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hypericum perforatum extract
extract of the capsules, flowers, leaves and stem heads of the st. john's wort, hypericum perforatum l., hypericaceae

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Name:hypericum perforatum l. extract
CAS Number: 84082-80-4
ECHA EC Number:282-026-4
Category:cosmetic and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
Soluble in:
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antimicrobial agents
skin conditioning
skin protecting agents
soothing agents
St. John’s Wort, AF – 5554
St. John’s Wort, FE – 5410
BOC Sciences
For experimental / research use only.
Hypericum perforatum extract 0.3% (Hypericin); 10:1
Bristol Botanicals
St Johnswort fluid extract Hypericum perforatum 1:1 35%
hypericum perforatum extract
Changsha Organic Herb
St. John’s Wort Extract Hypericum perforatum
Dongguan Meiherb Biotech
Hypericum Perforatum Extract
Odor: characteristic
Use: The active ingredient hypericin can treat moderately depressed patients without side effects and is also anti-tussive, analgesic and hepato-protective.
Grau Aromatics
Grau Aromatics
Indo World Trading
St. John's Wort Extract
Qingdao Dacon Trading
St john's wort extract
Shaanxi Y-Herb Biotechnology
Hypericum Perforatum P.E. Hypericin 0.3% Hyperforin 3% St. John's Wort Extract Powder
SRS Aromatics
SRS Aromatics
Extrapone® St. John's Wort GW
Life Essentials - Botanicals
Vege Tech
hypericum extract
Xi'an Greena Biotech
St.John’s Wort Extract
Odor: characteristic
Use: St.John’s Wort Extract is extraction from the dried herb of St.John’s Wort. It is native to the Eurasia.St.John’s Wort is contains hypericin,hyperesin,tannin, pseudohypericin,pro-tohypericin,emodinanthranol and other active ingredients.Hypericin belong to two anthracene ketone,is most biologically active substances in St.John’s Wort,with a wide range of anti-virus,cough and asthma,anti-inflammatory,fever,bleeding convergence function.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for hypericum perforatum extract flavor usage levels up to:
 not for flavor use.
Safety References:
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):84082-80-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
hypericum perforatum l. extract
 hypericum perforatum l. extract
Canada Domestic Sub. List:84082-80-4
Pubchem (sid):135317821
Other Information:
Export Tariff Code:1302.19.0000
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 st. john's wort
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 extract of the capsules, flowers, leaves and stem heads of the st. john's wort, hypericum perforatum l., hypericaceae
 hypericum extract (hypericum perforatum)
 millepertius plant extract
 st. john's wort extract
 st. john's wort extract, 0.3% hypericin
extrapone st. john's wort GW (Symrise)
 st. john’s wort extract hypericum perforatum


PubMed:Effect of Hypericum perforatum L. Extract on Insulin Resistance and Lipid Metabolic Disorder in High-Fat-Diet Induced Obese Mice.
PubMed:St John's Wort (Hypericum perforatum L.) photomedicine: hypericin-photodynamic therapy induces metastatic melanoma cell death.
PubMed:Effect of St John's wort on bone formation in the orthopaedically expanded premaxillary suture in rats: a histological study.
PubMed:St. John's wort promotes adipocyte differentiation and modulates NF-κB activation in 3T3-L1 cells.
PubMed:Comparative assessment of the therapeutic effects of the topical and systemic forms of Hypericum perforatum extract on induced oral mucositis in golden hamsters.
PubMed:Molecularly imprinted polymer for specific extraction of hypericin from Hypericum perforatum L. herbal extract.
PubMed:Hypericum perforatum: Influences of the habitat on chemical composition, photo-induced cytotoxicity, and antiradical activity.
PubMed:Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters.
PubMed:Effect of Hypericum perforatum on intraperitoneal adhesion formation in rats.
PubMed:In vitro growth inhibition by Hypericum extracts and isolated pure compounds of Paenibacillus larvae, a lethal disease affecting honeybees worldwide.
PubMed:The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats.
PubMed:Interaction between different extracts of Hypericum perforatum L. from Serbia and pentobarbital, diazepam and paracetamol.
PubMed:Anti-aging effects of some selected Iranian folk medicinal herbs-biochemical evidences.
PubMed:[Synergic antidepressive effect of quercetin and Hypericum perforatum extract in mice].
PubMed:Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury.
PubMed:Nature cures nature: Hypericum perforatum attenuates physical withdrawal signs in opium dependent rats.
PubMed:[Effects of hypericum perforatum extract on the autoimmune myocarditis of mice].
PubMed:[Effect of hypericum perforatum extract on gap junction protein Cx43 of the dilated cardiomyopathy rats].
PubMed:St. John's wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity.
PubMed:The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus.
