| PubMed:Isoliquiritigenin Induces Apoptosis and Inhibits Xenograft Tumor Growth of Human Lung Cancer Cells by Targeting Both Wildtype and L858R/T790M Mutant EGFR. |
| PubMed:Synthesis and anti-tumor activity of novel aminomethylated derivatives of isoliquiritigenin. |
| PubMed:Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis FISCH.) populations in northern China. |
| PubMed:Natural product inhibitors of ocular angiogenesis. |
| PubMed:Chalcones as positive allosteric modulators of α7 nicotinic acetylcholine receptors: A new target for a privileged structure. |
| PubMed:Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation. |
| PubMed:Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling. |
| PubMed:The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells. |
| PubMed:Downregulation of COX-2 and CYP 4A signaling by isoliquiritigenin inhibits human breast cancer metastasis through preventing anoikis resistance, migration and invasion. |
| PubMed:Function of chalcone reductase gene CHR1 in soybean. |
| PubMed:Isoliquiritigenin, a flavonoid from licorice, blocks M2 macrophage polarization in colitis-associated tumorigenesis through downregulating PGE2 and IL-6. |
| PubMed:MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. |
| PubMed:Isoliquiritigenin, a chalcone compound, enhances spontaneous inhibitory postsynaptic response. |
| PubMed:Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols. |
| PubMed:Distribution patterns of the contents of five active components in taproot and stolon of Glycyrrhiza uralensis. |
| PubMed:Simultaneous Determination of 12 Index Components and Compatibility Changes in Longchai Decoction by Liquid Chromatography-Mass Spectrometry. |
| PubMed:The inhibitory effect of shakuyakukanzoto on K+ current in H9c2 cells. |
| PubMed:Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. |
| PubMed:Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. |
| PubMed:Transport of active flavonoids, based on cytotoxicity and lipophilicity: an evaluation using the blood-brain barrier cell and Caco-2 cell models. |
| PubMed:Correlation analysis between the rate of respiration in the root and the active components in licorice (Glycyrrhiza uralensis). |
| PubMed:Rikkunshito, a Japanese kampo medicine, ameliorates decreased feeding behavior via ghrelin and serotonin 2B receptor signaling in a novelty stress murine model. |
| PubMed:In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. |
| PubMed:Identification of key licorice constituents which interact with cytochrome P450: evaluation by LC/MS/MS cocktail assay and metabolic profiling. |
| PubMed:Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. |
| PubMed:Isoliquiritigenin induces caspase-dependent apoptosis via downregulation of HPV16 E6 expression in cervical cancer Ca Ski cells. |
| PubMed:Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. |
| PubMed:Pharmacokinetics of isoliquiritigenin and its metabolites in rats: low bioavailability is primarily due to the hepatic and intestinal metabolism. |
| PubMed:Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. |
| PubMed:Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. |
| PubMed:Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. |
| PubMed:Isoliquiritigen enhances the antitumour activity and decreases the genotoxic effect of cyclophosphamide. |
| PubMed:Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. |
| PubMed:Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. |
| PubMed:Employing bifunctional enzymes for enhanced extraction of bioactives from plants: flavonoids as an example. |
| PubMed:Pharmacokinetic comparisons of two different combinations of Shaoyao-Gancao Decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid. |
| PubMed:Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. |
| PubMed:[Anti-inflammation of flavonoid compounds from Dalbergia odorifera T. Chen in lipopolysaccharide stimulated RAW264.7 macrophages]. |
| PubMed:Pharmacokinetic comparisons of different combinations of Shaoyao-Gancao-Decoction in rats: simultaneous determination of ten active constituents by HPLC-MS/MS. |
| PubMed:Screening and determination for potential α-glucosidase inhibitory constituents from Dalbergia odorifera T. Chen using ultrafiltration-LC/ESI-MS(n). |
| PubMed:Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase. |
| PubMed:Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells. |
