EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes


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CAS Number: 17650-84-9Picture of molecule3D/inchi
FDA UNII: 4056D20K3H
Nikkaji Web:J254.147E
XlogP3-AA:-0.90 (est)
Molecular Weight:594.52410000
Formula:C27 H30 O15
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 2285 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
skin conditioning - emollient
skin protecting agents
Alfa Biotechnology
For experimental / research use only.
Nicotiflorin 98%
BOC Sciences
For experimental / research use only.
Nicotiflorin 0.985
Odor: characteristic
Use: Nicotiflorin isolated from the herb of Carthamus tinctorius L.
For experimental / research use only.
Kaempferol-3-O-rutinoside (HPLC) ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Kaempferol 3-O-β -rutinoside ≥98.0% (HPLC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
natural substances and extractives
Recommendation for nictoflorin usage levels up to:
 not for fragrance use.
Recommendation for nictoflorin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5318767
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5318767
Pubchem (sid):135231896
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 anise star anise fruit
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 apricot leaf
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 basil leaf
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 bay laurel leaf
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 bean black bean shoot
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 caper flower
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 cotton plant
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 currant black currant fruit juice
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 fig fruit
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 ginkgo biloba leaf
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 pear plant
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 soybean leaf
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 soybean shoot
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 tea leaf
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4H-1-benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
 kaempferol 3-O-rutinose


PubMed:In-time and in-space tandem mass spectrometry to determine the metabolic profiling of flavonoids in a typical sweet cherry (Prunus avium L.) cultivar from Southern Italy.
PubMed:[Study of screening nephroprotective bioactive substances based on triple-color fluorescence probes in Carthami flos].
PubMed:A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells.
PubMed:A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves.
PubMed:Quality evaluation of Carthami Flos by HPLC-UV.
PubMed:Stress-responsive hydroxycinnamate glycosyltransferase modulates phenylpropanoid metabolism in Populus.
PubMed:Chemical composition and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching.
PubMed:Antiangiogenic activity of flavonoids from Melia azedarach.
PubMed:Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L.
PubMed:Metabolomic analysis of the polyphenols in germinating mung beans (Vigna radiata) seeds and sprouts.
PubMed:Bioactive components from flowers of Sambucus nigra L. increase glucose uptake in primary porcine myotube cultures and reduce fat accumulation in Caenorhabditis elegans.
PubMed:Flavonoids with acetylated branched glycans and bioactivity of Tipuana tipu (Benth.) Kuntze leaf extract.
PubMed:Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea.
PubMed:Linkage mapping, molecular cloning and functional analysis of soybean gene Fg2 encoding flavonol 3-O-glucoside (1 → 6) rhamnosyltransferase.
PubMed:Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities.
PubMed:Extraction, gas chromatography-mass spectrometry analysis and screening of fruits of Terminalia chebula Retz. for its antimicrobial potential.
PubMed:Developmental effects on phenolic, flavonol, anthocyanin, and carotenoid metabolites and gene expression in potatoes.
PubMed:Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.
PubMed:Light gazpachos contain higher phytochemical levels than conventional gazpachos.
PubMed:Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation.
PubMed:Phytochemical composition of Potentilla anserina L. analyzed by an integrative GC-MS and LC-MS metabolomics platform.
PubMed:Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts.
PubMed:A new ent-kaurane diterpenoid glycoside from Isodon japonica var. glaucocalyx.
PubMed:The influence of Bauhinia forficata Link subsp. pruinosa tea on lipid peroxidation and non-protein SH groups in human erythrocytes exposed to high glucose concentrations.
PubMed:Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke.
PubMed:Yeast α-glucosidase inhibitory phenolic compounds isolated from Gynura medica leaf.
PubMed:Simultaneous quantification and validation of caffeoylquinic acids and flavonoids in Hemistepta lyrata and peroxynitrite-scavenging activity.
PubMed:An optimized method for analysis of phenolic compounds in buds, leaves, and fruits of black currant ( Ribes nigrum L.).
PubMed:On line characterization of 58 phenolic compounds in Citrus fruit juices from Spanish cultivars by high-performance liquid chromatography with photodiode-array detection coupled to electrospray ionization triple quadrupole mass spectrometry.
PubMed:Quality control and analytical test method for Taxus baccata tincture preparation.
PubMed:Nicotiflorin, rutin and chlorogenic acid: phenylpropanoids involved differently in quantitative resistance of potato tubers to biotrophic and necrotrophic pathogens.
PubMed:[Study on flavonoid chemical constituents contained in Memorialis hirta].
PubMed:Synthesis and antiglycation activity of kaempferol-3-O-rutinoside (nicotiflorin).
PubMed:Antihyperlipidemic components of Cassia auriculata aerial parts: identification through in vitro studies.
PubMed:Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action.
PubMed:Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal.
PubMed:Stability of the phenolic and carotenoid profile of gazpachos during storage.
