triethyl citrate
citric acid triethyl ester
 
Notes:
Used in foods as a flavouring agent, solvent and surface-active agent Triethyl citrate is an ester of citric acid. It is a colorless, odorless liquid used as a food additive (E number E1505) to stabilize foams, especially as whipping aid for egg white. In pharmaceutical coatings and plastics.
  • Advanced Biotech
  • Berjé
    • Berje Inc.
      The solution is clear
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
      Email: For Sales
      Voice: 973-748-8980
      Fax: 973-680-9618
      Flavor Ingredients
      Fragrance Ingredients
      Functional Ingredients
      Happening at Berje
      Product(s):
      Triethyl Citrate
      Triethyl Citrate Natural
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
      Email: Sales
      Voice: 203-299-3220
      Fax: 203-299-1355
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      Products List: View
      Product(s):
      TRIETHYL CITRATE
      TRIETHYL CITRATE NATURAL
       
  • CTC Organics
    • CTC Organics
      For More Than 40 Year
      Your source for rare aroma chemicals for the flavor and fragrance industy.
      “The world is run by middle men.” The number of times I have heard Dr. Liu utter those words are innumerable. He loved reciting and recording famous quotes and had many of his own. Among his many talents, Dr. Liu had a unique genius in the area of chemistry. He had an uncanny understanding of the pulse of the chemical industry and was a superb salesman.
      US Email: Customer Service
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      Resources
      History
      Product(s):
      W0221 triethyl citrate
       
  • ECSA Chemicals
    • ECSA Chemicals
      International trading and distribution
      ECSA Group offers its customers in these business segments a complete 'one-stop shopping' solution.
      A hundred years on from its establishment, the Emanuele Centonze Holding SA has developed a solid presence in Switzerland and in Europe. The Group currently includes: ECSA Chemicals AG/ECSA Italia SRL Societŕ con Unico Socio – ECSA Maintenance AG – ECSA Energy SA – Porta Ticino Easy Stop SA. The Group operates in the distribution of chemical and petroleum products, in the international trading of commodities, and in the distribution of maintenance systems. With 285 employees, a consolidated turnover of 335 million Swiss Francs in 2015, and more than 15,000 active customers, the Group ranks among the top 500 companies in Switzerland. ECSA operates in Switzerland and the EU, and in particular has consolidated its geographical position on the main axis linking northern and southern Europe, thus creating a competitive and privileged logistical hub.
      Email: Info
      Email: Sales
      Email: Trading
      Email: Maintenance
      Email: Energy
      Voice: +41 91 695 88 00
      Fax: +41 91 695 88 01
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      Company Profile
      Products List: View
      Product(s):
      Triethyl Citrate
       
  • Global Essence
    • Global Essence Inc.
      Preferred Partner
      Accommodate each customers unique needs.
      Global Essence was founded in 1993 as a two person operation servicing regional customers in the New York/ New Jersey area. In the twenty years since, it has grown into a multinational operation with offices in the US, UK, and Singapore. These offices allow Global to provide regional support to its customers worldwide. As the world continues become more connected, this approach positions Global to continue to offer the highest quality products and experience to all of its customers.
      Email: Info
      US Email: Info
      Voice: +44 (0) 1279 876666
      Fax: +44 (0)1279 876646
      US Voice: 001 732 677 1100
      US Fax: 001 732 677 1107
      Blog
      Press Release
      News
      Product(s):
      Triethyl Citrate
       
  • Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
      Linkedin
      Product(s):
      TRIETHYL CITRATE 99%
      TRIETHYL CITRATE NATURAL 99%
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
      News
      Product(s):
      N0136 NAT.TRIETHYL CITRATE, Kosher
       
  • Moellhausen
    • Moellhausen S.P.A.
      THE CHEMISTRY OF EMOTIONS
      Innovation and commitment in the name of excellence.
      After 50 years in business, Moellhausen stands out as one of the world’s leading family-run companies in the industry of flavors and fragrances, raw materials, and specialties. My personal history is inextricably bound to that of the company, and I continue to dedicate all my energy to it along with our partners and collaborators who have supported us thus far with dedication, passion, love, and experience. Continuous investments and a professionalism aimed at achieving the highest levels of performance in service and quality, along with that same dedication, passion, love, and experience, have together enabled us to reach the absolute avant-garde level that characterizes Moellhausen today, recognized worldwide for its modernity, innovation, creativity, and respect for the environment and the safety and rights of those who work with us. As President and CEO of the company for 32 years, I offer a well-deserved thank you to all of our numerous customers, suppliers, employees, and company friends for helping to sustain our unstoppable and honorable growth. And it is with the support of all of our stakeholders that we will confidently continue to pursue our commitment to further advancing the excellence that our industry demands.
      Voice: +39 039.685.6262
      Fax: +39 039.685.6263
      Linkedin
      A network of knowledge to grow together
      Sustainability is at the foundation of a
      Pervasive technology and total control
      Product(s):
      105920 TRIETHYL CITRATE
       
