EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

glyceryl trioctanoate
octanoic acid, 1,2,3-propanetriyl ester

Supplier Sponsors

Name:2,3-di(octanoyloxy)propyl octanoate
CAS Number: 538-23-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-686-5
FDA UNII:6P92858988
Nikkaji Web:J54.226A
Beilstein Number:1717202
MDL:MFCD00036236
XlogP3-AA:8.90 (est)
Molecular Weight:470.69070000
Formula:C27 H50 O6
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless to amber clear viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 9.00 to 11.00 °C. @ 760.00 mm Hg
Boiling Point: 232.00 to 234.00 °C. @ 760.00 mm Hg
Flash Point: 409.00 °F. TCC ( 209.30 °C. ) (est)
logP (o/w): 9.387 (est)
Soluble in:
 water, 0.4 mg/L @ 37 °C (exp)
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: emollients
masking agents
skin conditioning
solvents
 
Suppliers:
ABITEC
Captex 8000
Alzo International
Dermol G-38-E
American International Chemical, LLC.
Tricaprylin
BOC Sciences
For experimental / research use only.
TRIOCTANOIN >93.0%(GC)
ExtraSynthese
For experimental / research use only.
Tricaprylin
Kao Corporation
COCONAD RK
Flavor: characteristic
Edible oil, release agent for food processing, diluent for flavor. Additive for pharmaceuticals. Middle chain fatty acid triglyceride. High-security to bodies. Widely use for cosmetics, pharmaceuticals and foods. Accommodation to JP (Japan Pharmaceutical Excipients) as "middle chain triglyceride".
Santa Cruz Biotechnology
For experimental / research use only.
Glyceryl Trioctanoate ≥90%
Sigma-Aldrich: Sigma
For experimental / research use only.
Glyceryl trioctanoate ≥99%
Stepan Company
NEOBEE® 895
TCI AMERICA
For experimental / research use only.
Tricaprylin >93.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 33300 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 871, 1970.

oral-mouse LD50 29600 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 871, 1970.

intravenous-mouse LD50 3700 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Acta Physiologica Scandinavica. Vol. 40, Pg. 338, 1957.

intraperitoneal-mouse LD > 27800 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 871, 1970.

intraperitoneal-rat LD > 27800 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 871, 1970.

intravenous-rat LDLo 4000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 871, 1970.

Dermal Toxicity:
subcutaneous-rat LD > 27800 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 871, 1970.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: solvents
Recommendation for glyceryl trioctanoate usage levels up to:
 not for fragrance use.
 
Recommendation for glyceryl trioctanoate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NLM Hazardous Substances Data Bank:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):538-23-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10850
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:nwg
2,3-di(octanoyloxy)propyl octanoate
Chemidplus:0000538238
EPA/NOAA CAMEO:hazardous materials
RTECS:YJ7700000 for cas# 538-23-8
 
References:
 2,3-di(octanoyloxy)propyl octanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:538-23-8
Pubchem (cid):10850
Pubchem (sid):134978188
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C13044
HMDB (The Human Metabolome Database):HMDB11187
FooDB:FDB003135
Export Tariff Code:2915.90.1800
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emollients
 
Occurrence (nature, food, other):note
 natural product
 
Synonyms:
 caprylic acid 1,2,3-propanetriyl ester
 caprylic acid triglyceride
 caprylic acid, 1,2,3-propanetriyl ester
 caprylin
 captex 8000
 coconad RK
 dermol G-38-E
2,3-di(octanoyloxy)propyl octanoate
 glycerin tricaprylate
 glycerol tricaprylate
 glycerol trioctanoate
 glyceryl tricaprylate
 glyceryl trioctanoate
 maceight
 neobee 895
 octanoic acid 1,2,3-propanetriyl ester
 octanoic acid, 1,2,3-propanetriyl ester
 octanoin, tri-
1,2,3-tris-(octanoyl oxy) propane
2-octanoyloxy-1-(octanoyloxymethyl)ethyl octanoate
 panacete 800
 propane-1,2,3-triyl trioctanoate
1,2,3-propanetriol trioctanoate
1,2,3-propanetriyl trioctanoate
 sefsol 800
1,2,3-tri-N-octanoylglycerol
 tricaprilin
 tricaprylic glyceride
1,2,3-tricapryloylglycerol
 trioctanoin
 trioctanoylglycerol
1,2,3-trioctanoylglycerol
 trioctonoin
 