| PubMed:Rikkunshito and isoliquiritigenin counteract 5-HT-induced 2C receptor-mediated activation of pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus. |
| PubMed:Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. |
| PubMed:Pharmacokinetic study of four flavones of Glycyrrhiza in rat plasma using HPLC-MS. |
| PubMed:Preparation of isoliquiritigenin-loaded nanostructured lipid carrier and the in vivo evaluation in tumor-bearing mice. |
| PubMed:HPLC of flavanones and chalcones in different species and clones of Salix. |
| PubMed:[Study on in vitro anti-inflammatory activity of total flavonoids from Glycyrrhizae Radix et Rhizoma and its ingredients]. |
| PubMed:Simultaneous quantification of paeoniflorin, nobiletin, tangeretin, liquiritigenin, isoliquiritigenin, liquiritin and formononetin from Si-Ni-San extract in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. |
| PubMed:Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. |
| PubMed:Dynamic residual complexity of the isoliquiritigenin-liquiritigenin interconversion during bioassay. |
| PubMed:Novel plant-derived target drugs: a step forward from licorice? |
| PubMed:The inhibitory effect of roasted licorice extract on human metastatic breast cancer cell-induced bone destruction. |
| PubMed:A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system. |
| PubMed:Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method. |
| PubMed:Inhibitory effects of isoliquiritigenin on the migration and invasion of human breast cancer cells. |
| PubMed:Isoliquiritigenin-induced differentiation in mouse melanoma B16F0 cell line. |
| PubMed:Development of sample preparation method for isoliquiritigenin, liquiritin, and glycyrrhizic acid analysis in licorice by ionic liquids-ultrasound based extraction and high-performance liquid chromatography detection. |
| PubMed:Isoliquiritigenin showed strong inhibitory effects towards multiple UDP-glucuronosyltransferase (UGT) isoform-catalyzed 4-methylumbelliferone (4-MU) glucuronidation. |
| PubMed:Isoliquiritigenin inhibits proliferation and induces apoptosis of U87 human glioma cells in vitro. |
| PubMed:Polyphenols inhibit indoleamine 3,5-dioxygenase-1 enzymatic activity--a role of immunomodulation in chemoprevention. |
| PubMed:Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo. |
| PubMed:Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. |
| PubMed:NADPH oxidase-derived reactive oxygen species are involved in the HL-60 cell monocytic differentiation induced by isoliquiritigenin. |
| PubMed:Isoliquiritigenin enhances radiosensitivity of HepG2 cells via disturbance of redox status. |
| PubMed:Molecular signatures in response to Isoliquiritigenin in lymphoblastoid cell lines. |
| PubMed:Involvement of endoplasmic reticulum stress in isoliquiritigenin-induced SKOV-3 cell apoptosis. |
| PubMed:Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. |
| PubMed:Decrease of microRNA-122 causes hepatic insulin resistance by inducing protein tyrosine phosphatase 1B, which is reversed by licorice flavonoid. |
| PubMed:The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. |
| PubMed:Natural chalcones as dual inhibitors of HDACs and NF-κB. |
| PubMed:Isoliquiritigenin treatment induces apoptosis by increasing intracellular ROS levels in HeLa cells. |
| PubMed:Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. |
| PubMed:Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons. |
| PubMed:Tracking antiangiogenic components from Glycyrrhiza uralensis Fisch. based on zebrafish assays using high-speed countercurrent chromatography. |
| PubMed:Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. |
| PubMed:Licorice isoliquiritigenin suppresses RANKL-induced osteoclastogenesis in vitro and prevents inflammatory bone loss in vivo. |
| PubMed:A new flavonol from Oxytropis ochrocephala Bunge. |
| PubMed:Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. |
| PubMed:Isoliquiritigenin isolated from licorice Glycyrrhiza uralensis prevents 6-hydroxydopamine-induced apoptosis in dopaminergic neurons. |
| PubMed:Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner. |
| PubMed:Analgesic and uterine relaxant effects of isoliquiritigenin, a flavone from Glycyrrhiza glabra. |
| PubMed:Comparative metabolite profiling and fingerprinting of medicinal licorice roots using a multiplex approach of GC-MS, LC-MS and 1D NMR techniques. |
| PubMed:Characterization and quantification of major constituents of Xue Fu Zhu Yu by UPLC-DAD-MS/MS. |
| PubMed:Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease. |