  • OQEMA
    • OQEMA
      With a focus on providing the highest level of service
      OQEMA has established itself at the forefront of the global chemical industry.
      The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories.
      Email: Contact Us:
      US Email: Dean Matienzo - Sales Manager
      Voice: +44 1993 843081
      Fax: +44 1993 841261
      US Voice: +1 973 886 3778
      US Fax: +1 973 346 1106
      Whats New
      Global Distribution
      Product(s):
      Triethyl Citrate (Citroflex)
       
  • Pell Wall Perfumes
    • Pell Wall Perfumes
      Hand-made fragrances
      Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.
      Pell Wall was founded by perfumer Chris Bartlett to provide exclusive hand-made fragrances to a select few people who love them. All our products are created using fine quality ingredients, many of which we also offer for sale to other perfumers and enthusiasts. Pell Wall make fragrances for men, for women and for the home. If you’re looking for something even more exclusive our bespoke fragrance design service could be what you’re looking for: we design custom fragrances for individuals, other perfume brands, hotels, corporations and organisations.
      Email: Info
      Email: Sales
      Voice: +44 1630 652546
      Mobile+44 7792 580511
      Blog
      Product(s):
      TEC
      Arctander considered that it had other values as well however: “Very mild, but sweet and pleasant, winey – fruity, Plum-1ike odor … The title ester was developed for purposes other than perfumery and flavor work, but it has become quite popular as a blender, solvent or diluent in perfumes and – particularly – in flavor compositions. The effect in a perfume composition is somewhat more than that of a diluent, since the ester, when blended with more volatile materials, does contribute a soft, mellow, warm-fruity undertone and often also a winey-sweet topnote to a fragrance. It is particularly interesting in Rose bases”
       
       
  • Penta International
  • Treatt
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
      News
      Product(s):
      Triethyl Citrate
       
  • Sigma-Aldrich
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      Sales0512-57995626
      Sales0512-57570299
      News
      Product(s):
      N0151 nat.Triethyl Citrate
       
  • Taytonn
    • TAYTONN PTE LTD
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
      Email: Info
      Email: Sales
      Voice: + 65 - 6861 8113
      Fax: + 65 - 6861 8115
      Product(s):
      Triethyl Citrate
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      Email: Sales
      US Email: Sales
      Email: Global Business
      Voice: +81-3-5640-8878
      Fax: +81-3-5640-8902
      US Voice: 800-423-8616
      US Fax: 888-520-1075
      Tokyo Tel:03-5640-8851
      Tokyo Fax:03-5640-8865
      Facebook
      Twitter
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      RSS
      Product(s):
      C0367 Triethyl Citrate >99.0%(GC)
       
  • The Good Scents Company
  • The John D. Walsh Company
    • The John D. Walsh Company, Inc
      Suppliers Since 1942
      Supplying the fragrance and flavor industry with high quality products.
      The John D. Walsh Company, Inc. has evolved from its beginnings as an agent/broker into a distributor of essential oils, aroma chemicals, concretes and absolutes. We currently represent the following companies, as their North American distributor: Destilerias Munoz Galvez, S.A. International Flavors & Fragrances PFW Aroma Chemicals B.V. Innospec Widnes Limited Hydrodiffusion de Guatemala, S. A. DSM Nutritional Products The John D. Walsh Company, Inc. is proud to be a founding member of IFEAT, an active member of IFRA, North America, and a corporate sponsor of the WFFC.
      Email: Information
      Email: Sales
      Email: Firmenich Flavor inquiries
      Voice: 973-962-1400
      Fax: 973-962-1557
      Firmenich Flavor Phone:973-962-1888
      Firmenich Flavor Fax:973-962-1898
      History
      Product(s):
      Triethyl Citrate (Citroflex)
      SDS
       