Articles:

PubMed:Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.
PubMed:Unit cell structure of water-filled monoolein in inverted hexagonal mesophase in the presence of incorporated tricaprylin and entrapped lysozyme.
PubMed:Effects of a Tricaprylin Emulsion on Anti-glomerular Basement Membrane Glomerulonephritis in Rats: In Vivo and in Silico Studies.
PubMed:Ligand specific variation in cardiac response to stimulation of peroxisome proliferator-activated receptor-alpha in spontaneously hypertensive rat.
PubMed:A broad pH range indicator-based spectrophotometric assay for true lipases using tributyrin and tricaprylin.
PubMed:First co-expression of a lipase and its specific foldase obtained by metagenomics.
PubMed:Refining in silico simulation to study digestion parameters affecting the bioaccessibility of lipophilic nutrients and micronutrients.
PubMed:Enhancing vitamin E bioaccessibility: factors impacting solubilization and hydrolysis of α-tocopherol acetate encapsulated in emulsion-based delivery systems.
PubMed:Rational design of K173A substitution enhances thermostability coupled with catalytic activity of Enterobacter sp. Bn12 lipase.
PubMed:Cloning and characterization of newly isolated lipase from Enterobacter sp. Bn12.
PubMed:Protein engineering of Bacillus thermocatenulatus lipase via deletion of the α5 helix.
PubMed:The role of the hydrophobic phase in the unique rheological properties of saponin adsorption layers.
PubMed:pH-responsive micelles based on caprylic acid.
PubMed:Liquid extraction surface analysis (LESA) of hydrophobic TLC plates coupled to chip-based nanoelectrospray high-resolution mass spectrometry.
PubMed:Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.
PubMed:Short-chain flavor ester synthesis in organic media by an E. coli whole-cell biocatalyst expressing a newly characterized heterologous lipase.
PubMed:Study of the effect of F17A mutation on characteristics of Bacillus thermocatenulatus lipase expressed in Pichia pastoris using in silico and experimental methods.
PubMed:Reversed hexagonal lyotropic liquid-crystal and open-shell glycodendrimers as potential vehicles for sustained release of sodium diclofenac.
PubMed:Characterization and a point mutational approach of a psychrophilic lipase from an arctic bacterium, Bacillus pumilus.
PubMed:The effect of oil type on the aggregation stability of nanostructured lipid carriers.
PubMed:Influence of N- and/or C-terminal regions on activity, expression, characteristics and structure of lipase from Geobacillus sp. 95.
PubMed:Influence of dietary fat type on benzo(a)pyrene [B(a)P] biotransformation in a B(a)P-induced mouse model of colon cancer.
PubMed:Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides.
PubMed:Cyclodextrin stabilised emulsions and cyclodextrinosomes.
PubMed:Structural characterization of lyotropic liquid crystals containing a dendrimer for solubilization and release of gallic acid.
PubMed:Synergistic antioxidant activity of milk sphingomyeline and its sphingoid base with α-tocopherol on fish oil triacylglycerol.
PubMed:Porcine pancreatic lipase related protein 2 has high triglyceride lipase activity in the absence of colipase.
PubMed:Influence of emulsifier structure on lipid bioaccessibility in oil-water nanoemulsions.
PubMed:Preparation and physicochemical properties of surfactant-free emulsions using electrolytic-reduction ion water containing lithium magnesium sodium silicate.
PubMed:Classification of ester oils according to their Equivalent Alkane Carbon Number (EACN) and asymmetry of fish diagrams of C10E4/ester oil/water systems.
PubMed:Isolation and biochemical characterization of Bacillus pumilus lipases from the Antarctic.
PubMed:Modifying the catalytic preference of tributyrin in Bacillus thermocatenulatus lipase through in-silico modeling of enzyme-substrate complex.
PubMed:Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism.
PubMed:Simultaneous detection of nonpolar and polar compounds by heat-assisted laser ablation electrospray ionization mass spectrometry.
PubMed:Chemically-specific dual/differential CARS micro-spectroscopy of saturated and unsaturated lipid droplets.
PubMed:Characterization of a new cold-adapted lipase from Pseudomonas sp. TK-3.
PubMed:Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein.
