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butylated hydroxytoluene
BHT

Sponsors

Fragrance Demo Formulas
Name:2,6-ditert-butyl-4-methylphenol
CAS Number: 128-37-0Picture of molecule3D/inchi
Other:102962-45-8
ECHA EINECS - REACH Pre-Reg:204-881-4
FDA UNII:1P9D0Z171K
Nikkaji Web:J2.939D
Beilstein Number:1911640
MDL:MFCD00011644
XlogP3-AA:5.30 (est)
Molecular Weight:220.35548000
Formula:C15 H24 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:antioxidants and preservatives for fragrance and flavor
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
172.115 Butylated Hydroxytoluene (BHT) View-review
EU SANCO Butylated hydroxytoluene (BHT) View-review
JECFA Food Additive: Butylated Hydroxytoluene
GSFA Codex: Butylated hydroxytoluene (321)
DG SANTE Food Additives:BHT
DG SANTE Food Contact Materials:BHT
FEMA Number:2184 butylated hydroxytoluene
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: BUTYLATED HYDROXYTOLUENE
FDA Regulation:
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.350 Enriched rice.


FDA PART 166 -- MARGARINE
Subpart B--Requirements for Specific Standardized Margarine
Sec. 166.110 Margarine.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.110 BHA.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.115 BHT.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.185 TBHQ.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart G--Gums, Chewing Gum Bases and Related Substances
Sec. 172.615 Chewing gum base.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.340 Defoaming agents.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.125 Pressure-sensitive adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.380 Xylene-formaldehyde resins condensed with 4,4'-isopropylidenediphenol-epichlorohydrin epoxy resins.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.390 Zinc-silicon dioxide matrix coatings.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1010 Acrylic and modified acrylic plastics, semirigid and rigid.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1210 Closures with sealing gaskets for food containers.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1350 Ethylene-vinyl acetate copolymers.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2260 Filters, resin-bonded.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2600 Rubber articles intended for repeated use.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart C--Antioxidants and Stabilizers
Sec. 178.2010 Antioxidants and/or stabilizers for polymers.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3570 Lubricants with incidental food contact.


FDA PART 179 -- IRRADIATION IN THE PRODUCTION, PROCESSING AND HANDLING OF FOOD
Subpart C--Packaging Materials for Irradiated Foods
Sec. 179.45 Packaging materials for use during the irradiation of prepackaged foods.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.24 Antioxidants.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart D--Chemical Preservatives
Sec. 182.3173 Butylated hydroxytoluene.
 
Physical Properties:
Appearance:colorless crystals (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: Yes
Melting Point: 70.00 to 73.00 °C. @ 760.00 mm Hg
Boiling Point: 265.00 °C. @ 760.00 mm Hg
Vapor Pressure:15.000000 mm/Hg @ 141.00 °C.
Vapor Density:7.6 ( Air = 1 )
Flash Point:> 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w): 5.100
Soluble in:
 alcohol
 water, 0.6 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Type: phenolic
Odor Strength:low
Substantivity:400 hour(s) at 20.00 % in dipropylene glycol
phenolic camphoreous
Odor Description:at 100.00 %. mild phenolic camphor
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
masking agents
 
