EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

carbitol
ethylene diglycol monoethyl ether

Supplier Sponsors

Fragrance Demo Formulas
Name:2-(2-ethoxyethoxy)ethanol
CAS Number: 111-90-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-919-7
FDA UNII:A1A1I8X02B
Nikkaji Web:J5.117I
Beilstein Number:1736441
MDL:MFCD00002872
XlogP3:-0.50 (est)
Molecular Weight:134.17518000
Formula:C6 H14 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:carrier solvents/deluents for flavors and/or fragrances
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
JECFA Food Additive: Diethylene Glycol Monoethyl Ether
FDA Mainterm (IAUFC):111-90-0 ; DIETHYLENE GLYCOL MONOETHYL ETHER

FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 76.00 °C. @ 760.00 mm Hg
Boiling Point: 196.00 to 202.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.126000 mmHg @ 25.00 °C.
Vapor Density:4.63 ( Air = 1 )
Flash Point: 205.00 °F. TCC ( 96.11 °C. )
logP (o/w): -0.540
Soluble in:
 alcohol
 water, 1.00E+06 mg/L @ 20 °C (exp)
 
Organoleptic Properties:
Odor Strength:none
Substantivity:12 Hour(s)
Odor Description:at 100.00 %. slightly ethereal
Luebke, William tgsc, (1987)
Odor sample from: Fritzsche Dodge & Olcott, Inc.
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
perfuming agents
solvents
 
Suppliers:
Augustus Oils
Ethyl Diglycol
Services
BOC Sciences
For experimental / research use only.
Diethylene glycol monoethyl ether 95%
Diffusions Aromatiques
ETHYL DI GLYCOL
Eastman Chemical
DE Solvent
Odor: characteristic
Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Eastman™ DE solvent is used as a coalescent in latex paints and floor polishes, and as penetrating solvent in wood stains.
EMD Millipore
For experimental / research use only.
Diethylene glycol monoethyl ether
Ernesto Ventós
ETHYL DIGLYCOL (EDG)
Gattefosse
Transcutol® CG
Odor: characteristic
Use: Solubilizer & Efficacy booster.
Indukern F&F
CARBITOL
Inoue Perfumery
DIETHYLENE GLYCOL MONOETHYL ETHER
Lluch Essence
ETHYLDIGLYCOL
Moellhausen
EDG COSMETIC GRADE, 99.5% MIN. ARTIFICAL KOSHER
Odor: slightly ethereal, practically odourless.
Penta International
CARBITOL (DIETHYLENE GLYCOL MONOETHYL ETHER)
Penta International
DIETHTYLENE GLYCOL MONOETHYL ETHER NF GRADE
Penta International
DIETHYLENE GLYCOL MONOETHYL ETHER NF - EP GRADE
Shiva Chemicals and Pharmaceuticals
Diethylene Glycol Monoethyl Ether
Sigma-Aldrich
Di(ethylene glycol) ethyl ether, ≥99%
Certified Food Grade Products
Silver Fern Chemical
Glycol Ether DE
Odor: characteristic
Use: Glycol Ether DE is widely used as a solvent in coating applications such as latex paint and wood stains and is a component of many industrial cleaners. Textile uses for Glycol Ether DE include dye and printing ink solvent, yarn and cloth conditioning.
Synerzine
2-(2-Ethoxyethoxy) Ethanol
TCI AMERICA
For experimental / research use only.
Diethylene Glycol Monoethyl Ether >99.0%(GC)
Universal Preserv-A-Chem Inc.
DIETHYLENE GLYCOL MONOETHYL ETHER
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3620 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

intravenous-rat LD50 4000 mg/kg
National Technical Information Service. Vol. OTS0516797

intraperitoneal-rat LD50 0.36 mg/kg
National Technical Information Service. Vol. OTS0516797

oral-rabbit LD50 3620 mg/kg
National Technical Information Service. Vol. OTS0516797

intravenous-rabbit LD50 2500 ul/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: COMA
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.

oral-mouse LD50 6600 ul/kg
BEHAVIORAL: COMA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

intravenous-mouse LD50 4300 ul/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.

intraperitoneal-mouse LD50 2300 mg/kg
LUNGS, THORAX, OR RESPIRATION: CYANOSIS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Pharmacology and Therapeutics. Vol. 5, Pg. 467, 1979.

oral-guinea pig LD50 3700 ul/kg
GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

intravenous-cat LDLo 1000 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1571, 1978.

intravenous-dog LD50 3 mL/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.

unreported-guinea pig LD50 3000 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(4), Pg. 74, 1981.

unreported-mouse LD50 7150 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(2), Pg. 14, 1981.

intraperitoneal-rat LD50 360 ug/kg
National Technical Information Service. Vol. OTS0516797

oral-rat LD50 5500 uL/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: COMA
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.

unreported-rat LD50 7500 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(4), Pg. 74, 1981.

