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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 518.60 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 513.00 °F. TCC ( 267.40 °C. ) (est)
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| logP (o/w): | 4.260 (est) |
| Soluble in: |
| | water, 0.9288 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for glabridin usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for glabridin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 124052 |
| Pubchem (sid): | 135079703 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,3- | benzenediol, 4-(3,4-dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)- | | 4-(3,4- | dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-1,3-benzenediol | | 4-[(3R)-8,8- | dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol |
Articles:
| PubMed:The use of enzyme-coupled magnetic nanoparticles for studying the spectra of unusual substrates of mushroom tyrosinase by direct surface-assisted laser desorption/ionisation and high-resolution electrospray ionisation quadrupole-quadrupole-time-of-flight mass spectrometry. |
| PubMed:Synergistic antifungal effect of glabridin and fluconazole. |
| PubMed:Effectively designed molecularly imprinted polymers for selective extraction of glabridin from Glycyrrhiza glabra L. residues by screening the library of non-imprinted polymers. |
| PubMed:Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells. |
| PubMed:Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. |
| PubMed:The repressive effect of miR-148a on TGF beta-SMADs signal pathway is involved in the glabridin-induced inhibition of the cancer stem cells-like properties in hepatocellular carcinoma cells. |
| PubMed:Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c. |
| PubMed:Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells. |
| PubMed:Enzyme-coupled nanoparticles-assisted laser desorption ionization mass spectrometry for searching for low-mass inhibitors of enzymes in complex mixtures. |
| PubMed:Crystal structures of human transthyretin complexed with glabridin. |
| PubMed:Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. |
| PubMed:Glabridin induces oxidative stress mediated apoptosis like cell death of malaria parasite Plasmodium falciparum. |
| PubMed:Absolute configuration of naturally occurring glabridin. |
| PubMed:Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons. |
| PubMed:Phytochemistry and biological properties of glabridin. |
| PubMed:The effects and mechanism of flavonoid-rePON1 interactions. Structure-activity relationship study. |
| PubMed:Glabridin. |
| PubMed:Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus. |
| PubMed:In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action. |
| PubMed:The flavonoid glabridin attenuates 2-deoxy-D-ribose-induced oxidative damage and cellular dysfunction in MC3T3-E1 osteoblastic cells. |
| PubMed:Preparing glabridin-in-water nanoemulsions by high pressure homogenization with response surface methodology. |
| PubMed:Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice. |
| PubMed:Rapid RP-HPLC method for the quantification of glabridin in crude drug and in polyherbal formulation. |
| PubMed:AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. |
| PubMed:Novel phytonutrient contributors to antioxidant protection against cardiovascular disease. |
| PubMed:Tyrosinase inhibitor-loaded microsponge drug delivery system: new approach for hyperpigmentation disorders. |
| PubMed:Glabridin protects paraoxonase 1 from linoleic acid hydroperoxide inhibition via specific interaction: a fluorescence-quenching study. |
| PubMed:The inhibitory effect and the molecular mechanism of glabridin on RANKL-induced osteoclastogenesis in RAW264.7 cells. |
| PubMed:Licorice and its potential beneficial effects in common oro-dental diseases. |
| PubMed:Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts. |
| PubMed:Traditional chinese medicine for senile dementia. |
| PubMed:18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures. |
| PubMed:Glabridin protects osteoblastic MC3T3-E1 cells against antimycin A induced cytotoxicity. |
| PubMed:Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. |
| PubMed:Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans. |
| PubMed:Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra). |
| PubMed:Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. |
| PubMed:Factors influencing glabridin stability. |
| PubMed:Natural products and body weight control. |
| PubMed:Glabridin inhibits migration, invasion, and angiogenesis of human non-small cell lung cancer A549 cells by inhibiting the FAK/rho signaling pathway. |
| PubMed:Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress. |
| PubMed:Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. |
| PubMed:Inhibition of bone marrow-derived dendritic cell maturation by glabridin. |
| PubMed:Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. |
| PubMed:Antidyslipidaemic activity of Glycyrrhiza glabra in high fructose diet induced dsyslipidaemic Syrian golden hamsters. |