PubMed:Novel metagenome-derived, cold-adapted alkaline phospholipase with superior lipase activity as an intermediate between phospholipase and lipase.
PubMed:Activation of rat intestinal mucosal mast cells by fat absorption.
PubMed:High-throughput screening method for lipases/esterases.
PubMed:Lipolysis and structure controlled drug release from reversed hexagonal mesophase.
PubMed:Penetratin-induced transdermal delivery from H(II) mesophases of sodium diclofenac.
PubMed:Conformational changes of α-lactalbumin adsorbed at oil-water interfaces: interplay between protein structure and emulsion stability.
PubMed:Strategy for improving extracellular lipolytic activities by a novel thermotolerant Staphylococcus sp. strain.
PubMed:Identification and characterization of a new true lipase isolated through metagenomic approach.
PubMed:Structural rearrangement of β-lactoglobulin at different oil-water interfaces and its effect on emulsion stability.
PubMed:Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice.
PubMed:Hydrolysis of mixed monomolecular films of tricaprylin/dilauroylphosphatidylcholine by lipase and phospholipase A₂.
PubMed:Blood D-(-)-3-hydroxybutyrate concentrations after oral administration of trioctanoin, trinonanoin, or tridecanoin to newborn rhesus monkeys (Macaca mulatta).
PubMed:Solubilization of gabapentin into HII mesophases.
PubMed:Fervidobacterium changbaicum Lip1: identification, cloning, and characterization of the thermophilic lipase as a new member of bacterial lipase family V.
PubMed:Influence of cyclosporine A on molecular interactions in lyotropic reverse hexagonal liquid crystals.
PubMed:Pulmonary modulation of benzo[a]pyrene-induced hemato- and hepatotoxicity in broilers.
PubMed:Label-free imaging of lipophilic bioactive molecules during lipid digestion by multiplex coherent anti-Stokes Raman scattering microspectroscopy.
PubMed:Biochemical characterization and mutational improvement of a thermophilic esterase from Sulfolobus solfataricus P2.
PubMed:Structural rearrangements and interaction within H(II) mesophase induced by cosolubilization of vitamin E and ascorbic acid.
PubMed:Fatty acid selectivity of lipases during acidolysis reaction between oleic acid and monoacid triacylglycerols.
PubMed:Lysozyme entrapped within reverse hexagonal mesophases: physical properties and structural behavior.
PubMed:Soft matter dispersions with ordered inner structures, stabilized by ethoxylated phytosterols.
PubMed:Molecular dynamics simulations of functional group effects on solvation thermodynamics of model solutes in decane and tricaprylin.
PubMed:Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis.
PubMed:Molecular interactions in reverse hexagonal mesophase in the presence of Cyclosporin A.
PubMed:Esterification and hydrolytic activities of Candida rugosa lipase isoform 1 (LIP1) immobilized on celite 545, duolite A7, and sephadex G-25.
PubMed:Cloning and characterization of a new cold-active lipase from a deep-sea sediment metagenome.
PubMed:Solubilization of nutraceuticals into reverse hexagonal mesophases.
PubMed:Competition between lipases and monoglycerides at interfaces.
PubMed:Vehicle-dependent disposition kinetics of fluoranthene in Fisher-344 rats.
PubMed:Low viscosity reversed hexagonal mesophases induced by hydrophilic additives.
PubMed:From the microscopic to the mesoscopic properties of lyotropic reverse hexagonal liquid crystals.
PubMed:Action of Humicola lanuginosa lipase on mixed monomolecular films of tricaprylin and polyethylene glycol stearate.
PubMed:Quantitative solubility relationships and the effect of water uptake in triglyceride/monoglyceride microemulsions.
PubMed:A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity.
PubMed:Thermally induced fluid reversed hexagonal (H(II)) mesophase.
PubMed:[Microstructure of novel solid lipid nanoparticle loaded triptolide].
PubMed:Effect of permeation enhancers on the in vitro percutaneous absorption of pentazocine.
PubMed:Isolation of lipase producing Bacillus sp. from olive mill wastewater and improving its enzyme activity.
PubMed:Hexosome and hexagonal phases mediated by hydration and polymeric stabilizer.
PubMed:An HII liquid crystal-based delivery system for cyclosporin A: physical characterization.
