EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

menthyl pyrrolidone carboxylate
(5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate

Supplier Sponsors

Name:(5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate
CAS Number: 68127-22-0Picture of molecule3D/inchi
Other(deleted CASRN):52528-10-6
ECHA EINECS - REACH Pre-Reg:268-568-4
FDA UNII:Y27B4585KO
XlogP3-AA:3.00 (est)
Molecular Weight:267.36885000
Formula:C15 H25 N O3
NMR Predictor:Predict (works with chrome or firefox)
Name:[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate
CAS Number: 64519-44-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:264-935-8
FDA UNII:C7ZIB25BE7
Nikkaji Web:J307.247I
XlogP3-AA:3.00 (est)
Molecular Weight:267.36885000
Formula:C15 H25 N O3
NMR Predictor:Predict (works with chrome or firefox)
Category:flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
JECFA Food Flavoring:1858 menthyl pyrrolidone carboxylate
FEMA Number:4155 menthyl pyrrolidone carboxylate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):52528-10-6 ; MENTHYL PYRROLIDONECARBOXYLATE
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 68.00 to 72.00 °C. @ 760.00 mm Hg
Boiling Point: 409.00 to 410.00 °C. @ 760.00 mm Hg
Flash Point: 394.00 °F. TCC ( 201.11 °C. )
logP (o/w): 3.195 (est)
Soluble in:
 alcohol
 water, slightly
 water, 14.07 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Description:cooling
Flavor Type: cooling
cooling mentholic minty
Taste Description: cooling mentholic minty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
[1R-(1alpha,2Beta,5alpha)]-2-isopropyl-5-methylcyclohexyl 5-oxo-D-prolinate
Givaudan
Questice®
Odor: characteristic
Use: Questice® long-lasting cooling active releasing Menthol over several hours. It also releases a natural moisturizing factor to condition the skin. It can be used as a perception trigger for other actives. Ecocert® approved.
Jiangyin Healthway
Menthyl PCA
New functional food ingredients
Jiangyin Healthway
Menthyl PCA
Parchem
menthyl pyrrolidone carboxylate
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
flavoring agents
Recommendation for menthyl pyrrolidone carboxylate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 22
Click here to view publication 22
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: 3000.000003000.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 500.00000500.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
EPA Substance Registry Services (TSCA):68127-22-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :109140
National Institute of Allergy and Infectious Diseases:Data
(5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate
Chemidplus:0068127220
[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate
Chemidplus:0064519444
 
References:
Leffingwell:Chirality or Article
 (5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):109140
Pubchem (sid):135066234
 [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):115834
Pubchem (sid):135071737
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):C03962
HMDB (The Human Metabolome Database):HMDB32368
FooDB:FDB009781
ChemSpider:View
 
Potential Blenders and core components note
For Odor
herbal
1,4-
cineole
FL/FR
spike
lavender oil
FL/FR
piperitone
FL/FR
mentholic
cornmint oil
FL/FR
cornmint oil china
FL/FR
cornmint oil terpeneless
FL/FR
dextro-neo
menthol
FL/FR
(±)-
menthol
FL/FR
dextro,laevo-
menthol
FL/FR
(±)-iso
menthone
FL/FR
(+)-
menthone
FL/FR
laevo-
menthyl acetate
FL/FR
peppermint cyclohexanone
FL/FR
dextro-
piperitone
FL/FR
minty
cornmint oil japan
FL/FR
homo
menthol
FL/FR
(±)-
menthone
FL/FR
laevo-
menthyl lactate
FL/FR
pennyroyal oil
FL/FR
peppermint oil special fractions
FL/FR
peppermint oil terpeneless
FL/FR
laevo-
piperitone
FL/FR
(-)-iso
pulegol
FL/FR
For Flavor
cooling
1,4-
cineole
FL/FR
spike
lavender oil
FL/FR
iso
menthol
FL
dextro,laevo-
menthol
FL/FR
laevo-
menthyl lactate
FL/FR
mentholic
cornmint oil
FL/FR
cornmint oil terpeneless
FL/FR
dextro-neo
menthol
FL/FR
(±)-
menthol
FL/FR
menthol flavor
FL
(+)-
menthone
FL/FR
peppermint cyclohexanone
FL/FR
minty
cherry menthol flavor
FL
cornmint oil china
FL/FR
cornmint oil japan
FL/FR
homo
menthol
FL/FR
(±)-
menthone
FL/FR
(±)-iso
menthone
FL/FR
laevo-
menthyl acetate
FL/FR
mint flavor
FL
pennyroyal oil
FL/FR
peppermint oil special fractions
FL/FR
peppermint oil terpeneless
FL/FR
piperitone
FL/FR
dextro-
piperitone
FL/FR
laevo-
piperitone
FL/FR
(-)-iso
pulegol
FL/FR
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(-)-menthyl (+)-2-pyrrolidone-5-carboxylate
 menthyl PCA
(5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate
[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate
(1R-(1alpha,2beta,5alpha))-2-isopropyl-5-methyl cyclohexyl 5-oxo-dextro-prolinate
(1R-(1alpha,2beta,5alpha))-2-isopropyl-5-methylcyclohexyl 5-oxo-D-prolinate
 questice (Givaudan)
 

Articles:

 None found yet.
 
Notes:
Used as a food additive [EAFUS]
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