Dermal Toxicity:
skin-rabbit LD50 4200 ul/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
National Technical Information Service. Vol. OTS0516797

subcutaneous-rat LD50 6000 mg/kg
Bollettino Chimico Farmaceutico. Vol. 125, Pg. 401, 1986.

skin-rat LD50 6 ml/kg
BEHAVIORAL: COMA BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.

subcutaneous-mouse LD50 5500 ul/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.

skin-mouse LD50 6 ml/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.

skin-guinea pig LD50 32000 mg/kg
National Technical Information Service. Vol. OTS0516797

skin-guinea pig LD50 > 32000 mg/kg
National Technical Information Service. Vol. OTS0516797

Inhalation Toxicity:
inhalation-rat LC50 > 5240 mg/m3/4H
LIVER: OTHER CHANGES
BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 91, 1993.

 
Safety in Use Information:
Category: carrier solvents/deluents for flavors and/or fragrances
Recommendation for carbitol usage levels up to:
 not for fragrance use.
 
Recommendation for carbitol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):111-90-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8146
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
2-(2-ethoxyethoxy)ethanol
Chemidplus:0000111900
EPA/NOAA CAMEO:hazardous materials
RTECS:111-90-0
 
References:
 2-(2-ethoxyethoxy)ethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:111-90-0
Pubchem (cid):8146
Pubchem (sid):134975513
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D08904
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.44.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
grade: technical
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 deluents
 humectants
 solvents
FRwitch hazel
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 carbitol
 carbitol cellosolve
 DE solvent
 di(ethylene glycol) ethyl ether
 diethylene glycol ethyl ether
 diethylene glycol monoethyl ether
 diglycol monoethyl ether
 dioxitol
 dowanol 17
 dowanol DE
 EDG
 EDG cosmetic grade, 99.5% min. artifical
 EDG plus pharma grade
 ektasolve DE
 ethanol, 2-(2-ethoxyethoxy)-
 ethoxy diglycol
 ethoxydiglycol
2-(2-ethoxyethoxy) ethanol
2-(2-ethoxyethoxy)-ethanol
2-(2-ethoxyethoxy)ethan-1-ol
2-(2-ethoxyethoxy)ethanol
2-(2-ethoxyethoxy)ethanol 99%
 ethyl carbitol
 ethyl diethylene glycol
 ethyl diglycol
 ethyl digol
monoethyl ether of diethylene glycol
 ethyldiglycol
 ethylene diglycol monoethyl ether
 glycol ether DE
1-hydroxy-3,6-dioxaoctane
 losungsmittel APV
 poly-solv DE
 solvolsol
 transcutol
 

Articles:

PubMed:Water-soluble 1,2,4-triazole with diethylene glycol monoethyl ether groups: synthesis, characterization and application as an electron injection layer for PLEDs.
PubMed:Comparative analysis of toxicological evaluations for dermal exposure performed under two different EU regulatory frameworks.
PubMed:Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles.
PubMed:Effects of eight vehicles on transdermal lidocaine penetration in sheep skin in vitro.
PubMed:In vitro and in vivo evaluation of a self-microemulsifying drug delivery system for the poorly soluble drug fenofibrate.
PubMed:Enhancement of human oral bioavailability and in vitro antitumor activity of rosuvastatin via spray dried self-nanoemulsifying drug delivery system.
PubMed:Effect of chemical permeation enhancers on stratum corneum barrier lipid organizational structure and interferon alpha permeability.
PubMed:Enhanced bioavailability of total paeony glycoside by self-microemulsifying drug delivery system.
PubMed:One-dimensional self-assembly of phenylacetylene macrocycles: effect of peripheral substituents.
PubMed:Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability.
PubMed:Effects of spray-drying and choice of solid carriers on concentrations of Labrasol® and Transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS).
PubMed:Comparative evaluation of the effect of permeation enhancers, lipid nanoparticles and colloidal silica on in vivo human skin penetration of quercetin.
PubMed:Fertility and developmental toxicity studies of diethylene glycol monobutyl ether (DGBE) in rats.
PubMed:Development and optimization of self-nanoemulsifying drug delivery system with enhanced bioavailability by Box-Behnken design and desirability function.
PubMed:Formulation optimization, skin irritation, and efficacy characterization of a novel skin-lightening agent.
PubMed:Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique.
PubMed:[Modelling of pecutaneous drug permeation and investigation of penetration enhancer effect].
PubMed:Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil: in vitro evaluation of drug permeation by infrared spectroscopy.
PubMed:Characterization of semi-solid Self-Emulsifying Drug Delivery Systems (SEDDS) of atorvastatin calcium by Raman image spectroscopy and chemometrics.
PubMed:Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts.
PubMed:Self nano-emulsifying simvastatin based tablets: design and in vitro/in vivo evaluation.
PubMed:Assessment of the percutaneous penetration of indomethacin from soybean oil microemulsion: effects of the HLB value of mixed surfactants.
PubMed:Formulation of microemulsion systems for dermal delivery of silymarin.
PubMed:Preparation, characterization, and in vivo evaluation of a self-nanoemulsifying drug delivery system (SNEDDS) loaded with morin-phospholipid complex.
PubMed:Development of udenafil-loaded microemulsions for intranasal delivery: in vitro and in vivo evaluations.
PubMed:Permeation and skin retention of quercetin from microemulsions containing Transcutol® P.
PubMed:Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan.
PubMed:Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products.
PubMed:Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential.
PubMed:Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier.
PubMed:Design of fenofibrate microemulsion for improved bioavailability.
PubMed:Optimization of topical gels with betamethasone dipropionate: selection of gel forming and optimal cosolvent system.
PubMed:Penetration enhancer containing vesicles as carriers for dermal delivery of tretinoin.
PubMed:Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery.
PubMed:Effects of vehicles on the percutaneous absorption of donepezil hydrochloride across the excised hairless mouse skin.
PubMed:[Effect of three penetration enhancers on corneal permeability of mangiferin in vitro].
PubMed:The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients.
PubMed:Enhancing percutaneous delivery of methotrexate using different types of surfactants.
PubMed:Formulation of creams with betamethasone dipropionate: evaluation of chemical stability.
PubMed:Uptake of microemulsion components into the stratum corneum and their molecular effects on skin barrier function.
PubMed:Transcutol containing vesicles for topical delivery of minoxidil.
PubMed:A field study on clinical signs and symptoms in cleaners at floor polish removal and application in a Swedish hospital.
PubMed:Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein.
PubMed:Assessment of Labrasol/Labrafil/Transcutol (4/4/2, v/v/v) as a non-clinical vehicle for poorly water-soluble compounds after 4-week oral toxicity study in Wistar rats.
PubMed:Effect of Labrasol on self-nanoemulsification efficiency of ramipril nanoemulsion.
PubMed:Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique.
PubMed:Preparation of lorazepam-loaded microemulsions for intranasal delivery and its pharmacokinetics.
PubMed:Enhancement of percutaneous absorption of finasteride by cosolvents, cosurfactant and surfactants.
PubMed:Application of Box-Behnken design in understanding the quality of genistein self-nanoemulsified drug delivery systems and optimizing its formulation.
PubMed:Nanocarrier for the transdermal delivery of an antiparkinsonian drug.
PubMed:Docetaxel microemulsion for enhanced oral bioavailability: preparation and in vitro and in vivo evaluation.
PubMed:Different approaches for improving skin accumulation of topical corticosteroids.