PubMed:Synergistic stabilization of emulsions by a mixture of surface-active nanoparticles and surfactant.
PubMed:Kinetic model of 1,3-specific triacylglycerols alcoholysis catalyzed by lipases.
PubMed:Effects of protein composition and enzymatic activity on formation and properties of potato protein stabilized emulsions.
PubMed:Technological properties of Enterococcus faecium isolated from ewe's milk and cheese with importance for flavour development.
PubMed:Lymphatic transport of a physical mixture of medium- and long-chain TAG in rats.
PubMed:Stability of triglyceride liquid films on hydrophilic and hydrophobic glasses.
PubMed:Val-407 and Ile-408 in the beta5'-loop of pancreatic lipase mediate lipase-colipase interactions in the presence of bile salt micelles.
PubMed:Secretion of pro- and mature Rhizopus arrhizus lipases by Pichia pastoris and properties of the proteins.
PubMed:Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases.
PubMed:Multivesicular liposome formulation for the sustained delivery of breviscapine.
PubMed:An extracellular lipase from the dimorphic yeast Arxula adeninivorans: molecular cloning of the ALIP1 gene and characterization of the purified recombinant enzyme.
PubMed:Tricaprylin microemulsion for oral delivery of low molecular weight heparin conjugates.
PubMed:Transitions induced by solubilized fat into reverse hexagonal mesophases.
PubMed:Topical absorption of piroxicam from organogels--in vitro and in vivo correlations.
PubMed:Mutations in the "lid" region affect chain length specificity and thermostability of a Pseudomonas fragi lipase.
PubMed:Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides.
PubMed:Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach.
PubMed:Predictive relationships for the effects of triglyceride ester concentration and water uptake on solubility and partitioning of small molecules into lipid vehicles.
PubMed:Enzymatic synthesis of medium-chain triglycerides in a solvent-free system.
PubMed:Sequence-based approach to finding functional lipases from microbial genome databases.
PubMed:Structural characterisation of water-Tween 40/Imwitor 308-isopropyl myristate microemulsions using different experimental methods.
PubMed:[Effect of triester glycerol type of plasticizers on release of albumin from biodegradable polymer matrices].
PubMed:On the calculation of disjoining pressure isotherms for nonaqueous films.
PubMed:Quantitative evaluation of reconstruction methods after gastrectomy using a new type of examination: digestion and absorption test with stable isotope 13C-labeled lipid compound.
PubMed:The sustained granulopoietic effect of progenipoietin encapsulated in multivesicular liposomes.
PubMed:Preparation of a water-in-oil-in-water (W/O/W) type microcapsules by a single-droplet-drying method and change in encapsulation efficiency of a hydrophilic substance during storage.
PubMed:Influence of type and level of water-soluble additives on drug release and surface and mechanical properties of Surelease films.
PubMed:Influence of plasticizer type and coat level on Surelease film properties.
PubMed:Esterolytic and lipolytic activities of lactic acid bacteria isolated from ewe's milk and cheese.
PubMed:The beta 5' loop of the pancreatic lipase C2-like domain plays a critical role in the lipase-lipid interactions.
PubMed:Flavor production from edible oils and their constituents by Penicillium corylophilum.
PubMed:Process development for production of medium chain triglycerides using immobilized lipase in a solvent-free system.
PubMed:A comparison of the potential energy parameters of aliphatic alkanes: molecular dynamics simulations of triacylglycerols in the alpha phase.
PubMed:Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length.
PubMed:Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer.
PubMed:Influence of solvent absorption on the migration of Irganox 1076 from LDPE.
PubMed:Final report on the safety assessment of trilaurin, triarachidin, tribehenin, tricaprin, tricaprylin, trierucin, triheptanoin, triheptylundecanoin, triisononanoin, triisopalmitin, triisostearin, trilinolein, trimyristin, trioctanoin, triolein, tripalmitin, tripalmitolein, triricinolein, tristearin, triundecanoin, glyceryl triacetyl hydroxystearate, glyceryl triacetyl ricinoleate, and glyceryl stearate diacetate.