| PubMed:[Chemical constituents from the roots of Hedysarum polybotrys]. |
| PubMed:Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum. |
| PubMed:Determination of isoliquiritigenin and its distribution in mice by synchronous fluorescence spectrometry. |
| PubMed:Screening for natural chemoprevention agents that modify human Keap1. |
| PubMed:Mammalian target of rapamycin regulates isoliquiritigenin-induced autophagic and apoptotic cell death in adenoid cystic carcinoma cells. |
| PubMed:Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. |
| PubMed:Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential. |
| PubMed:Determination of pinostrobin in rat plasma by LC-MS/MS: application to pharmacokinetics. |
| PubMed:Elucidation of the methyl transfer mechanism catalyzed by chalcone O-methyltransferase: a density functional study. |
| PubMed:Traditional chinese medicine for senile dementia. |
| PubMed:Isoliquiritigenin (4,2',4'-trihydroxychalcone): a new matrix-assisted laser desorption/ionization matrix with outstanding properties for the analysis of neutral oligosaccharides. |
| PubMed:A new phenolic compound with anticancer activity from the wood of Millettia leucantha. |
| PubMed:Reinvestigation of the synthesis of isoliquiritigenin: application of Horner-Wadsworth-Emmons reaction and Claisen-Schmidt condensation. |
| PubMed:Isoliquiritigenin from licorice root suppressed neovascularisation in experimental ocular angiogenesis models. |
| PubMed:Potential utility of natural products as regulators of breast cancer-associated aromatase promoters. |
| PubMed:Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. |
| PubMed:Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry. |
| PubMed:Brazilian red propolis: unreported substances, antioxidant and antimicrobial activities. |
| PubMed:Molecular characterization of a membrane-bound prenyltransferase specific for isoflavone from Sophora flavescens. |
| PubMed:Preparation and assay of C-glucosyltransferase from roots of Pueraria lobata. |
| PubMed:Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents. |
| PubMed:Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. |
| PubMed:HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos. |
| PubMed:[Chemical constituents of Indigofera pseudotinctoria]. |
| PubMed:Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). |
| PubMed:The role of chalcones in suppression of NF-κB-mediated inflammation and cancer. |
| PubMed:[On-line sample stacking for the analysis of glycyrrhiza flavonoids by anion selective exhaustive injection-sweeping micellar electrokinetic chromatography]. |
| PubMed:Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol. |
| PubMed:20S proteasome inhibitory activity of flavonoids isolated from Spatholobus suberectus. |
| PubMed:Chemical constituents of the bark of Dipteryx alata vogel, an active species against Bothrops jararacussu venom. |
| PubMed:Effects of ILTG on DAPK1 promoter methylation in colon and leukemia cancer cell lines. |
| PubMed:[Studies on changes of in vitro and in vivo material base of Shaoyao Gancao decoction based on HPLC-DAD-ESI-MS]. |
| PubMed:Antidiarrheal activity of extracts and compound from Trilepisium madagascariense stem bark. |
| PubMed:Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. |
| PubMed:Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. |
| PubMed:Liquiritigenin derivatives and their hepatotoprotective activity. |
| PubMed:Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. |
| PubMed:Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin. |
| PubMed:In vitro screening for angiostatic potential of herbal chemicals. |
| PubMed:Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics. |
| PubMed:Mammalian target of rapamycin pathway promotes tumor-induced angiogenesis in adenoid cystic carcinoma: its suppression by isoliquiritigenin through dual activation of c-Jun NH2-terminal kinase and inhibition of extracellular signal-regulated kinase. |
| PubMed:Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. |
| PubMed:Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. |
| PubMed:Isoliquiritigenin suppresses the Toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent signaling pathway of Toll-like receptors by targeting TBK1. |
| PubMed:Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction. |
| PubMed:Isoliquiritigenin entails blockade of TGF-beta1-SMAD signaling for retarding high glucose-induced mesangial matrix accumulation. |