PubMed:Life span effects of Hypericum perforatum extracts on Caenorhabditis elegans under heat stress.
PubMed:The hepatoprotective effects of Hypericum perforatum L. on hepatic ischemia/reperfusion injury in rats.
PubMed:St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein.
PubMed:Behavioral profile of Hypericum perforatum (St. John's Wort) extract. A comparison with standard antidepressants in animal models of depression.
PubMed:Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
PubMed:Radical protection in the visible and infrared by a hyperforin-rich cream--in vivo versus ex vivo methods.
PubMed:St. John's wort reversal of meningeal nociception: a natural therapeutic perspective for migraine pain.
PubMed:Antimicrobial activity of southern African medicinal plants with dermatological relevance: From an ethnopharmacological screening approach, to combination studies and the isolation of a bioactive compound.
PubMed:Hypericum perforatum L. subsp. perforatum induces inhibition of free radicals and enhanced phototoxicity in human melanoma cells under ultraviolet light.
PubMed:Neuroprotective Properties of Standardized Extracts of Hypericum perforatum on Rotenone Model of Parkinson's Disease.
PubMed:The use of an extract of Hypericum perforatum and Azadirachta indica in advanced diabetic foot: an unexpected outcome.
PubMed:[The antiradical activity of plant extracts and healthful preventive combinations of these exrtacts with the phospholipid complex].
PubMed:The neurocognitive effects of Hypericum perforatum Special Extract (Ze 117) during smoking cessation.
PubMed:Hypericum perforatum extract therapy for chickens experimentally infected with infectious bursal disease virus and its influence on immunity.
PubMed:Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets.
PubMed:Synthese and characterization of boronic acid functionalized macroporous uniform poly(4-chloromethylstyrene-co-divinylbenzene) particles and its use in the isolation of antioxidant compounds from plant extracts.
PubMed:Effect of Hypericum perforatum Extract in an Experimental Model of Binge Eating in Female Rats.
PubMed:Effect of hydroalcoholic extract of Hypericum perforatum on selected traditional and novel biochemical factors of cardiovascular diseases and atherosclerotic lesions in hypercholesterolemic rabbits: A comparison between the extract and lovastatin.
PubMed:Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca(2+) -permeable TRPC6 channels.
PubMed:Systematic review of breastfeeding and herbs.
PubMed:Effect of hydroalcoholic extract of Hypericum perforatum L. leaves on ethylene glycol-induced kidney calculi in rats.
PubMed:Content of hypericins from plants and in vitro shoots of Hypericum undulatum Schousb. ex Willd.
PubMed:Local clinical phototreatment of herpes infection in São Paulo.
PubMed:St John's wort (Hypericum perforatum) versus sertraline and placebo in major depressive disorder: continuation data from a 26-week RCT.
PubMed:Water-extractable magnesium, manganese and copper in leaves and herbs of medicinal plants.
PubMed:SNP-mediated neuroprotection under glucose deprivation is enhanced by Hypericum perforatum.
PubMed:In vivo photoprotective and anti-inflammatory effect of hyperforin is associated with high antioxidant activity in vitro and ex vivo.
PubMed:Investigating the effectiveness of St John's wort herb as an antimicrobial agent against mycobacteria.
PubMed:The effect of St John's wort (hypericum perforatum) on cytochrome p450 1a2 activity in perfused rat liver.
PubMed:Metabolome classification of commercial Hypericum perforatum (St. John's Wort) preparations via UPLC-qTOF-MS and chemometrics.
PubMed:Therapeutic efficacy of Hypericum perforatum L. extract for mice infected with an influenza A virus.
PubMed:The inhibition of lipopolysaccharide-induced macrophage inflammation by 4 compounds in Hypericum perforatum extract is partially dependent on the activation of SOCS3.
PubMed:The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner.
PubMed:Beneficial effect of Hypericum perforatum on depression and anxiety in a type 2 diabetic rat model.
PubMed:Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats.
PubMed:Effects of Hypericum perforatum extract on rat irritable bowel syndrome.
PubMed:Antihyperglycemic effect of Hypericum perforatum ethyl acetate extract on streptozotocin-induced diabetic rats.
PubMed:Effects of St John's wort (Hypericum perforatum L.) extracts on epileptogenesis.
PubMed:Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages.
PubMed:[Influence of electroacupuncture plus intragastric administration of extract of hypericum perforatum L on ethology and brain microcirculation in depression rats].
PubMed:In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts.
PubMed:Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stressinduced behavioral and biochemical alteration in male albino mice.
PubMed:Dermocosmetics for dry skin: a new role for botanical extracts.
PubMed:Antioxidant activity relationship of phenolic compounds in Hypericum perforatum L.
PubMed:The effect of Hypericum perforatum on isolated rat aorta.