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
triethyl 2-hydroxypropane-1,2,3-tricarboxylate (Click)
CAS Number: 77-93-0Picture of molecule
ECHA EINECS - REACH Pre-Reg: 201-070-7
FDA UNII: 8Z96QXD6UM
Nikkaji Web: J4.215C
Beilstein Number: 1801199
MDL: MFCD00009201
CoE Number: 11762
XlogP3-AA: 0.10 (est)
Molecular Weight: 276.28580000
Formula: C12 H20 O7
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: ADI: 0-20 (JECFA, 1984a).
Category: carrier solvents/deluents for flavors and/or fragrances
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1911 Triethyl citrate View-review
EU SANCO Triethyl citrate View-review
JECFA Food Flavoring: 629  triethyl citrate
JECFA Food Additive: Triethyl Citrate
GSFA Codex: Triethyl citrate (1505)
Flavis Number: 09.512 (Old)
DG SANTE Food Flavourings: 09.512  triethyl citrate
DG SANTE Food Additives: triethyl citrate
DG SANTE Food Contact Materials: triethyl citrate
FEMA Number: 3083  triethyl citrate
FDA Mainterm: TRIETHYL CITRATE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.320 Resinous and polymeric coatings for polyolefin films.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.27 Plasticizers.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear oily liquid (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 1.13500 to 1.13900 @  25.00 °C.
Pounds per Gallon - (est).: 9.444 to  9.478
Refractive Index: 1.43200 to 1.44400 @  20.00 °C.
Melting Point: -46.00 °C. @ 760.00 mm Hg
Boiling Point: 127.00 °C. @ 1.00 mm Hg
Acid Value: 0.50 max. KOH/g
Vapor Pressure: 0.000175 mm/Hg @ 25.00 °C. (est)
Vapor Density: 9.7 ( Air = 1 )
Flash Point: 245.00 °F. TCC ( 118.33 °C. )
logP (o/w): 1.267 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 water, 6.5 gm/100 ml water
 cellulose acetate
 cellulose acetate butyrate
 cellulose nitrate
 chlorinated rubber
 ethyl cellulose
 polyvinyl acetate
 polyvinyl butyral
 polyvinyl chloride
 polyvinyl chloride acetate
 polyvinyl vinylidene chloride
 water, 6.50E+04 mg/L @ 25 °C (exp)
Insoluble in:
 water
Stability:
 will not support fungous grouth in resins
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
odorless to mild fruity wine
Luebke, William tgsc, (1981)
Taste Description:
fruty medicinal floral bitter
Substantivity: 216 Hour(s)
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
deodorants
masking agents
plasticisers
solvents
Synonyms   Articles   Notes   Search   Top
Suppliers:
A.C.S. International
Triethyl Citrate
Operational Capabilities
Aceto
Triethyl Citrate
Advanced Biotech
TRIETHYL CITRATE NATURAL
99% min.
Odor: Faintly, Wine, Plum
Advanced Biotech
TRIETHYL CITRATE SYNTHETIC
99% min.
Odor: Odorless
Allan Chemical
Triethyl Citrate
Anhui Haibei
Triethyl Citrate natural
Apple Flavor & Fragrance
Triethyl Cirtrate
Aurochemicals
TRIETHYL CITRATE, Natural
Berjé
Triethyl Citrate Natural
Happening at Berje
Berjé
Triethyl Citrate
BOC Sciences
For experimental / research use only.
Triethyl Citrate >98.0%(GC)
Charkit Chemical
TRIETHYL CITRATE NATURAL
Charkit Chemical
TRIETHYL CITRATE
Connect Chemicals
Triethylcitrate (TEC)
Odor: characteristic