Suppliers:
Aceto
BHT FCC/NF
Anhui Haibei
BHT
Augustus Oils
Butyl Hydroxy Toluene (BHT)
Services
BOC Sciences
For experimental / research use only.
2,6-Di-tert-butyl-4-methylphenol >99.0%(GC)
Charkit Chemical
BUTYLATED HYDROXY TOLUENE NF/FCC BHT
Charkit Chemical
BUTYLATED HYDROXY TOLUENE
Diffusions Aromatiques
BHT
Eastman Chemical
Eastman Tenox™ BHT Food-Grade Antioxidant, Kosher
ECSA Chemicals
butylated Hydroxytoluene
Company Profile
EMD Millipore
For experimental / research use only.
2,6-Di-tert-butyl-4-methylphenol
Foodchem International
Butylated Hydroxy Toluene
Global Essence
Butylated Hydroxy Toluene
Graham Chemical
BHT
HallStar
BHT
Odor: characteristic
Use: BHT (Butylated hydroxytoluene) is a white solid of melting point 70°C with mild characteristic odor. It is readily fat-soluble and sparingly water soluble and is used primarily an antioxidant additive, extending the shelf life of products with unsaturated (and especially polyunsaturated) fatty acid moieties.
Indenta Group
BHT
Kraft Chemical
BHT
Lluch Essence
BHT
M&U International
BUTYLATED HYDROXY TOLUENE
Moellhausen
BHT
OQEMA
Butylated Hydroxy Toluene (BHT Tech./Feed)
OQEMA
Butylated Hydroxy Toluene (BHT Technical, Food & Feed grades all available)
OQEMA
Embanox BHT
Pell Wall Perfumes
BHT – anti-oxidant
Odor: odourless at the levels used in perfumes, slightly camphoraceous / phenolic in concentration
Use: Arctander gives this description: “insoluble in water, soluble in alcohol and Propylene glycol. Soluble in most oils and essential oils at 0.05 to 1% Used as an Antioxidant in foods, chemicals, perfume materials (natural and synthetic), etc., often in combination with Butyl hydroxy anisole (BHA) and Propyl gallale, Citric acid, etc. in Propylene glycol solution.
Penta International
BUTYLATED HYDROXY TOLUENE (BHT) N.F. GRADE POWDER (40 MESH), Kosher, Halal
Penta International
BUTYLATED HYDROXYTOLUENE (BHT) FCC GRADE, Kosher
Penta International
BUTYLATED HYDROXYTOLUENE (BHT) N.F. GRADE POWDER (60 MESH)
Penta International
BUTYLATED HYDROXYTOLUENE (BHT) N.F. GRADE, Kosher
Penta International
BUTYLATED HYDROXYTOLUENE (BHT) NF & EP GRADE, Kosher, Halal
Penta International
BUTYLATED HYDROXYTOLUENE NF & EP GRADE POWDER (325 MESH), Kosher, Halal
Penta International
BUTYLATED HYDROXYTOLUENE NF & EP GRADE POWDER (60 MESH), Kosher
Penta International
BUTYLATED HYDROXYTOLUENE NF & EP GRADE POWDER (80 MESH), Kosher, Halal
Prinova
BHT
Reincke & Fichtner
Butylated Hydroxytoluene
Santa Cruz Biotechnology
For experimental / research use only.
butylated Hydroxytoluene >98%
Sigma-Aldrich
Butylated hydroxytoluene, ≥99%, FCC, FG
Certified Food Grade Products
Silver Fern Chemical
Butylated Hydroxytoluene (BHT)
Odor: characteristic
Use: BHT is used as an antioxidant and can be a food additive. It is also found in some cosmetics, pharmaceuticals, rubbers, and is often used in the oil industry.
Sinofi Food Ingredients
Butylated Hydroxytoluene
Odor: characteristic
Use: Antioxidants, Food Preservative, Oils and Fats, Chewing Gum, Potato Chip, Fried Food, Frozen Food, Dairy Products, Baking Food, Shortening, Margarine, Flavoring Agent, Packaging Material, Meat, Nutrient, Dietary Supplement, Cosmetics, Feed, Pharmaceutical, Plastic and Rubber, Lubricant.
Sinoway Industrial
For experimental / research use only.
2,6-Di-tert-butyl-4-methylphenol
(99% up, powder)
TCI AMERICA
For experimental / research use only.
2,6-Di-tert-butyl-p-cresol >99.0%(GC)
The John D. Walsh Company
Butylated Hydroxy Toluene
The Lermond Company
Butylated Hydroxy Toluene
Treatt
B.H.T.
Vigon International
BHT (Butylated Hydroxy Toluene)
Zanos
Butyl hydroxy toluene
Zhong Ya Chemical
BHT (Butylated Hydroxy Toluene) Tech Grade
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 07 - Keep container tightly closed.
S 22 - Do not breath dust.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Chronic aquatic toxicity (Category 1), H410
GHS Label elements, including precautionary statements
 
Pictogramenvironment.jpg
 
Signal word Warning
Hazard statement(s)
H410 - Very toxic to aquatic life with long lasting effects
Precautionary statement(s)
P273 - Avoid release to the environment.
P391 - Collect spillage. Hazardous to the aquatic environment
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50 890 mg/kg
Neoplasma. Vol. 24, Pg. 253, 1977.

intravenous-mouse LD50 180 mg/kg
BEHAVIORAL: SLEEP
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

intraperitoneal-mouse LD50 138 mg/kg
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

oral-mouse LD50 650 mg/kg
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

oral-guinea pig LD50 10700 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: TREMOR GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.

oral-cat LDLo 940 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.

intraperitoneal-mouse LD50 138 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BLOOD: HEMORRHAGE LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Toxicology and Applied Pharmacology. Vol. 61, Pg. 475, 1981.

oral-rabbit LDLo 2100 mg/kg
BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: antioxidants and preservatives for fragrance and flavor
Recommendation for butylated hydroxytoluene usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of butylated hydroxytoluene BHT (E 321) as a food additive
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):128-37-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31404
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3077
WGK Germany:1
2,6-ditert-butyl-4-methylphenol
Chemidplus:0000128370
EPA/NOAA CAMEO:hazardous materials
RTECS:128-37-0
 
