Articles:
Notes:
Found in anise oil, fennel and vanilla. Flavouring ingredient
Anisaldehyde, or anisic aldehyde, is an organic compound that consists of a benzene ring substituted with an aldehyde and a methoxy group. It is a clear colorless liquid with a strong aroma. It comes in 3 varieties, ortho, meta, and para in which the two functional groups (methoxy and aldehyde) are alpha, beta, and gamma, respectively to each other. The unmodified term anisaldehyde generally refers to the para isomer. Anisaldehyde is found in anise, from which it gets its name. It is similar in structure to vanillin. (Wikipedia)
| Fragrance Demo Formulas Flavor Demo Formulas | ||
| Name: | 4-methoxybenzaldehyde | |
| CAS Number: | 123-11-5 |  3D/inchi
|
| Other: | 26249-15-0 | |
| ECHA EINECS - REACH Pre-Reg: | 204-602-6 | |
| FDA UNII: | 9PA5V6656V | |
| Nikkaji Web: | J3.618H | |
| Beilstein Number: | 0471382 | |
| MDL: | MFCD00003385 | |
| FEMA Number: | 2670 | |
| CoE Number: | 103 | |
| XlogP3: | 1.80 (est) | |
| Molecular Weight: | 136.15016000 | |
| Formula: | C8 H8 O2 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 878 p-methoxybenzaldehyde |
| Flavis Number: | 05.015 (Old) |
| DG SANTE Food Flavourings: | 05.015 4-methoxybenzaldehyde |
| FEMA Number: | 2670 p-methoxybenzaldehyde |
| FDA Mainterm: | P-METHOXYBENZALDEHYDE |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. | |
Physical Properties:
| Appearance: | colorless to pale yellow clear oily liquid (est) |
| Assay: | 98.00 to 100.00 % |
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 1.11900 to 1.12600 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 9.311 to 9.369 |
| Refractive Index: | 1.57000 to 1.57400 @ 20.00 °C. |
| Melting Point: | -1.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 248.00 to 249.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 121.00 to 122.00 °C. @ 10.00 mm Hg |
| Acid Value: | 4.00 max. KOH/g |
| Vapor Pressure: | 1.000000 mmHg @ 20.00 °C. |
| Vapor Density: | 4.7 ( Air = 1 ) |
| Flash Point: | 228.00 °F. TCC ( 108.89 °C. ) |
| logP (o/w): | 1.760 |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: | |
| ethyl alcohol, 1:7 in 50% alcohol | |
| ethyl alcohol, 7 vol. of 50% alcohol | |
| fatty oils | |
| kerosene | |
| propylene glycol | |
| sodium bisulfite, 99% soluble in solution | |
| water, 4290 mg/L @ 25 °C (exp) | |
| Insoluble in: | |
| paraffin oil | |
| alcohol | |
| Stability: | |
| bath foam | |
| cream | |
| detergent | |
| hair spray | |
| non-discoloring in most media | |
| powder | |
| soap | |
| stable in weak acids and bases | |
| Similar Items: note | |
| homoanisaldehyde | |
| meta-anisaldehyde | |
| ortho-anisaldehyde | |
Organoleptic Properties:
| Odor Type: | anisic |
| Odor Strength: | medium |
| Odor Description: at 100.00 %. | sweet powdery mimosa floral hawthorn balsam |
| Substantivity: | 44 hour(s) at 100.00 % |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
masking agents perfuming agents |
Safety Information:
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Human Experience: | 10 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: | |
|
gavage-rat LD50 [sex: M,F] 1510 mg/kg (Jenner et al., 1964) oral-mouse LD50 1859 mg/kg GASTROINTESTINAL: NECROTIC GHANGES GASTROINTESTINAL: OTHER CHANGES LIVER: FATTY LIVER DEGERATION Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 58(8), Pg. 20, 1993. gavage-guinea pig LD50 [sex: M,F] 1260 mg/kg (Jenner et al., 1964) oral-rat LD50 3210 mg/kg (BASF, 1981) gavage-rat LD50 [sex: M,F] 1510 mg/kg (Taylor et al., 1964) oral-guinea pig LD50 1260 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. oral-rat LD50 1510 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964. | |