Use: Triethylcitrate is an ester of Citric Acid. Connect Chemicals is offering different grades of this product suitable for industrial as well as food and pharma applications. Triethylcitrate is used as plasticizer in e.g. adhesives, inks, sealants, plastics and coatings. Here it does primarily reduce hardness of polymers and can be further used to regulate viscosity. In the personal care industry it is used as solvent or diluent as well as a fixative for perfumes. As an active ingredient it can be also used in deodorants. For use in cosmetics, Connect Chemicals does offer a grade based on natural raw materials only. This grade can be also used as flavor or flavor carrier in the food industry. An ECOCERT/COSMOS certificate is available.
Covalent Chemical
Triethyl Citrate
CTC Organics
triethyl citrate
ECSA Chemicals
Triethyl Citrate
Company Profile
Ernesto Ventós
TRIETHYL CITRATE NATURAL
Ernesto Ventós
TRIETHYL CITRATE
Global Essence
Triethyl Citrate
Indukern F&F
TRIETHYL CITRATE
CROP CALENDAR
Jungbunzlauer Suisse
CITROFOL® AI - Triethyl Citrate
Odor: bland
Use: CITROFOL® AI is produced by esterification of citric acid with ethanol. Natural triethyl citrate occurs in small amounts in wine. It is not irritant to skin and shows no sensitising effects on human beings. Therefore it is widely used in cosmetic, pharmaceutical and food applications. Due to its low migration potential, solvent power and compatibility in industrial uses it is favoured as plasticiser in materials with food contact.
Kunshan Sainty
Triethyl Citrate, Natural
Lluch Essence
TRIETHYL CITRATE 99%
Lluch Essence
TRIETHYL CITRATE NATURAL 99%
M&U International
NAT.TRIETHYL CITRATE, Kosher
Moellhausen
TRIETHYL CITRATE
OQEMA
Triethyl Citrate (Citroflex)
Pell Wall Perfumes
TEC
Odor: Practically odourless
Use: Arctander considered that it had other values as well however: “Very mild, but sweet and pleasant, winey – fruity, Plum-1ike odor … The title ester was developed for purposes other than perfumery and flavor work, but it has become quite popular as a blender, solvent or diluent in perfumes and – particularly – in flavor compositions. The effect in a perfume composition is somewhat more than that of a diluent, since the ester, when blended with more volatile materials, does contribute a soft, mellow, warm-fruity undertone and often also a winey-sweet topnote to a fragrance. It is particularly interesting in Rose bases”
Penta International
TRIETHYL CITRATE BP PHARMACEUTICAL GRADE, Kosher
Penta International
TRIETHYL CITRATE FCC GRADE, Kosher
Penta International
TRIETHYL CITRATE N.F. GRADE, Kosher
Penta International
TRIETHYL CITRATE REGULAR GRADE, Kosher
Penta International
TRIETHYL CITRATE, NATURAL, Kosher
Penta International
TRIETHYL CTIRATE BP/EP PHARMACEUTICAL GRADE, Kosher
Reincke & Fichtner
Triethyl Citrate
Sigma-Aldrich
Triethyl citrate, ≥99%, FCC, FG
Odor: wine-like; plum; sweet
Certified Food Grade Products
Sigma-Aldrich
Triethyl citrate, natural, ≥99%, FG
Stearinerie Dubois
DUB CTE
Sunaux International
nat.Triethyl Citrate
Taytonn
Triethyl Citrate
Odor: Fruity, Sweet, Wine
TCI AMERICA
For experimental / research use only.
Triethyl Citrate >99.0%(GC)
The Good Scents Company
triethyl citrate
Odor: odorless to mild fruity wine
The John D. Walsh Company
Triethyl Citrate (Citroflex)
The Perfumers Apprentice
Triethyl Citrate
Treatt
Triethyl Citrate
Vigon International
Triethyl Citrate Natural
Vigon International
Triethyl Citrate
Odor: ESSENTIALLY ODORLESS
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Acute toxicity, Inhalation (Category 4), H332
GHS Label elements, including precautionary statements
 