PubMed:Hypericum perforatum differentially affects corticosteroid receptor-mRNA expression in human monocytic U-937 cells.
PubMed:Duration of response after treatment of mild to moderate depression with Hypericum extract STW 3-VI, citalopram and placebo: a reanalysis of data from a controlled clinical trial.
PubMed:Analysis of secondary plant metabolites by indirect desorption electrospray ionization imaging mass spectrometry.
PubMed:Investigation of Hypericum perforatum extract on convulsion induced by picrotoxin in mice.
PubMed:Metabolic drug interactions between antidepressants and anticancer drugs: focus on selective serotonin reuptake inhibitors and hypericum extract.
PubMed:Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway.
PubMed:Isolation and purification of series bioactive components from Hypericum perforatum L. by counter-current chromatography.
PubMed:Hyperflav - perspective photosensitizer for PDT: cell studies.
PubMed:A novel wound healing ointment: a formulation of Hypericum perforatum oil and sage and oregano essential oils based on traditional Turkish knowledge.
PubMed:Potential of St John's Wort for the treatment of depression: the economic perspective.
PubMed:Profiling of hypothalamic and hippocampal gene expression in chronically stressed rats treated with St. John's wort extract (STW 3-VI) and fluoxetine.
PubMed:Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.
PubMed:Impact of plant extracts tested in attention-deficit/hyperactivity disorder treatment on cell survival and energy metabolism in human neuroblastoma SH-SY5Y cells.
PubMed:Effects of Hypericum perforatum extract on diabetes-induced learning and memory impairment in rats.
PubMed:Xanthine oxidase inhibitory properties of Czech medicinal plants.
PubMed:Pharmacological studies on Hypericum perforatum fractions and constituents.
PubMed:Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression.
PubMed:Which plant for which skin disease? Part 1: Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex.
PubMed:Evaluation of the wound healing potentials of two subspecies of Hypericum perforatum on cultured NIH3T3 fibroblasts.
PubMed:Effect of St. John's Wort standardized extract and hypericin on in vitro placental calcium transport.
PubMed:Hyperforin is a modulator of inducible nitric oxide synthase and phagocytosis in microglia and macrophages.
PubMed:Identification of JAK-STAT pathways as important for the anti-inflammatory activity of a Hypericum perforatum fraction and bioactive constituents in RAW 264.7 mouse macrophages.
PubMed:A hypericum extract in the treatment of depressive symptoms in outpatients: an open study.
PubMed:Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents.
PubMed:The TRPC6 channel activator hyperforin induces the release of zinc and calcium from mitochondria.
PubMed:Investigations on the in vivo wound healing potential of Hypericum perforatum L.
PubMed:Beneficial effects of a standardized Hypericum perforatum extract in rats with experimentally induced hyperglycemia.
PubMed:In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey.
PubMed:Hypericum perforatum L. (St John's wort) extract Ze 117 inhibits dopamine re-uptake in rat striatal brain slices. An implication for use in smoking cessation treatment?
PubMed:Protective effects of a flavonoid-rich extract of Hypericum perforatum L. against hydrogen peroxide-induced apoptosis in PC12 cells.
PubMed:The inhibitory effect of Hypericum perforatum extract on morphine withdrawal syndrome in rat and comparison with clonidine.
PubMed:Evaluation of Hypericum perforatum oil extracts for an antiinflammatory and gastroprotective activity in rats.
PubMed:Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC.
PubMed:Long-term effects of St. John's wort (Hypericum perforatum) treatment: a 1-year safety study in mild to moderate depression.
PubMed:Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent.
PubMed:Treatment of osteomyelitis in the feet of diabetic patients by photodynamic antimicrobial chemotherapy.
PubMed:Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial.
PubMed:Proapoptotic and prepulse inhibition (PPI) disrupting effects of Hypericum perforatum in rats.
PubMed:Separation of epigallocatechin and flavonoids from Hypericum perforatum L. by high-speed counter-current chromatography and preparative high-performance liquid chromatography.
PubMed:Adulterant profile of illicit street heroin and reduction of its precipitated physical dependence withdrawal syndrome by extracts of St John's wort (Hypericum perforatum).
PubMed:Xanthone biosynthesis in Hypericum perforatum cells provides antioxidant and antimicrobial protection upon biotic stress.
PubMed:St John's wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive.
PubMed:Identification of human intracellular targets of the medicinal Herb St. John's Wort by chemical-genetic profiling in yeast.
PubMed:The effect of Hypericum perforatum (St. John's Wort) on experimental colitis in rat.
PubMed:Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
PubMed:Skin tolerance of a new bath oil containing St. John's wort extract.
PubMed:Hypericin lights up the way for the potential treatment of nasopharyngeal cancer by photodynamic therapy.