PubMed:Optimization of a thermostable lipase from Bacillus stearothermophilus P1: overexpression, purification, and characterization.
PubMed:Effects of gum arabic on lipase interfacial binding and activity.
PubMed:Characterisation and quantification of medium chain and long chain triglycerides and their in vitro digestion products, by HPTLC coupled with in situ densitometric analysis.
PubMed:The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice.
PubMed:Nutritional effects of enzymatically modified soybean oil with caprylic acid versus physical mixture analogue in obese Zucker rats.
PubMed:A novel extracellular esterase from Bacillus subtilis and its conversion to a monoacylglycerol hydrolase.
PubMed:Tricaproin, tricaprin and trilaurin are utilized more efficiently than tricaprylin by carp (Cyprinus carpio L.) larvae.
PubMed:Static and Dynamic Wetting Behavior of Triglycerides on Solid Surfaces.
PubMed:Biotransformation of the double bond in allyl glycidyl ether to an epoxide ring. Evidence from hemoglobin adducts in mice.
PubMed:Fat absorption after pylorus-preserving pancreatoduodenectomy reconstructed with Billroth II pancreaticojejunostomy or Billroth I pancreaticogastrostomy.
PubMed:Review of the toxicologic properties of medium-chain triglycerides.
PubMed:Enhancement of both reaction yield and rate of synthesis of structured triacylglycerol containing eicosapentaenoic acid under vacuum with water activity control.
PubMed:Coalescence of Lipid Emulsions in Floating and Freeze-Thawing Processes: Examination of the Coalescence Transition State Theory.
PubMed:Identification of the gene encoding esterase, a homolog of hormone-sensitive lipase, from an oil-degrading bacterium, strain HD-1.
PubMed:Human pancreatic lipase: colipase dependence and interfacial binding of lid domain mutants.
PubMed:Comparative tumorigenicity of 1- and 3-nitrobenzo[a]pyrenes, and 3,6- and 1,6-dinitrobenzo[a]pyrenes in F344/DuCrj rats.
PubMed:Total parenteral nutrition supplemented with medium-chain triacylglycerols prevents atrophy of the intestinal mucosa in septic rats.
PubMed:Nutrients regulate diamine oxidase release from intestinal mucosa.
PubMed:Identification of optimal conditions for the detection of benzo[a]pyrene-DNA adducts by enzyme-linked immunoadsorbent assays (ELISA).
PubMed:Bile salt-stimulated lipase and digestion of non-breast milk fat.
PubMed:Isolation and characterization of a tributyrin esterase from Lactobacillus plantarum 2739.
PubMed:Dibenzo[a,l]pyrene-induced DNA adduction, tumorigenicity, and Ki-ras oncogene mutations in strain A/J mouse lung.
PubMed:Effect of medium-chain triglyceride emulsion in total parenteral nutrition on experimental hepatic metastasis in the rat.
PubMed:Altered acyl chain length specificity of Rhizopus delemar lipase through mutagenesis and molecular modeling.
PubMed:Effects of carotenoid-rich food extracts on the development of preneoplastic lesions in rat liver and on in vivo and in vitro antioxidant status.
PubMed:Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV vary with chain length of intestinally infused fatty acids in rats.
PubMed:Estimation of fat absorption with the 13C-trioctanoin breath test after pancreatoduodenectomy or pancreatic head resection.
PubMed:Immobilization of a recombinant cutinase by entrapment and by covalent binding. Kinetic and stability studies.
PubMed:Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.
PubMed:Benzo[b]fluoranthene: tumorigenicity in strain A/J mouse lungs, DNA adducts and mutations in the Ki-ras oncogene.
PubMed:Incorporation of medium chain triacylglycerols into phospholipid bilayers: effect of long chain triacylglycerols, cholesterol, and cholesteryl esters.
PubMed:Biomarker alterations produced in rat lung by intratracheal instillations of air particulate extracts and chemoprevention with oral N-acetylcysteine.
PubMed:Developmental effects of trichloroacetonitrile administered in corn oil to pregnant Long-Evans rats.
PubMed:Transdermal delivery of dideoxynucleoside-type anti-HIV drugs. 2. The effect of vehicle and enhancer on skin permeation.
PubMed:Differential diagnosis of malignant tumours in the abdominal cavity of rats after intraperitoneal injection of crocidolite or benzo[a]pyrene.
