EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

agarospirol
hinesol

Supplier Sponsors

Name:2-[(2R,6S)-6,10-dimethylspiro[4.5]dec-9-en-2-yl]propan-2-ol
CAS Number: 23811-08-7Picture of molecule3D/inchi
Other(deleted CASRN):26934-83-8
XlogP3-AA:3.70 (est)
Molecular Weight:222.37142000
Formula:C15 H26 O
NMR Predictor:Predict (works with chrome or firefox)
Category:fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 90.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 56.00 to 58.00 °C. @ 760.00 mm Hg
Boiling Point: 311.00 to 312.00 °C. @ 760.00 mm Hg (est)
Flash Point: 238.00 °F. TCC ( 114.60 °C. ) (est)
logP (o/w): 4.703 (est)
Soluble in:
 alcohol
 water, 2.216 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Type: spicy
Odor Strength:medium
spicy peppery woody
Odor Description:at 100.00 %. spicy peppery woody
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Hinesol 98%
BOC Sciences
For experimental / research use only.
Hinesol >98%
Odor: characteristic
Use: Source from Rhizomes of Atractylodes lancea DC. Protect liver, antioxidant, antibacterial, antiviral, anti oxygen
Santa Cruz Biotechnology
For experimental / research use only.
Hinesol
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for agarospirol usage levels up to:
  1.0000 % in the fragrance concentrate.
 
Recommendation for agarospirol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :161437
National Institute of Allergy and Infectious Diseases:Data
2-[(2R,6S)-6,10-dimethylspiro[4.5]dec-9-en-2-yl]propan-2-ol
Chemidplus:0023811087
 
