honokiol
3,5'-diallyl-4,2'-dihydroxybiphenyl
 
Notes:
component of magnolia obovata thunb..
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2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol (Click)
CAS Number: 35354-74-6Picture of molecule
FDA UNII: 11513CCO0N
Nikkaji Web: J138.358B
MDL: MFCD00016674
XlogP3-AA: 5.00 (est)
Molecular Weight: 266.33986000
Formula: C18 H18 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
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Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 400.10 °C. @ 760.00 mm Hg (est)
Flash Point: 363.00 °F. TCC ( 184.00 °C. ) (est)
logP (o/w): 4.200 (est)
Soluble in:
 water, 1.244 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
bleaching agents
skin conditioning
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Suppliers:
ExtraSynthese
For experimental / research use only.
Honokiol (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Honokiol ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Honokiol ≥98% (HPLC), powder
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for honokiol usage levels up to:
 not for fragrance use.
 
Recommendation for honokiol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 72303
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
Chemidplus: 0035354746
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References:
 2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 72303
Pubchem (sid): 135030736
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C10630
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 magnolia obovata
Search Trop  Picture
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Synonyms:
[1,1'-biphenyl]-2,4'-diol, 3',5-di-2-propen-1-yl-
3,5'-diallyl-4,2'-dihydroxybiphenyl
3',5-diallylbiphenyl-2,4'-diol
2-(4-hydroxy-3-prop-2-enylphenyl)-4-prop-2-enylphenol
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Articles:
PubMed: Polyethylene glycol-based ultrasound-assisted extraction of magnolol and honokiol from Cortex Magnoliae Officinalis.
PubMed: Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARĪ³): a review.
PubMed: Discovery of soluble epoxide hydrolase inhibitors from natural products.
PubMed: Long-term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high-fat fed mice.
PubMed: Neuroprotective effects of neolignans isolated from Magnoliae Cortex against glutamate-induced apoptotic stimuli in HT22 cells.
PubMed: Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.
PubMed: Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators.
PubMed: Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.
PubMed: Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.
PubMed: Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression.
PubMed: Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.
PubMed: Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.
PubMed: Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.
PubMed: [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed: Cytotoxic neolignans: an SAR study.
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