| PubMed:Plasma pharmacokinetics and tissue distribution study of cajaninstilbene acid in rats by liquid chromatography with tandem mass spectrometry. |
| PubMed:Fuscacarpans A-C, new pterocarpans from the stems of Erythrina fusca. |
| PubMed:Cancer chemopreventive activity and metabolism of isoliquiritigenin, a compound found in licorice. |
| PubMed:Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. |
| PubMed:Isoliquiritigenin 2'-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1. |
| PubMed:The licorice flavonoid isoliquiritigenin suppresses phorbol ester-induced cyclooxygenase-2 expression in the non-tumorigenic MCF-10A breast cell line. |
| PubMed:AMPK-mediated GSK3beta inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress. |
| PubMed:Real-time detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip. |
| PubMed:Determination of flavonoids in licorice using acid hydrolysis and reversed-phase HPLC and evaluation of the chemical quality of cultivated licorice. |
| PubMed:Anticancer effects of flavonoid derivatives isolated from Millettia reticulata Benth in SK-Hep-1 human hepatocellular carcinoma cells. |
| PubMed:Interactions between thrombin and natural products of Millettia nitita var. hirsutissima using capillary zone electrophoresis. |
| PubMed:Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'. |
| PubMed:Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. |
| PubMed:[Chalcones from Bauhinia glauca subsp. pernervosa]. |
| PubMed:Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice. |
| PubMed:Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages. |
| PubMed:Structures of new flavonoids and benzofuran-type stilbene and degranulation inhibitors of rat basophilic leukemia cells from the Brazilian herbal medicine Cissus sicyoides. |
| PubMed:Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection. |
| PubMed:[Studies on chemical constituents of root of Millettia speciosa]. |
| PubMed:Integrated metabolite and transcript profiling identify a biosynthetic mechanism for hispidol in Medicago truncatula cell cultures. |
| PubMed:Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cells. |
| PubMed:Shallot and licorice constituent isoliquiritigenin arrests cell cycle progression and induces apoptosis through the induction of ATM/p53 and initiation of the mitochondrial system in human cervical carcinoma HeLa cells. |
| PubMed:Cytoprotective constituents of the heartwood of Caesalpinia sappan on glutamate-induced oxidative damage in HT22 cells. |
| PubMed:Proteomic and behavioral analysis of response to isoliquiritigenin in brains of acute cocaine treated rats. |
| PubMed:Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles. |
| PubMed:Bioactive flavonoids of the flowers of Butea monosperma. |
| PubMed:Induction of cell cycle arrest in prostate cancer cells by the dietary compound isoliquiritigenin. |
| PubMed:Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. |
| PubMed:Cytotoxic activity of isoliquiritigenin towards CCRF-CEM leukemia cells and its effect on DNA damage. |
| PubMed:Isoliquiritigenin, from Dalbergia odorifera, up-regulates anti-inflammatory heme oxygenase-1 expression in RAW264.7 macrophages. |
| PubMed:Isoliquiritigenin induces G2 and M phase arrest by inducing DNA damage and by inhibiting the metaphase/anaphase transition. |
| PubMed:Licorice isoliquiritigenin dampens angiogenic activity via inhibition of MAPK-responsive signaling pathways leading to induction of matrix metalloproteinases. |
| PubMed:Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. |
| PubMed:Small molecule modifier screen for kit-dependent functions in zebrafish embryonic melanocytes. |
| PubMed:Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro. |
| PubMed:Isoliquiritigenin induces monocytic differentiation of HL-60 cells. |
| PubMed:Inhibitory effects of isoliquiritigenin and licorice extract on voltage-dependent K(+) currents in H9c2 cells. |
| PubMed:Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo. |
| PubMed:Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix. |
| PubMed:Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. |
| PubMed:Isoliquiritigenin inhibits migration and invasion of prostate cancer cells: possible mediation by decreased JNK/AP-1 signaling. |
| PubMed:Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. |
| PubMed:Biotransformation of the chemopreventive agent 2',4',4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases. |