PubMed:Hypericum perforatum and substance dependence: a review.
PubMed:Hypericum perforatum extract in burning mouth syndrome: a randomized placebo-controlled study.
PubMed:Liquid chromatography-tandem mass spectrometry of I3,II8-biapigenin, the major biflavone in Hypericum perforatum extracts.
PubMed:Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and Grape seed proanthocyanidins extract in mice.
PubMed:Protective effects of St. John's wort extract and its component hyperforin against cytokine-induced cytotoxicity in a pancreatic beta-cell line.
PubMed:Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
PubMed:Photodynamic therapy of nonmelanoma skin cancer with topical hypericum perforatum extract--a pilot study.
PubMed:Inhibitory effect of the herbal antidepressant St. John's wort (Hypericum perforatum) on rat gastric motility.
PubMed:Comparative study of Rhodiola preparations on behavioral despair of rats.
PubMed:Effect of hyperforin-enriched extract on pro-ejaculatory effect of 8-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats.
PubMed:Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease.
PubMed:Serotonergic anti-depressants and ethanol withdrawal syndrome: a review.
PubMed:Protective effect of St. John's wort (Hypericum perforatum) extract on 72-hour sleep deprivation-induced anxiety-like behavior and oxidative damage in mice.
PubMed:Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells.
PubMed:Placebo controlled continuation treatment with Hypericum extract WS 5570 after recovery from a mild or moderate depressive episode.
PubMed:St. John's wort: role of active compounds for its mechanism of action and efficacy.
PubMed:Serotonin mediates beneficial effects of Hypericum perforatum on nicotine withdrawal signs.
PubMed:Variability in PXR-mediated induction of CYP3A4 by commercial preparations and dry extracts of St. John's wort.
PubMed:Topical anti-inflammatory activity of extracts and compounds from Hypericum perforatum L.
PubMed:Recovering effects of aqueous extracts of some selected medical plants on the teratogenic effects during the development of D. melanogaster.
PubMed:Black cohosh and St. John's wort (GYNO-Plus) for climacteric symptoms.
PubMed:Modulating effect of Hypericum perforatum extract on astrocytes in MPTP induced Parkinson's disease in mice.
PubMed:Antagonism of antinociceptive effect of hydro-ethanolic extract of Hypericum perforatum Linn. by a non selective opioid receptor antagonist, naloxone.
PubMed:Extract of Hypericum perforatum blocks caffeine-induced locomotor activity in mice: a possible role of nitric oxide.
PubMed:Wound-healing activity of St. John's Wort (Hypericum perforatum L.) on chicken embryonic fibroblasts.
PubMed:Analysis of selected constituents in methanolic extracts of Hypericum perforatum collected in different localities by capillary ITP-CZE.
PubMed:Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats.
PubMed:[Evaluation of preparing process of extract of hypericum perforatum using HPLC fingerprint analysis].
PubMed:Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats.
PubMed:Plant-environment interactions: Accumulation of hypericin in dark glands of Hypericum perforatum.
PubMed:Protective effect of Hypericum perforatum in zymosan-induced multiple organ dysfunction syndrome: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity.
PubMed:Enhanced neuroprotective effect by combination of bromocriptine and Hypericum perforatum extract against MPTP-induced neurotoxicity in mice.
PubMed:Reduction in hypericin-induced phototoxicity by Hypericum perforatum extracts and pure compounds.
PubMed:A radioassay for synaptic core complex assembly: screening of herbal extracts for effectors.
PubMed:Superior efficacy of St John's wort extract WS 5570 compared to placebo in patients with major depression: a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298].
PubMed:Multivariate analysis of integrated and full-resolution 1H-NMR spectral data from complex pharmaceutical preparations: St. John's wort.
PubMed:Hypericum perforatum: which constituents may induce intestinal MDR1 and CYP3A4 mRNA expression?
PubMed:Neuroprotection and enhanced recovery with hypericum perforatum extract after experimental spinal cord injury in mice.
PubMed:Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients.
PubMed:Effect of eluent pH on the HPLC-UV analysis of hyperforin from St. John's Wort (Hypericum perforatum L.).
PubMed:Application of high-speed counter-current chromatography coupled with high-performance liquid chromatography-diode array detection for the preparative isolation and purification of hyperoside from Hypericum perforatum with online purity monitoring.
PubMed:St John's wort modulation and developmental expression of multidrug transporters in the rat.
PubMed:Evaluation of the light-sensitive cytotoxicity of Hypericum perforatum extracts, fractions, and pure compounds.
PubMed:A pilot randomised, open, uncontrolled, clinical study of two dosages of St John's wort (Hypericum perforatum) herb extract (LI-160) as an aid to motivational/behavioural support in smoking cessation.