PubMed:Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil.
PubMed:Biocompatible microemulsions of dicephalic aldonamide-type surfactants: formulation, structure and temperature influence.
PubMed:Formulation and evaluation of ubidecarenone transdermal delivery systems.
PubMed:Transdermal delivery of ketorolac.
PubMed:Preparation and evaluation of self-nanoemulsifying tablets of carvedilol.
PubMed:Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid.
PubMed:In vitro permeation of carvedilol through porcine skin: effect of vehicles and penetration enhancers.
PubMed:Effect of penetration modifiers on the dermal and transdermal delivery of drugs and cosmetic active ingredients.
PubMed:A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers.
PubMed:Low viscosity reversed hexagonal mesophases induced by hydrophilic additives.
PubMed:Inhibition of experimental periodontitis by a topical boron-based antimicrobial.
PubMed:Pharmacokinetics of formulated tenoxicam transdermal delivery systems.
PubMed:Effects of vehicles and enhancers on transdermal delivery of clebopride.
PubMed:Development and evaluation of a microemulsion formulation for transdermal delivery of terbinafine.
PubMed:VOC and carbonyl emissions from carpets: a comparative study using four types of environmental chambers.
PubMed:Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats.
PubMed:Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential.
PubMed:Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems.
PubMed:26-Week dermal oncogenicity study evaluating pure trans-capsaicin in Tg.AC hemizygous mice (FBV/N).
PubMed:Formulation and evaluation of ketorolac transdermal systems.
PubMed:Formulation and biopharmaceutical evaluation of silymarin using SMEDDS.
PubMed:Development and bioavailability assessment of ramipril nanoemulsion formulation.
PubMed:Percutaneous penetration of methyl nicotinate from ointments using the laser Doppler technique: bioequivalence and enhancer effects.
PubMed:Time of erythema onset after application of methyl nicotinate ointments as response parameter: influence of penetration kinetics and enhancing agents.
PubMed:Bioadhesive monolayer film for the in vitro transdermal delivery of sumatriptan.
PubMed:[Effect of self-microemulsifying system on cell tight junctions].
PubMed:Effect of vehicles and enhancers on the topical delivery of cyclosporin A.
PubMed:Preparation of bupleurum nasal spray and evaluation on its safety and efficacy.
PubMed:Effects of Transcutol P on the corneal permeability of drugs and evaluation of its ocular irritation of rabbit eyes.
PubMed:A new self-emulsifying formulation of itraconazole with improved dissolution and oral absorption.
PubMed:Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole.
PubMed:Preparation and evaluation of SEDDS and SMEDDS containing carvedilol.
PubMed:Removal of organic contaminants by RO and NF membranes.
PubMed:In vivo skin permeation of sodium naproxen formulated in pluronic F-127 gels: effect of Azone and Transcutol.
PubMed:Influence of deposition parameters on chemical properties of calcium phosphate coatings prepared by using electrostatic spray deposition.
PubMed:[Principles in the standardization of chemical compounds having an olfactive effect in the working area air].
PubMed:Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids.
PubMed:Effects of diethylene glycol butyl ether and butoxyethoxyacetic acid on rat and human erythrocytes.
PubMed:Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats.
PubMed:Sodium tetradecyl sulfate for sclerotherapy treatment of veins: is compounding pharmacy solution safe?
PubMed:The effect of vehicles and pressure sensitive adhesives on the percutaneous absorption of quercetin through the hairless mouse skin.
PubMed:Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery.
PubMed:Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers.
PubMed:Preparation and evaluation of microemulsion of vinpocetine for transdermal delivery.
PubMed:Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers.
PubMed:Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs.
PubMed:Dermal exposure during filling, loading and brushing with products containing 2-(2-butoxyethoxy)ethanol.
PubMed:Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model.
PubMed:Identification of diethylene glycol monobutyl ether as a source of contamination in an ion trap mass spectrometer.
PubMed:In vitro percutaneous absorption of ondansetron hydrochloride from pressure-sensitive adhesive matrices through hairless mouse skin.
PubMed:A single-dose pharmacokinetic study of oxolinic acid and vetoquinol, an oxolinic acid ester, in cod, Gadus morhua L., held in sea water at 8 degrees C and in vitro antibacterial activity of oxolinic acid against Vibrio anguillarum strains isolated from diseased cod.
PubMed:Structure elucidation, synthesis, and contact allergenic activity of a major hydroperoxide formed at autoxidation of the ethoxylated surfactant C12E5.
PubMed:Butoxyethoxyacetic acid, a biomarker of exposure to water-based cleaning agents.
PubMed:Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin.
PubMed:Oleic acid, a skin penetration enhancer, affects Langerhans cells and corneocytes.
PubMed:Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin.
PubMed:In vitro percutaneous absorption of tenoxicam from pressure-sensitive adhesive matrices across the hairless mouse skin.
PubMed:Preformulation study of epigallocatechin gallate, a promising antioxidant for topical skin cancer prevention.
