dithiothreitol
2,3-butanediol, 1,4-dimercapto-, (R-(R*,R*))- (9CI)

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  BOC Sciences

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  CODE168465 CODE168465
  Product(s):
  3483-12-3 1,4-Dithio-DL-threitol,Threo-1,4-dimercapto-2,3-butandiol,Threo-2,3-dihydroxy-1,4-dithiobutane,1,4-Dithiothreitol,Cleland's reagent,DTT

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  Charkit Chemical Corporation

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  Product(s):
  DITHIOTHREITOL

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  GC1199 DL-Dithiothreitol, 99%

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  Product(s):
  D1071 DL-Dithiothreitol >98.0%(T)
  SDS

CAS Number: 3483-12-3 3D/inchi Other(deleted CASRN): 1377983-58-8 ECHA EINECS - REACH Pre-Reg: 222-468-7 FDA UNII: T8ID5YZU6Y Nikkaji Web: J307.897C Beilstein Number: 1719757 MDL: MFCD00004877 XlogP3-AA: -0.40 (est) Molecular Weight: 154.25210000 Formula: C4 H10 O2 S2 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:cosmetic agents   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 42.50 °C. @ 760.00 mm Hg Boiling Point: 364.50 °C. @ 760.00 mm Hg (est) Flash Point: 346.00 °F. TCC ( 174.20 °C. ) (est) logP (o/w): 0.070 (est) Soluble in:   water, 1.856e+005 mg/L @ 25 °C (est)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: CosIng: cosmetic data Cosmetic Uses: hair straightening agents hair waving agents reducing agents   Suppliers: BOC Sciences For experimental / research use only. 1,4-Dithio-DL-threitol,Threo-1,4-dimercapto-2,3-butandiol,Threo-2,3-dihydroxy-1,4-dithiobutane,1,4-Dithiothreitol,Cleland's reagent,DTT Charkit Chemical DITHIOTHREITOL Glentham Life Sciences DL-Dithiothreitol, 99% Sigma-Aldrich: Aldrich For experimental / research use only. DL-Dithiothreitol sds TCI AMERICA For experimental / research use only. DL-Dithiothreitol >98.0%(T) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intramuscular-mouse LD50 108 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949. intraperitoneal-mouse LD50 154 mg/kg Yakugaku Zasshi. Journal of Pharmacy. Vol. 94, Pg. 1419, 1974. Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: cosmetic agents Recommendation for dithiothreitol usage levels up to:   not for fragrance use.   Recommendation for dithiothreitol flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):3483-12-3 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :19001 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 1,4-bis(sulfanyl)butane-2,3-diol Chemidplus:0003483123 RTECS:EK1610000 for cas# 3483-12-3   References:   1,4-bis(sulfanyl)butane-2,3-diol NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 3483-12-3 Pubchem (cid): 19001 Pubchem (sid): 134985466   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C00265 HMDB (The Human Metabolome Database): HMDB13593 FooDB: FDB029593 YMDB (Yeast Metabolome Database): YMDB01407 Export Tariff Code: 2930.90.9190 ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: 2,3- butanediol, 1,4-dimercapto- 2,3- butanediol, 1,4-dimercapto-, (R-(R*,R*))- (9CI) 2,3- butanediol, 1,4-dimercapto-, (R*,R*)- 2,3- butanediol, 1,4-dimercapto-, DL-threo- 2,3- butanediol, 1,4-dimercapto, (R*,R*)- threo-2,3- dihydroxy-1,4-butanedithiol (±)-1,4- dimercapto-2,3-butanediol (±)-threo-1,4- dimercapto-2,3-butanediol (R*,R*)-(±)-1,4- dimercapto-2,3-butanediol (R*,R*)-1,4- dimercapto-2,3-butanediol 1,4- dimercapto-2,3-butanediol DL-theo-1,4- dimercapto-2,3-butanediol threo-1,4- dimercapto-2,3-butanediol (R-(R*,R*))-1,4- dimercaptobutane-2,3-diol (R*,R*)-(1)-1,4- dimercaptobutane-2,3-diol (R*,R*)-1,4- dimercaptobutane-2,3-diol [R-(R*,R*)]-1,4- dimercaptobutane-2,3-diol 1,4- dimercaptobutane-2,3-diol 1,4- disulfanyl-2,3-butanediol 1,4- disulfanyl-2,3-butanediol, DL, threo- 1,4- disulfanylbutane-2,3-diol 1,4- dithio-DL-threitol 1,4- dithioerythritol (±)- dithiothreitol 1,4- dithiothreitol DL- dithiothreitol DL-1,4- dithiothreitol   erythritol, 1,4-dithio-   erythro-1,4-dimercapto-2,3-butanediol 1,4-bis( sulfanyl)butane-2,3-diol 1,4-bis sulfanylbutane-2,3-diol   threitol, 1,4-dithio-, DL-   Articles:   None found yet. Try the PubMed Search.

Notes: a reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of sh (thiol) groups and for reducing disulphides to dithiols. Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT has an epimeric compound, dithioerythritol. A common use of DTT is as a reducing or "deprotecting" agent for thiolated DNA. DTT is frequently used to reduce the disulfide bonds of proteins and, more generally, to prevent intramolecular and intermolecular disulfide bonds from forming between cysteine residues of proteins.