PubMed:Hypericum perforatum L. extract - novel photosensitizer against human bladder cancer cells.
PubMed:Hypericum perforatum attenuates the development of cerulein-induced acute pancreatitis in mice.
PubMed:Hypericum perforatum attenuates the development of carrageenan-induced lung injury in mice.
PubMed:Hyperforin in St. John's wort drug interactions.
PubMed:Effect of sub-chronic treatment with Jarsin (extract of St John's wort, Hypericum perforatum) at two dose levels on evening salivary melatonin and cortisol concentrations in healthy male volunteers.
PubMed:Black cohosh and St. John's wort for climacteric complaints: a randomized trial.
PubMed:Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection.
PubMed:Photophysical properties of Hypericum perforatum L. extracts--novel photosensitizers for PDT.
PubMed:Approach to novel functional foods for stress control 5. Antioxidant activity profiles of antidepressant herbs and their active components.
PubMed:The lipophilic extract of Hypericum perforatum exerts significant cytotoxic activity against T24 and NBT-II urinary bladder tumor cells.
PubMed:Antispasmodic and bronchodilator activities of St John's wort are putatively mediated through dual inhibition of calcium influx and phosphodiesterase.
PubMed:Investigation of pharmacokinetic data of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin revealed from single and multiple oral dose studies with a hypericum extract containing tablet in healthy male volunteers.
PubMed:Effects of St John's wort (Hypericum perforatum L.) extract on plasma androgen concentrations in healthy men and women: a pilot study.
PubMed:Development of pregnancy in rats treated with Hypericum perforatum.
PubMed:Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus.
PubMed:St John's wort versus placebo in obsessive-compulsive disorder: results from a double-blind study.
PubMed:[Effect of Hypericum perforatum extract on in vitro labelling of blood elements with technetium-99m and on biodisponibility of sodium pertechnetate in Wistar rats].
PubMed:Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats.
PubMed:Effects of Hypericum perforatum extract in a rat model of ischemia and reperfusion injury.
PubMed:[Evaluation of Hypericum perforatum toxicity when administered to pregnant rats].
PubMed:Effect of St John's wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver.
PubMed:Antioxidant properties of some hydroalcoholic plant extracts with antiinflammatory activity.
PubMed:Does Hypericum perforatum L. extract show any specificity as photosensitizer for HL-60 leukemic cells and cord blood hemopoietic progenitors during photodynamic therapy?
PubMed:The anti-depressant effect of Nelumbinis semen on rats under chronic mild stress induced depression-like symptoms.
PubMed:Photogenotoxicity of hypericin in HaCaT keratinocytes: implications for St. John's Wort supplements and high dose UVA-1 therapy.
PubMed:Effect of Hypericum perforatum CO2 extract on the motivational properties of ethanol in alcohol-preferring rats.
PubMed:Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet.
PubMed:Liquid chromatography-mass spectrometry studies of St. John's wort methanol extraction: active constituents and their transformation.
PubMed:Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin.
PubMed:The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms.
PubMed:St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro.
PubMed:Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs.
PubMed:Magnesium-deficient diet alters depression- and anxiety-related behavior in mice--influence of desipramine and Hypericum perforatum extract.
PubMed:Toxicity of Hypericum perforatum (St. John's wort) administered during pregnancy and lactation in rats.
PubMed:Hydroalcoholic plant extracts with anti-inflammatory activity.
PubMed:Role of hyperforin in the pharmacological activities of St. John's Wort.
PubMed:Hyperici herba extract interaction with artificial lipid bilayers.
PubMed:Neuroprotective effect of H. perforatum extracts on beta-amyloid-induced neurotoxicity.
PubMed:The effectiveness of St. John's Wort in major depressive disorder: a naturalistic phase 2 follow-up in which nonresponders were provided alternate medication.
PubMed:Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro.
PubMed:The antidepressant activity of Hypericum perforatum L. measured by two experimental methods on mice.
PubMed:Comparison of the synaptosomal uptake inhibition of serotonin by St John's wort products.
PubMed:Antioxidant properties and protective effects of a standardized extract of Hypericum perforatum on hydrogen peroxide-induced oxidative damage in PC12 cells.
PubMed:The antidepressant mechanism of Hypericum perforatum.
PubMed:Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John's Wort.
PubMed:First-episode psychosis after taking an extract of Hypericum perforatum (St John's Wort).
PubMed:Effect of Hypericum perforatum on marble-burying by mice.
PubMed:Hypericum perforatum methanolic extract inhibits growth of human prostatic carcinoma cell line orthotopically implanted in nude mice.
PubMed:Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex.
PubMed:Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.
PubMed:St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole.
PubMed:Endocrinological effects of high-dose Hypericum perforatum extract WS 5570 in healthy subjects.