References:
 2-[(2R,6S)-6,10-dimethylspiro[4.5]dec-9-en-2-yl]propan-2-ol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):161437
Pubchem (sid):135144562
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
HMDB (The Human Metabolome Database):Search
Typical G.C.
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
For Odor
amber
amber carane
FR
angelica seed oil CO2 extract
FL/FR
sarcocaulon mossamedense wood resinoid
FR
anisic
bitter
fennel seed oil spain
FR
balsamic
amyris wood oil
FL/FR
copaiba balsam oil
FL/FR
copaiba balsam oil replacer
FR
frankincense absolute
FL/FR
guaiyl acetate
FL/FR
hemlock western oil (tsuga heterophylla) canada
FR
opoponax absolute (balsamodendron kafal)
FL/FR
tolu balsam oil
FL/FR
earthy
cabralea cangerana root bark oil
FR
3-
octanol
FL/FR
floral
alpha-
bisabolol
FL/FR
dihydrojasmone
FL/FR
mimosa absolute france
FL/FR
green
2,5-
dimethyl bicyclo(3.2.1)oct-2-ene
FR
octanal diethyl acetal
FL/FR
herbal
anthemis nobilis flower oil roman
FL/FR
canarium luzonicum oil
FL/FR
curled
parsley seed oil
FL/FR
common
tansy flower oil
FR
common
tansy flower oil dutch
FR
theaspirane
FL/FR
peppery
asarum europaeum oil
FR
phenolic
4-
methyl-2,6-dimethoxyphenol
FL/FR
spicy
allspice berry absolute
FL/FR
atractylis root oil
FR
carvacrol
FL/FR
4-
carvomenthenol
FL/FR
caryophyllene
FL/FR
beta-
caryophyllene
FL/FR
alpha-
caryophyllene alcohol
FL/FR
cascarilla oil replacer
FL/FR
cinnamon bark oil ceylon
FL/FR
cinnamon leaf oil ceylon
FL/FR
cinnamon oleoresin ceylon
FL/FR
clove bud absolute
FL/FR
croton eluteria bark oil
FL/FR
ethyl vinyl ketone
FL/FR
galangal root oil
FL/FR
ginger oleoresin africa
FL/FR
ginger root oil brazil
FL/FR
ginger root oil china
FL/FR
grains of paradise oil
FL/FR
mace absolute
FL/FR
mace fragrance
FR
mace oil
FL/FR
methyl heptadienone
FL/FR
myrcene
FR
black
pepper absolute
FL/FR
pepper hexanone
FR
black
pepper oil
FL/FR
black
pepper oil replacer
FR
black
pepper oleoresin
FL/FR
pepper tree berry oil
FL/FR
(E,E)-
piperine
FL/FR
spicy carbonate
FR
(E)-
tiglic acid
FL/FR
turmeric root absolute
FL/FR
zvoulimba leaf oil
FR
terpenic
angelica seed oil
FL/FR
para-
cymene
FL/FR
elemi resinoid
FL/FR
frankincense oil
FL/FR
juniperus communis fruit oil
FL/FR
laevo-
limonene
FL/FR
pine needle oil dwarf
FL/FR
thujonic
common
tansy leaf oil dutch
FR
common
tansy oil canada
FR
vanilla
vanillin propylene glycol acetal
FL/FR
woody
iso
caryophyllene
CS
caryophyllene alcohol acetate
FR
caryophyllene formate
FL/FR
beta-
caryophyllene oxide
FL/FR
atlas
cedarwood oil
FR
dacrydium franklinii wood oil
FR
(3S,5R,8S)-3,8-
dimethyl-5-prop-1-en-2-yl-3,4,5,6,7,8-hexahydro-2H-azulen-1-one
FL/FR
frankincense fragrance
FR
frankincense oil replacer
FR
frankincense resinoid
FL/FR
(E)-
germacrene D
FL/FR
guaiacwood oil
FL/FR
alpha-
guaiene
FL/FR
juniper berry oleoresin
FL/FR
methyl vetivate
FR
olibanum specialty
FR
patchouli absolute
FR
rhubarb oxirane
FR
spicy pentanone
FL/FR
spikenard oil
FL/FR
sugi wood oil
FR
xanthoxylum alatum roxb. oil
FR
zedoary bark oil
FL/FR
For Flavor
No flavor group found for these
alpha-
bisabolol
FL/FR
alpha-
caryophyllene alcohol
FL/FR
caryophyllene formate
FL/FR
(3S,5R,8S)-3,8-
dimethyl-5-prop-1-en-2-yl-3,4,5,6,7,8-hexahydro-2H-azulen-1-one
FL/FR
(E)-
germacrene D
FL/FR
grains of paradise oil
FL/FR
alpha-
guaiene
FL/FR
guaiyl acetate
FL/FR
spikenard oil
FL/FR
amber
amber
angelica seed oil
FL/FR
balsamic
copaiba balsam oil
FL/FR
opoponax absolute (balsamodendron kafal)
FL/FR
tolu balsam oil
FL/FR
brown
(E)-
tiglic acid
FL/FR
cooling
4-
carvomenthenol
FL/FR
theaspirane
FL/FR
floral
dihydrojasmone
FL/FR
fruity
spicy pentanone
FL/FR
green
canarium luzonicum oil
FL/FR
elemi resinoid
FL/FR
methyl heptadienone
FL/FR
octanal diethyl acetal
FL/FR
herbal
angelica seed oil CO2 extract
FL/FR
anthemis nobilis flower oil roman
FL/FR
curled
parsley seed oil
FL/FR
medicinal
frankincense absolute
FL/FR
musty
3-
octanol
FL/FR
phenolic
4-
methyl-2,6-dimethoxyphenol
FL/FR
pine
pine needle oil dwarf
FL/FR
solvent
methyl phenyl sulfide
FL
spicy
allspice berry absolute
FL/FR
carvacrol
FL/FR
beta-
caryophyllene
FL/FR
caryophyllene
FL/FR
cascarilla oil replacer
FL/FR
cinnamon bark oil ceylon
FL/FR
cinnamon leaf oil ceylon
FL/FR
cinnamon oleoresin ceylon
FL/FR
clove bud absolute
FL/FR
croton eluteria bark oil
FL/FR
ethyl vinyl ketone
FL/FR
galangal root oil
FL/FR
ginger oleoresin africa
FL/FR
ginger root oil brazil
FL/FR
ginger root oil china
FL/FR
mace absolute
FL/FR
mace oil
FL/FR
black
pepper absolute
FL/FR
black
pepper oil
FL/FR
black
pepper oleoresin
FL/FR
pepper tree berry oil
FL/FR
(E,E)-
piperine
FL/FR
turmeric root absolute
FL/FR
terpenic
para-
cymene
FL/FR
juniperus communis fruit oil
FL/FR
laevo-
limonene
FL/FR
vanilla
vanillin propylene glycol acetal
FL/FR
waxy
mimosa absolute france
FL/FR
woody
amyris wood oil
FL/FR
beta-
caryophyllene oxide
FL/FR
frankincense oil
FL/FR
frankincense resinoid
FL/FR
guaiacwood oil
FL/FR
juniper berry oleoresin
FL/FR
zedoary bark oil
FL/FR
 
Potential Uses:
 fixer
FRspice
FRwoody
 
Occurrence (nature, food, other):note
 agarwood oil @ 0.03%
Data GC Search PMC Picture
 agarwood oil @ 4.80%
Data GC Search PMC Picture
 atractylis oil
Search Trop Picture
 atractylodes lancea
Search Trop Picture
 fungus infected agarwood aquillaria agalocha
Search PMC Picture
 phoebe oil brazil @ 3.25%
Data GC Search Trop Picture
 tansy oil (tanacetum annum l.) marocco @ 0.70%
Data GC Search Trop Picture
 zingiber officinale root oil china @ 3.00%
Data GC Search Trop Picture
 