Pictogramexclamation-mark.jpg
 
Signal word Warning
Hazard statement(s)
H332 - Harmful if inhaled
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 - Use only outdoors or in a well-ventilated area.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
Human Experience:
20 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50  5900 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 214, 1985.

gavage-rat LD50  7000 mg/kg
Actual LD50 not reported.Value reported as approximate LD50.
(Finkelstein & Gold, 1959)

intraperitoneal-rat LD50  4000 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 214, 1985.

intraperitoneal-mouse LD50  1750 mg/kg
VASCULAR: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmaceutical Sciences. Vol. 53, Pg. 774, 1964.

oral-guinea pig LD50  > 25 ml/kg
German Offenlegungsschrift Patent Document. Vol. #2703360

oral-cat LD50  3500 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING
Food and Cosmetics Toxicology. Vol. 17, Pg. 389, 1979.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 389, 1979.

subcutaneous-rat LD50 6600 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 214, 1985.

Inhalation Toxicity:
inhalation-rat LC50 1300 ppm/6H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: PLEURAL EFFUSION
"Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63Vol. 2, Pg. 1892, 1963.

Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: carrier solvents/deluents for flavors and/or fragrances
Recommendation for triethyl citrate usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 2900.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -230.00000
beverages(nonalcoholic): -12.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -47.00000
fruit ices: -47.00000
gelatins / puddings: -10.00000
granulated sugar: --
gravies: --
hard candy: -180.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
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Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
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Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
Scientific Opinion on the safety and efficacy of straight-chain primary aliphatic alcohols/aldehydes/acids, acetals and esters with esters containing saturated alcohols and acetals containing saturated aldehydes (chemical group 1) when used as flavourings for all animal species
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 77-93-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6506
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 triethyl 2-hydroxypropane-1,2,3-tricarboxylate
Chemidplus: 0000077930
RTECS: 77-93-0
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References:
 triethyl 2-hydroxypropane-1,2,3-tricarboxylate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 77-93-0
Pubchem (cid): 6506
Pubchem (sid): 134972806
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
KEGG (GenomeNet): D06228
HMDB (The Human Metabolome Database): HMDB34263
FooDB: FDB012587
Export Tariff Code: 2918.15.5000
Haz-Map: View
Household Products: Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
FAO: Triethyl citrate
Formulations/Preparations:
grades: technical; refinded; fcc
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 fixer 
 solvents 
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Occurrence (nature, food, other): note
 cabbage
Search Trop  Picture
 wine white wine
Search  Picture
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Synonyms:
 citric acid triethyl ester
 citroflex 2
 diethyl 3-(ethoxycarbonyl)-3-hydroxypentane-1,5-dioate
 ethyl citrate
 eudraflex
 hydragen cat
2-hydroxy-1,2,3-propane tricarboxylic acid triethyl ester
 triethyl 2-hydroxy-1,2,3-propane tricarboxylate
 triethyl 2-hydroxy-1,2,3-propane- tricarboxylate
 triethyl 2-hydroxy-1,2,3-propanetricarboxylate
 triethyl 2-hydroxypropane-1,2,3-tricarboxylate
1,2,3-triethyl 2-hydroxypropane-1,2,3-tricarboxylate
 triethyl cirtrate
nat.triethyl citrate
 triethyl citrate BP pharmaceutical grade
 triethyl citrate FCC grade
 triethyl citrate N.F. grade
 triethyl citrate natural
 triethyl citrate regular grade
 triethyl citrate synthetic
 triethyl citrate, natural
 triethyl ctirate BP/EP pharmaceutical grade
 uniplex 80
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Articles:
Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed: Near-infrared spectroscopic analysis of the breaking force of extended-release matrix tablets prepared by roller-compaction: influence of plasticizer levels and sintering temperature.
PubMed: "Green" films from renewable resources: properties of epoxidized soybean oil plasticized ethyl cellulose films.
PubMed: Physicochemical properties and anti-Propionibacterium acnes activity of film-forming solutions containing alpha-mangostin-rich extract.
PubMed: Design of innovated lipid-based floating beads loaded with an antispasmodic drug: in-vitro and in-vivo evaluation.
PubMed: Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers.
PubMed: Polyvinyl acetate-based film coatings.
PubMed: Effect of type and ratio of solubilising polymer on characteristics of hot-melt extruded orodispersible films.
PubMed: [Development and in vitro evaluation of estradiol transdermal film-forming spray].
PubMed: Plasticizer effects on physical-mechanical properties of solvent cast Soluplus® films.