PubMed:Correlation of hyperforin content of Hypericum perforatum (St John's Wort) extracts with their effects on alcohol drinking in C57BL/6J mice: a preliminary study.
PubMed:Cytotoxic activity of Hypericum perforatum L. on K562 erythroleukemic cells: differential effects between methanolic extract and hypericin.
PubMed:Commercially available Hypericum perforatum extracts do not decrease immobility of rats in the forced swimming test.
PubMed:Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum.
PubMed:Sub-chronic treatment with an extract of Hypericum perforatum (St John's wort) significantly reduces cortisol and corticosterone in the rat brain.
PubMed:Hypericum perforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine.
PubMed:The prototypic antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the rat.
PubMed:Hypericum perforatum CO2 extract and opioid receptor antagonists act synergistically to reduce ethanol intake in alcohol-preferring rats.
PubMed:A simple and reliable semipreparative high-performance liquid chromatography technique for the isolation of marker-grade hyperforin from Hypericum perforatum L extract.
PubMed:Fast high-performance liquid chromatographic analysis of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts.
PubMed:Comparison of the growth-inhibitory effect of Hypericum perforatum L. extracts, differing in the concentration of phloroglucinols and flavonoids, on leukaemia cells.
PubMed:Sub-chronic treatment effects of an extract of Hypericum perforatum (St. John's Wort, Li 160) on neuroendocrine responses to the 5-T2A agonist, DOI in the rat.
PubMed:Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse.
PubMed:Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines.
PubMed:Topical treatment of atopic dermatitis with St. John's wort cream--a randomized, placebo controlled, double blind half-side comparison.
PubMed:Effects of Hypericum perforatum and paroxetine on rat performance in the elevated T-maze.
PubMed:Mechanism of action of St John's wort in depression : what is known?
PubMed:Step by step removal of hyperforin and hypericin: activity profile of different Hypericum preparations in behavioral models.
PubMed:Effects of Hypericum extract on the acetylcholine release: a loose patch clamp approach.
PubMed:Treatment with Hypericum perforatum L. does not trigger decreased resistance in Staphylococcus aureus against antibiotics and hyperforin.
PubMed:Hypericum perforatum attenuates nicotine withdrawal signs in mice.
PubMed:[Therapeutic and toxicologic aspects of biological effects of Saint John's wort (Hypericum perforatum L.)].
PubMed:Effects of Hypericum perforatum and paroxetine in the mouse defense test battery.
PubMed:[Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study].
PubMed:Herbal remedies for alcoholism: promises and possible pitfalls.
PubMed:Effect of oral administration ofHypericum perforatum extract (St. John's Wort) on skin erythema and pigmentation induced by UVB, UVA, visible light and solar simulated radiation.
PubMed:Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. II. Study of roller compaction variables on granule and tablet properties by a 3(3) factorial design.
PubMed:Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches.
PubMed:Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers.
PubMed:Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts.
PubMed:Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line.
PubMed:Blockade of gamma-aminobutyric acid receptors does not modify the inhibiton of ethanol intake induced by Hypericum perforatum in rats.
PubMed:St. John's wort (Hypericum perforatum L.) and kindling epilepsy in rabbit.
PubMed:[Metabolic effects and drug interactions provoked by certain vegetables: grapefruit, St. John's wort and garlic].
PubMed:Transport of amentoflavone across the blood-brain barrier in vitro.
PubMed:The effects of St John's wort extract on heart rate variability, cognitive function and quantitative EEG: a comparison with amitriptyline and placebo in healthy men.
PubMed:Inhibition of vesicular uptake of monoamines by hyperforin.
PubMed:[Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects].
PubMed:Brain neurotransmitter receptor binding and nootropic studies on Indian Hypericum perforatum Linn.
PubMed:Efficacy of St. John's wort extract WS 5570 in major depression: a double-blind, placebo-controlled trial.
PubMed:Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test.
PubMed:In vitro receptor screening of pure constituents of St. John's wort reveals novel interactions with a number of GPCRs.
PubMed:Aqueous ethanolic extract of St. John's wort (Hypericum perforatum L.) induces growth inhibition and apoptosis in human malignant cells in vitro.
PubMed:Selected physical and chemical properties of commercial Hypericum perforatum extracts relevant for formulated product quality and performance.
PubMed:Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression.
PubMed:St John's wort (Hypericum perforatum) modulates evoked potentials in guinea pig hippocampal slices via AMPA and GABA receptors.
PubMed:Supercritical fluid extraction and high-performance liquid chromatographic determination of phloroglucinols in St. John's Wort (Hypericum perforatum L.).
PubMed:Excipient compatibility study of Hypericum perforatum extract (St. John's wort) using similarity metrics to track phytochemical profile changes.