| PubMed:Antioxidant effect of polyphenolic glabridin on LDL oxidation. |
| PubMed:A validated stability-indicating HPLC method for analysis of glabridin prodrugs in hydrolysis studies. |
| PubMed:Synthesis of glabridin derivatives as tyrosinase inhibitors. |
| PubMed:Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-kappaB and AP-1. |
| PubMed:Extraction of glycyrrhizic acid and glabridin from licorice. |
| PubMed:Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin. |
| PubMed:Glabridin from Chinese herb licorice inhibits fatigue in mice. |
| PubMed:The effect of an endogenous antioxidant glabridin on oxidized LDL. |
| PubMed:Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice. |
| PubMed:90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats. |
| PubMed:Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. |
| PubMed:Antimicrobial potential of Glycyrrhiza glabra roots. |
| PubMed:In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). |
| PubMed:Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. |
| PubMed:Absorption of dietary licorice isoflavan glabridin to blood circulation in rats. |
| PubMed:Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update. |
| PubMed:Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans. |
| PubMed:Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. |
| PubMed:Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra. |
| PubMed:Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). |
| PubMed:Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra. |
| PubMed:Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. |
| PubMed:Post TLC developing technique for tyrosinase inhibitor detection. |
| PubMed:Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. |
| PubMed:Determination of glabridin in human plasma by solid-phase extraction and LC-MS/MS. |
| PubMed:Identification of tyrosinase inhibitors from Glycyrrhiza uralensis. |
| PubMed:Analysis and comparison of Radix Glycyrrhizae (licorice) from Europe and China by capillary-zone electrophoresis (CZE). |
| PubMed:The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. |
| PubMed:Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs. |
| PubMed:Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. |
| PubMed:Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. |
| PubMed:Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice. |
| PubMed:Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. |
| PubMed:Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. |
| PubMed:Herbal bioactivation: the good, the bad and the ugly. |
| PubMed:Antinephritis and radical scavenging activity of prenylflavonoids. |
| PubMed:Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra. |
| PubMed:Field survey of Glycyrrhiza plants in Central Asia (3). Chemical characterization of G. glabra collected in Uzbekistan. |
| PubMed:Evaluation of the antioxidant activity of different flavonoids by the chemiluminescence method. |
| PubMed:Field survey of Glycyrrhiza plants in Central Asia (1). Characterization of G. uralensis, G. glabra and the putative intermediate collected in Kazakhstan. |
| PubMed:Inhibition of serotonin re-uptake by licorice constituents. |
| PubMed:Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. |
| PubMed:Anti-Helicobacter pylori flavonoids from licorice extract. |
| PubMed:Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice. |
| PubMed:The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. |
| PubMed:Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase. |
| PubMed:Estrogen-like activity of glabrene and other constituents isolated from licorice root. |
| PubMed:Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. |
| PubMed:Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. |
| PubMed:Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. |
| PubMed:Protection of mitochondrial functions against oxidative stresses by isoflavans from Glycyrrhiza glabra. |
| PubMed:Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C. |
| PubMed:Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. |
| PubMed:The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. |
| PubMed:Structural aspects of the inhibitory effect of glabridin on LDL oxidation. |
| PubMed:The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. |
| PubMed:Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. |
| PubMed:Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. |
| PubMed:[Phenolic constituents of licorice. IV. Correlation of phenolic constituents and licorice specimens from various sources, and inhibitory effects of licorice extracts on xanthine oxidase and monoamine oxidase]. |
| PubMed:Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins. |
| PubMed:Identification of antimicrobial and antioxidant constituents from licorice of Russian and Xinjiang origin. |
| PubMed:Antimicrobial agents from higher plants. Antimicrobial isoflavanoids and related substances from Glycyrrhiza glabra L. var. typica. |
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3D/inchi