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rheum palmatum root
dried, crushed roots of the rhubarb, rheum palmatum l., polygonaceae

Supplier Sponsors

Name:	rheum palmatum root
CAS Number:	90106-27-7
ECHA EC Number:	290-249-3
FDA UNII:	Search

Category:astringent, tonic agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
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Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
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PubMed:	Search
NCBI:	Search

Physical Properties:

Food Chemicals Codex Listed:

No

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	astringents tonic

Suppliers:

Qingdao Dacon Trading

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
astringent, tonic agents
Recommendation for rheum palmatum root usage levels up to:
	not for fragrance use.

Recommendation for rheum palmatum root flavor usage levels up to:
	not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to hydroxyanthracene derivatives and improvement of bowel function pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

Safety of hydroxyanthracene derivatives for use in food
View page or View pdf

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

rheum palmatum root

Chemidplus:0090106277

References:

	rheum palmatum root
Pubchem (sid):	135321840

Other Information:

Wikipedia:

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

rheum palmatum root
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Synonyms:

	dried, crushed roots of the rhubarb, rheum palmatum l., polygonaceae
	rheum potaninii root
	rheum qinlingense root
	rhubarb root

Articles:

PubMed:Emodin Suppresses Maintenance of Stemness by Augmenting Proteosomal Degradation of Epidermal Growth Factor Receptor/Epidermal Growth Factor Receptor Variant III in Glioma Stem Cells.

PubMed:Emodin enhances ATRA-induced differentiation and induces apoptosis in acute myeloid leukemia cells.

PubMed:Rheum palmatum L. and Coptis chinensis Franch., exert antipyretic effect on yeast-induced pyrexia rats involving regulation of TRPV1 and TRPM8 expression.

PubMed:Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a.

PubMed:Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice.

PubMed:Profiling of secondary metabolites in tissues from Rheum palmatum L. using laser microdissection and liquid chromatography mass spectrometry.

PubMed:Downregulation of phosphatase of regenerating liver-3 is involved in the inhibition of proliferation and apoptosis induced by emodin in the SGC-7901 human gastric carcinoma cell line.

PubMed:Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes.

PubMed:Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer.

PubMed:[Survey and pathogen identification of rhubarb diseases in Gansu province].

PubMed:Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

PubMed:Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.

PubMed:Involvement of matrix metalloproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells.

PubMed:[Biotransformation of podophyllotoxin by cell suspension culture and root culture of Rheum palmatum].

PubMed:The biogeochemistry of selenium in Sunan grassland, Gansu, Northwest China, casts doubt on the belief that Marco Polo reported selenosis for the first time in history.

PubMed:Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation.

PubMed:Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.

PubMed:Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor.

PubMed:Aloe-emodin induces in vitro G2/M arrest and alkaline phosphatase activation in human oral cancer KB cells.

PubMed:Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC).

PubMed:Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells.

PubMed:Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloe-emodin.

PubMed:[Induction of hairy roots and anthraquinone production in Rheum palmatum].

PubMed:Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities.

PubMed:Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation.

PubMed:Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis.

PubMed:Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.

PubMed:Botanical medicines for the urinary tract.

PubMed:Inducible nitric oxide synthase inhibitors of Chinese herbs III. Rheum palmatum.

PubMed:[Effect of salicylic acid on production of anthracene derivatives in a culture of Rheum palmatum L. in vitro].

PubMed:[Anthraquinone production and analysis in the hairy root cultures of Rheum palmatum L].

PubMed:Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.

PubMed:Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma.

PubMed:[Effect of the biotic elicitor, Candida utilis, on the production of anthracene derivatives in a tissue culture of Rheum palmatum L].

PubMed:[Production of anthracene derivatives in elicited tissue cultures of Rheum palmatum L].

PubMed:[Studies on polysaccharide of Rheum palmatum L].

PubMed:Antitrichomonal action of emodin in mice.

PubMed:[Experimental study on effects of 18 kinds of Chinese herbal medicine for synthesis of thromboxane A2 and PGI2].

PubMed:[Analysis of the polyphenols in the root of Rheum palmatum L].

Notes:

None found

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