PubMed:Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.
PubMed:Enhanced survival and regeneration of axotomized retinal ganglion cells by a mixture of herbal extracts.
PubMed:The separation of hypericine and pseudohypericine from Hypericum perforatum L.
PubMed:Long-term effects of St. John's wort and hypericin on monoamine levels in rat hypothalamus and hippocampus.
PubMed:Determination of naphthodianthrones and phloroglucinols from Hypericum perforatum extracts by liquid chromatography/tandem mass spectrometry.
PubMed:Effects of acute and chronic treatment with Hypericum perforatum L. (LI 160) on different anxiety-related responses in rats.
PubMed:Decreased plasma levels of amitriptyline and its metabolites on comedication with an extract from St. John's wort ( Hypericum perforatum ).
PubMed:Improved procedure for the quality control of Hypericum perforatum L.
PubMed:Synergy and other interactions in phytomedicines.
PubMed:Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation.
PubMed:[Mania during the use of a combination preparation with St. John's wort (Hypericum perforatum)].
PubMed:Final report on the safety assessment of Hypericum perforatum extract and Hypericum perforatum oil.
PubMed:High-performance liquid chromatography-electrospray ionization mass spectrometry and multiple mass spectrometry studies of hyperforin degradation products.
PubMed:Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices.
PubMed:Interleukin-6 involvement in antidepressant action of Hypericum perforatum.
PubMed:Modulation of ion channels in rat neurons by the constituents of Hypericum perforatum.
PubMed:Hyperforin stimulates intracellular calcium mobilisation and enhances extracellular acidification in DDT1-MF2 smooth muscle cells.
PubMed:St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells.
PubMed:Hypericum perforatum--a review of clinical studies.
PubMed:In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.
PubMed:A study of the antidepressant activity of Hypericum perforatum on animal models.
PubMed:Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man.
PubMed:Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment.
PubMed:Evaluation of synaptosomal uptake inhibition of most relevant constituents of St. John's wort.
PubMed:Neurochemical studies with St. John's wort in vitro.
PubMed:Neuroendocrine effects of Hypericum extract WS 5570 in 12 healthy male volunteers.
PubMed:Acute and chronic actions of a dry methanolic extract of Hypericum perforatum and a hyperforin-rich extract on dopaminergic and serotonergic neurones in rat nucleus accumbens.
PubMed:A current review of the antimicrobial activity of Hypericum perforatum L.
PubMed:In vivo neurotransmitter release in the locus coeruleus--effects of hyperforin, inescapable shock and fear.
PubMed:Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.
PubMed:Neurochemical studies on Indian Hypericum perforatum L.
PubMed:An investigation into the acute nootropic effects of Hypericum perforatum L. (St. John's Wort) in healthy human volunteers.
PubMed:Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media.
PubMed:Procyanidins from the herb of Hypericum perforatum.
PubMed:Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial.
PubMed:Experience with St John's Wort (Hypericum perforatum) in children under 12 years with symptoms of depression and psychovegetative disturbances.
PubMed:Hypericum perforatum as a nootropic drug: enhancement of retrieval memory of a passive avoidance conditioning paradigm in mice.
PubMed:Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats.
PubMed:Effect of light on hypericins contents in fresh flowering top parts and in an extract of St. John's Wort (Hypericum perforatum).
PubMed:Single-dose and steady-state administration of Hypericum perforatum extract (St John's Wort) does not influence skin sensitivity to UV radiation, visible light, and solar-simulated radiation.
PubMed:Serotonin, norepinephrine and dopamine involvement in the antidepressant action of hypericum perforatum.
PubMed:St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature.
PubMed:Anxiolytic activity of Indian Hypericum perforatum Linn: an experimental study.
PubMed:Acute effects of LI 160 (extract of Hypericum perforatum, St John's wort) and two of its constituents on neuroendocrine responses in the rat.
PubMed:Oral bioavailability of active principles from herbal products in humans. A study on Hypericum perforatum extracts using the soft gelatin capsule technology.
PubMed:Pharmacodynamic study of Hypericum perforatum L.
PubMed:St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4.
PubMed:Evaluation of chemical stability of St. John's wort commercial extract and some preparations.
PubMed:Bisanthraquinone glycosides of Hypericum perforatum with binding inhibition to CRH-1 receptors.
PubMed:Hazardous pharmacokinetic interaction of Saint John's wort (Hypericum perforatum) with the immunosuppressant cyclosporin.
PubMed:[Saint John's Wort as an antidepressant].
PubMed:Simultaneous determination of the predominant hyperforins and hypericins in St. John's Wort (Hypericum perforatum L.) by liquid chromatography.
PubMed:St John's wort, a herbal antidepressant, activates the steroid X receptor.