PubMed:0/w-emulsion of alpha-linolenic acid stabilized with hydrophobized polysaccharide. Its effect on the growth of human colon cancer cells.
PubMed:Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A/J mice.
PubMed:Transdermal delivery of zalcitabine: in vitro skin permeation study.
PubMed:Coconut oil and beef tallow, but not tricaprylin, can replace menhaden oil in the diet of red drum (Sciaenops ocellatus) without adversely affecting growth or fatty acid composition.
PubMed:Covalent binding of polycyclic aromatic hydrocarbon components of manufactured gas plant residue to mouse lung and forestomach DNA.
PubMed:Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion: benzo[a]pyrene vs manufactured gas plant residue.
PubMed:An improved GLC method for a rapid, simultaneous analysis of both medium chain fatty acids and medium chain triglycerides in plasma.
PubMed:Fatty acid selectivity of a lipase purified from Vernonia galamensis seed.
PubMed:Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels.
PubMed:Transdermal delivery of theophylline using an ethanol/panasate 800-ethylcellulose gel preparation.
PubMed:Two-phase culture system for plant cells.
PubMed:Plasma ketone levels in neonatal calves fed medium chain triglycerides in milk.
PubMed:Alteration of chain length selectivity of a Rhizopus delemar lipase through site-directed mutagenesis.
PubMed:NTP Comparative Toxicology Studies of Corn Oil, Safflower Oil, and Tricaprylin (CAS Nos. 8001-30-7, 8001-23-8, and 538-23-8) in Male F344/N Rats as Vehicles for Gavage.
PubMed:Cyclopenta[cd]pyrene-induced tumorigenicity, Ki-ras codon 12 mutations and DNA adducts in strain A/J mouse lung.
PubMed:Skin permeability of various drugs with different lipophilicity.
PubMed:Effect of hydrophilic and lipophilic vehicles on skin permeation of tegafur, alclofenac and ibuprofen with or without permeation enhancers.
PubMed:Skin permeation enhancement of tegafur by ethanol/panasate 800 or ethanol/water binary vehicle and combined effect of fatty acids and fatty alcohols.
PubMed:Tumor promotion by an anticonvulsant agent, phenytoin, in mouse liver: correlation with CYP2B induction.
PubMed:Effect of various vehicles on ketoprofen permeation across excised hairless mouse skin.
PubMed:Purification and characterization of Pseudomonas fluorescens SIK W1 lipase expressed in Escherichia coli.
PubMed:Gelatin-acacia microcapsules for trapping micro oil droplets containing lipophilic drugs and ready disintegration in the gastrointestinal tract.
PubMed:Formation and persistence of safrole-DNA adducts over a 10,000-fold dose range in mouse liver.
PubMed:The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lung.
PubMed:Lipase activity in vesicular systems: characterization of candida cylindracea lipase and its activity in polymerizable dialkylammonium surfactant vesicles.
PubMed:Tensile properties of free films cast from aqueous ethylcellulose dispersions.
PubMed:Feeding behaviour in chickens given diets containing medium chain triglyceride.
PubMed:Enhancement effect of an ethanol/Panasate 800 binary vehicle on anti-inflammatory drug permeation across excised hairless mouse skin.
PubMed:13C-labeled trioctanoin breath test for exocrine pancreatic function test in patients after pancreatoduodenectomy.
PubMed:[13C] breath test of medium-chain triglycerides and oligosaccharides in neonates.
PubMed:Feeding behavior in rats fed diets containing medium chain triglyceride.
PubMed:Different effects of long-chain and medium-chain triglycerides on glucose oxidation during total parenteral nutrition.
PubMed:Medium-chain triacylglycerols enhance release of cholecystokinin in chicks.
PubMed:The effect of triacylglycerol chain length on food intake in domestic fowl.
PubMed:Effect of dietary medium chain triglyceride on protein and energy utilisation in growing chicks.
PubMed:[Preparation of stable W/O/W type multiple emulsion containing water-soluble drugs and in vitro evaluation of its drug-releasing properties].
PubMed:Effects of phorbol esters and secretagogues on nitrobenzylthioinosine binding to nucleoside transporters and nucleoside uptake in cultured chromaffin cells.
PubMed:The effect of pancreatic procolipase and colipase on pancreatic lipase activation.
PubMed:[Exocrine pancreatic function tests].
