hypochlorous acid
an oxyacid of chlorine (hclo) containing monovalent chlorine that acts as an oxidizing or reducing agent.
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hypochlorous acid (Click)
CAS Number: 7790-92-3Picture of molecule
Other: 1338439-06-7
ECHA EINECS - REACH Pre-Reg: 232-232-5
Nikkaji Web: J202.839E
XlogP3-AA: 0.30 (est)
Molecular Weight: 52.45917000
Formula: Cl H O
NMR Predictor: Predict (works with chrome or firefox)
Category: antiseborrhoeic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 0.710 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antiseborrhoeic agents
oxidising agents
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antiseborrhoeic agents
Recommendation for hypochlorous acid usage levels up to:
 not for fragrance use.
Recommendation for hypochlorous acid flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 7790-92-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 24341
National Institute of Allergy and Infectious Diseases: Data
 hypochlorous acid
Chemidplus: 0007790923
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 hypochlorous acid
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 24341
Pubchem (sid): 134989347
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): C19697
HMDB (The Human Metabolome Database): Search
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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PubMed: C-phycocyanin prevents cisplatin-induced nephrotoxicity through inhibition of oxidative stress.
PubMed: Advanced oxidation protein products are generated by bovine neutrophils and inhibit free radical production in vitro.
PubMed: 4-methylcoumarin derivatives inhibit human neutrophil oxidative metabolism and elastase activity.
PubMed: Protection of flavonoids against hypochlorite-induced protein modifications.
PubMed: Antioxidant activity and inhibitory effects of lead (Leucaena leucocephala) seed extracts against lipid oxidation in model systems.
PubMed: Phytochemical profile of a blend of black chokeberry and lemon juice with cholinesterase inhibitory effect and antioxidant potential.
PubMed: Carotenoids and phenolic compounds from Solanum sessiliflorum, an unexploited Amazonian fruit, and their scavenging capacities against reactive oxygen and nitrogen species.
PubMed: Discrimination of infectious hepatitis A viruses by propidium monoazide real-time RT-PCR.
PubMed: Antiviral activity of Ecasol against feline calicivirus, a surrogate of human norovirus.
PubMed: Sensitive and simple determination of bromate in foods disinfected with hypochlorite reagents using high performance liquid chromatography with post-column derivatization.
PubMed: Scavenging capacity of marine carotenoids against reactive oxygen and nitrogen species in a membrane-mimicking system.
PubMed: Microbicidal effect of weak acid hypochlorous solution on various microorganisms.
PubMed: Antioxidant characteristics of extracts from cereal residues by their subcritical water treatment.
PubMed: Hypohalous acid-mediated halogenation of resveratrol and its role in antioxidant and antimicrobial activities.
PubMed: Semicarbazide in selected bird's nest products.
PubMed: Enhanced inactivation of Salmonella and Pseudomonas biofilms on stainless steel by use of T-128, a fresh-produce washing aid, in chlorinated wash solutions.
PubMed: New beverages of lemon juice enriched with the exotic berries maqui, açaı́, and blackthorn: bioactive components and in vitro biological properties.
PubMed: Transmission electron microscopic analysis showing structural changes to bacterial cells treated with electrolyzed water and an acidic sanitizer.
PubMed: Laccase- and chloroperoxidase-nanotube paint composites with bactericidal and sporicidal activity.
PubMed: Effect of anolyte on background microflora, Salmonella, and Listeria monocytogenes on catfish fillets.
PubMed: Protective Effect of γ-Irradiation Against Hypochlorous Acid-Induced Haemolysis in Human Erythrocytes.
PubMed: The real-time-based assessment of the microbial killing by the antimicrobial compounds of neutrophils.
PubMed: Comparison of different washing treatments for reducing pathogens on orange surfaces and for preventing the transfer of bacterial pathogens to fresh-squeezed orange juice.
PubMed: Amelioration of collagen-induced arthritis by Salix nigra bark extract via suppression of pro-inflammatory cytokines and oxidative stress.
PubMed: Antioxidant activity of flavonoids evaluated with myoglobin method.
PubMed: The antioxidant protection of CELLFOOD against oxidative damage in vitro.
PubMed: Hydrogen [corrected] peroxide-dependent photocytotoxicity by phloxine B, a xanthene-type food colorant.