| Dermal Toxicity: | |
|
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 823, 1974. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| Recommendation for para-anisaldehyde usage levels up to: | |||
| 10.0000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 370.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 580.00 (μg/capita/day) | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 16.00000 | |
| beverages(nonalcoholic): | - | 6.30000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 18.00000 | 76.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 5.60000 | |
| fruit ices: | - | 5.60000 | |
| gelatins / puddings: | 0.50000 | 30.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 14.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): | |
| The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients.View pdf | |
| European Food Safety Athority(efsa): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| EPI System: | View |
| NLM Hazardous Substances Data Bank: | Search |
| Chemical Carcinogenesis Research Information System: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| Env. Mutagen Info. Center: | Search |
| NLM Developmental and Reproductive Toxicity: | Search |
| EPA Substance Registry Services (TSCA): | 123-11-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 31244 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| 4-methoxybenzaldehyde | |
| Chemidplus: | 0000123115 |
| RTECS: | BZ26625000 for cas# 123-11-5 |
References:
| 4-methoxybenzaldehyde | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 123-11-5 |
| Pubchem (cid): | 31244 |
| Pubchem (sid): | 134974383 |
| Flavornet: | 123-11-5 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2009 |
| (IUPAC): | Atomic Weights of the Elements 2009 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Everything Added to Food in the United States (EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C10761 |
| HMDB (The Human Metabolome Database): | HMDB29686 |
| FooDB: | FDB000872 |
| Export Tariff Code: | 2912.49.1000 |
| Haz-Map: | View |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| RSC Learn Chemistry: | View |
| Formulations/Preparations: grades: liq & crystals, latter being the disulfite compd. | |
Potential Blenders and core components note
Potential Uses:
| acacia | FR | |
| almond | FR | |
| amber | FR | |
| ambrene | FR | |
| angel essence | FR | |
| anise | FR | |
| apple | FR | |
| apres l'ondee | ||
| apricot | FR | |
| balsam | FR | |
| banana | FR | |
| benzoinett | FR | |
| bluebell | FR | |
| bouquet | FR | |
| buchu leaf | FL | |
| butterscotch | FR | |
| cherry | FR | |
| cherry blossom | FR | |
| christmas | FR | |
| chypre | FR | |
| clover | FR | |
| coconut tropical coconut | FR | |
| cologne | FR | |
| crabapple blossom | FR | |
| decumaria | FR | |
| elder flower | FR | |
| fennel | FR | |
| fern | FR | |
| floral | FR | |
| gardenia | FR | |
| genet | FR | |
| ginger white ginger | FR | |
| gooseberry | FR | |
| grape | FR | |
| hawthorn | FR | |
| hay new mown hay | FR | |
| heliotrope | FR | |
| herbal | FR | |
| hibiscus | FR | |
| honey | FR | |
| honeysuckle | FR | |
| hop | FR | |
| jasmin | FR | |
| jonquil | FR | |
| lemon | FR | |
| lilac | FR | |
| lime | FR | |
| linden flower | FR | |
| lux beauty shower soap | ||