PubMed: Salicylic acid peel incorporating triethyl citrate and ethyl linoleate in the treatment of moderate acne: a new therapeutic approach.
PubMed: Analysis of curing of a sustained release coating formulation by application of NIR spectroscopy to monitor changes physical-mechanical properties.
PubMed: The effect of plasticizers on the erosion and mechanical properties of polymeric films.
PubMed: Preparation and evaluation of sustained-release doxazosin mesylate pellets.
PubMed: [Preliminary study on chemical constituents seperated from Cayratia japonica].
PubMed: A novel electrostatic dry coating process for enteric coating of tablets with Eudragit(®) L100-55.
PubMed: Mucoadhesive multiparticulate patch for the intrabuccal controlled delivery of lidocaine.
PubMed: Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding.
PubMed: Comparison of plasticizer effect on thermo-responsive properties of Eudragit RS films.
PubMed: Osmotic pellet system comprising osmotic core and in-process amorphized drug in polymer-surfactant layer for controlled delivery of poorly water-soluble drug.
PubMed: Inactivation of Salmonella spp. in liquid whole egg using pulsed electric fields, heat, and additives.
PubMed: In vitro and in vivo evaluation of gliclazide push-pull osmotic pump coated with aqueous colloidal polymer dispersions.
PubMed: Moisture plasticization for enteric Eudragit® L30D-55-coated pellets prior to compression into tablets.
PubMed: Eudragit(®) RS PO/RL PO as rate-controlling matrix-formers via roller compaction: Influence of formulation and process variables on functional attributes of granules and tablets.
PubMed: In vitro and in vivo evaluation of multilayered pastilles for chronotherapeutic management of nocturnal asthma.
PubMed: Vascular effects of paclitaxel following drug-eluting balloon angioplasty in a porcine coronary model: the importance of excipients.
PubMed: Ethylcellulose-based matrix-type microspheres: influence of plasticizer RATIO as pore-forming agent.
PubMed: Evaluating the process parameters of the dry coating process using a 2(5-1) factorial design.
PubMed: Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo.
PubMed: Development and evaluation of in situ novel intragastric controlled-release formulation of hydrochlorothiazide.
PubMed: Design of a combined process for the inactivation of Salmonella Enteritidis in liquid whole egg at 55°C.
PubMed: Comparison of physicomechanical properties of films prepared from organic solutions and aqueous dispersion of Eudragit RL.
PubMed: Evaluation of certain food additives. Seventy-first report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed: The use of long acting subcutaneous levonorgestrel (LNG) gel depot as an effective contraceptive option for cotton-top tamarins (Saguinus oedipus).
PubMed: The use of dynamic mechanical analysis (DMA) to evaluate plasticization of acrylic polymer films under simulated gastrointestinal conditions.
PubMed: Sustained release coating of tablets with Eudragit(®) RS/RL using a novel electrostatic dry powder coating process.
PubMed: Influence of plasticizer type and level on the properties of Eudragit S100 matrix pellets prepared by hot-melt extrusion.
PubMed: Applications of KinetiSol dispersing for the production of plasticizer free amorphous solid dispersions.
PubMed: Curing of aqueous polymeric film coatings: Importance of the coating level and type of plasticizer.
PubMed: Properties of theophylline tablets dry powder coated with Eudragit E PO and Eudragit L 100-55.
PubMed: Properties of melt extruded enteric matrix pellets.
PubMed: Precursor effects of citric acid and citrates on ZnO crystal formation.
PubMed: Properties of theophylline tablets dry powder coated with Eudragit((R)) E PO and Eudragit((R)) L 100-55.
PubMed: Preparation and in vitro characterization of piroxicam enteric coated pellets using powder layering technique.
PubMed: Development and characterization of extended release Kollidon SR mini-matrices prepared by hot-melt extrusion.
PubMed: Development and evaluation of a time-specific pulsatile-release tablet of aceclofenac: a solution for morning pain in rheumatoid arthritis.
PubMed: Influence of additives on melt viscosity, surface tension, and film formation of dry powder coatings.
PubMed: Effect of plasticizer on release kinetics of diclofenac sodium pellets coated with Eudragit RS 30 D.
PubMed: Influence of the components of Kollicoat SR film on mechanical properties of floating pellets from the point of view of tableting.
PubMed: Designing, optimisation & characterization of sustained release matrix pellets prepared by extrusion spheronization containing mixture of proteolytic enzymes.
PubMed: Influence of plasticizers on the stability and release of a prodrug of Delta(9)-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices.
PubMed: Iron sequestration on skin: a new route to improved deodorancy.
PubMed: Influence of fumed silicon dioxide on the stabilization of Eudragit RS/RL 30 D film-coated theophylline pellets.
PubMed: Investigation of the drug release and surface morphological properties of film-coated pellets, and physical, thermal and mechanical properties of free films as a function of various curing conditions.
