandem mass spectrometry.
PubMed:Selective separation of the major whey proteins using ion exchange membranes.
PubMed:Alkynyl polysaccharides: synthesis of propargyl potato starch followed by subsequent derivatizations.
PubMed:A simple and rapid method for simultaneous determination of benzoic and sorbic acids in food using in-tube solid-phase microextraction coupled with high-performance liquid chromatography.
PubMed:HPLC determination and steady-state bioavailability study of levodropropizine sustained-release tablets in dogs.
PubMed:Synthesis of diethylamine-functionalized soybean oil.
PubMed:Mammary blood flow does not limit milk yield in lactating goats.
PubMed:Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparum.
PubMed:Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease.
PubMed:The analysis of beta-agonists by packed-column supercritical fluid chromatography with ultra-violet and atmospheric pressure chemical ionisation mass spectrometric detection.
PubMed:Dietary secondary amines and liver hepatoma in Port Harcourt, Nigeria.
PubMed:Local secretion of nitric oxide and the control of mammary blood flow.
PubMed:Effects of food, ceruletide and ranitidine on the pharmacokinetics of the oral cephalosporin S-1108 in humans.
PubMed:Increased exposure to dietary amines and nitrate in a population at high risk of oesophageal and gastric cancer in Kashmir (India).
PubMed:Modulation of mycotoxin and nitrosamine carcinogenesis by indole-3-carbinol: quantitative analysis of inhibition versus promotion.
PubMed:Determination of aliphatic amines in air by on-line solid-phase derivatization with HPLC-UV/FL.
PubMed:[The effect of lysine-enriched bread on the formation of N-nitrosamines from their precursors in the stomach of dogs].
PubMed:Ion-pair reverse-phase liquid chromatographic determination of amprolium in complete feeds and premixes.
PubMed:Possible underestimation of nitrosatable amine levels in artificial saliva extracts of children's rubber pacifiers and baby-bottle teats.
PubMed:The effect of food and time of administration on the absorption of diethylamine chromocarbe.
PubMed:Abundance of dimethylamine in seafoods: possible implications in the incidence of human cancer.
PubMed:Mutagenicity of pyrolysates from guanidine, ureide, secondary amines and polyamines found by the Salmonella/mammalian-microsome test.
PubMed:Failure to induce tumours in guinea-pigs after concurrent administration of nitrite and diethylamine.
 
Notes:
None found
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