| magnolia | FR | |
| melon | FR | |
| mimosa | FR | |
| orange | FR | |
| orchid | FR | |
| oriental | FR | |
| pear | FR | |
| peppermint | FR | |
| pineapple | FR | |
| powder | FR | |
| raspberry | FR | |
| sassafras | FR | |
| spearmint | FR | |
| strawberry | FR | |
| sweet grass | FR | |
| sweet pea | FR | |
| tide | ||
| tuberose | FR | |
| valerian | FL/FR | |
| vanilla | FR | |
| violet | FR | |
| wallflower | FR | |
| walnut | FL | |
| wisteria | FR | |
| ylang ylang | FR |
Occurrence (nature, food, other): note
| acacia sweet acacia Search Trop Picture | |
| anise Search Trop Picture | |
| anise oil Search Trop Picture | |
| anise seed Search Trop Picture | |
| anise seed oil colombia @ 0.17% Data GC Search Trop Picture | |
| anise seed oil star china @ 0.28% Data GC Search Trop Picture | |
| anise star anise Search Trop Picture | |
| anise star anise fruit Search Trop Picture | |
| basil plant Search Trop Picture | |
| boswelha senata Search Trop Picture | |
| cassie absolute @ 34.36% Data GC Search Trop Picture | |
| cinnamon Search PMC Picture | |
| cornmint shoot Search Trop Picture | |
| cranberry fruit Search Trop Picture | |
| cumin seed Search Trop Picture | |
| cumin seed at 37.00 ppm Search Trop Picture | |
| currant black currant fruit Search Trop Picture | |
| dill plant Search Trop Picture | |
| erica arborea Search Trop Picture | |
| fennel flower oil bitter lithuania @ 0.29% Data GC Search Trop Picture | |
| fennel oil Search Trop Picture | |
| fennel plant Search Trop Picture | |
| fennel seed Search Trop Picture | |
| fennel seed oil Search Trop Picture | |
| fennel sprout Search Trop Picture | |
| helichrysum arenarium (l.) moench oil hungary @ 0.30% Data GC Search Trop Picture | |
| heracleum paphlagonicum czeczott fruit oil turkey @ <0.10% Data GC Search Trop Picture | |
| lecythis usitata miers. var. paraensis (ducke) r. kunth. flower oil brazil @ 0.20% Data GC Search Trop Picture | |
| magnolia salicifolia maxim. Search Trop Picture | |
| pinus spp. Search Trop Picture | |
| pirus communis Search Trop Picture | |
| roselle fruit Search Trop Picture | |
| roselle leaf Search Trop Picture | |
| tagete oil CO2 extract @ 2.10% Data GC Search Trop Picture | |
| tarragon oil Search Trop Picture | |
| tea leaf Search Trop Picture | |
| vanilla Search Picture | |
| vanilla spp. Search Trop Picture |
Synonyms:
| 4- | anisaldehyde |
| p- | anisaldehyde |
| anisaldehyde (4-methoxybenzaldehyde) | |
| anisaldehyde natural | |
| p- | anisaldehyde natural |
| anisaldehyde PQ | |
| anisaldehyde, technical | |
| anise aldehyde | |
| anisic aldehyde | |
| p- | anisic aldehyde |
| para- | anisic aldehyde |
| anisic aldehyde (natural) | |
| p- | anisic aldehyde cosemetic grade |
| anisic aldehyde FCC | |
| p- | anisic aldehyde fcc |
| p- | anisic aldehyde fcc no additives or stabilizers |
| anisic aldehyde FCC with 0.04% BHT added | |
| anisic aldehyde FCC without BHT | |
| anisic aldehyde natural | |
| anisic aldehyde pure | |
| anisic aldehyde, natural | |
| anisyl aldehyde | |
| anisyl aldehyde natural | |
| aubepine | |
| benzaldehyde, 4-methoxy- | |
| crategine | |
| p- | formyl anisole |
| para- | formyl anisole |
| p- | formylanisole |
| formylanisole, p- | |
| 4- | methoxy benzaldehyde |
| 4- | methoxy-benzaldehyde |
| 4- | methoxybenzaldehyde |
| p- | methoxybenzaldehyde |
| para- | methoxybenzaldehyde |
| para- | methoxybenzaldehyde (natural) |
| 4- | methoxybenzaldhyde |
| (4- | methoxyphenyl)methanone |
| obepin |