Synonyms:
2-[(2R,10S)-6,10-dimethyl spiro[4.5]dec-6-en-2-yl]-2-propanol
2-[(2R,10S)-6,10-dimethylspiro[4.5]dec-6-en-2-yl]-2-propanol
2-[(2R,6S)-6,10-dimethylspiro[4.5]dec-9-en-2-yl]propan-2-ol
 hinesol
epi-hinesol
 spiro(4.5)dec-6-ene-2-methanol, a,a,6,10-tetramethyl-, (2R-(2a,5a(S*)))-
(2R-(2alpha,5alpha(S*)))- alpha,alpha,6,10-tetramethyl spiro(4.5)dec-6-ene-2-methanol
 

Articles:

PubMed:[Studies on terpenoids from Zygophyllum fabago].
PubMed:Sulphur-containing compounds in the essential oil of Ferula alliacea roots and their mass spectral fragmentation patterns.
PubMed:[Effects of Lime on Seedling Growth,Yield and Volatile Constituents of Atractylodes lancea].
PubMed:Hinesol, a compound isolated from the essential oils of Atractylodes lancea rhizome, inhibits cell growth and induces apoptosis in human leukemia HL-60 cells.
PubMed:Traditional herbal medicine for the control of tropical diseases.
PubMed:[Study on the chemical components of volatile oil from Euphorbia pekinensis radix].
PubMed:Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity.
PubMed:Composition and evaluation of the anti-inflammatory and anticancer activities of the essential oil from Annona sylvatica A. St.-Hil.
PubMed:Chemical composition and in vitro antimicrobial activity of the essential oil of Cyclotrichium leucotrichum from Iran.
PubMed:In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
PubMed:Insecticidal compounds from the essential oil of Chinese medicinal herb Atractylodes chinensis.
PubMed:Chemical composition of volatile oils of Aquilaria malaccensis (Thymelaeaceae) from Malaysia.
PubMed:[Simultaneous determination of atractylone, hinesol, beta-eudesmol, atrctylodin in Atractylodes lancea and hierarchical cluster analysis].
PubMed:[Advances in chemistry, molecular biology and pharmacological of Cangzhu].
PubMed:Identification of volatile compounds of Atractylode lancea rhizoma using supercritical fluid extraction and GC-MS.
PubMed:[Fingerprint of volatile oil of Atractylodes lancea by GC-MS].
PubMed:[GC-MS analysis of volatile constituents from five different kinds of Chinese eaglewood].
PubMed:[Studies on chemical constituents in essential oil from wild Atractylodes lancea in dabie mountains].
PubMed:A phosphine-catalyzed [3+2] cycloaddition strategy leading to the first total synthesis of (-)-hinesol.
PubMed:[The naphtha composing characteristics of geoherbs of Atractylodes lancea].
PubMed:[GC-MS analysis of essential oils from rhizomes of Atractylodes lancea (Thunb.) DC. and A. chinensis (DC.) Koidz].
PubMed:Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying.
PubMed:Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain.
PubMed:Inhibition of H+,K+ -ATPase by hinesol, a major component of So-jutsu, by interaction with enzyme in the E1 state.
PubMed:Biotransformation of hinesol isolated from the crude drug Atractylodes lancea by Aspergillus niger and Aspergillus cellulosae.
PubMed:Atractylodes lancea autotetraploids induced by colchicine treatment of shoot cultures.
PubMed:Random amplified polymorphic DNA analysis and variation of essential oil components of Atractylodes plants.
PubMed:A comparative study on essential oil components of wild and cultivated Atractylodes lancea and A. chinensis.
PubMed:[Study of components in crude drugs by headspace gas chromatography. II. Components of atractylodes].
PubMed:Effect of jinkoh-eremol and agarospirol from agarwood on the central nervous system in mice.
PubMed:Botanical and chemical evaluation of Atractylodes lancea plants propagated in vitro and by division of the rhizome.
PubMed:Intestinal motility enhancing effect of Atractylodes lancea rhizome.
PubMed:Antihepatotoxic principles of Atractylodes rhizomes.
PubMed:Stereochemical relationships in spirovetivane sesquiterpenes: the total synthesis of hinesol.
PubMed:Studies on the constituents of atractylodes. X. Correlation of hinesol and beta-vetivone.
 
Notes:
from atractylodes lance rhizome.
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