PubMed: Preparation and evaluation of diltiazem hydrochloride diffusion-controlled transdermal delivery system.
PubMed: The manufacture and characterisation of hot-melt extruded enteric tablets.
PubMed: Myotoxicity studies of O/W-in situ forming microparticle systems.
PubMed: Design and study of ibuprofen disintegrating sustained-release tablets comprising coated pellets.
PubMed: Effect of curing on water diffusivities in acrylate free films as measured via a sorption technique.
PubMed: Formulation and statistical optimization of a novel crosslinked polymeric anti-tuberculosis drug delivery system.
PubMed: Double-blind, randomized, placebo-controlled study of a lotion containing triethyl citrate and ethyl linoleate in the treatment of acne vulgaris.
PubMed: Controlled release multiparticulate beads coated with starch acetate: material characterization, and identification of critical formulation and process variables.
PubMed: Influence of processing parameters and formulation factors on the drug release from tablets powder-coated with Eudragit L 100-55.
PubMed: [Measurement of adhesive properties of polymers in vitro].
PubMed: Stability of poly(D,L-lactide-co-glycolide) and leuprolide acetate in in-situ forming drug delivery systems.
PubMed: Influence of plasticizer level on the drug release from sustained release film coated and hot-melt extruded dosage forms.
PubMed: Relationship between drug dissolution and leaching of plasticizer for pellets coated with an aqueous Eudragit S100:L100 dispersion.
PubMed: Controlled release of a poorly water-soluble drug from hot-melt extrudates containing acrylic polymers.
PubMed: The influence of different plasticizers and polymers on the mechanical and thermal properties, porosity and drug permeability of free shellac films.
PubMed: Development of near zero-order release dosage forms using three-dimensional printing (3-DP) technology.
PubMed: Physicochemical properties of enteric films prepared from aqueous dispersions and organic solutions.
PubMed: Development and validation of a gradient HPLC method for the determination of clindamycin and related compounds in a novel tablet formulation.
PubMed: Physicochemical characterization and mechanisms of release of theophylline from melt-extruded dosage forms based on a methacrylic acid copolymer.
PubMed: Enhanced efficacy of triprolidine by transdermal application of the EVA matrix system in rabbits and rats.
PubMed: Asymmetric membrane capsules for delivery of poorly water-soluble drugs by osmotic effects.
PubMed: Quantification of the leaching of triethyl citrate/polysorbate 80 mixtures from Eudragit RS films by differential scanning calorimetry.
PubMed: Compressibility of floating pellets with verapamil hydrochloride coated with dispersion Kollicoat SR 30 D.
PubMed: Antihistamine effects of triprolidine from the transdermal administration of the TPX matrix in rats.
PubMed: XEDS-mapping for explaining release patterns from single pellets.
PubMed: The effect of solvent interactions on alpha-, beta-, and gamma-cyclodextrin/flavor molecular inclusion complexes.
PubMed: Study of triethyl citrate migration from coating polymers to tablet cores.
PubMed: Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid.
PubMed: Physical characterization of coupled poly(lactic acid)/starch/maleic anhydride blends plasticized by acetyl triethyl citrate.
PubMed: "Green" nanocomposites from cellulose acetate bioplastic and clay: effect of eco-friendly triethyl citrate plasticizer.
PubMed: Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer.
PubMed: Compression of pellets coated with various aqueous polymer dispersions.
PubMed: Biodegradable films of partly branched poly(l-lactide)-co-poly(epsilon-caprolactone) copolymer: modulation of phase morphology, plasticization properties and thermal depolymerization.
PubMed: Medications as a source of human exposure to phthalates.
PubMed: Preparation of buccal patch composed of carbopol, poloxamer and hydroxypropyl methylcellulose.
PubMed: Effect of curing conditions and plasticizer level on the release of highly lipophilic drug from coated multiparticulate drug delivery system.
PubMed: Formulation study for lansoprazole fast-disintegrating tablet. II. Effect of triethyl citrate on the quality of the products.
PubMed: Drug release from Kollicoat SR 30D-coated nonpareil beads: evaluation of coating level, plasticizer type, and curing condition.
PubMed: Formulation study for lansoprazole fast-disintegrating tablet. I. Effect of compression on dissolution behavior.
PubMed: Enhanced film-forming properties for ethyl cellulose and starch acetate using n-alkenyl succinic anhydrides as novel plasticizers.
PubMed: Time-dependent mechanical properties of polymeric coatings used in rupturable pulsatile release dosage forms.
PubMed: Influence of methylparaben as a solid-state plasticizer on the physicochemical properties of Eudragit RS PO hot-melt extrudates.
PubMed: Press-coating of immediate release powders onto coated controlled release tablets with adhesives.
PubMed: Statistical optimisation of diclofenac sustained release pellets coated with polymethacrylic films.
PubMed: Influence of thermal processing on the properties of chlorpheniramine maleate tablets containing an acrylic polymer.
PubMed: Effects of fragrance inhalation on sympathetic activity in normal adults.