| PubMed:Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication. |
| PubMed:Isoliquiritigenin inhibits cell proliferation by a heme oxygenase-dependent pathway in rat hepatic stellate cells. |
| PubMed:Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor. |
| PubMed:Induction of growth inhibition and apoptosis in human uterine leiomyoma cells by isoliquiritigenin. |
| PubMed:Dynamic effects on reaction rates in a Michael addition catalyzed by chalcone isomerase. Beyond the frozen environment approach. |
| PubMed:Antimicrobial and antioxidative activities of bioactive constituents from Hydnophytum formicarum Jack. |
| PubMed:Isoliquiritigenin, a flavonoid from licorice, relaxes guinea-pig tracheal smooth muscle in vitro and in vivo: role of cGMP/PKG pathway. |
| PubMed:Same-single-cell analysis for the study of drug efflux modulation of multidrug resistant cells using a microfluidic chip. |
| PubMed:Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. |
| PubMed:Isoliquiritigenin inhibits tumor growth and protects the kidney and liver against chemotherapy-induced toxicity in a mouse xenograft model of colon carcinoma. |
| PubMed:[Chemical constituents from Spatholobus sinensis]. |
| PubMed:[Studies on chemical constituents from stems and leaves of Adenanthera pavanina]. |
| PubMed:Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. |
| PubMed:Down-regulation of androgen-receptor and PSA by phytochemicals. |
| PubMed:Determination of nine active components in Radix Hedysari and Radix Astragali using capillary HPLC with diode array detection and MS detection. |
| PubMed:Estrogenic activities of isoflavones and flavones and their structure-activity relationships. |
| PubMed:Saireito probably prevents mesangial cell proliferation in HIGA mice via PDGF-BB tyrosine kinase inhibition. |
| PubMed:Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery. |
| PubMed:In vitro metabolism of isoliquiritigenin by human liver microsomes. |
| PubMed:Sites of alkylation of human Keap1 by natural chemoprevention agents. |
| PubMed:2-Hydroxyisoflavanone dehydratase is a critical determinant of isoflavone productivity in hairy root cultures of Lotus japonicus. |
| PubMed:Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. |
| PubMed:Simultaneous analysis of glycyrrhizin, paeoniflorin, quercetin, ferulic acid, liquiritin, formononetin, benzoic acid and isoliquiritigenin in the Chinese proprietary medicine Xiao Yao Wan by HPLC. |
| PubMed:Enzymatic effects on reactant and transition states. The case of chalcone isomerase. |
| PubMed:Crystal structure of Medicago truncatula UGT85H2--insights into the structural basis of a multifunctional (iso)flavonoid glycosyltransferase. |
| PubMed:[Relative adscriptions of components in the effective fractions of Yinqiao decoction and its composing individual herbs]. |
| PubMed:Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). |
| PubMed:Isoliquiritigenin (ISL) inhibits ErbB3 signaling in prostate cancer cells. |
| PubMed:Simultaneous quantification of multiple licorice flavonoids in rat plasma. |
| PubMed:Isoliquiritigenin inhibits IkappaB kinase activity and ROS generation to block TNF-alpha induced expression of cell adhesion molecules on human endothelial cells. |
| PubMed:Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide. |
| PubMed:Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappaB signal disruption. |
| PubMed:Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC. |
| PubMed:Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. |
| PubMed:Pathway engineering for healthy phytochemicals leading to the production of novel flavonoids in tomato fruit. |
| PubMed:Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation. |
| PubMed:Isoliquiritigenin selectively inhibits H(2) histamine receptor signaling. |
| PubMed:Quinone reductase induction as a biomarker for cancer chemoprevention. |
| PubMed:Antagonism of ethanol ataxia by intracerebellar nicotine: possible modulation by mouse cerebellar nitric oxide and cGMP. |
| PubMed:Isoliquiritigenin induces apoptosis by depolarizing mitochondrial membranes in prostate cancer cells. |
| PubMed:Protective effects of isoliquiritigenin in transient middle cerebral artery occlusion-induced focal cerebral ischemia in rats. |
| PubMed:Isoflavonoids and other compounds from Psorothamnus arborescens with antiprotozoal activities. |
| PubMed:Genista tinctoria hairy root cultures for selective production of isoliquiritigenin. |
