cyclomethicone
polydimethylcyclosiloxane
 
Notes:
None found
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CAS Number: 69430-24-6 
FDA UNII: NMQ347994Z
Formula: unspecified
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.55 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antistatic agents
emollients
hair conditioning
humectants
solvents
viscosity controlling agents
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Suppliers:
Lonza Group
Gel Base SIL
Odor: characteristic
Use: Film-former with outstanding silky feel.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  > 16 ml/kg
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 578, 1993.

Dermal Toxicity:
skin-rabbit LD50 > 16 ml/kg
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 578, 1993.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for cyclomethicone usage levels up to:
 not for fragrance use.
 
Recommendation for cyclomethicone flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 69430-24-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
Chemidplus: 0069430246
EPA/NOAA CAMEO: hazardous materials
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References:
Canada Domestic Sub. List: 69430-24-6
Pubchem (sid): 135019244
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Other Information:
HMDB (The Human Metabolome Database): Search
Household Products: Search
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antistatic agents 
 emollients 
 humectants 
 solvents 
 viscosity controlling agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 cyclopolydimethyl siloxane
 cyclopolydimethylsiloxane
 dimethyl cyclopolysiloxane
 dimethylcyclopolysiloxane
 dow corning 344
 dow corning X 2-1401
 gel base SIL
 polydimethyl siloxy cyclics
 polydimethylcyclosiloxane
 sentry cyclomethicone
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Articles:
PubMed: Dry oil powders and oil foams stabilised by fluorinated clay platelet particles.
PubMed: Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.
PubMed: Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment.
PubMed: Tocopheryl acetate 20% spray for elimination of head louse infestation: a randomised controlled trial comparing with 1% permethrin creme rinse.
PubMed: Pilot study to evaluate the effect of topical dimethicone on clinical signs and skin barrier function in dogs with naturally occurring atopic dermatitis.
PubMed: Burns due to dimeticone with cyclometicone 5 excipient anti-lice lotion.
PubMed: Effectiveness of isopropyl myristate/cyclomethicone D5 solution of removing cuticular hydrocarbons from human head lice (Pediculus humanus capitis).
PubMed: Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
PubMed: [Head louce... an update].
PubMed: [In vitro efficacy of three novel delousing formulations against the head louse (Pediculus capitis L.)].
PubMed: Update on treatments for head lice.
PubMed: Update on treatments for head lice.
PubMed: Clinical efficacy evaluation of a novel barrier protection cream.
PubMed: Clinical safety evaluation of a novel barrier protection cream.
PubMed: Study of sensory properties of emollients used in cosmetics and their correlation with physicochemical properties.
PubMed: Novel anhydrous emulsions: formulation as controlled release vehicles.
PubMed: Effects of silicone emulsifiers on in vitro skin permeation of sunscreens from cosmetic emulsions.
PubMed: Texture optimization of water-in-oil emulsions.
PubMed: Stabilization of emulsions using polymeric surfactants based on inulin.
PubMed: Compound allergy to Vea Oil.
PubMed: O/W microemulsion as a vehicle for sunscreens.
PubMed: Migration of antioxidant additives from various polyolefinic plastics into oleaginous vehicles.
PubMed: Effect of occlusion on the percutaneous penetration of linoleic acid and glycerol.
PubMed: Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats.
PubMed: Effective sunscreen ingredients and cutaneous irritation in patients with rosacea.
PubMed: Rheology of siloxane-stabilized water in silicone emulsions.
PubMed: Study of a ternary diagram gel according to a methodology of experimental research.
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