PubMed: Final report on the safety assessment of acetyl triethyl citrate, acetyl tributyl citrate, acetyl trihexyl citrate, and acetyl trioctyl citrate.
PubMed: Properties of heat-humidity cured cellulose acetate phthalate free films.
PubMed: Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate.
PubMed: Alleviating effects of plant-derived fragrances on stress-induced hyperthermia in rats.
PubMed: Starch acetate--a novel film-forming polymer for pharmaceutical coatings.
PubMed: The influence of plasticizer on heat-humidity curing of cellulose acetate phthalate coated beads.
PubMed: Influence of plasticization time, curing conditions, storage time, and core properties on the drug release from Aquacoat-coated pellets.
PubMed: Acrylic resins as rate-controlling membranes in novel formulation of a nine-day 17beta-estradiol transdermal delivery system: in vitro and release modifier effect evaluation.
PubMed: Control and stability of drug release from diffusion pellets coated with the aqueous quaternary polymethacrylate dispersion Eudragit RS 30 D.
PubMed: Influence of film additives on stabilizing drug release rates from pellets coated with acrylic polymers.
PubMed: Drug release from and mechanical properties of press-coated tablets with hydroxypropylmethylcellulose acetate succinate and plasticizers in the outer shell.
PubMed: Formulation, characterization, and in vitro release of glyburide from proliposomal beads.
PubMed: Influence of curing on the adhesive and thermomechanical properties of an applied acrylic polymer.
PubMed: Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix.
PubMed: Physicomechanical properties of biodegradable poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) films in the dry and wet states.
PubMed: Controlled release of drugs from injectable in situ formed biodegradable PLGA microspheres: effect of various formulation variables.
PubMed: Influence of vitamin E TPGS on the properties of hydrophilic films produced by hot-melt extrusion.
PubMed: Comparative studies with Kollicoat MAE 30 D and Kollicoat MAE 30 DP in aqueous spray dispersions and enteric coatings on highly swellable caffeine cores.
PubMed: Development of matrix-based theophylline sustained-release microtablets.
PubMed: The effects of plasticizers on the release of metoprolol tartrate from granules coated with a polymethacrylate film.
PubMed: Variation of composition of an enteric formulation based on Kollicoat MAE 30 D.
PubMed: Aqueous ethyl cellulose dispersion containing plasticizers of different water solubility and hydroxypropyl methyl-cellulose as coating material for diffusion pellets II: properties of sprayed films.
PubMed: Factors affecting membrane-controlled drug release for an osmotic pump tablet (OPT) utilizing (SBE)(7m)-beta-CD as both a solubilizer and osmotic agent.
PubMed: Tackiness of acrylic and cellulosic polymer films used in the coating of solid dosage forms.
PubMed: Dry coating: an innovative enteric coating method using a cellulose derivative.
PubMed: Influence of aqueous coatings on the stability of enteric coated pellets and tablets.
PubMed: Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion.
PubMed: Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methylcellulose as coating material for diffusion pellets. I. Drug release rates from coated pellets.
PubMed: Thermal and mechanical characterization of cellulose acetate phthalate films for pharmaceutical tablet coating: effect of humidity during measurements.
PubMed: Fabrication of multiunit controlled-release phenylpropanolamine hydrochloride tablets.
PubMed: Effects of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification.
PubMed: Gas chromatographic determination of organic acids from fruit juices by combined resin mediated methylation and extraction in supercritical carbon dioxide.
PubMed: Formulation and preparation of controlled release pellets of salbutamol by the air suspension technique.
PubMed: An in vitro method to investigate food effects on drug release from film-coated beads.
PubMed: Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes.
PubMed: Calcium alginate beads as core carriers of 5-aminosalicylic acid.
PubMed: Spontaneous formation of drug-containing acrylic nanoparticles.
PubMed: [Antiperspirants and deodorants--ingredients and evaluation].
PubMed: Skin metabolism and transdermal absorption of viprostol, a synthetic PGE2 analog, in the rat: effect of vehicle.
PubMed: Fluorometric documentation of increased cutaneous blood flow after topical application of a PGE2 analog in man.
PubMed: Nontoxic nerve guide tubes support neovascular growth in transected rat optic nerve.
PubMed: Synthesis and characterization of phosphocitric acid, a potent inhibitor of hydroxylapatite crystal growth.
PubMed: Mechanistic toxicology of triethyl citrate in cultured mammalian cells by cinematography.
PubMed: Mechanistic toxicology of triethyl citrate in mouse fibroblast cells by liquid scintillation techniques.
PubMed: Growth changes in mammalian cell cultures by plastic additives (effect of triethyl citrate).
PubMed: Toxicology of the citric acid esters: tributyl citrate, acetyl tributyl citrate, triethyl citrate, and acetyl triethyl citrate.
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