PubMed: Formation of semicarbazide upon hypochlorous acid treatment of nitrogen containing compounds.
PubMed: Effects of slightly acidic electrolysed drinking water on mice.
PubMed: Hypochlorous and peracetic acid induced oxidation of dairy proteins.
PubMed: Inhibitory activities of soluble and bound millet seed phenolics on free radicals and reactive oxygen species.
PubMed: Hypochlorous acid scavenging activities of thioallyl compounds from garlic.
PubMed: Microbicidal and cytotoxic effects of functional water in vitro.
PubMed: Antimicrobial effects of hypochlorite on Escherichia coli in water and selected vegetables.
PubMed: Effectiveness of low concentration electrolyzed water to inactivate foodborne pathogens under different environmental conditions.
PubMed: Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application.
PubMed: Modulating effect of flavonoids and their derivatives on sarcoplasmic reticulum Ca2+-ATPase oxidized by hypochloric acid and peroxynitrite.
PubMed: Mitigation of Alicyclobacillus spp. spores on food contact surfaces with aqueous chlorine dioxide and hypochlorite.
PubMed: Semicarbazide is non-specific as a marker metabolite to reveal nitrofurazone abuse as it can form under Hofmann conditions.
PubMed: Protective effect of isorhamnetin 3-O-beta-D-glucopyranoside from Salicornia herbacea against oxidation-induced cell damage.
PubMed: Hypochlorite treatments are not a significant source of perchlorate exposure in lettuce.
PubMed: Pieris brassicae inhibits xanthine oxidase.
PubMed: Hypochlorite-induced oxidation of dairy proteins: impact of pH and oxidant concentration.
PubMed: Antioxidant activity, ascorbic acid and total phenol of exotic fruits occurring in Brazil.
PubMed: Targeted metabolite analysis and antioxidant potential of Rumex induratus.
PubMed: Galloylated catechins as potent inhibitors of hypochlorous acid-induced DNA damage.
PubMed: Identification and antioxidant activity of melanin isolated from Hypoxylon archeri, a companion fungus of Tremella fuciformis.
PubMed: New C-deoxyhexosyl flavones and antioxidant properties of Passiflora edulis leaf extract.
PubMed: Reduction of bacteria on spinach, lettuce, and surfaces in food service areas using neutral electrolyzed oxidizing water.
PubMed: Locations of hypochlorite oxidation in corn starches varying in amylose content.
PubMed: New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol.
PubMed: S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK(1) cells of potassium dichromate-induced toxicity.
PubMed: Proteomic analysis of a hypochlorous acid-tolerant Listeria monocytogenes cultural variant exhibiting enhanced biofilm production.
PubMed: Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
PubMed: Phenolic compounds, organic acids profiles and antioxidative properties of beefsteak fungus (Fistulina hepatica).
PubMed: Investigation of pathways of advanced glycation end-products accumulation in macrophages.
PubMed: Comparison of rinsing and sanitizing procedures for reducing bacterial pathogens on fresh cantaloupes and bell peppers.
PubMed: Reaction pathways of the diketonitrile degradate of isoxaflutole with hypochlorite in water.
PubMed: Estrogenic activity of the chlorinated derivatives of estrogens and flavonoids using a GFP expression system.
PubMed: Mechanisms of actions of sodium hypochlorite in cleaning and disinfection processes.
PubMed: Hypochlorous acid-derived modification of phospholipids: characterization of aminophospholipids as regulatory molecules for lipid peroxidation.
PubMed: Study on inactivation kinetics of hepatitis A virus and enteroviruses with peracetic acid and chlorine. New ICC/PCR method to assess disinfection effectiveness.
PubMed: Protective effect of Ugni molinae Turcz against oxidative damage of human erythrocytes.
PubMed: Characterization of the microbial flora in disinfecting footbaths with hypochlorite.
PubMed: Structural characteristics and physicochemical properties of oxidized corn starches varying in amylose content.
PubMed: Antioxidant screening of medicinal herbal teas.
PubMed: Investigation into the resistance of lactoperoxidase tolerant Escherichia coli mutants to different forms of oxidative stress.
PubMed: Inactivation of Escherichia coli O157:H7 in biofilm on stainless steel by treatment with an alkaline cleaner and a bacteriophage.