PubMed:Comparison of St John's wort and imipramine for treating depression: randomised controlled trial.
PubMed:Effect of Indian Hypericum perforatum Linn on animal models of cognitive dysfunction.
PubMed:A pilot study of Hypericum perforatum for the treatment of premenstrual syndrome.
PubMed:Effect of topical application of Hypericum perforatum extract (St. John's wort) on skin sensitivity to solar simulated radiation.
PubMed:Individuals at Risk of Coronary Heart Disease (CHD), its Prevention and Management by an Indigenous Compound.
PubMed:Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.
PubMed:Antidepressant activity of Indian Hypericum perforatum Linn in rodents.
PubMed:Effects of Hypericum perforatum extract on ethanol intake, and on behavioral despair: a search for the neurochemical systems involved.
PubMed:Topical application of St John's wort (Hypericum perforatum L.) and of its metabolite hyperforin inhibits the allostimulatory capacity of epidermal cells.
PubMed:St John's wort: a potential therapy for elderly depressed patients?
PubMed:Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.
PubMed:Effect of the Hypericum perforatum extract on serotonin turnover in the mouse brain.
PubMed:The effects of St. John's Wort (Hypericum perforatum) on NK cell activity in vitro.
PubMed:Effect of acute administration of hypericum perforatum-CO2 extract on dopamine and serotonin release in the rat central nervous system.
PubMed:Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test.
PubMed:Stimulation of the production of hypericins by mannan in Hypericum perforatum shoot cultures.
PubMed:Role of alcoholic extract of shoot of Hypericum perforatum Linn on lipid peroxidation and various species of free radicals in rats.
PubMed:High performance liquid chromatography/electrospray mass spectrometry of Hypericum perforatum extracts.
PubMed:Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum).
PubMed:Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex.
PubMed:Attenuation of alcohol intake by extract of Hypericum perforatum (St. John's Wort) in two different strains of alcohol-preferring rats.
PubMed:Effects of Hypericum perforatum extraction on alcohol intake in Marchigian Sardinian alcohol-preferring rats.
PubMed:The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.).
PubMed:Screening of Turkish anti-ulcerogenic folk remedies for anti-Helicobacter pylori activity.
PubMed:Hypericin levels in human serum and interstitial skin blister fluid after oral single-dose and steady-state administration of Hypericum perforatum extract (St. John's wort).
PubMed:Neuroendocrine evidence for dopaminergic actions of hypericum extract (LI 160) in healthy volunteers.
PubMed:A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hypericum perforatum L.
PubMed:Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats.
PubMed:Hypericin as a non-antioxidant inhibitor of NF-kappa B.
PubMed:Biochemical activities of extracts from Hypericum perforatum L. 4th Communication: influence of different cultivation methods.
PubMed:Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system.
PubMed:Phototoxic effects of Hypericum extract in cultures of human keratinocytes compared with those of psoralen.
PubMed:Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes.
PubMed:The quantitative EEG as a screening instrument to identify sedative effects of single doses of plant extracts in comparison with diazepam.
PubMed:Hypericum for fatigue - a pilot study.
PubMed:St John's Wort (Hypericum perforatum)--a herbal antidepressant.
PubMed:Hyperforin as a possible antidepressant component of hypericum extracts.
PubMed:Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers.
PubMed:Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John's Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG).
PubMed:Antidepressant activity of hypericum perforatum and hyperforin: the neglected possibility.
PubMed:Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test.
PubMed:St. John's Wort (Hypericum perforatum): clinical effects on depression and other conditions.
PubMed:Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding.
PubMed:Phytochemical characterization of various St. John's Wort extracts.
PubMed:Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity.
PubMed:Effects of long-term administration of hypericum extracts on the affinity and density of the central serotonergic 5-HT1 A and 5-HT2 A receptors.
PubMed:In vitro receptor binding and enzyme inhibition by Hypericum perforatum extract.
PubMed:Hypericin and pseudohypericin: pharmacokinetics and effects on photosensitivity in humans.
PubMed:[St John's wort against depression in favour again].
PubMed:Pharmacokinetics of hypericin and pseudohypericin after oral intake of the hypericum perforatum extract LI 160 in healthy volunteers.
PubMed:[The modification of a radiation lesion in animals with an aqueous extract of Hypericum perforatum L. 2].
PubMed:[The modification of a radiation lesion in animals with an aqueous extract of Hypericum perforatum L. 1].
PubMed:[Cefaktivon "novum". RES stimulant and cell activator. Documentation No. 8].
PubMed:Biflavonoids in Hypericum perforatum1; Part 1. Isolation of I3, II8-Biapigenin.
PubMed:[Animal experiments on the psychotropic action of a Hypericum extract].
PubMed:[Uterotonic action of extracts from a group of medicinal plants].
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