PubMed:Examination of factors that may influence disposition of benzo[a]pyrene in vivo: vehicles and asbestos.
PubMed:Lymphatic absorption of structured glycerolipids containing medium-chain fatty acids and linoleic acid, and their effect on cholesterol absorption in rats.
PubMed:Oncolytic effects of fatty acids in mice and rats.
PubMed:Metabolic and neurologic effects of an intravenous medium-chain triglyceride emulsion.
PubMed:[A clinical evaluation of reconstruction methods after pancreatoduodenectomy from a view of fat digestion and absorption].
PubMed:Control of nucleoside transport in neural cells. Effect of protein kinase C activation.
PubMed:Stereoselectivity of lipases. II. Stereoselective hydrolysis of triglycerides by gastric and pancreatic lipases.
PubMed:Topical effects of absorption enhancing agents on the rectal mucosa of rats in vivo.
PubMed:Medium-chain-triglyceride lipid emulsion: metabolism and tissue distribution.
PubMed:Limits of medium-chain and long-chain triacylglycerol utilization by neonatal piglets.
PubMed:Non-invasive assessment of intraluminal lipolysis using a 13CO2 breath test.
PubMed:Pulmonary carcinogenesis in rats given implants of shale oil in beeswax pellets.
PubMed:The effect of tricaprylin emulsion on protein turnover in scald burn rats.
PubMed:Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
PubMed:Comparative dose-response study on the pulmonary carcinogenicity of 1,6-dinitropyrene and benzo[a]pyrene in F344 rats.
PubMed:Developmental toxicity of dichloroacetonitrile: a by-product of drinking water disinfection.
PubMed:The effect of dietary fatty acid composition on liver retinyl ester (vitamin A ester) composition in the rat.
PubMed:[Influences of endotoxin on oxidation of fatty acid in rabbits: a comparison between medium chain- and long chain-fatty acids].
PubMed:Utilization of medium-chain triglycerides and octanoic acid by cultured human fibroblasts and lymphoblasts.
PubMed:The influence of components on the rectal absorption of cefazolin in rats.
PubMed:Teratogenic effects of trichloroacetonitrile in the Long-Evans rat.
PubMed:[Oxidation rate of intravenously administered medium-chain triglycerides in premature and mature infants].
PubMed:[Determination of the oxidation rate of medium-chain triglycerides in newborn infants with the 13C trioctanoin breath test].
PubMed:Experimental lung tumors following specific intrabronchial application of chrysotile asbestos. Longitudinal light and electron microscopic investigations in rats.
PubMed:[Carcinogenic activity of ethylene oxide and its reaction products 2-chloroethanol, 2-bromoethanol, ethylene glycol and diethylene glycol. III. Research on ethylene glycol and diethylene glycol for carcinogenic effects].
PubMed:Purification and general properties of a metal-insensitive lipase from Rhizopus japonicus NR 400.
PubMed:Lung tumor induction in strain A mice with benzotrichloride.
PubMed:Trioctanoin infusion increases in vivo leucine oxidation: a lesson in isotope modeling.
PubMed:Stimulation of cell growth and proliferation in NIH-3T3 cells by onion and garlic oils.
PubMed:Effects of dietary triglycerides on serum and liver lipids and sterol excretion of rats.
PubMed:Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene.
PubMed:Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
PubMed:Suppressive effects of 3-methylcholanthrene on the in vitro antitumor activity of naturally cytotoxic cells.
PubMed:Comparison of two routes of chemical administration on the lung adenoma response in strain A/J mice.
PubMed:Pathogenesis of pulmonary fibrosis induced by chrysotile asbestos. Longitudinal light and electron microscopic studies on the rat model.
PubMed:Effects of dietary fat level and aflatoxin B1 treatment on rat hepatic lipid composition.
PubMed:Secretion of human gastric lipase from dispersed gastric glands.
PubMed:Apparent decreased oxidation and turnover of leucine during infusion of medium-chain triglycerides.
PubMed:Dietary fat dependence of intestinal 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity in rats.
PubMed:Characterization of response of gut GLI to fat ingestion in dogs.
PubMed:Further studies on the physico-chemical properties of Rhizopus nodosus acid lipase.