PubMed:Influence of Transcutol CG on the skin accumulation and transdermal permeation of ultraviolet absorbers.
PubMed:Investigation of the utility of an in vitro release test for optimizing semisolid dosage forms.
PubMed:Air and biological monitoring of solvent exposure during graffiti removal.
PubMed:Occupational contact dermatitis from diethylene glycol monobutyl ether in a podiatrist.
PubMed:Pharmacokinetic profiles in rats after intravenous, oral, or dermal administration of dapsone.
PubMed:Investigation of the absorption of hypericin into the skin of hairless mice.
PubMed:Scale-up of an oil/water cream containing 40% diethylene glycol monoethyl ether.
PubMed:In vitro permeation through porcine buccal mucosa of Salvia desoleana Atzei & Picci essential oil from topical formulations.
PubMed:Evaluation of transcutol as a clonazepam transdermal permeation enhancer from hydrophilic gel formulations.
PubMed:[Emissions from building products and investigation of their toxicity with the bioluminescence inhibition test].
PubMed:Contact dermatitis due to a cream containing chitin and a Carbitol.
PubMed:Twenty-eight-day repeated-dose inhalation exposure of rats to diethylene glycol monoethyl ether.
PubMed:Reproductive toxicology. Diethylene glycol monoethyl ether.
PubMed:Influence of vehicle on patch test response to nickel sulfate.
PubMed:The relative effect of Azone and Transcutol on permeant diffusivity and solubility in human stratum corneum.
PubMed:Diethylene glycol monoethyl ether (Transcutol) displays antiproliferative properties alone and in combination with xanthines.
PubMed:Assessment of the toxic and potential teratogenic effects of four glycol ethers and two derivatives using the hydra regeneration assay and rat whole embryo culture.
PubMed:Fluorescent vs. radioactive microsphere measurement of regional myocardial blood flow.
PubMed:The effect of diethylene glycol monoethyl ether as a vehicle for topical delivery of ivermectin.
PubMed:Hypersensitivity to 2-(2-butoxyethoxy)ethanol.
PubMed:The effect of topical application of the platelet-activating factor-antagonist, Ro 24-0238, in psoriasis vulgaris--a clinical and immunohistochemical study.
PubMed:Determination of volatile chemicals released from microwave-heat-susceptor food packaging.
PubMed:Development and evaluation of an intracutaneous depot formulation of corticosteroids using Transcutol as a cosolvent: in-vitro, ex-vivo and in-vivo rat studies.
PubMed:Diethylene glycol mono butyl ether concentrations in room air from application of cleaner formulations to hard surfaces.
PubMed:Development of an intracutaneous depot for drugs. Binding, drug accumulation and retention studies, and mechanism of depot.
PubMed:Application of multidimensional gas chromatography-mass spectrometry to the determination of glycol ethers in air.
PubMed:Reproductive effects of diethylene glycol and diethylene glycol monoethyl ether in Swiss CD-1 mice assessed by a continuous breeding protocol.
PubMed:Delayed and immediate hypersensitivity to carbitols.
PubMed:Teratology study of diethylene glycol mono-n-butyl ether in rats.
PubMed:In vivo and in vitro toxicity of carbitol.
PubMed:Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits.
PubMed:A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig.
PubMed:Fertility and teratogenic studies of diethylene glycol monobutyl ether in rats and rabbits.
PubMed:[Skin-irritating and sensitizing action of diethylene glycol monethyl ether].
PubMed:Developmental toxicity of four glycol ethers applied cutaneously to rats.
PubMed:Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment.
PubMed:Mutagenicity testing of diethylene glycol monobutyl ether.
PubMed:The toxic effect of some industrial chemicals on rabbit ileum in vitro compared with eye irritancy in vivo.
PubMed:Reproductive toxicity of the glycol ethers.
PubMed:[Data on establishing the maximum permissible concentration of diethylene glycol monoethyl ether in reservoir water].
PubMed:[Medico-toxicological characteristics of diethylene glycol ethers (carbitols) applicable to air pollution control].
PubMed:[Experimental substantiation of the maximum permissible concentration of the ester of ethylcarbitol and fatty acids in the water of reservoirs].
PubMed:Application of solvent extraction to the refining of precious metals-III Purification of gold.
PubMed:Short-term feeding study with diethylene glycol monoethyl ether in rats.
PubMed:A 2-YR STUDY OF DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS.
PubMed:[Not Available].
PubMed:External use of carbitol solvent, carbitol and other agents.
PubMed:Purification of phosphoglucomutase with carbitol acetate.
PubMed:Epidermal application of diethylene glycol monoethyl ether (carbitol) and some other glycols; absorption, toxicity and visceral damage.
PubMed:Excretion and fate of diethylene glycol monoethyl ether (carbitol) after epidermal and other methods of administration.
PubMed:Comparative chronic toxicity of die thylene glycol monoethyl ether (carbitol) and some related glycols; results of continued drinking and feeding.
PubMed:Acute toxicity and general systemic actions of diethylene glycol monoethyl ether (carbitol).
PubMed:Glucuronic acid excretion after diethylene glycol monoethyl ether (carbitol) and some other glycols.
PubMed:Toxicity, excretion and fate of diethylene glycol monoethyl ether compared with other glycols applied epidermally.
 
Notes:
used as lubricating oil & in braking fluid.
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