| PubMed:Cyclooxygenase-2 plays a suppressive role for induction of apoptosis in isoliquiritigenin-treated mouse colon cancer cells. |
| PubMed:Norditerpenoid alkaloids and other components from the processed tubers of Aconitum carmichaeli. |
| PubMed:Two new isoflavonoids from Bowdichia virgilioides. |
| PubMed:Isoflavonoids isolated from Cuban propolis. |
| PubMed:CYP3A4 inhibitors isolated from Licorice. |
| PubMed:Binding of phytoestrogens to rat uterine estrogen receptors and human sex hormone-binding globulins. |
| PubMed:Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. |
| PubMed:Brazilian phytopharmaceuticals--evaluation against hospital bacteria. |
| PubMed:One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography. |
| PubMed:Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. |
| PubMed:Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. |
| PubMed:Cytotoxic allyl retrochalcone from the roots of Glycyrrhiza inflata. |
| PubMed:Effect of isoliquiritigenin on viability and differentiated functions of human hepatocytes maintained on PEEK-WC-polyurethane membranes. |
| PubMed:Isolation and synthesis of a dimeric dihydrochalcone from Agapanthus africanus. |
| PubMed:Isoliquiritigenin induces apoptosis and cell cycle arrest through p53-dependent pathway in Hep G2 cells. |
| PubMed:Cytotoxic flavonoids from Platymiscium floribundum. |
| PubMed:Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells. |
| PubMed:[Studies on chemical constituents of sini tang]. |
| PubMed:Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters. |
| PubMed:Chemical analysis of raw, dry-roasted, and honey-roasted licorice by capillary electrophoresis. |
| PubMed:Natural inhibitors of carcinogenesis. |
| PubMed:Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. |
| PubMed:Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer a549 cells. |
| PubMed:Chalcones as potent tyrosinase inhibitors: the effect of hydroxyl positions and numbers. |
| PubMed:Molecular cytotoxic mechanisms of anticancer hydroxychalcones. |
| PubMed:Transport, retention and fluorescent measurement of single biological cells studied in microfluidic chips. |
| PubMed:Isoliquiritigenin, a flavonoid from licorice, reduces prostaglandin E2 and nitric oxide, causes apoptosis, and suppresses aberrant crypt foci development. |
| PubMed:First bacterial chalcone isomerase isolated from Eubacterium ramulus. |
| PubMed:Induction of cell cycle arrest and p21(CIP1/WAF1) expression in human lung cancer cells by isoliquiritigenin. |
| PubMed:Cytoprotective effects of Glycyrrhizae radix extract and its active component liquiritigenin against cadmium-induced toxicity (effects on bad translocation and cytochrome c-mediated PARP cleavage). |
| PubMed:[Studies on chemical constituents from the root of Polygonatum kingianum]. |
| PubMed:New prenylated isoflavanones and other constituents of Lespedeza bicolor. |
| PubMed:The inhibitory effects of flavonoids and antiestrogens on the Glut1 glucose transporter in human erythrocytes. |
| PubMed:Flavonoids from Dalbergia louvelii and their antiplasmodial activity. |
| PubMed:[Studies on chemical constituents of Hedysarum polybotrys]. |
| PubMed:Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. |
| PubMed:Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria. |
| PubMed:Cloning, characterization and regulation of a family of phi class glutathione transferases from wheat. |
| PubMed:Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). |
| PubMed:Isoliquiritigenin inhibits the growth of prostate cancer. |
| PubMed:Legume natural products: understanding and manipulating complex pathways for human and animal health. |
| PubMed:Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. |
| PubMed:Estrogenic and antiproliferative activities of isoliquiritigenin in MCF7 breast cancer cells. |
| PubMed:Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. |
| PubMed:[Determination of three flavonoids and ferulic acid in Pleurospermum hookeri C. B. Clarke var. thomsonii C. B. Clarke by HPLC]. |
| PubMed:Isoliquiritigenin suppresses pulmonary metastasis of mouse renal cell carcinoma. |
| PubMed:Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora. |
| PubMed:Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. |
| PubMed:Chalcones: structural requirements for antioxidant, estrogenic and antiproliferative activities. |
| PubMed:Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis. |