PubMed:Response of gastric inhibitory polypeptide to fat ingestion in normal dogs.
PubMed:[Effect of the replacement of a part of the tallow in a milk supply with tricaprylin or coconut oil on the use of energy and nitrogen by the preruminant calf].
PubMed:Free fatty acid and triglyceride content of Mycobacterium avium cultured under different growth conditions.
PubMed:Effect of fat retention on the rachitogenic effect of rye fed to broiler chicks.
PubMed:3-methylcholanthrene: transient inhibition of the lytic step of mouse natural killer cells.
PubMed:Experimental studies on the carcinogenicity of five nitrogen containing polycyclic aromatic compounds directly injected into rat lungs.
PubMed:Influence of dietary lipids on intestinal bile acid absorption.
PubMed:[Carcinogenic activity of ethylene oxide and its reaction products 2-chlorethanol, 2-bromoethanol, ethylene glycol and diethylene glycol. II. Testing of 2-chlorethanol and 2-bromoethanol for carcinogenic activity].
PubMed:[Effect of short- or medium-chain fatty acids on cholesterol dynamics in the rat].
PubMed:Diagnosis and differentiation of fat malabsorption in children using 13C-labeled lipids: trioctanoin, triolein, and palmitic acid breath tests.
PubMed:Studies on the substrate specificity of purified human milk lipoprotein lipase.
PubMed:Promotion by polychlorinated biphenyls of enzyme-altered foci in rat liver.
PubMed:[Carcinogenic activity of ethylene oxide and its reaction products 2-chloroethanol, 2-bromoethanol, ethylene glycol and diethylene glycol. I. Carcinogenicity of ethylene oxide in comparison with 1,2-propylene oxide after subcutaneous administration in mice (author's transl)].
PubMed:[13C-trioctanoin breath test for diagnosis of fat malabsorption (author's transl)].
PubMed:Inhibition of benzo(a)pyrene carcinogenesis in rats with vitamin C.
PubMed:Dietary fat-dependent changes in hepatic cholesterogenesis and the activity of 3-hydroxy-3-methylglutaryl-CoA reductase in fasted-refed rats.
PubMed:Symplasma formation and decidualization in the pseudopregnant rabbit after intraluminal instillation of tricaprylin.
PubMed:Effects of piperonyl butoxide on the toxicity and hepatocarcinogenicity of 2-acetylaminofluorene and 4-acetylaminobiphenyl, and their n-hydroxylated derivatives, following administration of newborn mice.
PubMed:Increase of urinary putrescine in 3,4-benzopyrene carcinogenesis and its inhibition by putrescine.
PubMed:Pulmonary carcinogenesis in rats given implants of cigarette smoke condensate in beeswax pellets.
PubMed:Tumours in mice after subcutaneous injection of automobile exhaust condensates.
PubMed:Prevention of 3,4-benzopyrene carcinogenesis in presence of putrescine.
PubMed:[An animal experimental study on the retention rate of polycyclic aromatic hydrocarbons in the lung and in the subcutaneous tissue (author's transl)].
PubMed:Cytotoxic carcinogeneic response to monocrotaline pyrrole.
PubMed:Evaluation of beeswax-tricaprylin vehicle for pulmonary carcinogenesis studies.
PubMed:Carcinogenic activity of di- and trifunctional alpha-chloro ethers and of 1,4-dichlorobutene-2 in ICR/HA swiss mice.
PubMed:Investigations on the carcinogenic burden by air pollution in man. XI. About the effect of aluminiumhydroxid upon the benzo(a)pyrene carcinogenesis.
PubMed:Studies on the effects of tricaprylin on gluconeogenesis and ketogenesis in isolated perfused liver.
PubMed:Tetracycline inhibition of a lipase from Corynebacterium acnes.
PubMed:Rheological properties of the liquid crystalline phase of monocaprylin and water and the effect of solubilized tricaprylin.
PubMed:Purification and properties of a glycerol ester hydrolase (lipase) from Propionibacterium shermanii.
PubMed:Lipase from Pseudomonas fragi. II. Properties of the Enzyme.
PubMed:Factors affecting carcinogenesis; the effect of tricaprylin solutions of cholesterol and phospholipins.
PubMed:THE EFFECT OF TEMPERATURE ON THE RATE OF HYDROLYSIS OF TRIGLYCERIDES BY PANCREATIC LIPASE.
PubMed:The preparation of tricaprylin.
PubMed:ON THE MECHANISM OF THE SERUM SENSITIZATION OF ACID-FAST BACTERIA.
 
Notes:
13c-labeled trioctanoin used in breath tests to detect fat malabsorption. Used in bakery products. Carrier for essential oils and flavours
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