PubMed:New acylated anthocyanins and other flavonoids from the red flowers of Clematis cultivars.
PubMed:Potent antiviral flavone glycosides from Ficus benjamina leaves.
PubMed:Phenolic composition and antioxidant activity of aqueous infusions from Capparis spinosa L. and Crithmum maritimum L. before and after submission to a two-step in vitro digestion model.
PubMed:Antioxidant flavonol glycosides from Elaeocarpus serratus and Filicium decipiens.
PubMed:Bioactivities of Chuquiraga straminea sandwith.
PubMed:A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt.
PubMed:[Study on chemical constituents from leaves of Naudea officinalis].
PubMed:Isolation and identification of phenolic compounds from Gynura divaricata leaves.
PubMed:[Aromatic constituents of Heteroplexis micocephal and their bioactivities].
PubMed:A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside.
PubMed:Production of flavonoids in organogenic cultures of Alpinia zerumbet.
PubMed:Sap phytochemical compositions of some bananas in Thailand.
PubMed:Extracts from the Mongolian traditional medicinal plants Dianthus versicolorFisch. and Lilium pumilum Delile stimulate bile flow in an isolated perfused rat liver model.
PubMed:Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook.
PubMed:Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma.
PubMed:Flavonoid glycosides from the leaves of Cissus ibuensis hook (vitaceae).
PubMed:Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC-DAD-ESI-MS.
PubMed:[Quality evaluation of Flos Carthami].
PubMed:Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 cells.
PubMed:Tronchuda cabbage (Brassica oleracea L. var. costata DC): scavenger of reactive nitrogen species.
PubMed:Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum.
PubMed:Quali-quantitative analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits.
PubMed:[Glycosides from flowers of Jasminum officinale L. var. grandiflorum].
PubMed:Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.
PubMed:Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana.
PubMed:Phenolic profile of Cydonia oblonga Miller leaves.
PubMed:Chemical constituents from leaves of Celastrus gemmatus Loes.
PubMed:Platelet-activating factor (PAF) receptor binding antagonist activity of the methanol extracts and isolated flavonoids from Chromolaena odorata (L.) King and Robinson.
PubMed:Experimental design for extraction and quantification of phenolic compounds and organic acids in white "Vinho Verde" grapes.
PubMed:In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves.
PubMed:Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana.
PubMed:Antioxidant compounds from Ebenus pinnata.
PubMed:Cytotoxic C-benzylated chalcone and other constituents of Ellipeiopsis cherrevensis.
PubMed:Determination of flavonoids and phenolics and their distribution in almonds.
PubMed:Antioxidant polyphenols in almond and its coproducts.
PubMed:Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.
PubMed:Topical anti-inflammatory activity of Solenostemma argel leaves.
PubMed:[Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].
PubMed:Phenylpropanoids, phenylalanine ammonia lyase and peroxidases in elicitor-challenged cassava (Manihot esculenta) suspension cells and leaves.
PubMed:Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste.
PubMed:Phytochemical constituents of the aerial parts from Solidago virga-aurea var. gigantea.
PubMed:Phytochemical constituents from Diodia teres.
PubMed:Metabolite profiling of tomato (Lycopersicon esculentum) using 1H NMR spectroscopy as a tool to detect potential unintended effects following a genetic modification.
PubMed:Characterization and content of flavonoid glycosides in genetically modified tomato (Lycopersicon esculentum) fruits.
PubMed:Study of the collision-induced radical cleavage of flavonoid glycosides using negative electrospray ionization tandem quadrupole mass spectrometry.
PubMed:Difference in flavonoid and isoflavone profile between soybean and soy leaf.
PubMed:[Studies on chemical components of Carthamus tinctorius petals].
PubMed:Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols.
PubMed:Flavonoids and phenylpropanoid derivatives from Campanula barbata.
PubMed:New jujubogenin glycosides from Colubrina asiatica.
PubMed:Antimicrobial constituents of the leaves of Acalypha wilkesiana and Aacalypha hispida.
PubMed:Triterpene saponins from Randia formosa.
PubMed:Flavonoids from Goodyera schlechtendaliana.
PubMed:Antimicrobial activity of Mitracarpus scaber extract and isolated constituents.
PubMed:Antioxidant properties of flavonol glycosides from green beans.
PubMed:Flavonol glycosides from cassia hirsuta
PubMed:Antibacterial and chemical evaluation of Chromolaena moritziana.
PubMed:Identification and quantitative analysis of phenolic compounds from the dry extract of Hedera helix.
PubMed:Cyanogenic and non-cyanogenic glycosides from Manihot esculenta.
PubMed:Saponins from leaves of Acanthopanax sieboldianus.
PubMed:Karsoside and scropolioside D, two new iridoid glycosides from Scrophularia ilwensis.
PubMed:[Glycosides of phenolic acid and flavonoids from the leaves of Glycyrrhiza uralensis Ficsh].
PubMed:[Flavonoids in the flowers of Primula officinalis].
None found
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