| PubMed:Apoptosis induced by isoliquiritigenin in human gastric cancer MGC-803 cells. |
| PubMed:Estrogen-like activity of glabrene and other constituents isolated from licorice root. |
| PubMed:In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. |
| PubMed:Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography. |
| PubMed:Influence of natural and synthetic compounds on cell surface expression of cell adhesion molecules, ICAM-1 and VCAM-1. |
| PubMed:Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. |
| PubMed:A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. |
| PubMed:Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. |
| PubMed:Minor phenolics from Crinum bulbispermum bulbs. |
| PubMed:Inhibition of xanthine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis. |
| PubMed:Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug. |
| PubMed:An isoflavone from Pterocarpus santalinus. |
| PubMed:Migration behavior and separation of active components in Glycyrrhiza uralensis Fisch and its commercial extract by micellar electrokinetic capillary chromatography. |
| PubMed:Seasonal variation of glycyrrhizin and isoliquiritigenin glycosides in the root of Glycyrrhiza glabra L. |
| PubMed:Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. |
| PubMed:Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera. |
| PubMed:Anthocyanin-producing dandelion callus as a chalcone synthase source in recombinant polyketide reductase assay. |
| PubMed:Cardiac effects of isoliquiritigenin. |
| PubMed:Differential effects of isoliquiritigenin and YC-1 in rat aortic smooth muscle. |
| PubMed:Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures. |
| PubMed:Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. |
| PubMed:Antitumorigenic activities of chalcones. I. Inhibitory effects of chalcone derivatives on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoyl-phorbol 13-acetate (TPA). |
| PubMed:Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro. |
| PubMed:Reaction mechanisms of homodimeric plant polyketide synthase (stilbenes and chalcone synthase). A single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones, and 6'-deoxychalcones. |
| PubMed:Vasorelaxant effect of isoliquiritigenin, a novel soluble guanylate cyclase activator, in rat aorta. |
| PubMed:Molecular characterization and expression of alfalfa isoliquiritigenin 2'-O-methyltransferase, an enzyme specifically involved in the biosynthesis of an inducer of Rhizobium meliloti nodulation genes. |
| PubMed:Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside. |
| PubMed:Enzymatic synthesis of 6'-deoxychalcone in cultured Glycyrrhiza echinata cells. |
| PubMed:Inhibitory effects of some natural products on the activation of hyaluronidase and their anti-allergic actions. |
| PubMed:Isoliquiritigenin, a strong nod gene- and glyceollin resistance-inducing flavonoid from soybean root exudate. |
| PubMed:Anti-platelet action of isoliquiritigenin, an aldose reductase inhibitor in licorice. |
| PubMed:Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.). |
| PubMed:The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy. |
| PubMed:Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes. |
| PubMed:Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins. |
| PubMed:Induced plant responses to pathogen attack. Analysis and heterologous expression of the key enzyme in the biosynthesis of phytoalexins in soybean (Glycine max L. Merr. cv. Harosoy 63). |
| PubMed:The potent anti-tumor-promoting agent isoliquiritigenin. |
| PubMed:[Quality evaluation of Chinese licorice]. |
| PubMed:Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. |
| PubMed:Phytoalexin synthesis in soybean cells: elicitor induction of reductase involved in biosynthesis of 6'-deoxychalcone. |
| PubMed:NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract. |
| PubMed:Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. |
| PubMed:Metabolism and excretion of butein, 2',3,4-trihydroxychalcone, 3-O-methylbutein, 4-O-methylbutein and 2',4',4-trihydroxychalcone in the rat. |
| PubMed:Mutagenicities of 61 flavonoids and 11 related compounds. |
| PubMed:Regulation of Phytoalexin Synthesis in Jackbean Callus Cultures: Stimulation of Phenylalanine Ammonia-Lyase and o-Methyltransferase. |
| PubMed:Purification and kinetic properties of chalcone-flavanone isomerase from soya bean. |
| PubMed:The peroxidase-catalysed oxidation of a chalcone and its possible physiological significance. |
3D/inchi