PubMed: 5,5-Dimethyl-2-pyrrolidone-N-oxyl formation in electron spin resonance studies of electrolyzed NaCl solution using 5,5-dimethyl-1-pyrroline-N-oxide as a spin trapping agent.
PubMed: [Semicarbazide in food].
PubMed: Antioxidant activity of A-type proanthocyanidins from Geranium niveum (Geraniaceae).
PubMed: Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation.
PubMed: Comparison of the inhibition of myeloperoxidase-catalyzed hypochlorite formation in vitro and in whole blood by different plant extracts contained in a phytopharmacon treating functional dyspepsia.
PubMed: Hypochlorite inactivation kinetics of Listeria monocytogenes in phosphate buffer.
PubMed: Efficacy of chlorine dioxide gas as a sanitizer of lettuce leaves.
PubMed: Internalization of bacterial pathogens in tomatoes and their control by selected chemicals.
PubMed: Hypochlorite scavenging activity of flavonoids.
PubMed: Renibacterium salmoninarum: effect of hypochlorite treatment, and survival in water.
PubMed: Formation of semicarbazide (SEM) in food by hypochlorite treatment: is SEM a specific marker for nitrofurazone abuse?
PubMed: Degradation of isoxaflutole (balance) herbicide by hypochlorite in tap water.
PubMed: Isolation and identification of terpene chlorohydrins found in cold-pressed orange oil.
PubMed: Infectivity of RNA from inactivated poliovirus.
PubMed: Capsid functions of inactivated human picornaviruses and feline calicivirus.
PubMed: Scavenging property of three cresol isomers against H2O2, hypochlorite, superoxide and hydroxyl radicals.
PubMed: Development of a standard test to assess the resistance of Staphylococcus aureus biofilm cells to disinfectants.
PubMed: Antioxidative properties of cardoon (Cynara cardunculus L.) infusion against superoxide radical, hydroxyl radical, and hypochlorous acid.
PubMed: Mechanisms contributing to hypochlorous acid resistance of a Salmonella isolate from a poultry-processing plant.
PubMed: Decontamination of aflatoxin-forming fungus and elimination of aflatoxin mutagenicity with electrolyzed NaCl anode solution.
PubMed: Melatonin in plants.
PubMed: The physiological role and pharmacological potential of nitric oxide in neutrophil activation.
PubMed: Biofilm formation by salmonella spp. on food contact surfaces and their sensitivity to sanitizers.
PubMed: Ultraviolet spectrophotometric characterization and bactericidal properties of electrolyzed oxidizing water as influenced by amperage and pH.
PubMed: Survival of Yersinia enterocolitica and mesophilic aerobic bacteria on eggshell after washing with hypochlorite and organic acid solutions.
PubMed: Efficacy of novel organic acid and hypochlorite treatments for eliminating Escherichia coli O157:H7 from alfalfa seeds prior to sprouting.
PubMed: The effectiveness of hygiene procedures for prevention of cross-contamination from chicken carcases in the domestic kitchen.
PubMed: Antioxidant and other biological activities of olive mill waste waters.
PubMed: Effectiveness of various disinfectants in the elimination of Yersinia enterocolitica on fresh lettuce.
PubMed: Isolation of Salmonella resistant to hypochlorous acid from a poultry abattoir.
PubMed: Rapid monitoring method to assess efficacy of sanitizers against Pseudomonas putida biofilms.
PubMed: Acid adaptation sensitizes Salmonella typhimurium to hypochlorous acid.
PubMed: Nutrition and health aspects of free radicals and antioxidants.
PubMed: Evaluation of the antioxidant actions of ferulic acid and catechins.
PubMed: An assessment of cleaning and sampling methods for food-contact surfaces in premises preparing and selling high-risk foods.
PubMed: In vivo bioluminescence: a cellular reporter for research and industry.
PubMed: Reactions of aqueous chlorine and chlorine dioxide with model food compounds.
PubMed: Use of nitrite and hypochlorite treatments in determination of the contributions of IQ-type and non-IQ-type heterocyclic amines to the mutagenicities in crude pyrolyzed materials.
PubMed: Oxidative inactivation of ethylenethiourea by hypochlorite in alkaline medium.
PubMed: Methods in coccidiosis research: separation of oocysts from faeces.
PubMed: The effects of various treatments on the microbial flora of whole poultry carcasses with particular reference to Staphylococcus aureus contamination.
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