References:
 2,6-ditert-butyl-4-methylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:128-37-0
Pubchem (cid):31404
Pubchem (sid):134974578
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C14693
HMDB (The Human Metabolome Database):HMDB33826
FooDB:FDB011992
Export Tariff Code:2907.19.1000
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•the antioxidant formulations most commonly used in edible products contain various combinations of bha, bht, &or propyl gallate together with citric acid in a suitable solvent. •grades: technical; feed; "food chemical codex" •inol cp shell •embanox 2 rhone-poulenc •hydagen deo henkel
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antioxidants
 preservatives
 
Occurrence (nature, food, other):note
 garlic bulb
Search Trop Picture
 rue oil china @ 0.05%
Data GC Search Trop Picture
 
Synonyms:
 advastab 401
 agidol
 alkofen BP
 annulex BHT
 antioxidant 264
 antioxidant 29
 antioxidant 30
 antioxidant 4
 antioxidant DBPC
 antioxidant KB
 antioxidant MPJ
 antioxidant T 501
 antox QT
 antracine 8
 antrancine 8
 B.H.T.
 BHT
 BHT (butylated hydroxy toluene) tech grade
 BHT FCC/NF
2,6-bis(tert-butyl)-4-methylphenol
 catalin antioxydant 1
 catalin CAO-3
 chemanox 11
(2,5-cyclohexadiene-1,4-diylidene)-dimalononitrile
 dalpac
 deenax
2,6-di-(tert-butyl)-4-methylphenol
2,6-di-t-butyl-4-methylphenol
2,6-di-t-butyl-p-cresol
2,6-di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-di-tert-butyl-4-cresol
2,6-di-tert-butyl-4-hydroxytoluene
2,6-di-tert-butyl-4-methyl phenol
2,6-di-tert-butyl-4-methylhydroxybenzene
2,6-di-tert-butyl-4-methylphenol
2,6-di-tert-butyl-p-cresol
2,6-di-tert-butyl-p-methylphenol
2,6-di-tert-butyl-para-cresol
2,6-di-tert-butylcresol
2,6-bis(1,1-dimethylethyl)-4-methylphenol
 embanox BHT
 hydagen DEO
butylated hydroxy toluene
butylated hydroxy toluene (BHT) N.F. grade powder (40 mesh)
4-hydroxy-3,5-di-tert-butyltoluene
1-hydroxy-4-methyl-2,6-di-tert-butylbenzene
butylated hydroxytoluene (BHT) N.F. grade powder (60 mesh)
butylated hydroxytoluene (BHT) FCC grade
butylated hydroxytoluene (BHT) N.F. grade
butylated hydroxytoluene (BHT) NF & EP grade
butylated hydroxytoluene NF & EP grade powder (325 mesh)
butylated hydroxytoluene NF & EP grade powder (60 mesh)
butylated hydroxytoluene NF & EP grade powder (80 mesh)
 impruvol
 ional
 kerabit
4-methyl-2,6-di-t-butyl-phenol
4-methyl-2,6-ditertbutylphenol
4-methyl-2,6-tert-butylphenol
 nocrac 200
 nonox TBC
 parabar
 paranox 441
 tenox BHT food-grade antioxidant
 vianol
 

Articles:

Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:Effect of peanut skin extract on chemical stability and sensory properties of salami during storage.
PubMed:Identification of tartary buckwheat tea aroma compounds with gas chromatography-mass spectrometry.
PubMed:Utilization of adzuki bean extract as a natural antioxidant in cured and uncured cooked pork sausages.
PubMed:Oxidative stability of cooked, frozen, reheated beef patties: effect of antioxidants.
PubMed:Effects of sodium lactate and acetic acid derivatives on the quality and sensory characteristics of hot-boned pork sausage patties.
PubMed:Sensory evaluation and consumer acceptance of eggs from hens fed flax seed and 2 different antioxidants.
PubMed:Antioxidants in bakery products: a review.
PubMed:Antioxidant properties of dried plum ingredients in raw and precooked pork sausage.
PubMed:Flavor authentication studies of alpha-ionone, beta-ionone, and alpha-ionol from various sources.
PubMed:Bioconversion of lutein using a microbial mixture--maximizing the production of tobacco aroma compounds by manipulation of culture medium.
PubMed:Effect of enrobing and antioxidants on quality characteristics of precooked pork patties under chilled and frozen storage conditions.
PubMed:Effects of olive, canola, and sunflower oils on the formation of volatiles from the Maillard reaction of lysine with xylose and glucose.
 
Notes:
a di-tert-butyl phenol with antioxidant properties. Antioxidant, used in cosmetics, foods and pharmaceuticals Butylated hydroxytoluene (BHT), also known as butylhydroxytoluene, is a lipophilic (fat-soluble) organic compound that is primarily used as an antioxidant food additive (E number E321) as well as an antioxidant additive in cosmetics, pharmaceuticals, jet fuels, rubber, petroleum products, electrical transformer oil, and embalming fluid. (Wikipedia)
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